B-Chronic Lymphocytic Leukemia Autophagyc Cell Death by the Use of Manganese Doped Zinc Oxide Nanoparticles and PhotoDynamic Therapy

Autores
Peña Luengas, Sandra; Marin, Gustavo Horacio; Rodríguez Nieto, Felipe Jorge; Dreon, Marcos Sebastian; Roque, Gustavo; Nuñez, Luis; Sanchez, Francisco Homero; Tarditti, Adrian; Schinella, Guillermo Raúl; Pistaccio, Luis; Goya, Rodolfo Gustavo; Tau, Jose María; Ichim, Thomas; Riordan, Neil; Rivera Montalvo, Luis; Mansilla, Eduardo
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
B-Chronic Lymphocytic Leukemia (B-CLL) usually follows an adverse, relentless clinical course by slowly developing drug resistance to fludarabine and other chemotherapeutic agents, as well as by acquiring new different genetic abnormalities. As B-CLL cells spontaneously produce high amounts of Reactive Oxygen Species (ROS) having an altered redox state in relation to that of normal B lymphocytes, we decided to probe different metal Zinc nanoparticles (ZnNPs) and quantify the levels of Singlet Oxigen (SO) to see if variations of its intracellular concentrations could execute and accelerate deadly programs in leukemic cells rather than in normal B lymphocytes, when applied with Photodynamic Therapy (PDT). In this way, we developed and tested a variety of metal ZnNPs of which one made of 0.5% Manganese Doped Zinc Oxide (ZnO:Mn) was finally selected for further testing as it had the best fludarabine resistant B-CLL cells in vitro killing activity, specially when combined with PDT. An interesting and rapidly dying process of B-CLL cells, known as autophagy, was always seen under Transmission Electronic Microscopy (TEM) when incubated with these 0.5% Mn doped ZnO NPs. This phenomenon correlated well with those intracellular increases of SO when PDT was administered, and measured by a novel method first described by us. As this therapy seems to be very specific to fludarabine resistant B-CLL cells, producing almost no damage to normal lymphocytes, it could surely contribute in the near future as a new innovative targeted strategy to be delivered in the clinical setting for the definitive benefit of these bad prognostic patients.
Fil: Peña Luengas, Sandra. Universidad de Puerto Rico; Puerto Rico
Fil: Marin, Gustavo Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Rodríguez Nieto, Felipe Jorge. Universidad Nacional Arturo Jauretche; Argentina
Fil: Dreon, Marcos Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Roque, Gustavo. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Nuñez, Luis. Universidad de Puerto Rico; Puerto Rico
Fil: Sanchez, Francisco Homero. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Tarditti, Adrian. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Schinella, Guillermo Raúl. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Pistaccio, Luis. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Goya, Rodolfo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Tau, Jose María. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Ichim, Thomas. Medistem; Estados Unidos
Fil: Riordan, Neil. Medistem; Estados Unidos
Fil: Rivera Montalvo, Luis. Universidad de Puerto Rico; Puerto Rico
Fil: Mansilla, Eduardo. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Materia
LEUKEMIA
NANOPARTICLES
PHOTODYNAMIC THERAPY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/136950
