Variable Temporal Integration of Stimulus Patterns in the Mouse Barrel Cortex

Autores
Pitas, Anna; Albarracin, Ana Lia; Molano Mazón, Manuel; Maravall, Miguel
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Making sense of the world requires distinguishing temporal patterns and sequences lasting hundreds of milliseconds or more. How cortical circuits integrate over time to represent specific sensory sequences remains elusive. Here we assessed whether neurons in the barrel cortex (BC) integrate information about temporal patterns of whisker movements. We performed cell-attached recordings in anesthetized mice while delivering whisker deflections at variable intervals and compared the information carried by neurons about the latest interstimulus interval (reflecting sensitivity to instantaneous frequency) and earlier intervals (reflecting integration over timescales up to several hundred milliseconds). Neurons carried more information about the latest interval than earlier ones. The amount of temporal integration varied with neuronal responsiveness and with the cortical depth of the recording site, that is, with laminar location. A subset of neurons in the upper layers displayed the strongest integration. Highly responsive neurons in the deeper layers encoded the latest interval but integrated particularly weakly. Under these conditions, BC neurons act primarily as encoders of current stimulation parameters; however, our results suggest that temporal integration over hundreds of milliseconds can emerge in some neurons within BC.
Fil: Pitas, Anna. University of Sussex; Reino Unido. Consejo Superior de Investigaciones Científicas. Instituto de Neurociencia de Alicante; España. Universidad de Miguel Hernández; España
Fil: Albarracin, Ana Lia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Consejo Superior de Investigaciones Científicas. Instituto de Neurociencia de Alicante; España. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; Argentina
Fil: Molano Mazón, Manuel. Consejo Superior de Investigaciones Científicas. Instituto de Neurociencia de Alicante; España
Fil: Maravall, Miguel. Consejo Superior de Investigaciones Científicas. Instituto de Neurociencia de Alicante; España. University of Sussex; Reino Unido
Materia
Cell-Attached
In Vivo
Sensory Coding
Somatosensory
Vibrissae
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/75350
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Variable Temporal Integration of Stimulus Patterns in the Mouse Barrel CortexPitas, AnnaAlbarracin, Ana LiaMolano Mazón, ManuelMaravall, MiguelCell-AttachedIn VivoSensory CodingSomatosensoryVibrissaehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Making sense of the world requires distinguishing temporal patterns and sequences lasting hundreds of milliseconds or more. How cortical circuits integrate over time to represent specific sensory sequences remains elusive. Here we assessed whether neurons in the barrel cortex (BC) integrate information about temporal patterns of whisker movements. We performed cell-attached recordings in anesthetized mice while delivering whisker deflections at variable intervals and compared the information carried by neurons about the latest interstimulus interval (reflecting sensitivity to instantaneous frequency) and earlier intervals (reflecting integration over timescales up to several hundred milliseconds). Neurons carried more information about the latest interval than earlier ones. The amount of temporal integration varied with neuronal responsiveness and with the cortical depth of the recording site, that is, with laminar location. A subset of neurons in the upper layers displayed the strongest integration. Highly responsive neurons in the deeper layers encoded the latest interval but integrated particularly weakly. Under these conditions, BC neurons act primarily as encoders of current stimulation parameters; however, our results suggest that temporal integration over hundreds of milliseconds can emerge in some neurons within BC.Fil: Pitas, Anna. University of Sussex; Reino Unido. Consejo Superior de Investigaciones Científicas. Instituto de Neurociencia de Alicante; España. Universidad de Miguel Hernández; EspañaFil: Albarracin, Ana Lia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Consejo Superior de Investigaciones Científicas. Instituto de Neurociencia de Alicante; España. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; ArgentinaFil: Molano Mazón, Manuel. Consejo Superior de Investigaciones Científicas. Instituto de Neurociencia de Alicante; EspañaFil: Maravall, Miguel. Consejo Superior de Investigaciones Científicas. Instituto de Neurociencia de Alicante; España. University of Sussex; Reino UnidoOxford University Press2017-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/75350Pitas, Anna; Albarracin, Ana Lia; Molano Mazón, Manuel; Maravall, Miguel; Variable Temporal Integration of Stimulus Patterns in the Mouse Barrel Cortex; Oxford University Press; Cerebral Cortex; 27; 3; 3-2017; 1758-17641047-32111460-2199CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/cercor/bhw006info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/cercor/article/27/3/1758/3056278info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:43Zoai:ri.conicet.gov.ar:11336/75350instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:43.543CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Variable Temporal Integration of Stimulus Patterns in the Mouse Barrel Cortex
