Sclerotium rolfsii scleroglucan: The promising behavior of a natural polysaccharide as a drug delivery vehicle, suspension stabilizer and emulsifier

Autores
Viñarta, Silvana Carolina; Francois, Nora; Daraio, Marta Edit; Castellanos, Lucia Ines; Fariña, Julia Ines
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Gel matrices of scleroglucans from Sclerotium rolfsii ATCC 201126 (EPS I and EPS II, from 48-h and 72-h fermentations, respectively) were evaluated on their release kinetics of theophylline (Th). Equivalent polymer (2%, w/w) and Th (0.2%, w/w) concentrations showed almost coincident drug release patterns, independently of polymer molecular weight or the microstructural properties of gel matrices. Dynamic rheological studies of scleroglucan hydrogel structures (storage, G , and loss, G, moduli) indicated a solid-like behavior. Differences on pore size dimensions (EPS I = 20m and EPS II = 7m) were in accordance to the differences in G (EPS I = 113 Pa and EPS II = 161 Pa), a fact likely related to variations in the cross-linking density of polymer networks. Compared to already known biopolymers, EPS I and EPS II at 0.5 g/L showed a good dispersing ability against particulate suspensions of activated charcoal, bentonite, CaCO3, celite and quartz powder. Emulsifying ability of both EPSs at 2 g/L was high (E = 56?60%) when tested with kerosene, moderate (∼30%) with hexadecane, and negligible in the presence of olive oil-in-water emulsions.
Fil: Viñarta, Silvana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina
Fil: Francois, Nora. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Química; Argentina
Fil: Daraio, Marta Edit. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Química; Argentina
Fil: Castellanos, Lucia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Fariña, Julia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Materia
Scleroglucans
Sclerotium Rolfsii
Hydrogel
Suspensions
Drug Release
Emulsions
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/43187
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/43187
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sclerotium rolfsii scleroglucan: The promising behavior of a natural polysaccharide as a drug delivery vehicle, suspension stabilizer and emulsifierViñarta, Silvana CarolinaFrancois, NoraDaraio, Marta EditCastellanos, Lucia InesFariña, Julia InesScleroglucansSclerotium RolfsiiHydrogelSuspensionsDrug ReleaseEmulsionshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Gel matrices of scleroglucans from Sclerotium rolfsii ATCC 201126 (EPS I and EPS II, from 48-h and 72-h fermentations, respectively) were evaluated on their release kinetics of theophylline (Th). Equivalent polymer (2%, w/w) and Th (0.2%, w/w) concentrations showed almost coincident drug release patterns, independently of polymer molecular weight or the microstructural properties of gel matrices. Dynamic rheological studies of scleroglucan hydrogel structures (storage, G , and loss, G, moduli) indicated a solid-like behavior. Differences on pore size dimensions (EPS I = 20m and EPS II = 7m) were in accordance to the differences in G (EPS I = 113 Pa and EPS II = 161 Pa), a fact likely related to variations in the cross-linking density of polymer networks. Compared to already known biopolymers, EPS I and EPS II at 0.5 g/L showed a good dispersing ability against particulate suspensions of activated charcoal, bentonite, CaCO3, celite and quartz powder. Emulsifying ability of both EPSs at 2 g/L was high (E = 56?60%) when tested with kerosene, moderate (∼30%) with hexadecane, and negligible in the presence of olive oil-in-water emulsions.Fil: Viñarta, Silvana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; ArgentinaFil: Francois, Nora. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Química; ArgentinaFil: Daraio, Marta Edit. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Química; ArgentinaFil: Castellanos, Lucia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Fariña, Julia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaElsevier Science2007-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/43187Viñarta, Silvana Carolina; Francois, Nora; Daraio, Marta Edit; Castellanos, Lucia Ines; Fariña, Julia Ines; Sclerotium rolfsii scleroglucan: The promising behavior of a natural polysaccharide as a drug delivery vehicle, suspension stabilizer and emulsifier; Elsevier Science; International Journal of Biological Macromolecules; 41; 3; 8-2007; 314-3230141-8130CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijbiomac.2007.04.001info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0141813007001043info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:45:05Zoai:ri.conicet.gov.ar:11336/43187instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:45:05.7CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sclerotium rolfsii scleroglucan: The promising behavior of a natural polysaccharide as a drug delivery vehicle, suspension stabilizer and emulsifier
title Sclerotium rolfsii scleroglucan: The promising behavior of a natural polysaccharide as a drug delivery vehicle, suspension stabilizer and emulsifier
spellingShingle Sclerotium rolfsii scleroglucan: The promising behavior of a natural polysaccharide as a drug delivery vehicle, suspension stabilizer and emulsifier
Viñarta, Silvana Carolina
Scleroglucans
Sclerotium Rolfsii