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling B-Chronic Lymphocytic Leukemia Autophagyc Cell Death by the Use of Manganese Doped Zinc Oxide Nanoparticles and PhotoDynamic TherapyPeña Luengas, SandraMarin, Gustavo HoracioRodríguez Nieto, Felipe JorgeDreon, Marcos SebastianRoque, GustavoNuñez, LuisSanchez, Francisco HomeroTarditti, AdrianSchinella, Guillermo RaúlPistaccio, LuisGoya, Rodolfo GustavoTau, Jose MaríaIchim, ThomasRiordan, NeilRivera Montalvo, LuisMansilla, EduardoLEUKEMIANANOPARTICLESPHOTODYNAMIC THERAPYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3B-Chronic Lymphocytic Leukemia (B-CLL) usually follows an adverse, relentless clinical course by slowly developing drug resistance to fludarabine and other chemotherapeutic agents, as well as by acquiring new different genetic abnormalities. As B-CLL cells spontaneously produce high amounts of Reactive Oxygen Species (ROS) having an altered redox state in relation to that of normal B lymphocytes, we decided to probe different metal Zinc nanoparticles (ZnNPs) and quantify the levels of Singlet Oxigen (SO) to see if variations of its intracellular concentrations could execute and accelerate deadly programs in leukemic cells rather than in normal B lymphocytes, when applied with Photodynamic Therapy (PDT). In this way, we developed and tested a variety of metal ZnNPs of which one made of 0.5% Manganese Doped Zinc Oxide (ZnO:Mn) was finally selected for further testing as it had the best fludarabine resistant B-CLL cells in vitro killing activity, specially when combined with PDT. An interesting and rapidly dying process of B-CLL cells, known as autophagy, was always seen under Transmission Electronic Microscopy (TEM) when incubated with these 0.5% Mn doped ZnO NPs. This phenomenon correlated well with those intracellular increases of SO when PDT was administered, and measured by a novel method first described by us. As this therapy seems to be very specific to fludarabine resistant B-CLL cells, producing almost no damage to normal lymphocytes, it could surely contribute in the near future as a new innovative targeted strategy to be delivered in the clinical setting for the definitive benefit of these bad prognostic patients.Fil: Peña Luengas, Sandra. Universidad de Puerto Rico; Puerto RicoFil: Marin, Gustavo Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; ArgentinaFil: Rodríguez Nieto, Felipe Jorge. Universidad Nacional Arturo Jauretche; ArgentinaFil: Dreon, Marcos Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Roque, Gustavo. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; ArgentinaFil: Nuñez, Luis. Universidad de Puerto Rico; Puerto RicoFil: Sanchez, Francisco Homero. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Tarditti, Adrian. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; ArgentinaFil: Schinella, Guillermo Raúl. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; ArgentinaFil: Pistaccio, Luis. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; ArgentinaFil: Goya, Rodolfo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Tau, Jose María. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; ArgentinaFil: Ichim, Thomas. Medistem; Estados UnidosFil: Riordan, Neil. Medistem; Estados UnidosFil: Rivera Montalvo, Luis. Universidad de Puerto Rico; Puerto RicoFil: Mansilla, Eduardo. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; ArgentinaUniversity of Science and Technology2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/136950Peña Luengas, Sandra; Marin, Gustavo Horacio; Rodríguez Nieto, Felipe Jorge; Dreon, Marcos Sebastian; Roque, Gustavo; et al.; B-Chronic Lymphocytic Leukemia Autophagyc Cell Death by the Use of Manganese Doped Zinc Oxide Nanoparticles and PhotoDynamic Therapy; University of Science and Technology; International Journal of Drug Delivery Technology; 5; 1; 3-2015; 15-250975-4415CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://ijddt.com/volume5issue1/info:eu-repo/semantics/altIdentifier/url/http://impactfactor.org/PDF/IJDDT/5/IJDDT,Vol5,Issue1,Article2.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:23Zoai:ri.conicet.gov.ar:11336/136950instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:24.058CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv B-Chronic Lymphocytic Leukemia Autophagyc Cell Death by the Use of Manganese Doped Zinc Oxide Nanoparticles and PhotoDynamic Therapy
