Tick subolesin is an ortholog of the akirins described in insects and vertebrates

Autores
Galindo, Ruth C.; Doncel-Pérez, Ernesto; Zivkovic, Zorica; Naranjo, Victoria; Gortazar, Christian; Mangold, Atilio Jose; Martín-Hernando, María Paz; Kocan, Katherine M.; Rodríguez de la Fuente, José Javier
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The tick protective antigen, subolesin, is a regulatory protein involved in the control of multiple cellular pathways. Subolesin is evolutionary conserved in invertebrates and vertebrates with sequence homology to akirins, a recently renamed group of proteins that were proposed to function as transcription factors in Drosophila and mice. The objective of this research was to provide evidence of the sequence and functional homology between tick subolesin and akirins. The phylogenetic analysis of subolesin and akirins showed that they are evolutionary conserved. The effect of subolesin and akirin2 knockdown was compared in adult ticks and mice, respectively. The results demonstrated that tick subolesin is an ortholog of insect and vertebrate akirins and suggested that these proteins function in the regulation of NF-kB-dependent and independent expression of signal transduction and innate immune response genes. These results suggest that these proteins have an important role in host–pathogen interactions.
Fil: Galindo, Ruth C.. Instituto de Investigación en Recursos Cinegéticos; España
Fil: Doncel-Pérez, Ernesto. Hospital Nacional de Paraplejicos; España
Fil: Zivkovic, Zorica. Utrecht University; Estados Unidos
Fil: Naranjo, Victoria. Instituto de Investigación en Recursos Cinegéticos; España
Fil: Gortazar, Christian. Instituto de Investigación en Recursos Cinegéticos; España
Fil: Mangold, Atilio Jose. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Agencia de Extension Rural Rafaela.; Argentina
Fil: Martín-Hernando, María Paz. Instituto de Investigación en Recursos Cinegéticos; España
Fil: Kocan, Katherine M.. Oklahoma State University; Estados Unidos
Fil: Rodríguez de la Fuente, José Javier. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Agencia de Extension Rural Rafaela.; Argentina
Materia
Akirin
Subolesin
Tick
Innate immunity
NF-kB
Relish
Transcription
RNAi
Gene expression
Evolution
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/102233
Acceder
id CONICETDig_ec97ee13ddcb2345d620a6a1af921bd7
oai_identifier_str oai:ri.conicet.gov.ar:11336/102233
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Tick subolesin is an ortholog of the akirins described in insects and vertebratesGalindo, Ruth C.Doncel-Pérez, ErnestoZivkovic, ZoricaNaranjo, VictoriaGortazar, ChristianMangold, Atilio JoseMartín-Hernando, María PazKocan, Katherine M.Rodríguez de la Fuente, José JavierAkirinSubolesinTickInnate immunityNF-kBRelishTranscriptionRNAiGene expressionEvolutionhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The tick protective antigen, subolesin, is a regulatory protein involved in the control of multiple cellular pathways. Subolesin is evolutionary conserved in invertebrates and vertebrates with sequence homology to akirins, a recently renamed group of proteins that were proposed to function as transcription factors in Drosophila and mice. The objective of this research was to provide evidence of the sequence and functional homology between tick subolesin and akirins. The phylogenetic analysis of subolesin and akirins showed that they are evolutionary conserved. The effect of subolesin and akirin2 knockdown was compared in adult ticks and mice, respectively. The results demonstrated that tick subolesin is an ortholog of insect and vertebrate akirins and suggested that these proteins function in the regulation of NF-kB-dependent and independent expression of signal transduction and innate immune response genes. These results suggest that these proteins have an important role in host–pathogen interactions.Fil: Galindo, Ruth C.. Instituto de Investigación en Recursos Cinegéticos; EspañaFil: Doncel-Pérez, Ernesto. Hospital Nacional de Paraplejicos; EspañaFil: Zivkovic, Zorica. Utrecht University; Estados UnidosFil: Naranjo, Victoria. Instituto de Investigación en Recursos Cinegéticos; EspañaFil: Gortazar, Christian. Instituto de Investigación en Recursos Cinegéticos; EspañaFil: Mangold, Atilio Jose. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Agencia de Extension Rural Rafaela.; ArgentinaFil: Martín-Hernando, María Paz. Instituto de Investigación en Recursos Cinegéticos; EspañaFil: Kocan, Katherine M.. Oklahoma State University; Estados UnidosFil: Rodríguez de la Fuente, José Javier. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Agencia de Extension Rural Rafaela.; ArgentinaElsevier2009-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/102233Galindo, Ruth C.; Doncel-Pérez, Ernesto; Zivkovic, Zorica; Naranjo, Victoria; Gortazar, Christian; et al.; Tick subolesin is an ortholog of the akirins described in insects and vertebrates; Elsevier; Developmental And Comparative Immunology; 33; 4; 4-2009; 612-6170145-305XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.dci.2008.11.002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:51:30Zoai:ri.conicet.gov.ar:11336/102233instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:51:30.28CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tick subolesin is an ortholog of the akirins described in insects and vertebrates
title Tick subolesin is an ortholog of the akirins described in insects and vertebrates
spellingShingle Tick subolesin is an ortholog of the akirins described in insects and vertebrates
Galindo, Ruth C.
