Exploring the Potential of Invasive Species Sargassum muticum: Microwave-Assisted Extraction Optimization and Bioactivity Profiling

Autores
Silva, Aurora; Cassani, Lucía Victoria; Carpena, Maria; Lourenço Lopes, Catarina; Grosso, Clara; Chamorro, Franklin; García Pérez, Pascual; Carvalho, Ana; Domingues, Valentina F.; Barroso, M. Fátima; Simal Gándara, Jesús; Prieto, Miguel A.
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Sargassum muticum (SM) poses a serious environmental issue since it is a fast-expanding invasive species occupying key areas of the European shoreline, disrupting the autochthonous algae species, and disturbing the ecosystem. This problem has concerned the general population and the scientific community. Nevertheless, as macroalgae are recognized as a source of bioactive molecules, the abundance of SM presents an opportunity as a raw material. In this work, response surface methodology (RSM) was applied as a tool for the optimization of the extraction of bioactive compounds from SM by microwave-assisted extraction (MAE). Five different parameters were used as target functions: yield, total phenolic content (TPC); and the antioxidant measurements of 2,2-diphenyl-1- picrylhydrazyl radical scavenging activity (DPPH), 2,2′ -azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), and β-carotene bleaching (BC). After the optimal extraction conditions were determined (time = 14.00 min; pressure = 11.03 bar; ethanol = 33.31%), the chemical composition and bioactivity of the optimum extract was evaluated to appraise its antioxidant capability to scavenge reactive species and as a potential antibacterial, antidiabetic, antiproliferation, and neuroprotective agent. The results lead to the conclusion that MAE crude extract has bioactive properties, being especially active as an antiproliferation agent and as a nitric oxide and superoxide radical scavenger.
Fil: Silva, Aurora. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España. Instituto Politécnico do Porto; Portugal
Fil: Cassani, Lucía Victoria. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Carpena, Maria. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España
Fil: Lourenço Lopes, Catarina. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España
Fil: Grosso, Clara. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España
Fil: Chamorro, Franklin. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España
Fil: García Pérez, Pascual. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España. Università Cattolica del Sacro Cuore; Italia
Fil: Carvalho, Ana. Universidade Católica Portuguesa; Portugal
Fil: Domingues, Valentina F.. Instituto Politécnico do Porto; Portugal
Fil: Barroso, M. Fátima. Instituto Politécnico do Porto; Portugal
Fil: Simal Gándara, Jesús. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España
Fil: Prieto, Miguel A.. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España
Materia
MICROWAVE-ASSISTED EXTRACTION
ANTIOXIDANTS
BIOACTIVE COMPOUNDS
SARGASSUM MUTICUM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/268440
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Exploring the Potential of Invasive Species Sargassum muticum: Microwave-Assisted Extraction Optimization and Bioactivity ProfilingSilva, AuroraCassani, Lucía VictoriaCarpena, MariaLourenço Lopes, CatarinaGrosso, ClaraChamorro, FranklinGarcía Pérez, PascualCarvalho, AnaDomingues, Valentina F.Barroso, M. FátimaSimal Gándara, JesúsPrieto, Miguel A.MICROWAVE-ASSISTED EXTRACTIONANTIOXIDANTSBIOACTIVE COMPOUNDSSARGASSUM MUTICUMhttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1Sargassum muticum (SM) poses a serious environmental issue since it is a fast-expanding invasive species occupying key areas of the European shoreline, disrupting the autochthonous algae species, and disturbing the ecosystem. This problem has concerned the general population and the scientific community. Nevertheless, as macroalgae are recognized as a source of bioactive molecules, the abundance of SM presents an opportunity as a raw material. In this work, response surface methodology (RSM) was applied as a tool for the optimization of the extraction of bioactive compounds from SM by microwave-assisted extraction (MAE). Five different parameters were used as target functions: yield, total phenolic content (TPC); and the antioxidant measurements of 2,2-diphenyl-1- picrylhydrazyl radical scavenging