The depressor axis of the renin-angiotensin system and brain disorders: A translational approach

Autores
Gironacci, Mariela Mercedes; Vicario, Augusto; Cerezo, Gustavo; Silva, Mauro Gastón
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
All the components of the classic renin-angiotensin system (RAS) have been identified in the brain. Today, the RAS is considered to be composed mainly of two axes: the pressor axis, represented by angiotensin (Ang) II/angiotensin-converting enzyme/AT1 receptors, and the depressor and protective one, represented by Ang-(1-7)/ angiotensin-converting enzyme 2/Mas receptors. Although the RAS exerts a pivotal role on electrolyte homeostasis and blood pressure regulation, their components are also implicated in higher brain functions, including cognition, memory, anxiety and depression, and several neurological disorders. Overactivity of the pressor axis of the RAS has been implicated in stroke and several brain disorders, such as cognitive impairment, dementia, and Alzheimer or Parkinson's disease. The present review is focused on the role of the protective axis of the RAS in brain disorders beyond its effects on blood pressure regulation. Furthermore, the use of drugs targeting centrally RAS and its beneficial effects on brain disorders are also discussed.
Fil: Gironacci, Mariela Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Vicario, Augusto. Instituto Cardiovascular de Buenos Aires; Argentina
Fil: Cerezo, Gustavo. Instituto Cardiovascular de Buenos Aires; Argentina
Fil: Silva, Mauro Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Materia
Alzheimer?s disease
Mas receptor
angiotensin-(1-7)
hypertension
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/99112
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The depressor axis of the renin-angiotensin system and brain disorders: A translational approachGironacci, Mariela MercedesVicario, AugustoCerezo, GustavoSilva, Mauro GastónAlzheimer?s diseaseMas receptorangiotensin-(1-7)hypertensionhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1All the components of the classic renin-angiotensin system (RAS) have been identified in the brain. Today, the RAS is considered to be composed mainly of two axes: the pressor axis, represented by angiotensin (Ang) II/angiotensin-converting enzyme/AT1 receptors, and the depressor and protective one, represented by Ang-(1-7)/ angiotensin-converting enzyme 2/Mas receptors. Although the RAS exerts a pivotal role on electrolyte homeostasis and blood pressure regulation, their components are also implicated in higher brain functions, including cognition, memory, anxiety and depression, and several neurological disorders. Overactivity of the pressor axis of the RAS has been implicated in stroke and several brain disorders, such as cognitive impairment, dementia, and Alzheimer or Parkinson's disease. The present review is focused on the role of the protective axis of the RAS in brain disorders beyond its effects on blood pressure regulation. Furthermore, the use of drugs targeting centrally RAS and its beneficial effects on brain disorders are also discussed.Fil: Gironacci, Mariela Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Vicario, Augusto. Instituto Cardiovascular de Buenos Aires; ArgentinaFil: Cerezo, Gustavo. Instituto Cardiovascular de Buenos Aires; ArgentinaFil: Silva, Mauro Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaPortland Press2018-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99112Gironacci, Mariela Mercedes; Vicario, Augusto; Cerezo, Gustavo; Silva, Mauro Gastón; The depressor axis of the renin-angiotensin system and brain disorders: A translational approach; Portland Press; Clinical Science; 132; 10; 5-2018; 1021-10380143-5221CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://portlandpress.com/clinsci/article-abstract/132/10/1021/77789/The-depressor-axis-of-the-renin-angiotensin-system?redirectedFrom=fulltextinfo:eu-repo/semantics/altIdentifier/doi/10.1042/CS20180189info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:38:20Zoai:ri.conicet.gov.ar:11336/99112instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:38:21.147CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The depressor axis of the renin-angiotensin system and brain disorders: A translational approach
title The depressor axis of the renin-angiotensin system and brain disorders: A translational approach
spellingShingle The depressor axis of the renin-angiotensin system and brain disorders: A translational approach
Gironacci, Mariela Mercedes
Alzheimer?s disease
Mas receptor
angiotensin-(1-7)
hypertension