Hydrogel
Suspensions
Drug Release
Emulsions
title_short Sclerotium rolfsii scleroglucan: The promising behavior of a natural polysaccharide as a drug delivery vehicle, suspension stabilizer and emulsifier
title_full Sclerotium rolfsii scleroglucan: The promising behavior of a natural polysaccharide as a drug delivery vehicle, suspension stabilizer and emulsifier
title_fullStr Sclerotium rolfsii scleroglucan: The promising behavior of a natural polysaccharide as a drug delivery vehicle, suspension stabilizer and emulsifier
title_full_unstemmed Sclerotium rolfsii scleroglucan: The promising behavior of a natural polysaccharide as a drug delivery vehicle, suspension stabilizer and emulsifier
title_sort Sclerotium rolfsii scleroglucan: The promising behavior of a natural polysaccharide as a drug delivery vehicle, suspension stabilizer and emulsifier
dc.creator.none.fl_str_mv Viñarta, Silvana Carolina
Francois, Nora
Daraio, Marta Edit
Castellanos, Lucia Ines
Fariña, Julia Ines
author Viñarta, Silvana Carolina
author_facet Viñarta, Silvana Carolina
Francois, Nora
Daraio, Marta Edit
Castellanos, Lucia Ines
Fariña, Julia Ines
author_role author
author2 Francois, Nora
Daraio, Marta Edit
Castellanos, Lucia Ines
Fariña, Julia Ines
author2_role author
author
author
author
dc.subject.none.fl_str_mv Scleroglucans
Sclerotium Rolfsii
Hydrogel
Suspensions
Drug Release
Emulsions
topic Scleroglucans
Sclerotium Rolfsii
Hydrogel
Suspensions
Drug Release
Emulsions
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Gel matrices of scleroglucans from Sclerotium rolfsii ATCC 201126 (EPS I and EPS II, from 48-h and 72-h fermentations, respectively) were evaluated on their release kinetics of theophylline (Th). Equivalent polymer (2%, w/w) and Th (0.2%, w/w) concentrations showed almost coincident drug release patterns, independently of polymer molecular weight or the microstructural properties of gel matrices. Dynamic rheological studies of scleroglucan hydrogel structures (storage, G , and loss, G, moduli) indicated a solid-like behavior. Differences on pore size dimensions (EPS I = 20m and EPS II = 7m) were in accordance to the differences in G (EPS I = 113 Pa and EPS II = 161 Pa), a fact likely related to variations in the cross-linking density of polymer networks. Compared to already known biopolymers, EPS I and EPS II at 0.5 g/L showed a good dispersing ability against particulate suspensions of activated charcoal, bentonite, CaCO3, celite and quartz powder. Emulsifying ability of both EPSs at 2 g/L was high (E = 56?60%) when tested with kerosene, moderate (∼30%) with hexadecane, and negligible in the presence of olive oil-in-water emulsions.
Fil: Viñarta, Silvana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina
Fil: Francois, Nora. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Química; Argentina
Fil: Daraio, Marta Edit. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Química; Argentina
Fil: Castellanos, Lucia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Fariña, Julia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
description Gel matrices of scleroglucans from Sclerotium rolfsii ATCC 201126 (EPS I and EPS II, from 48-h and 72-h fermentations, respectively) were evaluated on their release kinetics of theophylline (Th). Equivalent polymer (2%, w/w) and Th (0.2%, w/w) concentrations showed almost coincident drug release patterns, independently of polymer molecular weight or the microstructural properties of gel matrices. Dynamic rheological studies of scleroglucan hydrogel structures (storage, G , and loss, G, moduli) indicated a solid-like behavior. Differences on pore size dimensions (EPS I = 20m and EPS II = 7m) were in accordance to the differences in G (EPS I = 113 Pa and EPS II = 161 Pa), a fact likely related to variations in the cross-linking density of polymer networks. Compared to already known biopolymers, EPS I and EPS II at 0.5 g/L showed a good dispersing ability against particulate suspensions of activated charcoal, bentonite, CaCO3, celite and quartz powder. Emulsifying ability of both EPSs at 2 g/L was high (E = 56?60%) when tested with kerosene, moderate (∼30%) with hexadecane, and negligible in the presence of olive oil-in-water emulsions.
publishDate 2007
dc.date.none.fl_str_mv 2007-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/43187
Viñarta, Silvana Carolina; Francois, Nora; Daraio, Marta Edit; Castellanos, Lucia Ines; Fariña, Julia Ines; Sclerotium rolfsii scleroglucan: The promising behavior of a natural polysaccharide as a drug delivery vehicle, suspension stabilizer and emulsifier; Elsevier Science; International Journal of Biological Macromolecules; 41; 3; 8-2007; 314-323
0141-8130
CONICET Digital
CONICET
url http://hdl.handle.net/11336/43187
identifier_str_mv Viñarta, Silvana Carolina; Francois, Nora; Daraio, Marta Edit; Castellanos, Lucia Ines; Fariña, Julia Ines; Sclerotium rolfsii scleroglucan: The promising behavior of a natural polysaccharide as a drug delivery vehicle, suspension stabilizer and emulsifier; Elsevier Science; International Journal of Biological Macromolecules; 41; 3; 8-2007; 314-323
0141-8130
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijbiomac.2007.04.001
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0141813007001043
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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