activity (DPPH), 2,2′ -azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), and β-carotene bleaching (BC). After the optimal extraction conditions were determined (time = 14.00 min; pressure = 11.03 bar; ethanol = 33.31%), the chemical composition and bioactivity of the optimum extract was evaluated to appraise its antioxidant capability to scavenge reactive species and as a potential antibacterial, antidiabetic, antiproliferation, and neuroprotective agent. The results lead to the conclusion that MAE crude extract has bioactive properties, being especially active as an antiproliferation agent and as a nitric oxide and superoxide radical scavenger.Fil: Silva, Aurora. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España. Instituto Politécnico do Porto; PortugalFil: Cassani, Lucía Victoria. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Carpena, Maria. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; EspañaFil: Lourenço Lopes, Catarina. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; EspañaFil: Grosso, Clara. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; EspañaFil: Chamorro, Franklin. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; EspañaFil: García Pérez, Pascual. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España. Università Cattolica del Sacro Cuore; ItaliaFil: Carvalho, Ana. Universidade Católica Portuguesa; PortugalFil: Domingues, Valentina F.. Instituto Politécnico do Porto; PortugalFil: Barroso, M. Fátima. Instituto Politécnico do Porto; PortugalFil: Simal Gándara, Jesús. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; EspañaFil: Prieto, Miguel A.. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; EspañaMolecular Diversity Preservation International2024-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/268440Silva, Aurora; Cassani, Lucía Victoria; Carpena, Maria; Lourenço Lopes, Catarina; Grosso, Clara; et al.; Exploring the Potential of Invasive Species Sargassum muticum: Microwave-Assisted Extraction Optimization and Bioactivity Profiling; Molecular Diversity Preservation International; Marine Drugs; 22; 8; 7-2024; 1-241660-3397CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1660-3397/22/8/352info:eu-repo/semantics/altIdentifier/doi/10.3390/md22080352info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:27Zoai:ri.conicet.gov.ar:11336/268440instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:27.515CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Exploring the Potential of Invasive Species Sargassum muticum: Microwave-Assisted Extraction Optimization and Bioactivity Profiling
title Exploring the Potential of Invasive Species Sargassum muticum: Microwave-Assisted Extraction Optimization and Bioactivity Profiling
spellingShingle Exploring the Potential of Invasive Species Sargassum muticum: Microwave-Assisted Extraction Optimization and Bioactivity Profiling
Silva, Aurora
MICROWAVE-ASSISTED EXTRACTION
ANTIOXIDANTS
BIOACTIVE COMPOUNDS
SARGASSUM MUTICUM
title_short Exploring the Potential of Invasive Species Sargassum muticum: Microwave-Assisted Extraction Optimization and Bioactivity Profiling
title_full Exploring the Potential of Invasive Species Sargassum muticum: Microwave-Assisted Extraction Optimization and Bioactivity Profiling
title_fullStr Exploring the Potential of Invasive Species Sargassum muticum: Microwave-Assisted Extraction Optimization and Bioactivity Profiling
title_full_unstemmed Exploring the Potential of Invasive Species Sargassum muticum: Microwave-Assisted Extraction Optimization and Bioactivity Profiling
title_sort Exploring the Potential of Invasive Species Sargassum muticum: Microwave-Assisted Extraction Optimization and Bioactivity Profiling
dc.creator.none.fl_str_mv Silva, Aurora
Cassani, Lucía Victoria
Carpena, Maria
Lourenço Lopes, Catarina
Grosso, Clara
Chamorro, Franklin
García Pérez, Pascual
Carvalho, Ana
Domingues, Valentina F.
Barroso, M. Fátima
Simal Gándara, Jesús
Prieto, Miguel A.
author Silva, Aurora
author_facet Silva, Aurora
Cassani, Lucía Victoria
Carpena, Maria
Lourenço Lopes, Catarina
Grosso, Clara
Chamorro, Franklin
García Pérez, Pascual
Carvalho, Ana
Domingues, Valentina F.
Barroso, M. Fátima
Simal Gándara, Jesús
Prieto, Miguel A.
author_role author
author2 Cassani, Lucía Victoria
Carpena, Maria
Lourenço Lopes, Catarina
Grosso, Clara
Chamorro, Franklin
García Pérez, Pascual
Carvalho, Ana
Domingues, Valentina F.