title Variable Temporal Integration of Stimulus Patterns in the Mouse Barrel Cortex
spellingShingle Variable Temporal Integration of Stimulus Patterns in the Mouse Barrel Cortex
Pitas, Anna
Cell-Attached
In Vivo
Sensory Coding
Somatosensory
Vibrissae
title_short Variable Temporal Integration of Stimulus Patterns in the Mouse Barrel Cortex
title_full Variable Temporal Integration of Stimulus Patterns in the Mouse Barrel Cortex
title_fullStr Variable Temporal Integration of Stimulus Patterns in the Mouse Barrel Cortex
title_full_unstemmed Variable Temporal Integration of Stimulus Patterns in the Mouse Barrel Cortex
title_sort Variable Temporal Integration of Stimulus Patterns in the Mouse Barrel Cortex
dc.creator.none.fl_str_mv Pitas, Anna
Albarracin, Ana Lia
Molano Mazón, Manuel
Maravall, Miguel
author Pitas, Anna
author_facet Pitas, Anna
Albarracin, Ana Lia
Molano Mazón, Manuel
Maravall, Miguel
author_role author
author2 Albarracin, Ana Lia
Molano Mazón, Manuel
Maravall, Miguel
author2_role author
author
author
dc.subject.none.fl_str_mv Cell-Attached
In Vivo
Sensory Coding
Somatosensory
Vibrissae
topic Cell-Attached
In Vivo
Sensory Coding
Somatosensory
Vibrissae
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Making sense of the world requires distinguishing temporal patterns and sequences lasting hundreds of milliseconds or more. How cortical circuits integrate over time to represent specific sensory sequences remains elusive. Here we assessed whether neurons in the barrel cortex (BC) integrate information about temporal patterns of whisker movements. We performed cell-attached recordings in anesthetized mice while delivering whisker deflections at variable intervals and compared the information carried by neurons about the latest interstimulus interval (reflecting sensitivity to instantaneous frequency) and earlier intervals (reflecting integration over timescales up to several hundred milliseconds). Neurons carried more information about the latest interval than earlier ones. The amount of temporal integration varied with neuronal responsiveness and with the cortical depth of the recording site, that is, with laminar location. A subset of neurons in the upper layers displayed the strongest integration. Highly responsive neurons in the deeper layers encoded the latest interval but integrated particularly weakly. Under these conditions, BC neurons act primarily as encoders of current stimulation parameters; however, our results suggest that temporal integration over hundreds of milliseconds can emerge in some neurons within BC.
Fil: Pitas, Anna. University of Sussex; Reino Unido. Consejo Superior de Investigaciones Científicas. Instituto de Neurociencia de Alicante; España. Universidad de Miguel Hernández; España
Fil: Albarracin, Ana Lia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Consejo Superior de Investigaciones Científicas. Instituto de Neurociencia de Alicante; España. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; Argentina
Fil: Molano Mazón, Manuel. Consejo Superior de Investigaciones Científicas. Instituto de Neurociencia de Alicante; España
Fil: Maravall, Miguel. Consejo Superior de Investigaciones Científicas. Instituto de Neurociencia de Alicante; España. University of Sussex; Reino Unido
description Making sense of the world requires distinguishing temporal patterns and sequences lasting hundreds of milliseconds or more. How cortical circuits integrate over time to represent specific sensory sequences remains elusive. Here we assessed whether neurons in the barrel cortex (BC) integrate information about temporal patterns of whisker movements. We performed cell-attached recordings in anesthetized mice while delivering whisker deflections at variable intervals and compared the information carried by neurons about the latest interstimulus interval (reflecting sensitivity to instantaneous frequency) and earlier intervals (reflecting integration over timescales up to several hundred milliseconds). Neurons carried more information about the latest interval than earlier ones. The amount of temporal integration varied with neuronal responsiveness and with the cortical depth of the recording site, that is, with laminar location. A subset of neurons in the upper layers displayed the strongest integration. Highly responsive neurons in the deeper layers encoded the latest interval but integrated particularly weakly. Under these conditions, BC neurons act primarily as encoders of current stimulation parameters; however, our results suggest that temporal integration over hundreds of milliseconds can emerge in some neurons within BC.
publishDate 2017
dc.date.none.fl_str_mv 2017-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/75350
Pitas, Anna; Albarracin, Ana Lia; Molano Mazón, Manuel; Maravall, Miguel; Variable Temporal Integration of Stimulus Patterns in the Mouse Barrel Cortex; Oxford University Press; Cerebral Cortex; 27; 3; 3-2017; 1758-1764
1047-3211
1460-2199
CONICET Digital
CONICET
url http://hdl.handle.net/11336/75350
identifier_str_mv Pitas, Anna; Albarracin, Ana Lia; Molano Mazón, Manuel; Maravall, Miguel; Variable Temporal Integration of Stimulus Patterns in the Mouse Barrel Cortex; Oxford University Press; Cerebral Cortex; 27; 3; 3-2017; 1758-1764
1047-3211
1460-2199
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/cercor/bhw006
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/cercor/article/27/3/1758/3056278
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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