title B-Chronic Lymphocytic Leukemia Autophagyc Cell Death by the Use of Manganese Doped Zinc Oxide Nanoparticles and PhotoDynamic Therapy
spellingShingle B-Chronic Lymphocytic Leukemia Autophagyc Cell Death by the Use of Manganese Doped Zinc Oxide Nanoparticles and PhotoDynamic Therapy
Peña Luengas, Sandra
LEUKEMIA
NANOPARTICLES
PHOTODYNAMIC THERAPY
title_short B-Chronic Lymphocytic Leukemia Autophagyc Cell Death by the Use of Manganese Doped Zinc Oxide Nanoparticles and PhotoDynamic Therapy
title_full B-Chronic Lymphocytic Leukemia Autophagyc Cell Death by the Use of Manganese Doped Zinc Oxide Nanoparticles and PhotoDynamic Therapy
title_fullStr B-Chronic Lymphocytic Leukemia Autophagyc Cell Death by the Use of Manganese Doped Zinc Oxide Nanoparticles and PhotoDynamic Therapy
title_full_unstemmed B-Chronic Lymphocytic Leukemia Autophagyc Cell Death by the Use of Manganese Doped Zinc Oxide Nanoparticles and PhotoDynamic Therapy
title_sort B-Chronic Lymphocytic Leukemia Autophagyc Cell Death by the Use of Manganese Doped Zinc Oxide Nanoparticles and PhotoDynamic Therapy
dc.creator.none.fl_str_mv Peña Luengas, Sandra
Marin, Gustavo Horacio
Rodríguez Nieto, Felipe Jorge
Dreon, Marcos Sebastian
Roque, Gustavo
Nuñez, Luis
Sanchez, Francisco Homero
Tarditti, Adrian
Schinella, Guillermo Raúl
Pistaccio, Luis
Goya, Rodolfo Gustavo
Tau, Jose María
Ichim, Thomas
Riordan, Neil
Rivera Montalvo, Luis
Mansilla, Eduardo
author Peña Luengas, Sandra
author_facet Peña Luengas, Sandra
Marin, Gustavo Horacio
Rodríguez Nieto, Felipe Jorge
Dreon, Marcos Sebastian
Roque, Gustavo
Nuñez, Luis
Sanchez, Francisco Homero
Tarditti, Adrian
Schinella, Guillermo Raúl
Pistaccio, Luis
Goya, Rodolfo Gustavo
Tau, Jose María
Ichim, Thomas
Riordan, Neil
Rivera Montalvo, Luis
Mansilla, Eduardo
author_role author
author2 Marin, Gustavo Horacio
Rodríguez Nieto, Felipe Jorge
Dreon, Marcos Sebastian
Roque, Gustavo
Nuñez, Luis
Sanchez, Francisco Homero
Tarditti, Adrian
Schinella, Guillermo Raúl
Pistaccio, Luis
Goya, Rodolfo Gustavo
Tau, Jose María
Ichim, Thomas
Riordan, Neil
Rivera Montalvo, Luis
Mansilla, Eduardo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv LEUKEMIA
NANOPARTICLES
PHOTODYNAMIC THERAPY
topic LEUKEMIA
NANOPARTICLES
PHOTODYNAMIC THERAPY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv B-Chronic Lymphocytic Leukemia (B-CLL) usually follows an adverse, relentless clinical course by slowly developing drug resistance to fludarabine and other chemotherapeutic agents, as well as by acquiring new different genetic abnormalities. As B-CLL cells spontaneously produce high amounts of Reactive Oxygen Species (ROS) having an altered redox state in relation to that of normal B lymphocytes, we decided to probe different metal Zinc nanoparticles (ZnNPs) and quantify the levels of Singlet Oxigen (SO) to see if variations of its intracellular concentrations could execute and accelerate deadly programs in leukemic cells rather than in normal B lymphocytes, when applied with Photodynamic Therapy (PDT). In this way, we developed and tested a variety of metal ZnNPs of which one made of 0.5% Manganese Doped Zinc Oxide (ZnO:Mn) was finally selected for further testing as it had the best fludarabine resistant B-CLL cells in vitro killing activity, specially when combined with PDT. An interesting and rapidly dying process of B-CLL cells, known as autophagy, was always seen under Transmission Electronic Microscopy (TEM) when incubated with these 0.5% Mn doped ZnO NPs. This phenomenon correlated well with those intracellular increases of SO when PDT was administered, and measured by a novel method first described by us. As this therapy seems to be very specific to fludarabine resistant B-CLL cells, producing almost no damage to normal lymphocytes, it could surely contribute in the near future as a new innovative targeted strategy to be delivered in the clinical setting for the definitive benefit of these bad prognostic patients.
