Building an experimental nutritional model of obesity. Evaluation of anthropometrical and nutritional parameters
- Autores
- Alfonso, Javier Oscar; Lopez, Mariana; Delgado, Silvia Marcela; Navigatore Fonzo, Lorena Silvina; Anzulovich Miranda, Ana Cecilia
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- The etiology of obesity is multifactorial, and includes genetic, environmental, and dietary factors, where hypercaloric diets play a central role in the development of the disease. It is known that obesity in adulthood can increase the risk of suffering neurodegenerative diseases. As a part of an institutional project that studies obesity as a base disease for the development of chronic age-associated diseases and the search for early biomarkers with predictive potential, one of our general objectives is to establish a nutritional model of obesity in rat. Particularly, the objective of this work was to evaluate the effects of a high saturated fat diet on different anthropometric and nutritional parameters. Male Wistar rats weaned at 21 days of age were fed with a normocaloric diet (ND) containing 366 kcal from lipids/kg diet. At 2 months old, they were randomly separated and fed with the NC diet (Control group) and a high saturated fat diet containing 1570.7 kcal from margarine/kg diet (HFD group) for the following 14 weeks. Animals were maintained under 12 h light:12 h dark and 22–24°C conditions, with food and water ad libitum. The anthropometric profile included the evaluation of food intake, body weight, body mass index (BMI), weight gain, dietary consumption, and Lee index, throughout the entire treatment period. The following nutritional parameters were also calculated: energy-intake, and feed efficiency. Statistical differences between groups and throughout the treatment period were analyzed by two-way ANOVA, followed by Bonferroni post-hoc test, with P < 0.05 to confirm significant differences between groups and weeks. Our results show that feeding HFD resulted in significant increases in the following anthropometric parameters: body weight (P < 0.001 from the 9th to the 21st week), BMI (P < 0.05 from the 14th to the 22nd week), weight gain (P < 0.05 from the 15th to the 22nd week) as well as in the nutritional parameter: energy-intake from lipids (P < 0.001 from the 9th to the 22nd week). We did not observe significant changes in food intake, Lee index, feed efficiency nor in the total energy intake. Thus, we could conclude that a high saturated fat, from margarine, diet modifies key anthropometrical and nutritional parameters, and it could be used to establish a nutritional model of obesity in rat.
Fil: Alfonso, Javier Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Lopez, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Delgado, Silvia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Navigatore Fonzo, Lorena Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Anzulovich Miranda, Ana Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
IV Reunión Conjunta de Sociedades de Biología de la República Argentina: “Nuevas Evidencias y Cambios de Paradigmas en Ciencias Biológicas”
Argentina
Sociedad de Biología de Cuyo
Universidad Nacional de Cuyo
Sociedad Argentina de Biología
Sociedad de Biología de Córdoba
Sociedad de Biología de Rosario
Asociación de Biología de Tucumán
Honorable Legislatura de la Provincia de Mendoza
Sociedad Chilena de Reproducción y Desarrollo
Ministerio de Salud Provincia de Mendoza
Gobierno de la Provincia de Mendoza - Materia
-
NUTRITIONAL MODEL
OBESITY
RAT
ANTROPOMETRIC PARAMETERS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/192253
Ver los metadatos del registro completo
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Building an experimental nutritional model of obesity. Evaluation of anthropometrical and nutritional parametersAlfonso, Javier OscarLopez, MarianaDelgado, Silvia MarcelaNavigatore Fonzo, Lorena SilvinaAnzulovich Miranda, Ana CeciliaNUTRITIONAL MODELOBESITYRATANTROPOMETRIC PARAMETERShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The etiology of obesity is multifactorial, and includes genetic, environmental, and dietary factors, where hypercaloric diets play a central role in the development of the disease. It is known that obesity in adulthood can increase the risk of suffering neurodegenerative diseases. As a part of an institutional project that studies obesity as a base disease for the development of chronic age-associated diseases and the search for early biomarkers with predictive potential, one of our general objectives is to establish a nutritional model of obesity in rat. Particularly, the objective of this work was to evaluate the effects of a high saturated fat diet on different anthropometric and nutritional parameters. Male Wistar rats weaned at 21 days of age were fed with a normocaloric diet (ND) containing 366 kcal from lipids/kg diet. At 2 months old, they were randomly separated and fed with the NC diet (Control group) and a high saturated fat diet containing 1570.7 kcal from margarine/kg diet (HFD group) for the following 14 weeks. Animals were maintained under 12 h light:12 h dark and 22–24°C conditions, with food and water ad libitum. The anthropometric profile