title_short The depressor axis of the renin-angiotensin system and brain disorders: A translational approach
title_full The depressor axis of the renin-angiotensin system and brain disorders: A translational approach
title_fullStr The depressor axis of the renin-angiotensin system and brain disorders: A translational approach
title_full_unstemmed The depressor axis of the renin-angiotensin system and brain disorders: A translational approach
title_sort The depressor axis of the renin-angiotensin system and brain disorders: A translational approach
dc.creator.none.fl_str_mv Gironacci, Mariela Mercedes
Vicario, Augusto
Cerezo, Gustavo
Silva, Mauro Gastón
author Gironacci, Mariela Mercedes
author_facet Gironacci, Mariela Mercedes
Vicario, Augusto
Cerezo, Gustavo
Silva, Mauro Gastón
author_role author
author2 Vicario, Augusto
Cerezo, Gustavo
Silva, Mauro Gastón
author2_role author
author
author
dc.subject.none.fl_str_mv Alzheimer?s disease
Mas receptor
angiotensin-(1-7)
hypertension
topic Alzheimer?s disease
Mas receptor
angiotensin-(1-7)
hypertension
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv All the components of the classic renin-angiotensin system (RAS) have been identified in the brain. Today, the RAS is considered to be composed mainly of two axes: the pressor axis, represented by angiotensin (Ang) II/angiotensin-converting enzyme/AT1 receptors, and the depressor and protective one, represented by Ang-(1-7)/ angiotensin-converting enzyme 2/Mas receptors. Although the RAS exerts a pivotal role on electrolyte homeostasis and blood pressure regulation, their components are also implicated in higher brain functions, including cognition, memory, anxiety and depression, and several neurological disorders. Overactivity of the pressor axis of the RAS has been implicated in stroke and several brain disorders, such as cognitive impairment, dementia, and Alzheimer or Parkinson's disease. The present review is focused on the role of the protective axis of the RAS in brain disorders beyond its effects on blood pressure regulation. Furthermore, the use of drugs targeting centrally RAS and its beneficial effects on brain disorders are also discussed.
Fil: Gironacci, Mariela Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Vicario, Augusto. Instituto Cardiovascular de Buenos Aires; Argentina
Fil: Cerezo, Gustavo. Instituto Cardiovascular de Buenos Aires; Argentina
Fil: Silva, Mauro Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
description All the components of the classic renin-angiotensin system (RAS) have been identified in the brain. Today, the RAS is considered to be composed mainly of two axes: the pressor axis, represented by angiotensin (Ang) II/angiotensin-converting enzyme/AT1 receptors, and the depressor and protective one, represented by Ang-(1-7)/ angiotensin-converting enzyme 2/Mas receptors. Although the RAS exerts a pivotal role on electrolyte homeostasis and blood pressure regulation, their components are also implicated in higher brain functions, including cognition, memory, anxiety and depression, and several neurological disorders. Overactivity of the pressor axis of the RAS has been implicated in stroke and several brain disorders, such as cognitive impairment, dementia, and Alzheimer or Parkinson's disease. The present review is focused on the role of the protective axis of the RAS in brain disorders beyond its effects on blood pressure regulation. Furthermore, the use of drugs targeting centrally RAS and its beneficial effects on brain disorders are also discussed.
publishDate 2018
dc.date.none.fl_str_mv 2018-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/99112
Gironacci, Mariela Mercedes; Vicario, Augusto; Cerezo, Gustavo; Silva, Mauro Gastón; The depressor axis of the renin-angiotensin system and brain disorders: A translational approach; Portland Press; Clinical Science; 132; 10; 5-2018; 1021-1038
0143-5221
CONICET Digital
CONICET
url http://hdl.handle.net/11336/99112
identifier_str_mv Gironacci, Mariela Mercedes; Vicario, Augusto; Cerezo, Gustavo; Silva, Mauro Gastón; The depressor axis of the renin-angiotensin system and brain disorders: A translational approach; Portland Press; Clinical Science; 132; 10; 5-2018; 1021-1038
0143-5221
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://portlandpress.com/clinsci/article-abstract/132/10/1021/77789/The-depressor-axis-of-the-renin-angiotensin-system?redirectedFrom=fulltext
info:eu-repo/semantics/altIdentifier/doi/10.1042/CS20180189
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Portland Press
publisher.none.fl_str_mv Portland Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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