Cost-effective fabrication of photopolymer molds with multi-level microstructures for pdms microfluidic device manufacture

Autores
Olmos Carreno, Carol Maritza; Penãherrera, Ana; Rosero Yánez, Gustavo Ivan; Vizuete, Karla; Ruarte, Darío; Follo, Marie; Vaca Mora, Andrea Vanessa; Arroyo, Carlos R.; Debut, Alexis; Cumbal Flores, Luis; Perez, Maximiliano Sebastian; Lerner, Betiana; Mertelsmann, Roland
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This paper describes a methodology of photopolymer mold fabrication with multi-level microstructures for polydimethylsiloxane (PDMS) microfluidic device manufacture. Multi-level microstructures can be performed by varying UVA exposure time and channel width. Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM) and profilometry techniques have been employed to characterize the molds. Multiple molds with multi-level microstructures can be formed in a unique piece. Overall height/depth of the structures reaches up to 677 μm and a minimum of 21 μm. The method provides several advantages such as reduction of fabrication time, multiple structures with diverse topologies, a great variety of depth and height in a single mold and low cost of fabrication. The effectiveness of multi-level microstructure fabrication was evaluated by constructing PDMS microfluidic devices for cell culture and proliferation.
Fil: Olmos Carreno, Carol Maritza. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Penãherrera, Ana. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Albert Ludwigs University of Freiburg; Alemania
Fil: Rosero Yánez, Gustavo Ivan. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Albert Ludwigs University of Freiburg; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vizuete, Karla. Universidad de Las Fuerzas Armadas; Ecuador
Fil: Ruarte, Darío. Albert Ludwigs University of Freiburg; Alemania
Fil: Follo, Marie. Albert Ludwigs University of Freiburg; Alemania
Fil: Vaca Mora, Andrea Vanessa. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Arroyo, Carlos R.. Universidad de Las Fuerzas Armadas; Ecuador
Fil: Debut, Alexis. Universidad de Las Fuerzas Armadas; Ecuador
Fil: Cumbal Flores, Luis. Universidad de Las Fuerzas Armadas; Ecuador
Fil: Perez, Maximiliano Sebastian. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Florida International University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lerner, Betiana. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Florida International University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mertelsmann, Roland. Albert Ludwigs University of Freiburg; Alemania
Materia
MULTI-LEVEL MICROESTRUCTURE
PDMS
FLEX
MICROFLUIDICA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/145893
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/145893
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cost-effective fabrication of photopolymer molds with multi-level microstructures for pdms microfluidic device manufactureOlmos Carreno, Carol MaritzaPenãherrera, AnaRosero Yánez, Gustavo IvanVizuete, KarlaRuarte, DaríoFollo, MarieVaca Mora, Andrea VanessaArroyo, Carlos R.Debut, AlexisCumbal Flores, LuisPerez, Maximiliano SebastianLerner, BetianaMertelsmann, RolandMULTI-LEVEL MICROESTRUCTUREPDMSFLEXMICROFLUIDICAhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2This paper describes a methodology of photopolymer mold fabrication with multi-level microstructures for polydimethylsiloxane (PDMS) microfluidic device manufacture. Multi-level microstructures can be performed by varying UVA exposure time and channel width. Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM) and profilometry techniques have been employed to characterize the molds. Multiple molds with multi-level microstructures can be formed in a unique piece. Overall height/depth of the structures reaches up to 677 μm and a minimum of 21 μm. The method provides several advantages such as reduction of fabrication time, multiple structures with diverse topologies, a great variety of depth and height in a single mold and low cost of fabrication. The effectiveness of multi-level microstructure fabrication was evaluated by constructing PDMS microfluidic devices for cell culture and proliferation.Fil: Olmos Carreno, Carol Maritza. