A new venomous scorpion responsible for severe envenomation in Argentina: Tityus confluens

Autores
de Roodt, Adolfo Rafael; Lago, Néstor Rubén; Salomón, Oscar Daniel; Laskowicz, Rodrigo Daniel; Neder, Lilia Estela; López, Raúl Alfredo; Montero, Teresa Eleonor; Vega, Valeria del Valle
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In Argentina the scorpions of medical importance belong to the genus Tityus (T.), particularly the species T. trivittatus, the only scorpion whose sting is recognized to be associated with severe human envenoming and death. This genus is distributed from the north of the Patagonian region to the center and some provinces in the north of the country. During the period 2003-2006 four children died following scorpion stings, of which one was certainly and three were probably by T. confluens. In 2006, in the province of Tucumán, a girl died by scorpion envenoming and the scorpion responsible for the death, found in her shoe, was T. confluens. We thus studied the toxicity of venom gland homogenates from T. confluens from the provinces of Jujuy and Catamarca, and of crude venom from specimens from Catamarca and the province of La Rioja. The lethal potencies of the telson homogenates were 7.0 and 18.6 μg/g for Jujuy and Catamarca, respectively, while the lethal potency of the crude venom was 0.7 μg/g. Injected mice showed generalized congestion and hepatic lesions. Pancreatic damage was observed in some animals. Lungs showed congestion and foci of hemorrhage and mild edema. The heart showed injury in the muscular fibers. The venom showed high reactivity against anti-T. trivittatus antivenom and against two anti-T. serrulatus antivenoms. The anti-T. trivittatus antivenom neutralized the lethal activity of T. confluens venom. In addition, the venom reacted very slightly against an anti-Centruroides antivenom. Therefore, the stings of this scorpion must be considered of risk for humans to the same degree as the stings of T. trivittatus
Fil: de Roodt, Adolfo Rafael. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Lago, Néstor Rubén. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología. Centro de Patología Experimental; Argentina
Fil: Salomón, Oscar Daniel. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
Fil: Laskowicz, Rodrigo Daniel. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Neder, Lilia Estela. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Jujuy. Universidad Nacional de Jujuy. Centro de Investigaciones y Transferencia de Jujuy; Argentina
Fil: López, Raúl Alfredo. Provincia de Catamarca; Argentina
Fil: Montero, Teresa Eleonor. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; Argentina
Fil: Vega, Valeria del Valle. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
Materia
Envenomation
Scorpion
Toxicity
Venom
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/61305
Acceder
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network_name_str CONICET Digital (CONICET)
spelling A new venomous scorpion responsible for severe envenomation in Argentina: Tityus confluensde Roodt, Adolfo RafaelLago, Néstor RubénSalomón, Oscar DanielLaskowicz, Rodrigo DanielNeder, Lilia EstelaLópez, Raúl AlfredoMontero, Teresa EleonorVega, Valeria del ValleEnvenomationScorpionToxicityVenomhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In Argentina the scorpions of medical importance belong to the genus Tityus (T.), particularly the species T. trivittatus, the only scorpion whose sting is recognized to be associated with severe human envenoming and death. This genus is distributed from the north of the Patagonian region to the center and some provinces in the north of the country. During the period 2003-2006 four children died following scorpion stings, of which one was certainly and three were probably by T. confluens. In 2006, in the province of Tucumán, a girl died by scorpion envenoming and the scorpion responsible for the death, found in her shoe, was T. confluens. We thus studied the toxicity of venom gland homogenates from T. confluens from the provinces of Jujuy and Catamarca, and of crude venom from specimens from Catamarca and the province of La Rioja. The lethal potencies of the telson homogenates were 7.0 and 18.6 μg/g for Jujuy and Catamarca, respectively, while the lethal potency of the crude venom was 0.7 μg/g. Injected mice showed generalized congestion and hepatic lesions. Pancreatic damage was observed in some animals. Lungs showed congestion and foci of hemorrhage and mild edema. The heart showed injury in the muscular fibers. The venom showed high reactivity against anti-T. trivittatus antivenom and against two anti-T. serrulatus antivenoms. The anti-T. trivittatus antivenom neutralized the lethal activity of T. confluens venom. In addition, the venom reacted very slightly against an anti-Centruroides antivenom. Therefore, the stings of this scorpion must be considered of risk for humans to the same degree as the stings of T. trivittatusFil: de Roodt, Adolfo Rafael. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; ArgentinaFil: Lago, Néstor Rubén. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología. Centro de Patología Experimental; ArgentinaFil: Salomón, Oscar Daniel. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; ArgentinaFil: Laskowicz, Rodrigo Daniel. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; ArgentinaFil: Neder, Lilia Estela. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Jujuy. Universidad Nacional de Jujuy. Centro de Investigaciones y Transferencia de Jujuy; ArgentinaFil: López, Raúl Alfredo. Provincia de Catamarca; ArgentinaFil: Montero, Teresa Eleonor. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; ArgentinaFil: Vega, Valeria del Valle. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; ArgentinaPergamon-Elsevier Science Ltd2009-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/61305de Roodt, Adolfo Rafael; Lago, Néstor Rubén; Salomón, Oscar Daniel; Laskowicz, Rodrigo Daniel; Neder, Lilia Estela; et al.; A new venomous scorpion responsible for severe envenomation in Argentina: Tityus confluens; Pergamon-Elsevier Science Ltd; Toxicon; 53; 1; 1-2009; 1-80041-01011879-3150CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.toxicon.2008.10.003info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0041010108005485info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:15:01Zoai:ri.conicet.gov.ar:11336/61305instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:15:02.18CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A new venomous scorpion responsible for severe envenomation in Argentina: Tityus confluens
title A new venomous scorpion responsible for severe envenomation in Argentina: Tityus confluens
spellingShingle A new venomous scorpion responsible for severe envenomation in Argentina: Tityus confluens
de Roodt, Adolfo Rafael
Envenomation
Scorpion
Toxicity
Venom
title_short A new venomous scorpion responsible for severe envenomation in Argentina: Tityus confluens
title_full A new venomous scorpion responsible for severe envenomation in Argentina: Tityus confluens
title_fullStr A new venomous scorpion responsible for severe envenomation in Argentina: Tityus confluens
title_full_unstemmed A new venomous scorpion responsible for severe envenomation in Argentina: Tityus confluens
title_sort A new venomous scorpion responsible for severe envenomation in Argentina: Tityus confluens
dc.creator.none.fl_str_mv de Roodt, Adolfo Rafael
Lago, Néstor Rubén
Salomón, Oscar Daniel
Laskowicz, Rodrigo Daniel
Neder, Lilia Estela
López, Raúl Alfredo
Montero, Teresa Eleonor
Vega, Valeria del Valle
author de Roodt, Adolfo Rafael
author_facet de Roodt, Adolfo Rafael
Lago, Néstor Rubén
Salomón, Oscar Daniel
Laskowicz, Rodrigo Daniel
Neder, Lilia Estela
López, Raúl Alfredo
Montero, Teresa Eleonor
Vega, Valeria del Valle
author_role author
author2 Lago, Néstor Rubén
Salomón, Oscar Daniel
Laskowicz, Rodrigo Daniel
Neder, Lilia Estela
López, Raúl Alfredo
Montero, Teresa Eleonor
Vega, Valeria del Valle
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Envenomation
Scorpion
Toxicity
Venom
topic Envenomation
Scorpion
Toxicity
Venom
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In Argentina the scorpions of medical importance belong to the genus Tityus (T.), particularly the species T. trivittatus, the only scorpion whose sting is recognized to be associated with severe human envenoming and death. This genus is distributed from the north of the Patagonian region to the center and some provinces in the north of the country. During the period 2003-2006 four children died following scorpion stings, of which one was certainly and three were probably by T. confluens. In 2006, in the province of Tucumán, a girl died by scorpion envenoming and the scorpion responsible for the death, found in her shoe, was T. confluens. We thus studied the