Barroso, M. Fátima
Simal Gándara, Jesús
Prieto, Miguel A.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MICROWAVE-ASSISTED EXTRACTION
ANTIOXIDANTS
BIOACTIVE COMPOUNDS
SARGASSUM MUTICUM
topic MICROWAVE-ASSISTED EXTRACTION
ANTIOXIDANTS
BIOACTIVE COMPOUNDS
SARGASSUM MUTICUM
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Sargassum muticum (SM) poses a serious environmental issue since it is a fast-expanding invasive species occupying key areas of the European shoreline, disrupting the autochthonous algae species, and disturbing the ecosystem. This problem has concerned the general population and the scientific community. Nevertheless, as macroalgae are recognized as a source of bioactive molecules, the abundance of SM presents an opportunity as a raw material. In this work, response surface methodology (RSM) was applied as a tool for the optimization of the extraction of bioactive compounds from SM by microwave-assisted extraction (MAE). Five different parameters were used as target functions: yield, total phenolic content (TPC); and the antioxidant measurements of 2,2-diphenyl-1- picrylhydrazyl radical scavenging activity (DPPH), 2,2′ -azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), and β-carotene bleaching (BC). After the optimal extraction conditions were determined (time = 14.00 min; pressure = 11.03 bar; ethanol = 33.31%), the chemical composition and bioactivity of the optimum extract was evaluated to appraise its antioxidant capability to scavenge reactive species and as a potential antibacterial, antidiabetic, antiproliferation, and neuroprotective agent. The results lead to the conclusion that MAE crude extract has bioactive properties, being especially active as an antiproliferation agent and as a nitric oxide and superoxide radical scavenger.
Fil: Silva, Aurora. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España. Instituto Politécnico do Porto; Portugal
Fil: Cassani, Lucía Victoria. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Carpena, Maria. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España
Fil: Lourenço Lopes, Catarina. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España
Fil: Grosso, Clara. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España
Fil: Chamorro, Franklin. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España
Fil: García Pérez, Pascual. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España. Università Cattolica del Sacro Cuore; Italia
Fil: Carvalho, Ana. Universidade Católica Portuguesa; Portugal
Fil: Domingues, Valentina F.. Instituto Politécnico do Porto; Portugal
Fil: Barroso, M. Fátima. Instituto Politécnico do Porto; Portugal
Fil: Simal Gándara, Jesús. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España
Fil: Prieto, Miguel A.. Universidad de Vigo. Facultad de Ciencias de Ourense. Departamento de Química Analitica y Alimentaria; España
description Sargassum muticum (SM) poses a serious environmental issue since it is a fast-expanding invasive species occupying key areas of the European shoreline, disrupting the autochthonous algae species, and disturbing the ecosystem. This problem has concerned the general population and the scientific community. Nevertheless, as macroalgae are recognized as a source of bioactive molecules, the abundance of SM presents an opportunity as a raw material. In this work, response surface methodology (RSM) was applied as a tool for the optimization of the extraction of bioactive compounds from SM by microwave-assisted extraction (MAE). Five different parameters were used as target functions: yield, total phenolic content (TPC); and the antioxidant measurements of 2,2-diphenyl-1- picrylhydrazyl radical scavenging activity (DPPH), 2,2′ -azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), and β-carotene bleaching (BC). After the optimal extraction conditions were determined (time = 14.00 min; pressure = 11.03 bar; ethanol = 33.31%), the chemical composition and bioactivity of the optimum extract was evaluated to appraise its antioxidant capability to scavenge reactive species and as a potential antibacterial, antidiabetic, antiproliferation, and neuroprotective agent. The results lead to the conclusion that MAE crude extract has bioactive properties, being especially active as an antiproliferation agent and as a nitric oxide and superoxide radical scavenger.
publishDate 2024
dc.date.none.fl_str_mv 2024-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/268440
Silva, Aurora; Cassani, Lucía Victoria; Carpena, Maria; Lourenço Lopes, Catarina; Grosso, Clara; et al.; Exploring the Potential of Invasive Species Sargassum muticum: Microwave-Assisted Extraction Optimization and Bioactivity Profiling; Molecular Diversity Preservation International; Marine Drugs; 22; 8; 7-2024; 1-24
1660-3397
CONICET Digital
CONICET
url http://hdl.handle.net/11336/268440
identifier_str_mv Silva, Aurora; Cassani, Lucía Victoria; Carpena, Maria; Lourenço Lopes, Catarina; Grosso, Clara; et al.; Exploring the Potential of Invasive Species Sargassum muticum: Microwave-Assisted Extraction Optimization and Bioactivity Profiling; Molecular Diversity Preservation International; Marine Drugs; 22; 8; 7-2024; 1-24
1660-3397
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1660-3397/22/8/352
info:eu-repo/semantics/altIdentifier/doi/10.3390/md22080352
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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