Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study
- Autores
- Coelho, Claudia; Figueiredo, Ricardo; Frank, Elmar; Burger, Julia; Schecklmann, Martin; Landgrebe, Michael; Langguth, Berthold; Elgoyhen, Ana Belen
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Tinnitus, the phantom perception of sounds, is a highly prevalent disorder. Although a wide variety of drugs have been investigated off label for the treatment of tinnitus, there is no approved pharmacotherapy. We report an open-label exploratory pilot study to assess the effect of muscle relaxants acting on the central nervous system on tinnitus patients. Cyclobenzaprine at high (30 mg) and low doses (10 mg), orphenadrine (100 mg), tizanidine (24 mg) and eperisone (50 mg) were administered to a maximum of 20 patients per group over a 12-week period. High-dose cyclobenzaprine resulted in a significant reduction in the Tinnitus Handicap Inventory (THI) score between baseline and week 12 in the intention-to-treat sample. On the other hand, other treatments were not effective. These results were confirmed in an explorative analysis where baseline corrected THI and Clinical Global Impression scores at week 12 were compared between groups. The present open trial presents a new promising pharmacotherapy for tinnitus that should be validated in placebo-controlled double-blind trials.
Fil: Coelho, Claudia. University of Iowa; Estados Unidos. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Figueiredo, Ricardo. Clinical and Research Tinnitus Center; Brasil
Fil: Frank, Elmar. Universitat Regensburg; Alemania
Fil: Burger, Julia. Universitat Regensburg; Alemania
Fil: Schecklmann, Martin. Universitat Regensburg; Alemania
Fil: Landgrebe, Michael. Universitat Regensburg; Alemania
Fil: Langguth, Berthold. Universitat Regensburg; Alemania
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina - Materia
-
Muscle Relaxants
Phantom Perception
Somatosensory System
Tinnitus - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/79403
Ver los metadatos del registro completo
id |
CONICETDig_e43ca25251c9a76cb458eda443e386a4 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/79403 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot studyCoelho, ClaudiaFigueiredo, RicardoFrank, ElmarBurger, JuliaSchecklmann, MartinLandgrebe, MichaelLangguth, BertholdElgoyhen, Ana BelenMuscle RelaxantsPhantom PerceptionSomatosensory SystemTinnitushttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Tinnitus, the phantom perception of sounds, is a highly prevalent disorder. Although a wide variety of drugs have been investigated off label for the treatment of tinnitus, there is no approved pharmacotherapy. We report an open-label exploratory pilot study to assess the effect of muscle relaxants acting on the central nervous system on tinnitus patients. Cyclobenzaprine at high (30 mg) and low doses (10 mg), orphenadrine (100 mg), tizanidine (24 mg) and eperisone (50 mg) were administered to a maximum of 20 patients per group over a 12-week period. High-dose cyclobenzaprine resulted in a significant reduction in the Tinnitus Handicap Inventory (THI) score between baseline and week 12 in the intention-to-treat sample. On the other hand, other treatments were not effective. These results were confirmed in an explorative analysis where baseline corrected THI and Clinical Global Impression scores at week 12 were compared between groups. The present open trial presents a new promising pharmacotherapy for tinnitus that should be validated in placebo-controlled double-blind trials.Fil: Coelho, Claudia. University of Iowa; Estados Unidos. Universidade Federal do Rio Grande do Sul; BrasilFil: Figueiredo, Ricardo. Clinical and Research Tinnitus Center; BrasilFil: Frank, Elmar. Universitat Regensburg; AlemaniaFil: Burger, Julia. Universitat Regensburg; AlemaniaFil: Schecklmann, Martin. Universitat Regensburg; AlemaniaFil: Landgrebe, Michael. Universitat Regensburg; AlemaniaFil: Langguth, Berthold. Universitat Regensburg; AlemaniaFil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaKarger2012-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79403Coelho, Claudia; Figueiredo, Ricardo; Frank, Elmar; Burger, Julia; Schecklmann, Martin; et al.; Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study; Karger; Audiology And Neuro-otology; 17; 3; 4-2012; 179-1881420-3030CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1159/000335657info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/335657info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:56:40Zoai:ri.conicet.gov.ar:11336/79403instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:56:40.773CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study |
title |
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study |
spellingShingle |
