Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis
- Autores
- Gañan, Nicolas Alberto; Brignole, Esteban Alberto
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Essential oils are an important source of compounds with different degree of biocidal activity against microorganisms, insects, weeds and other pathogens. They have potential application in pharmaceutical, cosmetic and food industry, as well as for agriculture and crop protection. Supercritical fluid fractionation is an interesting technology for the selective removal of monoterpenes (MT) and the purification or enrichment of the more bioactive oxygenated terpenes (OT), resulting in more effective, stable and water soluble products. In this work, the fractionation of Tagetes minuta and Salvia officinalis essential oils with carbon dioxide is experimentally studied in a semicontinuous apparatus at 313 K and 80 bar. Successive extracts are collected and the composition determined by gas chromatography. Process behavior is modeled with the group contribution equation of state (GC-EOS), showing a good agreement between model predictions and experimental results. The GC-EOS model is applied to the simulation and analysis of two continuous fractionation schemes: a simple countercurrent column and a countercurrent column with external reflux. The influence of operation variables (temperature, pressure, solvent-to-feed ratio, thermal gradient, reflux ratio) is studied in order to maximize OT concentration and recovery in the raffinate and to minimize carbon dioxide consumption. Experimental and simulation results are discussed in terms of the relative volatilities between MT and OT fractions. Particularly in the case of S. officinalis, the presence of several OT of intermediate volatility and a significant amount of higher molecular weight sesquiterpenes (ST) limits the separation performance, even when external reflux is applied.
Fil: Gañan, Nicolas Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina
Fil: Brignole, Esteban Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina - Materia
-
Supercritical Fluid Extraction
Fractionation
Essential Oil
Biocidal Agent
Tagetes Minuta
Salvia Officinalis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/11871
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Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysisGañan, Nicolas AlbertoBrignole, Esteban AlbertoSupercritical Fluid ExtractionFractionationEssential OilBiocidal AgentTagetes MinutaSalvia Officinalishttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2Essential oils are an important source of compounds with different degree of biocidal activity against microorganisms, insects, weeds and other pathogens. They have potential application in pharmaceutical, cosmetic and food industry, as well as for agriculture and crop protection. Supercritical fluid fractionation is an interesting technology for the selective removal of monoterpenes (MT) and the purification or enrichment of the more bioactive oxygenated terpenes (OT), resulting in more effective, stable and water soluble products. In this work, the fractionation of Tagetes minuta and Salvia officinalis essential oils with carbon dioxide is experimentally studied in a semicontinuous apparatus at 313 K and 80 bar. Successive extracts are collected and the composition determined by gas chromatography. Process behavior is modeled with the group contribution equation of state (GC-EOS), showing a good agreement between model predictions and experimental results. The GC-EOS model is applied to the simulation and analysis of two continuous fractionation schemes: a simple countercurrent column and a countercurrent column with external reflux. The influence of operation variables (temperature, pressure, solvent-to-feed ratio, thermal gradient, reflux ratio) is studied in order to maximize OT concentration and recovery in the raffinate and to minimize carbon dioxide consumption. Experimental and simulation results are discussed in terms of the relative volatilities between MT and OT fractions. Particularly in the case of S. officinalis, the presence of several OT of intermediate volatility and a significant amount of higher molecular weight sesquiterpenes (ST) limits the separation performance, even when external reflux is applied.Fil: Gañan, Nicolas Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; ArgentinaFil: Brignole, Esteban Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); ArgentinaElsevier Science2013-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11871Gañan, Nicolas Alberto; Brignole, Esteban Alberto; Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis; Elsevier Science; Journal of Supercritical Fluids; 78; 6-2013; 12-200896-8446enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0896844613001174info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1016/j.supflu.2013.03.019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:26Zoai:ri.conicet.gov.ar:11336/11871instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:26.423CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis |
title |
Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis |
spellingShingle |
Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis Gañan, Nicolas Alberto Supercritical Fluid Extraction Fractionation Essential Oil Biocidal Agent Tagetes Minuta Salvia Officinalis |
title_short |
Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis |
title_full |
Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis |
title_fullStr |
Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis |
title_full_unstemmed |
Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis |
title_sort |
Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis |
dc.creator.none.fl_str_mv |
Gañan, Nicolas Alberto Brignole, Esteban Alberto |
author |
Gañan, Nicolas Alberto |
author_facet |
Gañan, Nicolas Alberto Brignole, Esteban Alberto |
author_role |
author |
author2 |
Brignole, Esteban Alberto |
author2_role |
author |
dc.subject.none.fl_str_mv |
Supercritical Fluid Extraction Fractionation Essential Oil Biocidal Agent Tagetes Minuta Salvia Officinalis |
topic |
Supercritical Fluid Extraction Fractionation Essential Oil Biocidal Agent Tagetes Minuta Salvia Officinalis |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.4 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
Essential oils are an important source of compounds with different degree of biocidal activity against microorganisms, insects, weeds and other pathogens. They have potential application in pharmaceutical, cosmetic and food industry, as well as for agriculture and crop protection. Supercritical fluid fractionation is an interesting technology for the selective removal of monoterpenes (MT) and the purification or enrichment of the more bioactive oxygenated terpenes (OT), resulting in more effective, stable and water soluble products. In this work, the fractionation of Tagetes minuta and Salvia officinalis essential oils with carbon dioxide is experimentally studied in a semicontinuous apparatus at 313 K and 80 bar. Successive extracts are collected and the composition determined by gas chromatography. Process behavior is modeled with the group contribution equation of state (GC-EOS), showing a good agreement between model predictions and experimental results. The GC-EOS model is applied to the simulation and analysis of two continuous fractionation schemes: a simple countercurrent column and a countercurrent column with external reflux. The influence of operation variables (temperature, pressure, solvent-to-feed ratio, thermal gradient, reflux ratio) is studied in order to maximize OT concentration and recovery in the raffinate and to minimize carbon dioxide consumption. Experimental and simulation results are discussed in terms of the relative volatilities between MT and OT fractions. Particularly in the case of S. officinalis, the presence of several OT of intermediate volatility and a significant amount of higher molecular weight sesquiterpenes (ST) limits the separation performance, even when external reflux is applied. Fil: Gañan, Nicolas Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina Fil: Brignole, Esteban Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina |
description |
Essential oils are an important source of compounds with different degree of biocidal activity against microorganisms, insects, weeds and other pathogens. They have potential application in pharmaceutical, cosmetic and food industry, as well as for agriculture and crop protection. Supercritical fluid fractionation is an interesting technology for the selective removal of monoterpenes (MT) and the purification or enrichment of the more bioactive oxygenated terpenes (OT), resulting in more effective, stable and water soluble products. In this work, the fractionation of Tagetes minuta and Salvia officinalis essential oils with carbon dioxide is experimentally studied in a semicontinuous apparatus at 313 K and 80 bar. Successive extracts are collected and the composition determined by gas chromatography. Process behavior is modeled with the group contribution equation of state (GC-EOS), showing a good agreement between model predictions and experimental results. The GC-EOS model is applied to the simulation and analysis of two continuous fractionation schemes: a simple countercurrent column and a countercurrent column with external reflux. The influence of operation variables (temperature, pressure, solvent-to-feed ratio, thermal gradient, reflux ratio) is studied in order to maximize OT concentration and recovery in the raffinate and to minimize carbon dioxide consumption. Experimental and simulation results are discussed in terms of the relative volatilities between MT and OT fractions. Particularly in the case of S. officinalis, the presence of several OT of intermediate volatility and a significant amount of higher molecular weight sesquiterpenes (ST) limits the separation performance, even when external reflux is applied. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/11871 Gañan, Nicolas Alberto; Brignole, Esteban Alberto; Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis; Elsevier Science; Journal of Supercritical Fluids; 78; 6-2013; 12-20 0896-8446 |
url |
http://hdl.handle.net/11336/11871 |
identifier_str_mv |
Gañan, Nicolas Alberto; Brignole, Esteban Alberto; Supercritical carbon dioxide fractionation of T. minuta and S. officinalis essential oils: Experiments and process analysis; Elsevier Science; Journal of Supercritical Fluids; 78; 6-2013; 12-20 0896-8446 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0896844613001174 info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1016/j.supflu.2013.03.019 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269958451494912 |
score |
13.13397 |