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Penãherrera, Ana. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Albert Ludwigs University of Freiburg; AlemaniaFil: Rosero Yánez, Gustavo Ivan. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Albert Ludwigs University of Freiburg; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vizuete, Karla. Universidad de Las Fuerzas Armadas; EcuadorFil: Ruarte, Darío. Albert Ludwigs University of Freiburg; AlemaniaFil: Follo, Marie. Albert Ludwigs University of Freiburg; AlemaniaFil: Vaca Mora, Andrea Vanessa. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Arroyo, Carlos R.. Universidad de Las Fuerzas Armadas; EcuadorFil: Debut, Alexis. Universidad de Las Fuerzas Armadas; EcuadorFil: Cumbal Flores, Luis. Universidad de Las Fuerzas Armadas; EcuadorFil: Perez, Maximiliano Sebastian. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Florida International University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lerner, Betiana. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Florida International University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mertelsmann, Roland. Albert Ludwigs University of Freiburg; AlemaniaRoyal Society of Chemistry2020-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/145893Olmos Carreno, Carol Maritza; Penãherrera, Ana; Rosero Yánez, Gustavo Ivan; Vizuete, Karla; Ruarte, Darío; et al.; Cost-effective fabrication of photopolymer molds with multi-level microstructures for pdms microfluidic device manufacture; Royal Society of Chemistry; RSC Advances; 10; 7; 1-2020; 4071-40792046-2069CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2020/RA/C9RA07955Finfo:eu-repo/semantics/altIdentifier/doi/10.1039/C9RA07955Finfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:32Zoai:ri.conicet.gov.ar:11336/145893instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:32.294CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cost-effective fabrication of photopolymer molds with multi-level microstructures for pdms microfluidic device manufacture
title Cost-effective fabrication of photopolymer molds with multi-level microstructures for pdms microfluidic device manufacture
spellingShingle Cost-effective fabrication of photopolymer molds with multi-level microstructures for pdms microfluidic device manufacture
Olmos Carreno, Carol Maritza
MULTI-LEVEL MICROESTRUCTURE
PDMS
FLEX
MICROFLUIDICA
title_short Cost-effective fabrication of photopolymer molds with multi-level microstructures for pdms microfluidic device manufacture
title_full Cost-effective fabrication of photopolymer molds with multi-level microstructures for pdms microfluidic device manufacture
title_fullStr Cost-effective fabrication of photopolymer molds with multi-level microstructures for pdms microfluidic device manufacture
title_full_unstemmed Cost-effective fabrication of photopolymer molds with multi-level microstructures for pdms microfluidic device manufacture
title_sort Cost-effective fabrication of photopolymer molds with multi-level microstructures for pdms microfluidic device manufacture
dc.creator.none.fl_str_mv Olmos Carreno, Carol Maritza
Penãherrera, Ana
Rosero Yánez, Gustavo Ivan
Vizuete, Karla
Ruarte, Darío
Follo, Marie
Vaca Mora, Andrea Vanessa
Arroyo, Carlos R.
Debut, Alexis
Cumbal Flores, Luis
Perez, Maximiliano Sebastian
Lerner, Betiana
Mertelsmann, Roland
author Olmos Carreno, Carol Maritza
author_facet Olmos Carreno, Carol Maritza
Penãherrera, Ana
Rosero Yánez, Gustavo Ivan
Vizuete, Karla
Ruarte, Darío
Follo, Marie
Vaca Mora, Andrea Vanessa
Arroyo, Carlos R.
Debut, Alexis
Cumbal Flores, Luis
Perez, Maximiliano Sebastian
Lerner, Betiana
Mertelsmann, Roland
author_role author
author2 Penãherrera, Ana
Rosero Yánez, Gustavo Ivan
Vizuete, Karla
Ruarte, Darío
Follo, Marie
Vaca Mora, Andrea Vanessa
Arroyo, Carlos R.
