Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth

Autores
Low, Malcolm J.; Otero Corchon, Veronica; Parlow, Albert. F.; Ramirez, Jose L.; Kumar, Ujenda; Patel, Yogesh C.; Rubinstein, Marcelo
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pulsatile growth hormone (GH) secretion differs between males and females and regulates the sex-specific expression of cytochrome P450s in liver. Sex steroids influence the secretory dynamics of GH, but the neuroendocrine mechanisms have not been conclusively established. Because periventricular hypothalamic somatostatin (SST) expression is greater in males than in females, we generated knockout (Smst-/-) mice to investigate whether SST peptides are necessary for sexually differentiated GH secretion and action. Despite marked increases in nadir and median plasma GH levels in both sexes of Smst-/- compared with Smst+/+ mice, the mutant mice had growth curves identical to their sibling controls and retained a normal sexual dimorphism in weight and length. In contrast, the liver of male Smst-/- mice was feminized, resulting in an identical profile of GH-regulated hepatic mRNAs between male and female mutants. Male Smst-/- mice show higher expression of two SST receptors in the hypothalamus and pituitary than do females. These data indicate that SST is required to masculinize the ultradian GH rhythm by suppressing interpulse GH levels. In the absence of SST, male and female mice exhibit similarly altered plasma GH profiles that eliminate sexually dimorphic liver function but do not affect dimorphic growth.
Fil: Low, Malcolm J.. Oregon Health And Science University; Estados Unidos
Fil: Otero Corchon, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Oregon Health And Science University; Estados Unidos
Fil: Parlow, Albert. F.. University of California at Los Angeles; Estados Unidos
Fil: Ramirez, Jose L.. McGill University; Canadá
Fil: Kumar, Ujenda. McGill University; Canadá
Fil: Patel, Yogesh C.. McGill University; Canadá
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Materia
Somatostatina
Hormonas hepáticas
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79325
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growthLow, Malcolm J.Otero Corchon, VeronicaParlow, Albert. F.Ramirez, Jose L.Kumar, UjendaPatel, Yogesh C.Rubinstein, MarceloSomatostatinaHormonas hepáticashttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Pulsatile growth hormone (GH) secretion differs between males and females and regulates the sex-specific expression of cytochrome P450s in liver. Sex steroids influence the secretory dynamics of GH, but the neuroendocrine mechanisms have not been conclusively established. Because periventricular hypothalamic somatostatin (SST) expression is greater in males than in females, we generated knockout (Smst-/-) mice to investigate whether SST peptides are necessary for sexually differentiated GH secretion and action. Despite marked increases in nadir and median plasma GH levels in both sexes of Smst-/- compared with Smst+/+ mice, the mutant mice had growth curves identical to their sibling controls and retained a normal sexual dimorphism in weight and length. In contrast, the liver of male Smst-/- mice was feminized, resulting in an identical profile of GH-regulated hepatic mRNAs between male and female mutants. Male Smst-/- mice show higher expression of two SST receptors in the hypothalamus and pituitary than do females. These data indicate that SST is required to masculinize the ultradian GH rhythm by suppressing interpulse GH levels. In the absence of SST, male and female mice exhibit similarly altered plasma GH profiles that eliminate sexually dimorphic liver function but do not affect dimorphic growth.Fil: Low, Malcolm J.. Oregon Health And Science University; Estados UnidosFil: Otero Corchon, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Oregon Health And Science University; Estados UnidosFil: Parlow, Albert. F.. University of California at Los Angeles; Estados UnidosFil: Ramirez, Jose L.. McGill University; CanadáFil: Kumar, Ujenda. McGill University; CanadáFil: Patel, Yogesh C.. McGill University; CanadáFil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaAmerican Society for Clinical Investigation2001-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79325Low, Malcolm J.; Otero Corchon, Veronica; Parlow, Albert. F.; Ramirez, Jose L.; Kumar, Ujenda; et al.; Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth; American Society for Clinical Investigation; Journal of Clinical Investigation; 107; 12; 6-2001; 1571-15800021-9738CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.jci.org/articles/view/11941info:eu-repo/semantics/altIdentifier/doi/10.1172/JCI11941info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:40Zoai:ri.conicet.gov.ar:11336/79325instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:40.718CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth
title Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth
spellingShingle Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth
Low, Malcolm J.
Somatostatina
Hormonas hepáticas
title_short Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth
title_full Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth
title_fullStr Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth
title_full_unstemmed Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth
title_sort Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth
dc.creator.none.fl_str_mv Low, Malcolm J.
