The role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune response

Autores
Martinez, Fernando Fabian; Cervi, Laura Alejandra; Knubel, Carolina Paola; Panzetta-Dutari, Graciela Maria del Valle; Motran, Claudia Cristina
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Among several explanations for the acceptance of the fetus, the one that suggests that the maternal immune system is suppressed or modified has been the subject of many studies. Thus, it has been proposed that the cells of innate immune system might be able to distinguish the pregnant from the non-pregnant state producing a signal, the so-called signal P. We have previously proposed that pregnancy-specific glycoprotein 1a (PSG1a), a representative member of the main glycoprotein family secreted by placental trophoblast, may modulate the activation of antigen-presenting cells promoting the T-cell shift of the maternal cell immunity toward a less harmful phenotype. In this review, we summarize current knowledge concerning the contribution of pregnancyspecific glycoprotein 1a (PSG1a) to modulate the maternal innate and adaptive immune response in order to assure a successful pregnancy.
Fil: Martinez, Fernando Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Cervi, Laura Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Knubel, Carolina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Panzetta-Dutari, Graciela Maria del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Motran, Claudia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Materia
Dendritic Cells
Macrophages
Th1/Th2 Cells
Th17 Cells
Tolerance
Treg Cells
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25370
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling The role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune responseMartinez, Fernando FabianCervi, Laura AlejandraKnubel, Carolina PaolaPanzetta-Dutari, Graciela Maria del ValleMotran, Claudia CristinaDendritic CellsMacrophagesTh1/Th2 CellsTh17 CellsToleranceTreg Cellshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Among several explanations for the acceptance of the fetus, the one that suggests that the maternal immune system is suppressed or modified has been the subject of many studies. Thus, it has been proposed that the cells of innate immune system might be able to distinguish the pregnant from the non-pregnant state producing a signal, the so-called signal P. We have previously proposed that pregnancy-specific glycoprotein 1a (PSG1a), a representative member of the main glycoprotein family secreted by placental trophoblast, may modulate the activation of antigen-presenting cells promoting the T-cell shift of the maternal cell immunity toward a less harmful phenotype. In this review, we summarize current knowledge concerning the contribution of pregnancyspecific glycoprotein 1a (PSG1a) to modulate the maternal innate and adaptive immune response in order to assure a successful pregnancy.Fil: Martinez, Fernando Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Cervi, Laura Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Knubel, Carolina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Panzetta-Dutari, Graciela Maria del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Motran, Claudia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaWiley2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25370Martinez, Fernando Fabian; Cervi, Laura Alejandra; Knubel, Carolina Paola; Panzetta-Dutari, Graciela Maria del Valle; Motran, Claudia Cristina; The role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune response; Wiley; American Journal of Reproductive Immunology; 69; 4; 2-2013; 383-3941046-7408CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/aji.12089info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/aji.12089/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:25:09Zoai:ri.conicet.gov.ar:11336/25370instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:25:10.246CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune response
title The role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune response
spellingShingle The role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune response
Martinez, Fernando Fabian
Dendritic Cells
Macrophages
Th1/Th2 Cells
Th17 Cells
Tolerance
Treg Cells
title_short The role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune response
title_full The role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune response
title_fullStr The role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune response
title_full_unstemmed The role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune response
title_sort The role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune response
dc.creator.none.fl_str_mv Martinez, Fernando Fabian
Cervi, Laura Alejandra
Knubel, Carolina Paola
Panzetta-Dutari, Graciela Maria del Valle
Motran, Claudia Cristina
author Martinez, Fernando Fabian
author_facet Martinez, Fernando Fabian
Cervi, Laura Alejandra
Knubel, Carolina Paola
Panzetta-Dutari, Graciela Maria del Valle
Motran, Claudia Cristina
author_role author
author2 Cervi, Laura Alejandra
Knubel, Carolina Paola
Panzetta-Dutari, Graciela Maria del Valle
Motran, Claudia Cristina
author2_role author
author
author
author
dc.subject.none.fl_str_mv Dendritic Cells
Macrophages
Th1/Th2 Cells
Th17 Cells
Tolerance
Treg Cells
topic Dendritic Cells
Macrophages
Th1/Th2 Cells
Th17 Cells
Tolerance
Treg Cells
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Among several explanations for the acceptance of the fetus, the one that suggests that the maternal immune system is suppressed or modified has been the subject of many studies. Thus, it has been proposed that the cells of innate immune system might be able to distinguish the pregnant from the non-pregnant state producing a signal, the so-called signal P. We have previously proposed that pregnancy-specific glycoprotein 1a (PSG1a), a representative member of the main glycoprotein family secreted by placental trophoblast, may modulate the activation of antigen-presenting cells promoting the T-cell shift of the maternal cell immunity toward a less harmful phenotype. In this review, we summarize current knowledge concerning the contribution of pregnancyspecific glycoprotein 1a (PSG1a) to modulate the maternal innate and adaptive immune response in order to assure a successful pregnancy.
Fil: Martinez, Fernando Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Cervi, Laura Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Knubel, Carolina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Panzetta-Dutari, Graciela Maria del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Motran, Claudia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
description Among several explanations for the acceptance of the fetus, the one that suggests that the maternal immune system is suppressed or modified has been the subject of many studies. Thus, it has been proposed that the cells of innate immune system might be able to distinguish the pregnant from the non-pregnant state producing a signal, the so-called signal P. We have previously proposed that pregnancy-specific glycoprotein 1a (PSG1a), a representative member of the main glycoprotein family secreted by placental trophoblast, may modulate the activation of antigen-presenting cells promoting the T-cell shift of the maternal cell immunity toward a less harmful phenotype. In this review, we summarize current knowledge concerning the contribution of pregnancyspecific glycoprotein 1a (PSG1a) to modulate the maternal innate and adaptive immune response in order to assure a successful pregnancy.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25370
Martinez, Fernando Fabian; Cervi, Laura Alejandra; Knubel, Carolina Paola; Panzetta-Dutari, Graciela Maria del Valle; Motran, Claudia Cristina; The role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune response; Wiley; American Journal of Reproductive Immunology; 69; 4; 2-2013; 383-394
1046-7408
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25370
identifier_str_mv Martinez, Fernando Fabian; Cervi, Laura Alejandra; Knubel, Carolina Paola; Panzetta-Dutari, Graciela Maria del Valle; Motran, Claudia Cristina; The role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune response; Wiley; American Journal of Reproductive Immunology; 69; 4; 2-2013; 383-394
1046-7408
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/aji.12089
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/aji.12089/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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