A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat

Autores
Peredo, Horacio Angel; Lee, H.; Donoso, Adriana Susana; Andrade, V.; Sánchez Eluchans, N.; Puyó, Ana María
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the rat, a high-fat (HF) plus fructose (F) diet produces cardiovascular and metabolic alterations that resemble human metabolic syndrome. Prostanoids (PR), cyclo-oxygenase-derived arachidonic acid metabolites, have vasoactive properties and mediate inflammation. The aim of this study was to analyse the effect of a HF+F diet on blood pressure (BP), metabolic parameters and mesenteric vascular bed PR production in male Sprague-Dawley rats. Four groups were studied over 9 weeks (n = 6 each): control (C), standard diet (SD) and tap water to drink; F+SD and 10% w/v F solution to drink; HF 50% (w/w) bovine fat added to SD and tap water; and HFF, both treatments. PR were determined by HPLC. Blood pressure was elevated in all experimental groups. Triglyceridaemia, insulinaemia and HOMA-IR were increased in the F and HF groups. HF+F animals showed elevated glycaemia, insulinaemia, HOMA-IR and triglyceridaemia. F decreased the vasodilator prostanoids PGI2 and PGE2 in the mesenteric vascular bed. Body weight was not significantly altered. In HFF, production of PGE2, PGF2alpha and TXB2 was elevated. The increased BP in HF and HFF could be partly attributed to the imbalance in vascular PR production towards vasoconstrictors. On the other hand, this dietary modification could induce inflammation, which would explain the elevation of PGE2. In the F group, hypertension could be related to decreased vasodilator PRs. The simultaneous administration of HF and F in the rat produces deleterious effects greater than observed when treatments are applied separately.
Fil: Peredo, Horacio Angel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lee, H.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Donoso, Adriana Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Andrade, V.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Sánchez Eluchans, N.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Puyó, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Materia
Fructose
High Fat
Hypertension
Metabolic Syndrome
Prostanoids
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/39283
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A high-fat plus fructose diet produces a vascular prostanoid alterations in the ratPeredo, Horacio AngelLee, H.Donoso, Adriana SusanaAndrade, V.Sánchez Eluchans, N.Puyó, Ana MaríaFructoseHigh FatHypertensionMetabolic SyndromeProstanoidshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In the rat, a high-fat (HF) plus fructose (F) diet produces cardiovascular and metabolic alterations that resemble human metabolic syndrome. Prostanoids (PR), cyclo-oxygenase-derived arachidonic acid metabolites, have vasoactive properties and mediate inflammation. The aim of this study was to analyse the effect of a HF+F diet on blood pressure (BP), metabolic parameters and mesenteric vascular bed PR production in male Sprague-Dawley rats. Four groups were studied over 9 weeks (n = 6 each): control (C), standard diet (SD) and tap water to drink; F+SD and 10% w/v F solution to drink; HF 50% (w/w) bovine fat added to SD and tap water; and HFF, both treatments. PR were determined by HPLC. Blood pressure was elevated in all experimental groups. Triglyceridaemia, insulinaemia and HOMA-IR were increased in the F and HF groups. HF+F animals showed elevated glycaemia, insulinaemia, HOMA-IR and triglyceridaemia. F decreased the vasodilator prostanoids PGI2 and PGE2 in the mesenteric vascular bed. Body weight was not significantly altered. In HFF, production of PGE2, PGF2alpha and TXB2 was elevated. The increased BP in HF and HFF could be partly attributed to the imbalance in vascular PR production towards vasoconstrictors. On the other hand, this dietary modification could induce inflammation, which would explain the elevation of PGE2. In the F group, hypertension could be related to decreased vasodilator PRs. The simultaneous administration of HF and F in the rat produces deleterious effects greater than observed when treatments are applied separately.Fil: Peredo, Horacio Angel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lee, H.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Donoso, Adriana Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Andrade, V.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Sánchez Eluchans, N.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Puyó, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaBlackwell Publishing2015-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39283Peredo, Horacio Angel; Lee, H.; Donoso, Adriana Susana; Andrade, V.; Sánchez Eluchans, N.; et al.; A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat; Blackwell Publishing; Autonomic and Autacoid Pharmacology; 34; 3-4; 4-2015; 35-401474-8673CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/aap.12021info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/aap.12021info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:27Zoai:ri.conicet.gov.ar:11336/39283instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:27.56CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat
title A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat
spellingShingle A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat
Peredo, Horacio Angel
Fructose
High Fat
Hypertension
Metabolic Syndrome
Prostanoids
title_short A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat
title_full A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat
title_fullStr A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat
title_full_unstemmed A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat
title_sort A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat
dc.creator.none.fl_str_mv Peredo, Horacio Angel
Lee, H.