Otero Corchon, Veronica
Parlow, Albert. F.
Ramirez, Jose L.
Kumar, Ujenda
Patel, Yogesh C.
Rubinstein, Marcelo
author Low, Malcolm J.
author_facet Low, Malcolm J.
Otero Corchon, Veronica
Parlow, Albert. F.
Ramirez, Jose L.
Kumar, Ujenda
Patel, Yogesh C.
Rubinstein, Marcelo
author_role author
author2 Otero Corchon, Veronica
Parlow, Albert. F.
Ramirez, Jose L.
Kumar, Ujenda
Patel, Yogesh C.
Rubinstein, Marcelo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Somatostatina
Hormonas hepáticas
topic Somatostatina
Hormonas hepáticas
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Pulsatile growth hormone (GH) secretion differs between males and females and regulates the sex-specific expression of cytochrome P450s in liver. Sex steroids influence the secretory dynamics of GH, but the neuroendocrine mechanisms have not been conclusively established. Because periventricular hypothalamic somatostatin (SST) expression is greater in males than in females, we generated knockout (Smst-/-) mice to investigate whether SST peptides are necessary for sexually differentiated GH secretion and action. Despite marked increases in nadir and median plasma GH levels in both sexes of Smst-/- compared with Smst+/+ mice, the mutant mice had growth curves identical to their sibling controls and retained a normal sexual dimorphism in weight and length. In contrast, the liver of male Smst-/- mice was feminized, resulting in an identical profile of GH-regulated hepatic mRNAs between male and female mutants. Male Smst-/- mice show higher expression of two SST receptors in the hypothalamus and pituitary than do females. These data indicate that SST is required to masculinize the ultradian GH rhythm by suppressing interpulse GH levels. In the absence of SST, male and female mice exhibit similarly altered plasma GH profiles that eliminate sexually dimorphic liver function but do not affect dimorphic growth.
Fil: Low, Malcolm J.. Oregon Health And Science University; Estados Unidos
Fil: Otero Corchon, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Oregon Health And Science University; Estados Unidos
Fil: Parlow, Albert. F.. University of California at Los Angeles; Estados Unidos
Fil: Ramirez, Jose L.. McGill University; Canadá
Fil: Kumar, Ujenda. McGill University; Canadá
Fil: Patel, Yogesh C.. McGill University; Canadá
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
description Pulsatile growth hormone (GH) secretion differs between males and females and regulates the sex-specific expression of cytochrome P450s in liver. Sex steroids influence the secretory dynamics of GH, but the neuroendocrine mechanisms have not been conclusively established. Because periventricular hypothalamic somatostatin (SST) expression is greater in males than in females, we generated knockout (Smst-/-) mice to investigate whether SST peptides are necessary for sexually differentiated GH secretion and action. Despite marked increases in nadir and median plasma GH levels in both sexes of Smst-/- compared with Smst+/+ mice, the mutant mice had growth curves identical to their sibling controls and retained a normal sexual dimorphism in weight and length. In contrast, the liver of male Smst-/- mice was feminized, resulting in an identical profile of GH-regulated hepatic mRNAs between male and female mutants. Male Smst-/- mice show higher expression of two SST receptors in the hypothalamus and pituitary than do females. These data indicate that SST is required to masculinize the ultradian GH rhythm by suppressing interpulse GH levels. In the absence of SST, male and female mice exhibit similarly altered plasma GH profiles that eliminate sexually dimorphic liver function but do not affect dimorphic growth.
publishDate 2001
dc.date.none.fl_str_mv 2001-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79325
Low, Malcolm J.; Otero Corchon, Veronica; Parlow, Albert. F.; Ramirez, Jose L.; Kumar, Ujenda; et al.; Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth; American Society for Clinical Investigation; Journal of Clinical Investigation; 107; 12; 6-2001; 1571-1580
0021-9738
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79325
identifier_str_mv Low, Malcolm J.; Otero Corchon, Veronica; Parlow, Albert. F.; Ramirez, Jose L.; Kumar, Ujenda; et al.; Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth; American Society for Clinical Investigation; Journal of Clinical Investigation; 107; 12; 6-2001; 1571-1580
0021-9738
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.jci.org/articles/view/11941
info:eu-repo/semantics/altIdentifier/doi/10.1172/JCI11941
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Clinical Investigation
publisher.none.fl_str_mv American Society for Clinical Investigation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268987309686784
score 13.13397

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