Associations between anticholinergic burden and adverse health outcomes in Parkinson disease
- Autores
- Crispo, James A. G.; Willis, Allison W.; Thibault, Dylan P.; Fortin, Yannick; Hays, Harlen D.; McNair, Douglas S.; Bjerre, Lise M.; Kohen, Dafna E.; Pérez Lloret, Santiago; Mattison, Donald R.; Krewski, Daniel
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background Elderly adults should avoid medications with anticholinergic effects since they may increase the risk of adverse events, including falls, delirium, and cognitive impairment. However, data on anticholinergic burden are limited in subpopulations, such as individuals with Parkinson disease (PD). The objective of this study was to determine whether anticholinergic burden was associated with adverse outcomes in a PD inpatient population. Methods Using the Cerner Health Facts1database, we retrospectively examined anticholinergic medication use, diagnoses, and hospital revisits within a cohort of 16,302 PD inpatients admitted to a Cerner hospital between 2000 and 2011. Anticholinergic burden was computed using the Anticholinergic Risk Scale (ARS). Primary outcomes were associations between ARS score and diagnosis of fracture and delirium. Secondary outcomes included associations between ARS score and 30-day hospital revisits. Results Many individuals (57.8%) were prescribed non-PD medications with moderate to very strong anticholinergic potential. Individuals with the greatest ARS score (4) were morelikely to be diagnosed with fractures (adjusted odds ratio (AOR): 1.56, 95% CI: 1.29-1.88) and delirium (AOR: 1.61, 95% CI: 1.08-2.40) relative to those with no anticholinergic burden. Similarly, inpatients with the greatest ARS score were more likely to visit the emergency department (adjusted hazard ratio (AHR): 1.32, 95% CI: 1.10-1.58) and be readmitted (AHR: 1.16, 95% CI: 1.01-1.33) within 30-days of discharge. Conclusions We found a positive association between increased anticholinergic burden and adverse outcomes among individuals with PD. Additional pharmacovigilance studies are needed to better understand risks associated with anticholinergic medication use in PD.
Fil: Crispo, James A. G.. University of Ottawa; Canadá. University of Pennsylvania; Estados Unidos
Fil: Willis, Allison W.. University of Pennsylvania; Estados Unidos
Fil: Thibault, Dylan P.. University of Pennsylvania; Estados Unidos. University of Ottawa; Canadá
Fil: Fortin, Yannick. University of Ottawa; Canadá
Fil: Hays, Harlen D.. Cerner Corporation; Estados Unidos
Fil: McNair, Douglas S.. Cerner Corporation; Estados Unidos
Fil: Bjerre, Lise M.. University of Ottawa; Canadá
Fil: Kohen, Dafna E.. University of Ottawa; Canadá
Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Mattison, Donald R.. University of Ottawa; Canadá. Risk Sciences International; Canadá
Fil: Krewski, Daniel. University of Ottawa; Canadá. Risk Sciences International; Canadá - Materia
-
Enfermedad de Parkinson
Medicamentos Anticolinérgicos
Delirio
Fracturas - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/84674
Ver los metadatos del registro completo
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Associations between anticholinergic burden and adverse health outcomes in Parkinson diseaseCrispo, James A. G.Willis, Allison W.Thibault, Dylan P.Fortin, YannickHays, Harlen D.McNair, Douglas S.Bjerre, Lise M.Kohen, Dafna E.Pérez Lloret, SantiagoMattison, Donald R.Krewski, DanielEnfermedad de ParkinsonMedicamentos AnticolinérgicosDelirioFracturashttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background Elderly adults should avoid medications with anticholinergic effects since they may increase the risk of adverse events, including falls, delirium, and cognitive impairment. However, data on anticholinergic burden are limited in subpopulations, such as individuals with Parkinson disease (PD). The objective of this study was to determine whether anticholinergic burden was associated with adverse outcomes in a PD inpatient population. Methods Using the Cerner Health Facts1database, we retrospectively examined anticholinergic medication use, diagnoses, and hospital revisits within a cohort of 16,302 PD inpatients admitted to a Cerner hospital between 2000 and 2011. Anticholinergic burden was computed using the Anticholinergic Risk Scale (ARS). Primary outcomes were associations between ARS score and diagnosis of fracture and delirium. Secondary outcomes included associations between ARS score and 30-day hospital revisits. Results Many individuals (57.8%) were prescribed non-PD medications with moderate to very strong anticholinergic potential. Individuals with the greatest ARS score (4) were morelikely to be diagnosed with fractures (adjusted odds ratio (AOR): 