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study Coelho, Claudia Muscle Relaxants Phantom Perception Somatosensory System Tinnitus |
title_short |
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study |
title_full |
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study |
title_fullStr |
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study |
title_full_unstemmed |
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study |
title_sort |
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study |
dc.creator.none.fl_str_mv |
Coelho, Claudia Figueiredo, Ricardo Frank, Elmar Burger, Julia Schecklmann, Martin Landgrebe, Michael Langguth, Berthold Elgoyhen, Ana Belen |
author |
Coelho, Claudia |
author_facet |
Coelho, Claudia Figueiredo, Ricardo Frank, Elmar Burger, Julia Schecklmann, Martin Landgrebe, Michael Langguth, Berthold Elgoyhen, Ana Belen |
author_role |
author |
author2 |
Figueiredo, Ricardo Frank, Elmar Burger, Julia Schecklmann, Martin Landgrebe, Michael Langguth, Berthold Elgoyhen, Ana Belen |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
Muscle Relaxants Phantom Perception Somatosensory System Tinnitus |
topic |
Muscle Relaxants Phantom Perception Somatosensory System Tinnitus |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Tinnitus, the phantom perception of sounds, is a highly prevalent disorder. Although a wide variety of drugs have been investigated off label for the treatment of tinnitus, there is no approved pharmacotherapy. We report an open-label exploratory pilot study to assess the effect of muscle relaxants acting on the central nervous system on tinnitus patients. Cyclobenzaprine at high (30 mg) and low doses (10 mg), orphenadrine (100 mg), tizanidine (24 mg) and eperisone (50 mg) were administered to a maximum of 20 patients per group over a 12-week period. High-dose cyclobenzaprine resulted in a significant reduction in the Tinnitus Handicap Inventory (THI) score between baseline and week 12 in the intention-to-treat sample. On the other hand, other treatments were not effective. These results were confirmed in an explorative analysis where baseline corrected THI and Clinical Global Impression scores at week 12 were compared between groups. The present open trial presents a new promising pharmacotherapy for tinnitus that should be validated in placebo-controlled double-blind trials. Fil: Coelho, Claudia. University of Iowa; Estados Unidos. Universidade Federal do Rio Grande do Sul; Brasil Fil: Figueiredo, Ricardo. Clinical and Research Tinnitus Center; Brasil Fil: Frank, Elmar. Universitat Regensburg; Alemania Fil: Burger, Julia. Universitat Regensburg; Alemania Fil: Schecklmann, Martin. Universitat Regensburg; Alemania Fil: Landgrebe, Michael. Universitat Regensburg; Alemania Fil: Langguth, Berthold. Universitat Regensburg; Alemania Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina |
description |
Tinnitus, the phantom perception of sounds, is a highly prevalent disorder. Although a wide variety of drugs have been investigated off label for the treatment of tinnitus, there is no approved pharmacotherapy. We report an open-label exploratory pilot study to assess the effect of muscle relaxants acting on the central nervous system on tinnitus patients. Cyclobenzaprine at high (30 mg) and low doses (10 mg), orphenadrine (100 mg), tizanidine (24 mg) and eperisone (50 mg) were administered to a maximum of 20 patients per group over a 12-week period. High-dose cyclobenzaprine resulted in a significant reduction in the Tinnitus Handicap Inventory (THI) score between baseline and week 12 in the intention-to-treat sample. On the other hand, other treatments were not effective. These results were confirmed in an explorative analysis where baseline corrected THI and Clinical Global Impression scores at week 12 were compared between groups. The present open trial presents a new promising pharmacotherapy for tinnitus that should be validated in placebo-controlled double-blind trials. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/79403 Coelho, Claudia; Figueiredo, Ricardo; Frank, Elmar; Burger, Julia; Schecklmann, Martin; et al.; Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study; Karger; Audiology And Neuro-otology; 17; 3; 4-2012; 179-188 1420-3030 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/79403 |
identifier_str_mv |
Coelho, Claudia; Figueiredo, Ricardo; Frank, Elmar; Burger, Julia; Schecklmann, Martin; et al.; Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study; Karger; Audiology And Neuro-otology; 17; 3; 4-2012; 179-188 1420-3030 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1159/000335657 info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/335657 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Karger |
publisher.none.fl_str_mv |
Karger |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844613700681465856 |
score |
13.070432 |