Comparative genomic analysis of chemosensory-related gene families in gastropods

Autores
Rondón Guerrero, Johnma José; Pisarenco, Vadim A.; Ramón Pardos Blas, José; Sánchez Gracia, Alejandro; Zardoya, Rafael; Rozas, Julio
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chemoreception is critical for the survival and reproduction of animals. Except for a reduced group of insects and chelicerates, the molecular identity of chemosensory proteins is poorly understood in invertebrates. Gastropoda is the extant mollusk class with the greatest species richness, including marine, freshwater, and terrestrial lineages, and likely, highly diverse chemoreception systems. Here, we performed a comprehensive comparative genome analysis taking advantage of the chromosome-level information of two Gastropoda species, one of which belongs to a lineage that underwent a whole genome duplication event. We identified thousands of previously uncharacterized chemosensory-related genes, the majority of them encoding G protein-coupled receptors (GPCR), mostly organized into clusters distributed across all chromosomes. We also detected gene families encoding degenerin epithelial sodium channels (DEG-ENaC), ionotropic receptors (IR), sensory neuron membrane proteins (SNMP), Niemann–Pick type C2 (NPC2) proteins, and lipocalins, although with a lower number of members. Our phylogenetic analysis of the GPCR gene family across protostomes revealed: (i) remarkable gene family expansions in Gastropoda; (ii) clades including members from all protostomes; and (iii) species-specific clades with a substantial number of receptors. For the first time, we provide new and valuable knowledge into the evolution of the chemosensory gene families in invertebrates other than arthropods.
Fil: Rondón Guerrero, Johnma José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina
Fil: Pisarenco, Vadim A.. Universidad de Barcelona; España
Fil: Ramón Pardos Blas, José. Consejo Superior de Investigaciones Científicas. Museo Nacional de Ciencias Naturales; España
Fil: Sánchez Gracia, Alejandro. Universidad de Barcelona; España
Fil: Zardoya, Rafael. Consejo Superior de Investigaciones Científicas. Museo Nacional de Ciencias Naturales; España
Fil: Rozas, Julio. Universidad de Barcelona; España
Materia
CHEMORECEPTORS
CHEMOSENSORY GENE FAMILIES
GASTROPODA
GENE CLUSTERS
GPCRS
WGD
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/261731
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/261731
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Comparative genomic analysis of chemosensory-related gene families in gastropodsRondón Guerrero, Johnma JoséPisarenco, Vadim A.Ramón Pardos Blas, JoséSánchez Gracia, AlejandroZardoya, RafaelRozas, JulioCHEMORECEPTORSCHEMOSENSORY GENE FAMILIESGASTROPODAGENE CLUSTERSGPCRSWGDhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Chemoreception is critical for the survival and reproduction of animals. Except for a reduced group of insects and chelicerates, the molecular identity of chemosensory proteins is poorly understood in invertebrates. Gastropoda is the extant mollusk class with the greatest species richness, including marine, freshwater, and terrestrial lineages, and likely, highly diverse chemoreception systems. Here, we performed a comprehensive comparative genome analysis taking advantage of the chromosome-level information of two Gastropoda species, one of which belongs to a lineage that underwent a whole genome duplication event. We identified thousands of previously uncharacterized chemosensory-related genes, the majority of them encoding G protein-coupled receptors (GPCR), mostly organized into clusters distributed across all chromosomes. We also detected gene families encoding degenerin epithelial sodium channels (DEG-ENaC), ionotropic receptors (IR), sensory neuron membrane proteins (SNMP), Niemann–Pick type C2 (NPC2) proteins, and lipocalins, although with a lower number of members. Our phylogenetic analysis of the GPCR gene family across protostomes revealed: (i) remarkable gene family expansions in Gastropoda; (ii) clades including members from all protostomes; and (iii) species-specific clades with a substantial number of receptors. For the first time, we provide new and valuable knowledge into the evolution of the chemosensory gene families in invertebrates other than arthropods.Fil: Rondón Guerrero, Johnma José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; ArgentinaFil: Pisarenco, Vadim A.. Universidad de Barcelona; EspañaFil: Ramón Pardos Blas, José. Consejo Superior de Investigaciones Científicas. Museo Nacional de Ciencias Naturales; EspañaFil: Sánchez Gracia, Alejandro. Universidad de Barcelona; EspañaFil: Zardoya, Rafael. Consejo Superior de Investigaciones Científicas. Museo Nacional de Ciencias Naturales; EspañaFil: Rozas, Julio. Universidad de Barcelona; EspañaAcademic Press Inc Elsevier Science2024-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/261731Rondón Guerrero, Johnma José; Pisarenco, Vadim A.; Ramón Pardos Blas, José; Sánchez Gracia, Alejandro; Zardoya, Rafael; et al.; Comparative genomic analysis of chemosensory-related gene families in gastropods; Academic Press Inc Elsevier Science; Molecular Phylogenetics and Evolution; 192; 3-2024; 1-111055-7903CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ympev.2023.107986info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:47:31Zoai:ri.conicet.gov.ar:11336/261731instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:47:32.04CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Comparative genomic analysis of chemosensory-related gene families in gastropods
title Comparative genomic analysis of chemosensory-related gene families in gastropods
spellingShingle Comparative genomic analysis of chemosensory-related gene families in gastropods
Rondón Guerrero, Johnma José
CHEMORECEPTORS
CHEMOSENSORY GENE FAMILIES
GASTROPODA
GENE CLUSTERS
GPCRS
WGD
title_short Comparative genomic analysis of chemosensory-related gene families in gastropods
title_full Comparative genomic analysis of chemosensory-related gene families in gastropods
title_fullStr Comparative genomic analysis of chemosensory-related gene families in gastropods
title_full_unstemmed Comparative genomic analysis of chemosensory-related gene families in gastropods
title_sort Comparative genomic analysis of chemosensory-related gene families in gastropods
dc.creator.none.fl_str_mv Rondón Guerrero, Johnma José
Pisarenco, Vadim A.
