The long arm of BRAF V600E gets to mTORC1

Autores
Lopez Bergami, Pablo Roberto
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Despite the disappointing results of early clinical studies, targeting the BRAF ⁄ MEK⁄ extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAPK) pathway is still a subject of investigation due to its biological relevance to melanoma. It is now evident that to antagonize redundant protein functions and compensatory signaling pathways BRAF inhibitors must be combined with inhibitors of other relevant pathways based on a strong rational basis. Thus, we must expand our understanding of MAPK effectors and how MAPK interacts with those other pathways.
Fil: Lopez Bergami, Pablo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Materia
Melanoma
Tumor Suppressor Proteins
Map Kinase Signaling System
Protein Serine Threonine Kinases
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24468
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/24468
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The long arm of BRAF V600E gets to mTORC1Lopez Bergami, Pablo RobertoMelanomaTumor Suppressor ProteinsMap Kinase Signaling SystemProtein Serine Threonine Kinaseshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Despite the disappointing results of early clinical studies, targeting the BRAF ⁄ MEK⁄ extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAPK) pathway is still a subject of investigation due to its biological relevance to melanoma. It is now evident that to antagonize redundant protein functions and compensatory signaling pathways BRAF inhibitors must be combined with inhibitors of other relevant pathways based on a strong rational basis. Thus, we must expand our understanding of MAPK effectors and how MAPK interacts with those other pathways.Fil: Lopez Bergami, Pablo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaWiley2009-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24468Lopez Bergami, Pablo Roberto; The long arm of BRAF V600E gets to mTORC1 ; Wiley; Pigment Cell & Melanoma Research; 22; 3; 3-2009; 244-2451755-14711755-148XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1755-148X.2009.00566.x/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1755-148X.2009.00566.xinfo:eu-repo/semantics/altIdentifier/pmid/19338646info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:25:58Zoai:ri.conicet.gov.ar:11336/24468instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:25:58.295CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The long arm of BRAF V600E gets to mTORC1
title The long arm of BRAF V600E gets to mTORC1
spellingShingle The long arm of BRAF V600E gets to mTORC1
Lopez Bergami, Pablo Roberto
Melanoma
Tumor Suppressor Proteins
Map Kinase Signaling System
Protein Serine Threonine Kinases
title_short The long arm of BRAF V600E gets to mTORC1
title_full The long arm of BRAF V600E gets to mTORC1
title_fullStr The long arm of BRAF V600E gets to mTORC1
title_full_unstemmed The long arm of BRAF V600E gets to mTORC1
title_sort The long arm of BRAF V600E gets to mTORC1
dc.creator.none.fl_str_mv Lopez Bergami, Pablo Roberto
author Lopez Bergami, Pablo Roberto
author_facet Lopez Bergami, Pablo Roberto
author_role author
dc.subject.none.fl_str_mv Melanoma
Tumor Suppressor Proteins
Map Kinase Signaling System
Protein Serine Threonine Kinases
topic Melanoma
Tumor Suppressor Proteins
Map Kinase Signaling System
Protein Serine Threonine Kinases
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Despite the disappointing results of early clinical studies, targeting the BRAF ⁄ MEK⁄ extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAPK) pathway is still a subject of investigation due to its biological relevance to melanoma. It is now evident that to antagonize redundant protein functions and compensatory signaling pathways BRAF inhibitors must be combined with inhibitors of other relevant pathways based on a strong rational basis. Thus, we must expand our understanding of MAPK effectors and how MAPK interacts with those other pathways.
Fil: Lopez Bergami, Pablo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
description Despite the disappointing results of early clinical studies, targeting the BRAF ⁄ MEK⁄ extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAPK) pathway is still a subject of investigation due to its biological relevance to melanoma. It is now evident that to antagonize redundant protein functions and compensatory signaling pathways BRAF inhibitors must be combined with inhibitors of other relevant pathways based on a strong rational basis. Thus, we must expand our understanding of MAPK effectors and how MAPK interacts with those other pathways.
publishDate 2009
dc.date.none.fl_str_mv 2009-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24468
Lopez Bergami, Pablo Roberto; The long arm of BRAF V600E gets to mTORC1 ; Wiley; Pigment Cell & Melanoma Research; 22; 3; 3-2009; 244-245
1755-1471
1755-148X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24468
identifier_str_mv Lopez Bergami, Pablo Roberto; The long arm of BRAF V600E gets to mTORC1 ; Wiley; Pigment Cell & Melanoma Research; 22; 3; 3-2009; 244-245
1755-1471
1755-148X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1755-148X.2009.00566.x/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1755-148X.2009.00566.x
info:eu-repo/semantics/altIdentifier/pmid/19338646
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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