Donoso, Adriana Susana
Andrade, V.
Sánchez Eluchans, N.
Puyó, Ana María
author Peredo, Horacio Angel
author_facet Peredo, Horacio Angel
Lee, H.
Donoso, Adriana Susana
Andrade, V.
Sánchez Eluchans, N.
Puyó, Ana María
author_role author
author2 Lee, H.
Donoso, Adriana Susana
Andrade, V.
Sánchez Eluchans, N.
Puyó, Ana María
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Fructose
High Fat
Hypertension
Metabolic Syndrome
Prostanoids
topic Fructose
High Fat
Hypertension
Metabolic Syndrome
Prostanoids
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In the rat, a high-fat (HF) plus fructose (F) diet produces cardiovascular and metabolic alterations that resemble human metabolic syndrome. Prostanoids (PR), cyclo-oxygenase-derived arachidonic acid metabolites, have vasoactive properties and mediate inflammation. The aim of this study was to analyse the effect of a HF+F diet on blood pressure (BP), metabolic parameters and mesenteric vascular bed PR production in male Sprague-Dawley rats. Four groups were studied over 9 weeks (n = 6 each): control (C), standard diet (SD) and tap water to drink; F+SD and 10% w/v F solution to drink; HF 50% (w/w) bovine fat added to SD and tap water; and HFF, both treatments. PR were determined by HPLC. Blood pressure was elevated in all experimental groups. Triglyceridaemia, insulinaemia and HOMA-IR were increased in the F and HF groups. HF+F animals showed elevated glycaemia, insulinaemia, HOMA-IR and triglyceridaemia. F decreased the vasodilator prostanoids PGI2 and PGE2 in the mesenteric vascular bed. Body weight was not significantly altered. In HFF, production of PGE2, PGF2alpha and TXB2 was elevated. The increased BP in HF and HFF could be partly attributed to the imbalance in vascular PR production towards vasoconstrictors. On the other hand, this dietary modification could induce inflammation, which would explain the elevation of PGE2. In the F group, hypertension could be related to decreased vasodilator PRs. The simultaneous administration of HF and F in the rat produces deleterious effects greater than observed when treatments are applied separately.
Fil: Peredo, Horacio Angel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lee, H.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Donoso, Adriana Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Andrade, V.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Sánchez Eluchans, N.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Puyó, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
description In the rat, a high-fat (HF) plus fructose (F) diet produces cardiovascular and metabolic alterations that resemble human metabolic syndrome. Prostanoids (PR), cyclo-oxygenase-derived arachidonic acid metabolites, have vasoactive properties and mediate inflammation. The aim of this study was to analyse the effect of a HF+F diet on blood pressure (BP), metabolic parameters and mesenteric vascular bed PR production in male Sprague-Dawley rats. Four groups were studied over 9 weeks (n = 6 each): control (C), standard diet (SD) and tap water to drink; F+SD and 10% w/v F solution to drink; HF 50% (w/w) bovine fat added to SD and tap water; and HFF, both treatments. PR were determined by HPLC. Blood pressure was elevated in all experimental groups. Triglyceridaemia, insulinaemia and HOMA-IR were increased in the F and HF groups. HF+F animals showed elevated glycaemia, insulinaemia, HOMA-IR and triglyceridaemia. F decreased the vasodilator prostanoids PGI2 and PGE2 in the mesenteric vascular bed. Body weight was not significantly altered. In HFF, production of PGE2, PGF2alpha and TXB2 was elevated. The increased BP in HF and HFF could be partly attributed to the imbalance in vascular PR production towards vasoconstrictors. On the other hand, this dietary modification could induce inflammation, which would explain the elevation of PGE2. In the F group, hypertension could be related to decreased vasodilator PRs. The simultaneous administration of HF and F in the rat produces deleterious effects greater than observed when treatments are applied separately.
publishDate 2015
dc.date.none.fl_str_mv 2015-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39283
Peredo, Horacio Angel; Lee, H.; Donoso, Adriana Susana; Andrade, V.; Sánchez Eluchans, N.; et al.; A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat; Blackwell Publishing; Autonomic and Autacoid Pharmacology; 34; 3-4; 4-2015; 35-40
1474-8673
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39283
identifier_str_mv Peredo, Horacio Angel; Lee, H.; Donoso, Adriana Susana; Andrade, V.; Sánchez Eluchans, N.; et al.; A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat; Blackwell Publishing; Autonomic and Autacoid Pharmacology; 34; 3-4; 4-2015; 35-40
1474-8673
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/aap.12021
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/aap.12021
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Blackwell Publishing
publisher.none.fl_str_mv Blackwell Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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