Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis

Autores
Gañan, Nicolas Alberto; Brignole, Esteban Alberto
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Essential oils are an important source of compounds with different degree of biocidal activity against microorganisms, insects, weeds and other pathogens. They have potential application in pharmaceutical, cosmetic and food industry, as well as for agriculture and crop protection. Supercritical fluid fractionation is an interesting technology for the selective removal of monoterpenes (MT) and the purification or enrichment of the more bioactive oxygenated terpenes (OT), resulting in more effective, stable and water soluble products. In this work, the fractionation of Tagetes minuta and Salvia officinalis essential oils with carbon dioxide is experimentally studied in a semicontinuous apparatus at 313 K and 80 bar. Successive extracts are collected and the composition determined by gas chromatography. Process behavior is modeled with the group contribution equation of state (GC-EOS), showing a good agreement between model predictions and experimental results. The GC-EOS model is applied to the simulation and analysis of two continuous fractionation schemes: a simple countercurrent column and a countercurrent column with external reflux. The influence of operation variables (temperature, pressure, solvent-to-feed ratio, thermal gradient, reflux ratio) is studied in order to maximize OT concentration and recovery in the raffinate and to minimize carbon dioxide consumption. Experimental and simulation results are discussed in terms of the relative volatilities between MT and OT fractions. Particularly in the case of S. officinalis, the presence of several OT of intermediate volatility and a significant amount of higher molecular weight sesquiterpenes (ST) limits the separation performance, even when external reflux is applied.
Fil: Gañan, Nicolas Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina
Fil: Brignole, Esteban Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina
Materia
Supercritical Fluid Extraction
Fractionation
Essential Oil
Biocidal Agent
Tagetes Minuta
Salvia Officinalis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11871

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spelling Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysisGañan, Nicolas AlbertoBrignole, Esteban AlbertoSupercritical Fluid ExtractionFractionationEssential OilBiocidal AgentTagetes MinutaSalvia Officinalishttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2Essential oils are an important source of compounds with different degree of biocidal activity against microorganisms, insects, weeds and other pathogens. They have potential application in pharmaceutical, cosmetic and food industry, as well as for agriculture and crop protection. Supercritical fluid fractionation is an interesting technology for the selective removal of monoterpenes (MT) and the purification or enrichment of the more bioactive oxygenated terpenes (OT), resulting in more effective, stable and water soluble products. In this work, the fractionation of Tagetes minuta and Salvia officinalis essential oils with carbon dioxide is experimentally studied in a semicontinuous apparatus at 313 K and 80 bar. Successive extracts are collected and the composition determined by gas chromatography. Process behavior is modeled with the group contribution equation of state (GC-EOS), showing a good agreement between model predictions and experimental results. The GC-EOS model is applied to the simulation and analysis of two continuous fractionation schemes: a simple countercurrent column and a countercurrent column with external reflux. The influence of operation variables (temperature, pressure, solvent-to-feed ratio, thermal gradient, reflux ratio) is studied in order to maximize OT concentration and recovery in the raffinate and to minimize carbon dioxide consumption. Experimental and simulation results are discussed in terms of the relative volatilities between MT and OT fractions. Particularly in the case of S. officinalis, the presence of several OT of intermediate volatility and a significant amount of higher molecular weight sesquiterpenes (ST) limits the separation performance, even when external reflux is applied.Fil: Gañan, Nicolas Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; ArgentinaFil: Brignole, Esteban Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); ArgentinaElsevier Science2013-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11871Gañan, Nicolas Alberto; Brignole, Esteban Alberto; Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis; Elsevier Science; Journal of Supercritical Fluids; 78; 6-2013; 12-200896-8446enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0896844613001174info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1016/j.supflu.2013.03.019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:26Zoai:ri.conicet.gov.ar:11336/11871instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:26.423CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis
title Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis
spellingShingle Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis
Gañan, Nicolas Alberto
Supercritical Fluid Extraction
Fractionation
Essential Oil
Biocidal Agent
Tagetes Minuta