Ramón Pardos Blas, José
Sánchez Gracia, Alejandro
Zardoya, Rafael
Rozas, Julio
author Rondón Guerrero, Johnma José
author_facet Rondón Guerrero, Johnma José
Pisarenco, Vadim A.
Ramón Pardos Blas, José
Sánchez Gracia, Alejandro
Zardoya, Rafael
Rozas, Julio
author_role author
author2 Pisarenco, Vadim A.
Ramón Pardos Blas, José
Sánchez Gracia, Alejandro
Zardoya, Rafael
Rozas, Julio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CHEMORECEPTORS
CHEMOSENSORY GENE FAMILIES
GASTROPODA
GENE CLUSTERS
GPCRS
WGD
topic CHEMORECEPTORS
CHEMOSENSORY GENE FAMILIES
GASTROPODA
GENE CLUSTERS
GPCRS
WGD
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Chemoreception is critical for the survival and reproduction of animals. Except for a reduced group of insects and chelicerates, the molecular identity of chemosensory proteins is poorly understood in invertebrates. Gastropoda is the extant mollusk class with the greatest species richness, including marine, freshwater, and terrestrial lineages, and likely, highly diverse chemoreception systems. Here, we performed a comprehensive comparative genome analysis taking advantage of the chromosome-level information of two Gastropoda species, one of which belongs to a lineage that underwent a whole genome duplication event. We identified thousands of previously uncharacterized chemosensory-related genes, the majority of them encoding G protein-coupled receptors (GPCR), mostly organized into clusters distributed across all chromosomes. We also detected gene families encoding degenerin epithelial sodium channels (DEG-ENaC), ionotropic receptors (IR), sensory neuron membrane proteins (SNMP), Niemann–Pick type C2 (NPC2) proteins, and lipocalins, although with a lower number of members. Our phylogenetic analysis of the GPCR gene family across protostomes revealed: (i) remarkable gene family expansions in Gastropoda; (ii) clades including members from all protostomes; and (iii) species-specific clades with a substantial number of receptors. For the first time, we provide new and valuable knowledge into the evolution of the chemosensory gene families in invertebrates other than arthropods.
Fil: Rondón Guerrero, Johnma José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina
Fil: Pisarenco, Vadim A.. Universidad de Barcelona; España
Fil: Ramón Pardos Blas, José. Consejo Superior de Investigaciones Científicas. Museo Nacional de Ciencias Naturales; España
Fil: Sánchez Gracia, Alejandro. Universidad de Barcelona; España
Fil: Zardoya, Rafael. Consejo Superior de Investigaciones Científicas. Museo Nacional de Ciencias Naturales; España
Fil: Rozas, Julio. Universidad de Barcelona; España
description Chemoreception is critical for the survival and reproduction of animals. Except for a reduced group of insects and chelicerates, the molecular identity of chemosensory proteins is poorly understood in invertebrates. Gastropoda is the extant mollusk class with the greatest species richness, including marine, freshwater, and terrestrial lineages, and likely, highly diverse chemoreception systems. Here, we performed a comprehensive comparative genome analysis taking advantage of the chromosome-level information of two Gastropoda species, one of which belongs to a lineage that underwent a whole genome duplication event. We identified thousands of previously uncharacterized chemosensory-related genes, the majority of them encoding G protein-coupled receptors (GPCR), mostly organized into clusters distributed across all chromosomes. We also detected gene families encoding degenerin epithelial sodium channels (DEG-ENaC), ionotropic receptors (IR), sensory neuron membrane proteins (SNMP), Niemann–Pick type C2 (NPC2) proteins, and lipocalins, although with a lower number of members. Our phylogenetic analysis of the GPCR gene family across protostomes revealed: (i) remarkable gene family expansions in Gastropoda; (ii) clades including members from all protostomes; and (iii) species-specific clades with a substantial number of receptors. For the first time, we provide new and valuable knowledge into the evolution of the chemosensory gene families in invertebrates other than arthropods.
publishDate 2024
dc.date.none.fl_str_mv 2024-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/261731
Rondón Guerrero, Johnma José; Pisarenco, Vadim A.; Ramón Pardos Blas, José; Sánchez Gracia, Alejandro; Zardoya, Rafael; et al.; Comparative genomic analysis of chemosensory-related gene families in gastropods; Academic Press Inc Elsevier Science; Molecular Phylogenetics and Evolution; 192; 3-2024; 1-11
1055-7903
CONICET Digital
CONICET
url http://hdl.handle.net/11336/261731
identifier_str_mv Rondón Guerrero, Johnma José; Pisarenco, Vadim A.; Ramón Pardos Blas, José; Sánchez Gracia, Alejandro; Zardoya, Rafael; et al.; Comparative genomic analysis of chemosensory-related gene families in gastropods; Academic Press Inc Elsevier Science; Molecular Phylogenetics and Evolution; 192; 3-2024; 1-11
1055-7903
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ympev.2023.107986
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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