included the evaluation of food intake, body weight, body mass index (BMI), weight gain, dietary consumption, and Lee index, throughout the entire treatment period. The following nutritional parameters were also calculated: energy-intake, and feed efficiency. Statistical differences between groups and throughout the treatment period were analyzed by two-way ANOVA, followed by Bonferroni post-hoc test, with P < 0.05 to confirm significant differences between groups and weeks. Our results show that feeding HFD resulted in significant increases in the following anthropometric parameters: body weight (P < 0.001 from the 9th to the 21st week), BMI (P < 0.05 from the 14th to the 22nd week), weight gain (P < 0.05 from the 15th to the 22nd week) as well as in the nutritional parameter: energy-intake from lipids (P < 0.001 from the 9th to the 22nd week). We did not observe significant changes in food intake, Lee index, feed efficiency nor in the total energy intake. Thus, we could conclude that a high saturated fat, from margarine, diet modifies key anthropometrical and nutritional parameters, and it could be used to establish a nutritional model of obesity in rat.Fil: Alfonso, Javier Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Lopez, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Delgado, Silvia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Navigatore Fonzo, Lorena Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Anzulovich Miranda, Ana Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaIV Reunión Conjunta de Sociedades de Biología de la República Argentina: “Nuevas Evidencias y Cambios de Paradigmas en Ciencias Biológicas”ArgentinaSociedad de Biología de CuyoUniversidad Nacional de CuyoSociedad Argentina de BiologíaSociedad de Biología de CórdobaSociedad de Biología de RosarioAsociación de Biología de TucumánHonorable Legislatura de la Provincia de MendozaSociedad Chilena de Reproducción y DesarrolloMinisterio de Salud Provincia de MendozaGobierno de la Provincia de MendozaTech Science PressAjmat, María TeresaBorioli, Graciela2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/192253Building an experimental nutritional model of obesity. Evaluation of anthropometrical and nutritional parameters; IV Reunión Conjunta de Sociedades de Biología de la República Argentina: “Nuevas Evidencias y Cambios de Paradigmas en Ciencias Biológicas”; Argentina; 2020; 104-1040327-95451667-5746CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.techscience.com/biocell/v45nSuppl.3/44000info:eu-repo/semantics/altIdentifier/url/https://www.biologia.org.ar/eventos/iv-reunion-conjunta-de-sociedades-de-biologia-de-la-republica-argentina/Nacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-03-31T14:44:05Zoai:ri.conicet.gov.ar:11336/192253instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-03-31 14:44:05.747CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Building an experimental nutritional model of obesity. Evaluation of anthropometrical and nutritional parameters |
| title |
Building an experimental nutritional model of obesity. Evaluation of anthropometrical and nutritional parameters |
| spellingShingle |
Building an experimental nutritional model of obesity. Evaluation of anthropometrical and nutritional parameters Alfonso, Javier Oscar NUTRITIONAL MODEL OBESITY RAT ANTROPOMETRIC PARAMETERS |
| title_short |
Building an experimental nutritional model of obesity. Evaluation of anthropometrical and nutritional parameters |
| title_full |
Building an experimental nutritional model of obesity. Evaluation of anthropometrical and nutritional parameters |
| title_fullStr |
Building an experimental nutritional model of obesity. Evaluation of anthropometrical and nutritional parameters |
| title_full_unstemmed |
Building an experimental nutritional model of obesity. Evaluation of anthropometrical and nutritional parameters |
| title_sort |
Building an experimental nutritional model of obesity. Evaluation of anthropometrical and nutritional parameters |
| dc.creator.none.fl_str_mv |
Alfonso, Javier Oscar Lopez, Mariana Delgado, Silvia Marcela Navigatore Fonzo, Lorena Silvina Anzulovich Miranda, Ana Cecilia |
| author |
Alfonso, Javier Oscar |
| author_facet |
Alfonso, Javier Oscar Lopez, Mariana Delgado, Silvia Marcela Navigatore Fonzo, Lorena Silvina Anzulovich Miranda, Ana Cecilia |
| author_role |
author |
| author2 |
Lopez, Mariana Delgado, Silvia Marcela Navigatore Fonzo, Lorena Silvina Anzulovich Miranda, Ana Cecilia |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
Ajmat, María Teresa Borioli, Graciela |
| dc.subject.none.fl_str_mv |
NUTRITIONAL MODEL OBESITY RAT ANTROPOMETRIC PARAMETERS |
| topic |
NUTRITIONAL MODEL OBESITY RAT ANTROPOMETRIC PARAMETERS |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