Debut, Alexis
Cumbal Flores, Luis
Perez, Maximiliano Sebastian
Lerner, Betiana
Mertelsmann, Roland
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MULTI-LEVEL MICROESTRUCTURE
PDMS
FLEX
MICROFLUIDICA
topic MULTI-LEVEL MICROESTRUCTURE
PDMS
FLEX
MICROFLUIDICA
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv This paper describes a methodology of photopolymer mold fabrication with multi-level microstructures for polydimethylsiloxane (PDMS) microfluidic device manufacture. Multi-level microstructures can be performed by varying UVA exposure time and channel width. Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM) and profilometry techniques have been employed to characterize the molds. Multiple molds with multi-level microstructures can be formed in a unique piece. Overall height/depth of the structures reaches up to 677 μm and a minimum of 21 μm. The method provides several advantages such as reduction of fabrication time, multiple structures with diverse topologies, a great variety of depth and height in a single mold and low cost of fabrication. The effectiveness of multi-level microstructure fabrication was evaluated by constructing PDMS microfluidic devices for cell culture and proliferation.
Fil: Olmos Carreno, Carol Maritza. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Penãherrera, Ana. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Albert Ludwigs University of Freiburg; Alemania
Fil: Rosero Yánez, Gustavo Ivan. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Albert Ludwigs University of Freiburg; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vizuete, Karla. Universidad de Las Fuerzas Armadas; Ecuador
Fil: Ruarte, Darío. Albert Ludwigs University of Freiburg; Alemania
Fil: Follo, Marie. Albert Ludwigs University of Freiburg; Alemania
Fil: Vaca Mora, Andrea Vanessa. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Arroyo, Carlos R.. Universidad de Las Fuerzas Armadas; Ecuador
Fil: Debut, Alexis. Universidad de Las Fuerzas Armadas; Ecuador
Fil: Cumbal Flores, Luis. Universidad de Las Fuerzas Armadas; Ecuador
Fil: Perez, Maximiliano Sebastian. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Florida International University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lerner, Betiana. Universidad Tecnológica Nacional. Facultad Regional Haedo; Argentina. Florida International University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mertelsmann, Roland. Albert Ludwigs University of Freiburg; Alemania
description This paper describes a methodology of photopolymer mold fabrication with multi-level microstructures for polydimethylsiloxane (PDMS) microfluidic device manufacture. Multi-level microstructures can be performed by varying UVA exposure time and channel width. Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM) and profilometry techniques have been employed to characterize the molds. Multiple molds with multi-level microstructures can be formed in a unique piece. Overall height/depth of the structures reaches up to 677 μm and a minimum of 21 μm. The method provides several advantages such as reduction of fabrication time, multiple structures with diverse topologies, a great variety of depth and height in a single mold and low cost of fabrication. The effectiveness of multi-level microstructure fabrication was evaluated by constructing PDMS microfluidic devices for cell culture and proliferation.
publishDate 2020
dc.date.none.fl_str_mv 2020-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/145893
Olmos Carreno, Carol Maritza; Penãherrera, Ana; Rosero Yánez, Gustavo Ivan; Vizuete, Karla; Ruarte, Darío; et al.; Cost-effective fabrication of photopolymer molds with multi-level microstructures for pdms microfluidic device manufacture; Royal Society of Chemistry; RSC Advances; 10; 7; 1-2020; 4071-4079
2046-2069
CONICET Digital
CONICET
url http://hdl.handle.net/11336/145893
identifier_str_mv Olmos Carreno, Carol Maritza; Penãherrera, Ana; Rosero Yánez, Gustavo Ivan; Vizuete, Karla; Ruarte, Darío; et al.; Cost-effective fabrication of photopolymer molds with multi-level microstructures for pdms microfluidic device manufacture; Royal Society of Chemistry; RSC Advances; 10; 7; 1-2020; 4071-4079
2046-2069
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2020/RA/C9RA07955F
info:eu-repo/semantics/altIdentifier/doi/10.1039/C9RA07955F
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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