Adolescence and Polycystic Ovary Syndrome: current concepts on diagnosis and treatment

Autores
Motta, Alicia Beatriz; Spritzer, Poli Mara
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Adolescence is a time characterized by changes in reproductive hormones and menstrual patterns, which makes it difficult to diagnose Polycystic Ovary Syndrome (PCOS) in this population. The diagnosis of PCOS has great physical and psychosocial impact in the young person. Despite the importance of a diagnosis of PCOS at adolescence, data available are limited. Aims: This review focuses on analyzing markers of PCOS diagnosis and possible treatments in adolescence. Results: Although during adolescence diagnosis criteria of PCOS overlap with physiological changes including clinical manifestations of hyperandrogenism (acne and hirsutism,), oligo/amenorrhea, anovulation and ovarian microcysts, there is agreement that irregular menses and hyperandrogenemia should be used to diagnose PCOS in this population. Moreover, considering that PCOS phenotype could change through the reproductive age and that adolescents display heterogeneous ovarian morphology, it has been proposed that diagnosis of PCOS should be confirmed after the age of 18. The first-line treatment for menstrual irregularity and hirsutism are oral contraceptive pills and for obesity and metabolic abnormalities are lifestyle changes. Insulin-sensitizer drugs, such as metformin, may be added to the treatment in the presence of metabolic alterations. Antiandrogen drugs may also be associated for treating moderate to severe hirsutism. Conclusions: During adolescence, physiological changes overlap with signs and symptoms of PCOS; thus the diagnosis criteria should be carefully considered. Regarding the treatment of adolescents with PCOS, non-pharmacological interventions include lifestyle changes. Pharmacological treatments comprise oral contraceptive pills, antiandrogens and metformin, used isolated or combined.
Fil: Motta, Alicia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Spritzer, Poli Mara. Universidade Federal do Rio Grande do Sul; Brasil
Materia
Polycystic Ovary Syndrome
Adolescence
Oligo/Amenorrhea
Anovulation
Cardiovascular Risk
Metformin
Oral Contraceptive Pills
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13652
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/13652
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Adolescence and Polycystic Ovary Syndrome: current concepts on diagnosis and treatmentMotta, Alicia BeatrizSpritzer, Poli MaraPolycystic Ovary SyndromeAdolescenceOligo/AmenorrheaAnovulationCardiovascular RiskMetforminOral Contraceptive Pillshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: Adolescence is a time characterized by changes in reproductive hormones and menstrual patterns, which makes it difficult to diagnose Polycystic Ovary Syndrome (PCOS) in this population. The diagnosis of PCOS has great physical and psychosocial impact in the young person. Despite the importance of a diagnosis of PCOS at adolescence, data available are limited. Aims: This review focuses on analyzing markers of PCOS diagnosis and possible treatments in adolescence. Results: Although during adolescence diagnosis criteria of PCOS overlap with physiological changes including clinical manifestations of hyperandrogenism (acne and hirsutism,), oligo/amenorrhea, anovulation and ovarian microcysts, there is agreement that irregular menses and hyperandrogenemia should be used to diagnose PCOS in this population. Moreover, considering that PCOS phenotype could change through the reproductive age and that adolescents display heterogeneous ovarian morphology, it has been proposed that diagnosis of PCOS should be confirmed after the age of 18. The first-line treatment for menstrual irregularity and hirsutism are oral contraceptive pills and for obesity and metabolic abnormalities are lifestyle changes. Insulin-sensitizer drugs, such as metformin, may be added to the treatment in the presence of metabolic alterations. Antiandrogen drugs may also be associated for treating moderate to severe hirsutism. Conclusions: During adolescence, physiological changes overlap with signs and symptoms of PCOS; thus the diagnosis criteria should be carefully considered. Regarding the treatment of adolescents with PCOS, non-pharmacological interventions include lifestyle changes. Pharmacological treatments comprise oral contraceptive pills, antiandrogens and metformin, used isolated or combined.Fil: Motta, Alicia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Spritzer, Poli Mara. Universidade Federal do Rio Grande do Sul; BrasilWiley2015-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13652Motta, Alicia Beatriz; Spritzer, Poli Mara; Adolescence and Polycystic Ovary Syndrome: current concepts on diagnosis and treatment; Wiley; International Journal of Clinical Practice; 69; 11; 11-2015; 1236-12461368-50311742-1241enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/ijcp.12719/fullinfo:eu-repo/semantics/altIdentifier/doi/10.1111/ijcp.12719info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:58:12Zoai:ri.conicet.gov.ar:11336/13652instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:58:12.522CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Adolescence and Polycystic Ovary Syndrome: current concepts on diagnosis and treatment
title Adolescence and Polycystic Ovary Syndrome: current concepts on diagnosis and treatment
spellingShingle Adolescence and Polycystic Ovary Syndrome: current concepts on diagnosis and treatment
Motta, Alicia Beatriz
Polycystic Ovary Syndrome
Adolescence
Oligo/Amenorrhea
Anovulation
Cardiovascular Risk