toxicity of venom gland homogenates from T. confluens from the provinces of Jujuy and Catamarca, and of crude venom from specimens from Catamarca and the province of La Rioja. The lethal potencies of the telson homogenates were 7.0 and 18.6 μg/g for Jujuy and Catamarca, respectively, while the lethal potency of the crude venom was 0.7 μg/g. Injected mice showed generalized congestion and hepatic lesions. Pancreatic damage was observed in some animals. Lungs showed congestion and foci of hemorrhage and mild edema. The heart showed injury in the muscular fibers. The venom showed high reactivity against anti-T. trivittatus antivenom and against two anti-T. serrulatus antivenoms. The anti-T. trivittatus antivenom neutralized the lethal activity of T. confluens venom. In addition, the venom reacted very slightly against an anti-Centruroides antivenom. Therefore, the stings of this scorpion must be considered of risk for humans to the same degree as the stings of T. trivittatus
Fil: de Roodt, Adolfo Rafael. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Lago, Néstor Rubén. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología. Centro de Patología Experimental; Argentina
Fil: Salomón, Oscar Daniel. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
Fil: Laskowicz, Rodrigo Daniel. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Neder, Lilia Estela. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Jujuy. Universidad Nacional de Jujuy. Centro de Investigaciones y Transferencia de Jujuy; Argentina
Fil: López, Raúl Alfredo. Provincia de Catamarca; Argentina
Fil: Montero, Teresa Eleonor. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; Argentina
Fil: Vega, Valeria del Valle. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
description In Argentina the scorpions of medical importance belong to the genus Tityus (T.), particularly the species T. trivittatus, the only scorpion whose sting is recognized to be associated with severe human envenoming and death. This genus is distributed from the north of the Patagonian region to the center and some provinces in the north of the country. During the period 2003-2006 four children died following scorpion stings, of which one was certainly and three were probably by T. confluens. In 2006, in the province of Tucumán, a girl died by scorpion envenoming and the scorpion responsible for the death, found in her shoe, was T. confluens. We thus studied the toxicity of venom gland homogenates from T. confluens from the provinces of Jujuy and Catamarca, and of crude venom from specimens from Catamarca and the province of La Rioja. The lethal potencies of the telson homogenates were 7.0 and 18.6 μg/g for Jujuy and Catamarca, respectively, while the lethal potency of the crude venom was 0.7 μg/g. Injected mice showed generalized congestion and hepatic lesions. Pancreatic damage was observed in some animals. Lungs showed congestion and foci of hemorrhage and mild edema. The heart showed injury in the muscular fibers. The venom showed high reactivity against anti-T. trivittatus antivenom and against two anti-T. serrulatus antivenoms. The anti-T. trivittatus antivenom neutralized the lethal activity of T. confluens venom. In addition, the venom reacted very slightly against an anti-Centruroides antivenom. Therefore, the stings of this scorpion must be considered of risk for humans to the same degree as the stings of T. trivittatus
publishDate 2009
dc.date.none.fl_str_mv 2009-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/61305
de Roodt, Adolfo Rafael; Lago, Néstor Rubén; Salomón, Oscar Daniel; Laskowicz, Rodrigo Daniel; Neder, Lilia Estela; et al.; A new venomous scorpion responsible for severe envenomation in Argentina: Tityus confluens; Pergamon-Elsevier Science Ltd; Toxicon; 53; 1; 1-2009; 1-8
0041-0101
1879-3150
CONICET Digital
CONICET
url http://hdl.handle.net/11336/61305
identifier_str_mv de Roodt, Adolfo Rafael; Lago, Néstor Rubén; Salomón, Oscar Daniel; Laskowicz, Rodrigo Daniel; Neder, Lilia Estela; et al.; A new venomous scorpion responsible for severe envenomation in Argentina: Tityus confluens; Pergamon-Elsevier Science Ltd; Toxicon; 53; 1; 1-2009; 1-8
0041-0101
1879-3150
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.toxicon.2008.10.003
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0041010108005485
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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