Salvia Officinalis
title_short Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis
title_full Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis
title_fullStr Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis
title_full_unstemmed Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis
title_sort Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis
dc.creator.none.fl_str_mv Gañan, Nicolas Alberto
Brignole, Esteban Alberto
author Gañan, Nicolas Alberto
author_facet Gañan, Nicolas Alberto
Brignole, Esteban Alberto
author_role author
author2 Brignole, Esteban Alberto
author2_role author
dc.subject.none.fl_str_mv Supercritical Fluid Extraction
Fractionation
Essential Oil
Biocidal Agent
Tagetes Minuta
Salvia Officinalis
topic Supercritical Fluid Extraction
Fractionation
Essential Oil
Biocidal Agent
Tagetes Minuta
Salvia Officinalis
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Essential oils are an important source of compounds with different degree of biocidal activity against microorganisms, insects, weeds and other pathogens. They have potential application in pharmaceutical, cosmetic and food industry, as well as for agriculture and crop protection. Supercritical fluid fractionation is an interesting technology for the selective removal of monoterpenes (MT) and the purification or enrichment of the more bioactive oxygenated terpenes (OT), resulting in more effective, stable and water soluble products. In this work, the fractionation of Tagetes minuta and Salvia officinalis essential oils with carbon dioxide is experimentally studied in a semicontinuous apparatus at 313 K and 80 bar. Successive extracts are collected and the composition determined by gas chromatography. Process behavior is modeled with the group contribution equation of state (GC-EOS), showing a good agreement between model predictions and experimental results. The GC-EOS model is applied to the simulation and analysis of two continuous fractionation schemes: a simple countercurrent column and a countercurrent column with external reflux. The influence of operation variables (temperature, pressure, solvent-to-feed ratio, thermal gradient, reflux ratio) is studied in order to maximize OT concentration and recovery in the raffinate and to minimize carbon dioxide consumption. Experimental and simulation results are discussed in terms of the relative volatilities between MT and OT fractions. Particularly in the case of S. officinalis, the presence of several OT of intermediate volatility and a significant amount of higher molecular weight sesquiterpenes (ST) limits the separation performance, even when external reflux is applied.
Fil: Gañan, Nicolas Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina
Fil: Brignole, Esteban Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina
description Essential oils are an important source of compounds with different degree of biocidal activity against microorganisms, insects, weeds and other pathogens. They have potential application in pharmaceutical, cosmetic and food industry, as well as for agriculture and crop protection. Supercritical fluid fractionation is an interesting technology for the selective removal of monoterpenes (MT) and the purification or enrichment of the more bioactive oxygenated terpenes (OT), resulting in more effective, stable and water soluble products. In this work, the fractionation of Tagetes minuta and Salvia officinalis essential oils with carbon dioxide is experimentally studied in a semicontinuous apparatus at 313 K and 80 bar. Successive extracts are collected and the composition determined by gas chromatography. Process behavior is modeled with the group contribution equation of state (GC-EOS), showing a good agreement between model predictions and experimental results. The GC-EOS model is applied to the simulation and analysis of two continuous fractionation schemes: a simple countercurrent column and a countercurrent column with external reflux. The influence of operation variables (temperature, pressure, solvent-to-feed ratio, thermal gradient, reflux ratio) is studied in order to maximize OT concentration and recovery in the raffinate and to minimize carbon dioxide consumption. Experimental and simulation results are discussed in terms of the relative volatilities between MT and OT fractions. Particularly in the case of S. officinalis, the presence of several OT of intermediate volatility and a significant amount of higher molecular weight sesquiterpenes (ST) limits the separation performance, even when external reflux is applied.
publishDate 2013
dc.date.none.fl_str_mv 2013-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11871
Gañan, Nicolas Alberto; Brignole, Esteban Alberto; Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis; Elsevier Science; Journal of Supercritical Fluids; 78; 6-2013; 12-20
0896-8446
url http://hdl.handle.net/11336/11871
identifier_str_mv Gañan, Nicolas Alberto; Brignole, Esteban Alberto; Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis; Elsevier Science; Journal of Supercritical Fluids; 78; 6-2013; 12-20
0896-8446
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0896844613001174
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1016/j.supflu.2013.03.019
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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