1.56, 95% CI: 1.29-1.88) and delirium (AOR: 1.61, 95% CI: 1.08-2.40) relative to those with no anticholinergic burden. Similarly, inpatients with the greatest ARS score were more likely to visit the emergency department (adjusted hazard ratio (AHR): 1.32, 95% CI: 1.10-1.58) and be readmitted (AHR: 1.16, 95% CI: 1.01-1.33) within 30-days of discharge. Conclusions We found a positive association between increased anticholinergic burden and adverse outcomes among individuals with PD. Additional pharmacovigilance studies are needed to better understand risks associated with anticholinergic medication use in PD.Fil: Crispo, James A. G.. University of Ottawa; Canadá. University of Pennsylvania; Estados UnidosFil: Willis, Allison W.. University of Pennsylvania; Estados UnidosFil: Thibault, Dylan P.. University of Pennsylvania; Estados Unidos. University of Ottawa; CanadáFil: Fortin, Yannick. University of Ottawa; CanadáFil: Hays, Harlen D.. Cerner Corporation; Estados UnidosFil: McNair, Douglas S.. Cerner Corporation; Estados UnidosFil: Bjerre, Lise M.. University of Ottawa; CanadáFil: Kohen, Dafna E.. University of Ottawa; CanadáFil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Mattison, Donald R.. University of Ottawa; Canadá. Risk Sciences International; CanadáFil: Krewski, Daniel. University of Ottawa; Canadá. Risk Sciences International; CanadáPublic Library of Science2016-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/84674Crispo, James A. G.; Willis, Allison W.; Thibault, Dylan P.; Fortin, Yannick; Hays, Harlen D.; et al.; Associations between anticholinergic burden and adverse health outcomes in Parkinson disease; Public Library of Science; Plos One; 11; 3; 3-2016; 21-28; e01506211932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0150621info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150621info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:22:32Zoai:ri.conicet.gov.ar:11336/84674instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:22:33.118CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Associations between anticholinergic burden and adverse health outcomes in Parkinson disease |
title |
Associations between anticholinergic burden and adverse health outcomes in Parkinson disease |
spellingShingle |
Associations between anticholinergic burden and adverse health outcomes in Parkinson disease Crispo, James A. G. Enfermedad de Parkinson Medicamentos Anticolinérgicos Delirio Fracturas |
title_short |
Associations between anticholinergic burden and adverse health outcomes in Parkinson disease |
title_full |
Associations between anticholinergic burden and adverse health outcomes in Parkinson disease |
title_fullStr |
Associations between anticholinergic burden and adverse health outcomes in Parkinson disease |
title_full_unstemmed |
Associations between anticholinergic burden and adverse health outcomes in Parkinson disease |
title_sort |
Associations between anticholinergic burden and adverse health outcomes in Parkinson disease |
dc.creator.none.fl_str_mv |
Crispo, James A. G. Willis, Allison W. Thibault, Dylan P. Fortin, Yannick Hays, Harlen D. McNair, Douglas S. Bjerre, Lise M. Kohen, Dafna E. Pérez Lloret, Santiago Mattison, Donald R. Krewski, Daniel |
author |
Crispo, James A. G. |
author_facet |
Crispo, James A. G. Willis, Allison W. Thibault, Dylan P. Fortin, Yannick Hays, Harlen D. McNair, Douglas S. Bjerre, Lise M. Kohen, Dafna E. Pérez Lloret, Santiago Mattison, Donald R. Krewski, Daniel |
author_role |
author |
author2 |
Willis, Allison W. Thibault, Dylan P. Fortin, Yannick Hays, Harlen D. McNair, Douglas S. Bjerre, Lise M. Kohen, Dafna E. Pérez Lloret, Santiago Mattison, Donald R. Krewski, Daniel |
author2_role |
author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Enfermedad de Parkinson Medicamentos Anticolinérgicos Delirio Fracturas |
topic |
Enfermedad de Parkinson Medicamentos Anticolinérgicos Delirio Fracturas |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Background Elderly adults should avoid medications with anticholinergic effects since they may increase the risk of adverse events, including falls, delirium, and cognitive impairment. However, data on anticholinergic burden are limited in subpopulations, such as individuals with Parkinson disease (PD). The objective of this study was to determine whether anticholinergic burden was associated with adverse outcomes in a PD inpatient population. Methods Using the Cerner Health Facts1database, we retrospectively examined anticholinergic medication use, diagnoses, and hospital revisits within a cohort of 16,302 PD inpatients admitted to a Cerner hospital between 2000 and 2011. Anticholinergic burden was computed using the Anticholinergic Risk Scale (ARS). Primary