Controlled release of thymol from poly(Lactic acid)-based silver nanocomposite films with antibacterial and antioxidant activity

Autores
Ramos, Marina; Beltran, Ana; Fortunati, Elena; Peltzer, Mercedes Ana; Cristofaro, Francesco; Visai, Livia; Valente, Artur J. M.; Jiménez, Alfonso; Kenny, José María; Garrigós, María Carmen
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Thymol and silver nanoparticles (Ag-NPs) were used to develop poly(lactic acid) (PLA)- based films with antioxidant and antibacterial performance. Different amounts of thymol (6 and 8 wt%) and 1 wt% Ag-NPs were added to PLA to produce the active films. Ag-NPs and thymol were successfully identified in the nanocomposite structures using spectroscopic techniques. A kinetic study was performed to evaluate the release of thymol and Ag-NPs from the nanocomposites to an aqueous food simulant (ethanol 10%, v/v) at 40 °C. The diffusion of thymol from the polymer matrix was affected by the presence of non-migrating Ag-NPs, which showed non-Fickian release behavior. The ternary system including 1 wt% Ag-NPs and 8 wt% thymol showed clear antibacterial performance by reducing the cell viability of Escherichia coli and Staphylococcus aureus by around 40% after 3 and 24 h of storage at 4, 25, and 37 °C compared to neat PLA. Significant antioxidant behavior of all active films was also confirmed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The obtained nanocomposite films based on PLA and the addition of Ag-NPs and thymol were proven to have combined antioxidant and antibacterial performance, with controlled release of thymol. These formulations have potential applications in the development of innovative and customized active packaging systems to increase the shelf-life of food products.
Fil: Ramos, Marina. Universidad de Alicante; España
Fil: Beltran, Ana. Universidad de Alicante; España
Fil: Fortunati, Elena. Università di Perugia; Italia
Fil: Peltzer, Mercedes Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Área Ingeniería en Alimentos; Argentina
Fil: Cristofaro, Francesco. Universita degli Studi di Pavia; Italia
Fil: Visai, Livia. Universita degli Studi di Pavia; Italia. Istituti Clinici Scientifici Maugeri; Italia
Fil: Valente, Artur J. M.. Universidad de Coimbra. Facultad de Ciencias E Tecnología. Department Of Chemistry; Portugal
Fil: Jiménez, Alfonso. Universidad de Alicante; España
Fil: Kenny, José María. Università di Perugia; Italia
Fil: Garrigós, María Carmen. Universidad de Alicante; España
Materia
ACTIVE PACKAGING
ANTIBACTERIAL
ANTIOXIDANT CAPACITY
KINETIC RELEASE
POLY(LACTIC ACID)
SILVER NANOPARTICLES
THYMOL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/168892
Acceder
id CONICETDig_ec416c518e898a7e47603792f6ed4498
oai_identifier_str oai:ri.conicet.gov.ar:11336/168892
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Controlled release of thymol from poly(Lactic acid)-based silver nanocomposite films with antibacterial and antioxidant activityRamos, MarinaBeltran, AnaFortunati, ElenaPeltzer, Mercedes AnaCristofaro, FrancescoVisai, LiviaValente, Artur J. M.Jiménez, AlfonsoKenny, José MaríaGarrigós, María CarmenACTIVE PACKAGINGANTIBACTERIALANTIOXIDANT CAPACITYKINETIC RELEASEPOLY(LACTIC ACID)SILVER NANOPARTICLESTHYMOLhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2Thymol and silver nanoparticles (Ag-NPs) were used to develop poly(lactic acid) (PLA)- based films with antioxidant and antibacterial performance. Different amounts of thymol (6 and 8 wt%) and 1 wt% Ag-NPs were added to PLA to produce the active films. Ag-NPs and thymol were successfully identified in the nanocomposite structures using spectroscopic techniques. A kinetic study was performed to evaluate the release of thymol and Ag-NPs from the nanocomposites to an aqueous food simulant (ethanol 10%, v/v) at 40 °C. The diffusion of thymol from the polymer matrix was affected by the presence of non-migrating Ag-NPs, which showed non-Fickian release behavior. The ternary system including 