Angiotensin-(1–7): beyond its central effects on blood pressure

Autores
Gironacci, Mariela Mercedes
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Angiotensin (Ang) (1–7) is the main component of the depressor and protective arm of the renin-angiotensin system. Ang-(1–7) induces vasodilation, natriuresis and diuresis, cardioprotection, inhibits angiogenesis and cell growth and opposes the pressor, proliferative, profibrotic, and prothrombotic actions mediated by Ang II. Centrally, Ang-(1–7) induces changes in mean arterial pressure and this effect may be linked with its inhibitory neuromodulatory action on norepinephrine neurotransmission. The present review is focused on the role of Ang-(1–7) as a protective agent in the brain.
Fil: Gironacci, Mariela Mercedes. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Materia
Angiotensin-(1-7)
Stroke
Mas Receptor
Angiogenesis
Norepinephrine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/18336
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/18336
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Angiotensin-(1–7): beyond its central effects on blood pressureGironacci, Mariela MercedesAngiotensin-(1-7)StrokeMas ReceptorAngiogenesisNorepinephrinehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Angiotensin (Ang) (1–7) is the main component of the depressor and protective arm of the renin-angiotensin system. Ang-(1–7) induces vasodilation, natriuresis and diuresis, cardioprotection, inhibits angiogenesis and cell growth and opposes the pressor, proliferative, profibrotic, and prothrombotic actions mediated by Ang II. Centrally, Ang-(1–7) induces changes in mean arterial pressure and this effect may be linked with its inhibitory neuromodulatory action on norepinephrine neurotransmission. The present review is focused on the role of Ang-(1–7) as a protective agent in the brain.Fil: Gironacci, Mariela Mercedes. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaSage Publications2015-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/18336Gironacci, Mariela Mercedes; Angiotensin-(1–7): beyond its central effects on blood pressure; Sage Publications; Therapeutic Advances in Cardiovascular Disease; 9; 4; 8-2015; 209-2191753-94471753-9455CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/abs/10.1177/1753944715599875info:eu-repo/semantics/altIdentifier/doi/10.1177/1753944715599875info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:02:32Zoai:ri.conicet.gov.ar:11336/18336instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:02:32.639CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Angiotensin-(1–7): beyond its central effects on blood pressure
title Angiotensin-(1–7): beyond its central effects on blood pressure
spellingShingle Angiotensin-(1–7): beyond its central effects on blood pressure
Gironacci, Mariela Mercedes
Angiotensin-(1-7)
Stroke
Mas Receptor
Angiogenesis
Norepinephrine
title_short Angiotensin-(1–7): beyond its central effects on blood pressure
title_full Angiotensin-(1–7): beyond its central effects on blood pressure
title_fullStr Angiotensin-(1–7): beyond its central effects on blood pressure
title_full_unstemmed Angiotensin-(1–7): beyond its central effects on blood pressure
title_sort Angiotensin-(1–7): beyond its central effects on blood pressure
dc.creator.none.fl_str_mv Gironacci, Mariela Mercedes
author Gironacci, Mariela Mercedes
author_facet Gironacci, Mariela Mercedes
author_role author
dc.subject.none.fl_str_mv Angiotensin-(1-7)
Stroke
Mas Receptor
Angiogenesis
Norepinephrine
topic Angiotensin-(1-7)
Stroke
Mas Receptor
Angiogenesis
Norepinephrine
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Angiotensin (Ang) (1–7) is the main component of the depressor and protective arm of the renin-angiotensin system. Ang-(1–7) induces vasodilation, natriuresis and diuresis, cardioprotection, inhibits angiogenesis and cell growth and opposes the pressor, proliferative, profibrotic, and prothrombotic actions mediated by Ang II. Centrally, Ang-(1–7) induces changes in mean arterial pressure and this effect may be linked with its inhibitory neuromodulatory action on norepinephrine neurotransmission. The present review is focused on the role of Ang-(1–7) as a protective agent in the brain.
Fil: Gironacci, Mariela Mercedes. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
description Angiotensin (Ang) (1–7) is the main component of the depressor and protective arm of the renin-angiotensin system. Ang-(1–7) induces vasodilation, natriuresis and diuresis, cardioprotection, inhibits angiogenesis and cell growth and opposes the pressor, proliferative, profibrotic, and prothrombotic actions mediated by Ang II. Centrally, Ang-(1–7) induces changes in mean arterial pressure and this effect may be linked with its inhibitory neuromodulatory action on norepinephrine neurotransmission. The present review is focused on the role of Ang-(1–7) as a protective agent in the brain.
publishDate 2015
dc.date.none.fl_str_mv 2015-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/18336
Gironacci, Mariela Mercedes; Angiotensin-(1–7): beyond its central effects on blood pressure; Sage Publications; Therapeutic Advances in Cardiovascular Disease; 9; 4; 8-2015; 209-219
1753-9447
1753-9455
CONICET Digital
CONICET
url http://hdl.handle.net/11336/18336
identifier_str_mv Gironacci, Mariela Mercedes; Angiotensin-(1–7): beyond its central effects on blood pressure; Sage Publications; Therapeutic Advances in Cardiovascular Disease; 9; 4; 8-2015; 209-219
1753-9447
1753-9455
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/abs/10.1177/1753944715599875
info:eu-repo/semantics/altIdentifier/doi/10.1177/1753944715599875
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sage Publications
publisher.none.fl_str_mv Sage Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782361630408704
score 12.982451

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