outcomes were associations between ARS score and diagnosis of fracture and delirium. Secondary outcomes included associations between ARS score and 30-day hospital revisits. Results Many individuals (57.8%) were prescribed non-PD medications with moderate to very strong anticholinergic potential. Individuals with the greatest ARS score (4) were morelikely to be diagnosed with fractures (adjusted odds ratio (AOR): 1.56, 95% CI: 1.29-1.88) and delirium (AOR: 1.61, 95% CI: 1.08-2.40) relative to those with no anticholinergic burden. Similarly, inpatients with the greatest ARS score were more likely to visit the emergency department (adjusted hazard ratio (AHR): 1.32, 95% CI: 1.10-1.58) and be readmitted (AHR: 1.16, 95% CI: 1.01-1.33) within 30-days of discharge. Conclusions We found a positive association between increased anticholinergic burden and adverse outcomes among individuals with PD. Additional pharmacovigilance studies are needed to better understand risks associated with anticholinergic medication use in PD. Fil: Crispo, James A. G.. University of Ottawa; Canadá. University of Pennsylvania; Estados Unidos Fil: Willis, Allison W.. University of Pennsylvania; Estados Unidos Fil: Thibault, Dylan P.. University of Pennsylvania; Estados Unidos. University of Ottawa; Canadá Fil: Fortin, Yannick. University of Ottawa; Canadá Fil: Hays, Harlen D.. Cerner Corporation; Estados Unidos Fil: McNair, Douglas S.. Cerner Corporation; Estados Unidos Fil: Bjerre, Lise M.. University of Ottawa; Canadá Fil: Kohen, Dafna E.. University of Ottawa; Canadá Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina Fil: Mattison, Donald R.. University of Ottawa; Canadá. Risk Sciences International; Canadá Fil: Krewski, Daniel. University of Ottawa; Canadá. Risk Sciences International; Canadá |
description |
Background Elderly adults should avoid medications with anticholinergic effects since they may increase the risk of adverse events, including falls, delirium, and cognitive impairment. However, data on anticholinergic burden are limited in subpopulations, such as individuals with Parkinson disease (PD). The objective of this study was to determine whether anticholinergic burden was associated with adverse outcomes in a PD inpatient population. Methods Using the Cerner Health Facts1database, we retrospectively examined anticholinergic medication use, diagnoses, and hospital revisits within a cohort of 16,302 PD inpatients admitted to a Cerner hospital between 2000 and 2011. Anticholinergic burden was computed using the Anticholinergic Risk Scale (ARS). Primary outcomes were associations between ARS score and diagnosis of fracture and delirium. Secondary outcomes included associations between ARS score and 30-day hospital revisits. Results Many individuals (57.8%) were prescribed non-PD medications with moderate to very strong anticholinergic potential. Individuals with the greatest ARS score (4) were morelikely to be diagnosed with fractures (adjusted odds ratio (AOR): 1.56, 95% CI: 1.29-1.88) and delirium (AOR: 1.61, 95% CI: 1.08-2.40) relative to those with no anticholinergic burden. Similarly, inpatients with the greatest ARS score were more likely to visit the emergency department (adjusted hazard ratio (AHR): 1.32, 95% CI: 1.10-1.58) and be readmitted (AHR: 1.16, 95% CI: 1.01-1.33) within 30-days of discharge. Conclusions We found a positive association between increased anticholinergic burden and adverse outcomes among individuals with PD. Additional pharmacovigilance studies are needed to better understand risks associated with anticholinergic medication use in PD. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/84674 Crispo, James A. G.; Willis, Allison W.; Thibault, Dylan P.; Fortin, Yannick; Hays, Harlen D.; et al.; Associations between anticholinergic burden and adverse health outcomes in Parkinson disease; Public Library of Science; Plos One; 11; 3; 3-2016; 21-28; e0150621 1932-6203 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/84674 |
identifier_str_mv |
Crispo, James A. G.; Willis, Allison W.; Thibault, Dylan P.; Fortin, Yannick; Hays, Harlen D.; et al.; Associations between anticholinergic burden and adverse health outcomes in Parkinson disease; Public Library of Science; Plos One; 11; 3; 3-2016; 21-28; e0150621 1932-6203 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0150621 info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150621 |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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Public Library of Science |
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Public Library of Science |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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