1 wt% Ag-NPs and 8 wt% thymol showed clear antibacterial performance by reducing the cell viability of Escherichia coli and Staphylococcus aureus by around 40% after 3 and 24 h of storage at 4, 25, and 37 °C compared to neat PLA. Significant antioxidant behavior of all active films was also confirmed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The obtained nanocomposite films based on PLA and the addition of Ag-NPs and thymol were proven to have combined antioxidant and antibacterial performance, with controlled release of thymol. These formulations have potential applications in the development of innovative and customized active packaging systems to increase the shelf-life of food products.Fil: Ramos, Marina. Universidad de Alicante; EspañaFil: Beltran, Ana. Universidad de Alicante; EspañaFil: Fortunati, Elena. Università di Perugia; ItaliaFil: Peltzer, Mercedes Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Área Ingeniería en Alimentos; ArgentinaFil: Cristofaro, Francesco. Universita degli Studi di Pavia; ItaliaFil: Visai, Livia. Universita degli Studi di Pavia; Italia. Istituti Clinici Scientifici Maugeri; ItaliaFil: Valente, Artur J. M.. Universidad de Coimbra. Facultad de Ciencias E Tecnología. Department Of Chemistry; PortugalFil: Jiménez, Alfonso. Universidad de Alicante; EspañaFil: Kenny, José María. Università di Perugia; ItaliaFil: Garrigós, María Carmen. Universidad de Alicante; EspañaMultidisciplinary Digital Publishing Institute2020-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/168892Ramos, Marina; Beltran, Ana; Fortunati, Elena; Peltzer, Mercedes Ana; Cristofaro, Francesco; et al.; Controlled release of thymol from poly(Lactic acid)-based silver nanocomposite films with antibacterial and antioxidant activity; Multidisciplinary Digital Publishing Institute; Antioxidants; 9; 5; 5-2020; 1-192076-3921CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-3921/9/5/395info:eu-repo/semantics/altIdentifier/doi/10.3390/antiox9050395info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:42:00Zoai:ri.conicet.gov.ar:11336/168892instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:42:00.578CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Controlled release of thymol from poly(Lactic acid)-based silver nanocomposite films with antibacterial and antioxidant activity
title Controlled release of thymol from poly(Lactic acid)-based silver nanocomposite films with antibacterial and antioxidant activity
spellingShingle Controlled release of thymol from poly(Lactic acid)-based silver nanocomposite films with antibacterial and antioxidant activity
Ramos, Marina
ACTIVE PACKAGING
ANTIBACTERIAL
ANTIOXIDANT CAPACITY
KINETIC RELEASE
POLY(LACTIC ACID)
SILVER NANOPARTICLES
THYMOL
title_short Controlled release of thymol from poly(Lactic acid)-based silver nanocomposite films with antibacterial and antioxidant activity
title_full Controlled release of thymol from poly(Lactic acid)-based silver nanocomposite films with antibacterial and antioxidant activity
title_fullStr Controlled release of thymol from poly(Lactic acid)-based silver nanocomposite films with antibacterial and antioxidant activity
title_full_unstemmed Controlled release of thymol from poly(Lactic acid)-based silver nanocomposite films with antibacterial and antioxidant activity
title_sort Controlled release of thymol from poly(Lactic acid)-based silver nanocomposite films with antibacterial and antioxidant activity
dc.creator.none.fl_str_mv Ramos, Marina
Beltran, Ana
Fortunati, Elena
Peltzer, Mercedes Ana
Cristofaro, Francesco
Visai, Livia
Valente, Artur J. M.
Jiménez, Alfonso
Kenny, José María
Garrigós, María Carmen
author Ramos, Marina
author_facet Ramos, Marina
Beltran, Ana
Fortunati, Elena
Peltzer, Mercedes Ana
Cristofaro, Francesco
Visai, Livia
Valente, Artur J. M.
Jiménez, Alfonso
Kenny, José María
Garrigós, María Carmen
author_role author
author2 Beltran, Ana
Fortunati, Elena
Peltzer, Mercedes Ana
Cristofaro, Francesco
Visai, Livia
Valente, Artur J. M.