Fil: Peña Luengas, Sandra. Universidad de Puerto Rico; Puerto Rico
Fil: Marin, Gustavo Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Rodríguez Nieto, Felipe Jorge. Universidad Nacional Arturo Jauretche; Argentina
Fil: Dreon, Marcos Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Roque, Gustavo. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Nuñez, Luis. Universidad de Puerto Rico; Puerto Rico
Fil: Sanchez, Francisco Homero. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Tarditti, Adrian. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Schinella, Guillermo Raúl. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Pistaccio, Luis. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Goya, Rodolfo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Tau, Jose María. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
Fil: Ichim, Thomas. Medistem; Estados Unidos
Fil: Riordan, Neil. Medistem; Estados Unidos
Fil: Rivera Montalvo, Luis. Universidad de Puerto Rico; Puerto Rico
Fil: Mansilla, Eduardo. Secretaria de Gobierno de Salud. Instituto Nacional Central Único Coordinador de Ablación e Implante; Argentina
description B-Chronic Lymphocytic Leukemia (B-CLL) usually follows an adverse, relentless clinical course by slowly developing drug resistance to fludarabine and other chemotherapeutic agents, as well as by acquiring new different genetic abnormalities. As B-CLL cells spontaneously produce high amounts of Reactive Oxygen Species (ROS) having an altered redox state in relation to that of normal B lymphocytes, we decided to probe different metal Zinc nanoparticles (ZnNPs) and quantify the levels of Singlet Oxigen (SO) to see if variations of its intracellular concentrations could execute and accelerate deadly programs in leukemic cells rather than in normal B lymphocytes, when applied with Photodynamic Therapy (PDT). In this way, we developed and tested a variety of metal ZnNPs of which one made of 0.5% Manganese Doped Zinc Oxide (ZnO:Mn) was finally selected for further testing as it had the best fludarabine resistant B-CLL cells in vitro killing activity, specially when combined with PDT. An interesting and rapidly dying process of B-CLL cells, known as autophagy, was always seen under Transmission Electronic Microscopy (TEM) when incubated with these 0.5% Mn doped ZnO NPs. This phenomenon correlated well with those intracellular increases of SO when PDT was administered, and measured by a novel method first described by us. As this therapy seems to be very specific to fludarabine resistant B-CLL cells, producing almost no damage to normal lymphocytes, it could surely contribute in the near future as a new innovative targeted strategy to be delivered in the clinical setting for the definitive benefit of these bad prognostic patients.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/136950
Peña Luengas, Sandra; Marin, Gustavo Horacio; Rodríguez Nieto, Felipe Jorge; Dreon, Marcos Sebastian; Roque, Gustavo; et al.; B-Chronic Lymphocytic Leukemia Autophagyc Cell Death by the Use of Manganese Doped Zinc Oxide Nanoparticles and PhotoDynamic Therapy; University of Science and Technology; International Journal of Drug Delivery Technology; 5; 1; 3-2015; 15-25
0975-4415
CONICET Digital
CONICET
url http://hdl.handle.net/11336/136950
identifier_str_mv Peña Luengas, Sandra; Marin, Gustavo Horacio; Rodríguez Nieto, Felipe Jorge; Dreon, Marcos Sebastian; Roque, Gustavo; et al.; B-Chronic Lymphocytic Leukemia Autophagyc Cell Death by the Use of Manganese Doped Zinc Oxide Nanoparticles and PhotoDynamic Therapy; University of Science and Technology; International Journal of Drug Delivery Technology; 5; 1; 3-2015; 15-25
0975-4415
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/url/http://impactfactor.org/PDF/IJDDT/5/IJDDT,Vol5,Issue1,Article2.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
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dc.publisher.none.fl_str_mv University of Science and Technology
publisher.none.fl_str_mv University of Science and Technology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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