The etiology of obesity is multifactorial, and includes genetic, environmental, and dietary factors, where hypercaloric diets play a central role in the development of the disease. It is known that obesity in adulthood can increase the risk of suffering neurodegenerative diseases. As a part of an institutional project that studies obesity as a base disease for the development of chronic age-associated diseases and the search for early biomarkers with predictive potential, one of our general objectives is to establish a nutritional model of obesity in rat. Particularly, the objective of this work was to evaluate the effects of a high saturated fat diet on different anthropometric and nutritional parameters. Male Wistar rats weaned at 21 days of age were fed with a normocaloric diet (ND) containing 366 kcal from lipids/kg diet. At 2 months old, they were randomly separated and fed with the NC diet (Control group) and a high saturated fat diet containing 1570.7 kcal from margarine/kg diet (HFD group) for the following 14 weeks. Animals were maintained under 12 h light:12 h dark and 22–24°C conditions, with food and water ad libitum. The anthropometric profile included the evaluation of food intake, body weight, body mass index (BMI), weight gain, dietary consumption, and Lee index, throughout the entire treatment period. The following nutritional parameters were also calculated: energy-intake, and feed efficiency. Statistical differences between groups and throughout the treatment period were analyzed by two-way ANOVA, followed by Bonferroni post-hoc test, with P < 0.05 to confirm significant differences between groups and weeks. Our results show that feeding HFD resulted in significant increases in the following anthropometric parameters: body weight (P < 0.001 from the 9th to the 21st week), BMI (P < 0.05 from the 14th to the 22nd week), weight gain (P < 0.05 from the 15th to the 22nd week) as well as in the nutritional parameter: energy-intake from lipids (P < 0.001 from the 9th to the 22nd week). We did not observe significant changes in food intake, Lee index, feed efficiency nor in the total energy intake. Thus, we could conclude that a high saturated fat, from margarine, diet modifies key anthropometrical and nutritional parameters, and it could be used to establish a nutritional model of obesity in rat. Fil: Alfonso, Javier Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Lopez, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Delgado, Silvia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Navigatore Fonzo, Lorena Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Anzulovich Miranda, Ana Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina IV Reunión Conjunta de Sociedades de Biología de la República Argentina: “Nuevas Evidencias y Cambios de Paradigmas en Ciencias Biológicas” Argentina Sociedad de Biología de Cuyo Universidad Nacional de Cuyo Sociedad Argentina de Biología Sociedad de Biología de Córdoba Sociedad de Biología de Rosario Asociación de Biología de Tucumán Honorable Legislatura de la Provincia de Mendoza Sociedad Chilena de Reproducción y Desarrollo Ministerio de Salud Provincia de Mendoza Gobierno de la Provincia de Mendoza |
| description |
The etiology of obesity is multifactorial, and includes genetic, environmental, and dietary factors, where hypercaloric diets play a central role in the development of the disease. It is known that obesity in adulthood can increase the risk of suffering neurodegenerative diseases. As a part of an institutional project that studies obesity as a base disease for the development of chronic age-associated diseases and the search for early biomarkers with predictive potential, one of our general objectives is to establish a nutritional model of obesity in rat. Particularly, the objective of this work was to evaluate the effects of a high saturated fat diet on different anthropometric and nutritional parameters. Male Wistar rats weaned at 21 days of age were fed with a normocaloric diet (ND) containing 366 kcal from lipids/kg diet. At 2 months old, they were randomly separated and fed with the NC diet (Control group) and a high saturated fat diet containing 1570.7 kcal from margarine/kg diet (HFD group) for the following 14 weeks. Animals were maintained under 12 h light:12 h dark and 22–24°C conditions, with food and water ad libitum. The anthropometric profile included the evaluation of food intake, body weight, body mass index (BMI), weight gain, dietary consumption, and Lee index, throughout the entire treatment period. The following nutritional parameters were also calculated: energy-intake, and feed efficiency. Statistical differences between groups and throughout the treatment period were analyzed by two-way ANOVA, followed by Bonferroni post-hoc test, with P < 0.05 to confirm significant differences between groups and weeks. Our results show that feeding HFD resulted in significant increases in the following anthropometric parameters: body weight (P < 0.001 from the 9th to the 21st week), BMI (P < 0.05 from the 14th to the 22nd week), weight gain (P < 0.05 from the 15th to the 22nd week) as well as in the nutritional parameter: energy-intake from lipids (P < 0.001 from the 9th to the 22nd week). We did not observe significant changes in food intake, Lee index, feed efficiency nor in the total energy intake. Thus, we could conclude that a high saturated fat, from margarine, diet modifies key anthropometrical and nutritional parameters, and it could be used to establish a nutritional model of obesity in rat. |
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2021 |
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