Jiménez, Alfonso
Kenny, José María
Garrigós, María Carmen
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ACTIVE PACKAGING
ANTIBACTERIAL
ANTIOXIDANT CAPACITY
KINETIC RELEASE
POLY(LACTIC ACID)
SILVER NANOPARTICLES
THYMOL
topic ACTIVE PACKAGING
ANTIBACTERIAL
ANTIOXIDANT CAPACITY
KINETIC RELEASE
POLY(LACTIC ACID)
SILVER NANOPARTICLES
THYMOL
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Thymol and silver nanoparticles (Ag-NPs) were used to develop poly(lactic acid) (PLA)- based films with antioxidant and antibacterial performance. Different amounts of thymol (6 and 8 wt%) and 1 wt% Ag-NPs were added to PLA to produce the active films. Ag-NPs and thymol were successfully identified in the nanocomposite structures using spectroscopic techniques. A kinetic study was performed to evaluate the release of thymol and Ag-NPs from the nanocomposites to an aqueous food simulant (ethanol 10%, v/v) at 40 °C. The diffusion of thymol from the polymer matrix was affected by the presence of non-migrating Ag-NPs, which showed non-Fickian release behavior. The ternary system including 1 wt% Ag-NPs and 8 wt% thymol showed clear antibacterial performance by reducing the cell viability of Escherichia coli and Staphylococcus aureus by around 40% after 3 and 24 h of storage at 4, 25, and 37 °C compared to neat PLA. Significant antioxidant behavior of all active films was also confirmed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The obtained nanocomposite films based on PLA and the addition of Ag-NPs and thymol were proven to have combined antioxidant and antibacterial performance, with controlled release of thymol. These formulations have potential applications in the development of innovative and customized active packaging systems to increase the shelf-life of food products.
Fil: Ramos, Marina. Universidad de Alicante; España
Fil: Beltran, Ana. Universidad de Alicante; España
Fil: Fortunati, Elena. Università di Perugia; Italia
Fil: Peltzer, Mercedes Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Área Ingeniería en Alimentos; Argentina
Fil: Cristofaro, Francesco. Universita degli Studi di Pavia; Italia
Fil: Visai, Livia. Universita degli Studi di Pavia; Italia. Istituti Clinici Scientifici Maugeri; Italia
Fil: Valente, Artur J. M.. Universidad de Coimbra. Facultad de Ciencias E Tecnología. Department Of Chemistry; Portugal
Fil: Jiménez, Alfonso. Universidad de Alicante; España
Fil: Kenny, José María. Università di Perugia; Italia
Fil: Garrigós, María Carmen. Universidad de Alicante; España
description Thymol and silver nanoparticles (Ag-NPs) were used to develop poly(lactic acid) (PLA)- based films with antioxidant and antibacterial performance. Different amounts of thymol (6 and 8 wt%) and 1 wt% Ag-NPs were added to PLA to produce the active films. Ag-NPs and thymol were successfully identified in the nanocomposite structures using spectroscopic techniques. A kinetic study was performed to evaluate the release of thymol and Ag-NPs from the nanocomposites to an aqueous food simulant (ethanol 10%, v/v) at 40 °C. The diffusion of thymol from the polymer matrix was affected by the presence of non-migrating Ag-NPs, which showed non-Fickian release behavior. The ternary system including 1 wt% Ag-NPs and 8 wt% thymol showed clear antibacterial performance by reducing the cell viability of Escherichia coli and Staphylococcus aureus by around 40% after 3 and 24 h of storage at 4, 25, and 37 °C compared to neat PLA. Significant antioxidant behavior of all active films was also confirmed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The obtained nanocomposite films based on PLA and the addition of Ag-NPs and thymol were proven to have combined antioxidant and antibacterial performance, with controlled release of thymol. These formulations have potential applications in the development of innovative and customized active packaging systems to increase the shelf-life of food products.
publishDate 2020
dc.date.none.fl_str_mv 2020-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/168892
Ramos, Marina; Beltran, Ana; Fortunati, Elena; Peltzer, Mercedes Ana; Cristofaro, Francesco; et al.; Controlled release of thymol from poly(Lactic acid)-based silver nanocomposite films with antibacterial and antioxidant activity; Multidisciplinary Digital Publishing Institute; Antioxidants; 9; 5; 5-2020; 1-19
2076-3921
CONICET Digital
CONICET
url http://hdl.handle.net/11336/168892
identifier_str_mv Ramos, Marina; Beltran, Ana; Fortunati, Elena; Peltzer, Mercedes Ana; Cristofaro, Francesco; et al.; Controlled release of thymol from poly(Lactic acid)-based silver nanocomposite films with antibacterial and antioxidant activity; Multidisciplinary Digital Publishing Institute; Antioxidants; 9; 5; 5-2020; 1-19
2076-3921
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-3921/9/5/395
info:eu-repo/semantics/altIdentifier/doi/10.3390/antiox9050395
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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