Metformin
Oral Contraceptive Pills
title_short Adolescence and Polycystic Ovary Syndrome: current concepts on diagnosis and treatment
title_full Adolescence and Polycystic Ovary Syndrome: current concepts on diagnosis and treatment
title_fullStr Adolescence and Polycystic Ovary Syndrome: current concepts on diagnosis and treatment
title_full_unstemmed Adolescence and Polycystic Ovary Syndrome: current concepts on diagnosis and treatment
title_sort Adolescence and Polycystic Ovary Syndrome: current concepts on diagnosis and treatment
dc.creator.none.fl_str_mv Motta, Alicia Beatriz
Spritzer, Poli Mara
author Motta, Alicia Beatriz
author_facet Motta, Alicia Beatriz
Spritzer, Poli Mara
author_role author
author2 Spritzer, Poli Mara
author2_role author
dc.subject.none.fl_str_mv Polycystic Ovary Syndrome
Adolescence
Oligo/Amenorrhea
Anovulation
Cardiovascular Risk
Metformin
Oral Contraceptive Pills
topic Polycystic Ovary Syndrome
Adolescence
Oligo/Amenorrhea
Anovulation
Cardiovascular Risk
Metformin
Oral Contraceptive Pills
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Adolescence is a time characterized by changes in reproductive hormones and menstrual patterns, which makes it difficult to diagnose Polycystic Ovary Syndrome (PCOS) in this population. The diagnosis of PCOS has great physical and psychosocial impact in the young person. Despite the importance of a diagnosis of PCOS at adolescence, data available are limited. Aims: This review focuses on analyzing markers of PCOS diagnosis and possible treatments in adolescence. Results: Although during adolescence diagnosis criteria of PCOS overlap with physiological changes including clinical manifestations of hyperandrogenism (acne and hirsutism,), oligo/amenorrhea, anovulation and ovarian microcysts, there is agreement that irregular menses and hyperandrogenemia should be used to diagnose PCOS in this population. Moreover, considering that PCOS phenotype could change through the reproductive age and that adolescents display heterogeneous ovarian morphology, it has been proposed that diagnosis of PCOS should be confirmed after the age of 18. The first-line treatment for menstrual irregularity and hirsutism are oral contraceptive pills and for obesity and metabolic abnormalities are lifestyle changes. Insulin-sensitizer drugs, such as metformin, may be added to the treatment in the presence of metabolic alterations. Antiandrogen drugs may also be associated for treating moderate to severe hirsutism. Conclusions: During adolescence, physiological changes overlap with signs and symptoms of PCOS; thus the diagnosis criteria should be carefully considered. Regarding the treatment of adolescents with PCOS, non-pharmacological interventions include lifestyle changes. Pharmacological treatments comprise oral contraceptive pills, antiandrogens and metformin, used isolated or combined.
Fil: Motta, Alicia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Spritzer, Poli Mara. Universidade Federal do Rio Grande do Sul; Brasil
description Background: Adolescence is a time characterized by changes in reproductive hormones and menstrual patterns, which makes it difficult to diagnose Polycystic Ovary Syndrome (PCOS) in this population. The diagnosis of PCOS has great physical and psychosocial impact in the young person. Despite the importance of a diagnosis of PCOS at adolescence, data available are limited. Aims: This review focuses on analyzing markers of PCOS diagnosis and possible treatments in adolescence. Results: Although during adolescence diagnosis criteria of PCOS overlap with physiological changes including clinical manifestations of hyperandrogenism (acne and hirsutism,), oligo/amenorrhea, anovulation and ovarian microcysts, there is agreement that irregular menses and hyperandrogenemia should be used to diagnose PCOS in this population. Moreover, considering that PCOS phenotype could change through the reproductive age and that adolescents display heterogeneous ovarian morphology, it has been proposed that diagnosis of PCOS should be confirmed after the age of 18. The first-line treatment for menstrual irregularity and hirsutism are oral contraceptive pills and for obesity and metabolic abnormalities are lifestyle changes. Insulin-sensitizer drugs, such as metformin, may be added to the treatment in the presence of metabolic alterations. Antiandrogen drugs may also be associated for treating moderate to severe hirsutism. Conclusions: During adolescence, physiological changes overlap with signs and symptoms of PCOS; thus the diagnosis criteria should be carefully considered. Regarding the treatment of adolescents with PCOS, non-pharmacological interventions include lifestyle changes. Pharmacological treatments comprise oral contraceptive pills, antiandrogens and metformin, used isolated or combined.
publishDate 2015
dc.date.none.fl_str_mv 2015-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13652
Motta, Alicia Beatriz; Spritzer, Poli Mara; Adolescence and Polycystic Ovary Syndrome: current concepts on diagnosis and treatment; Wiley; International Journal of Clinical Practice; 69; 11; 11-2015; 1236-1246
1368-5031
1742-1241
url http://hdl.handle.net/11336/13652
identifier_str_mv Motta, Alicia Beatriz; Spritzer, Poli Mara; Adolescence and Polycystic Ovary Syndrome: current concepts on diagnosis and treatment; Wiley; International Journal of Clinical Practice; 69; 11; 11-2015; 1236-1246
1368-5031
1742-1241
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/ijcp.12719/full
info:eu-repo/semantics/altIdentifier/doi/10.1111/ijcp.12719
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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