Akirin
Subolesin
Tick
Innate immunity
NF-kB
Relish
Transcription
RNAi
Gene expression
Evolution
title_short Tick subolesin is an ortholog of the akirins described in insects and vertebrates
title_full Tick subolesin is an ortholog of the akirins described in insects and vertebrates
title_fullStr Tick subolesin is an ortholog of the akirins described in insects and vertebrates
title_full_unstemmed Tick subolesin is an ortholog of the akirins described in insects and vertebrates
title_sort Tick subolesin is an ortholog of the akirins described in insects and vertebrates
dc.creator.none.fl_str_mv Galindo, Ruth C.
Doncel-Pérez, Ernesto
Zivkovic, Zorica
Naranjo, Victoria
Gortazar, Christian
Mangold, Atilio Jose
Martín-Hernando, María Paz
Kocan, Katherine M.
Rodríguez de la Fuente, José Javier
author Galindo, Ruth C.
author_facet Galindo, Ruth C.
Doncel-Pérez, Ernesto
Zivkovic, Zorica
Naranjo, Victoria
Gortazar, Christian
Mangold, Atilio Jose
Martín-Hernando, María Paz
Kocan, Katherine M.
Rodríguez de la Fuente, José Javier
author_role author
author2 Doncel-Pérez, Ernesto
Zivkovic, Zorica
Naranjo, Victoria
Gortazar, Christian
Mangold, Atilio Jose
Martín-Hernando, María Paz
Kocan, Katherine M.
Rodríguez de la Fuente, José Javier
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Akirin
Subolesin
Tick
Innate immunity
NF-kB
Relish
Transcription
RNAi
Gene expression
Evolution
topic Akirin
Subolesin
Tick
Innate immunity
NF-kB
Relish
Transcription
RNAi
Gene expression
Evolution
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The tick protective antigen, subolesin, is a regulatory protein involved in the control of multiple cellular pathways. Subolesin is evolutionary conserved in invertebrates and vertebrates with sequence homology to akirins, a recently renamed group of proteins that were proposed to function as transcription factors in Drosophila and mice. The objective of this research was to provide evidence of the sequence and functional homology between tick subolesin and akirins. The phylogenetic analysis of subolesin and akirins showed that they are evolutionary conserved. The effect of subolesin and akirin2 knockdown was compared in adult ticks and mice, respectively. The results demonstrated that tick subolesin is an ortholog of insect and vertebrate akirins and suggested that these proteins function in the regulation of NF-kB-dependent and independent expression of signal transduction and innate immune response genes. These results suggest that these proteins have an important role in host–pathogen interactions.
Fil: Galindo, Ruth C.. Instituto de Investigación en Recursos Cinegéticos; España
Fil: Doncel-Pérez, Ernesto. Hospital Nacional de Paraplejicos; España
Fil: Zivkovic, Zorica. Utrecht University; Estados Unidos
Fil: Naranjo, Victoria. Instituto de Investigación en Recursos Cinegéticos; España
Fil: Gortazar, Christian. Instituto de Investigación en Recursos Cinegéticos; España
Fil: Mangold, Atilio Jose. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Agencia de Extension Rural Rafaela.; Argentina
Fil: Martín-Hernando, María Paz. Instituto de Investigación en Recursos Cinegéticos; España
Fil: Kocan, Katherine M.. Oklahoma State University; Estados Unidos
Fil: Rodríguez de la Fuente, José Javier. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Agencia de Extension Rural Rafaela.; Argentina
description The tick protective antigen, subolesin, is a regulatory protein involved in the control of multiple cellular pathways. Subolesin is evolutionary conserved in invertebrates and vertebrates with sequence homology to akirins, a recently renamed group of proteins that were proposed to function as transcription factors in Drosophila and mice. The objective of this research was to provide evidence of the sequence and functional homology between tick subolesin and akirins. The phylogenetic analysis of subolesin and akirins showed that they are evolutionary conserved. The effect of subolesin and akirin2 knockdown was compared in adult ticks and mice, respectively. The results demonstrated that tick subolesin is an ortholog of insect and vertebrate akirins and suggested that these proteins function in the regulation of NF-kB-dependent and independent expression of signal transduction and innate immune response genes. These results suggest that these proteins have an important role in host–pathogen interactions.
publishDate 2009
dc.date.none.fl_str_mv 2009-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/102233
Galindo, Ruth C.; Doncel-Pérez, Ernesto; Zivkovic, Zorica; Naranjo, Victoria; Gortazar, Christian; et al.; Tick subolesin is an ortholog of the akirins described in insects and vertebrates; Elsevier; Developmental And Comparative Immunology; 33; 4; 4-2009; 612-617
0145-305X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/102233
identifier_str_mv Galindo, Ruth C.; Doncel-Pérez, Ernesto; Zivkovic, Zorica; Naranjo, Victoria; Gortazar, Christian; et al.; Tick subolesin is an ortholog of the akirins described in insects and vertebrates; Elsevier; Developmental And Comparative Immunology; 33; 4; 4-2009; 612-617
0145-305X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.dci.2008.11.002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613583184330752
score 13.070432

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