Early changes in the synapses of the neostriatum induced by perinatal asphyxia
- Autores
- Grimaldi, M.; Romer, I.; González de Apodaca, M. T.; Iturbe, L.; Catania, I. D.; González, J.; Kolliker Fres, R.; Barreto, G.; Capani, Francisco
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Perinatal asphyxia (PA) is a medical condition associated with a high short-term morbimortality and different long-term neurological diseases. In previous work we have observed at 6 months post-synaptic densities (PSDs) alterations compatible with neurodegeneration highly correlated with the increment in the ubiquitination. Although alterations in the synaptic organization and function have been related with neuronal death after hypoxia, little is known about the synaptic changes in young animals exposed to PA. The main aim of this work is to study the PSDs changes in striatum of 30-day-old rats subjected to PA. Using two-dimensional electron microscopic analyses of synapses staining with ethanolic phosphotungstic acid we observed an increment of PSD thickness in severe hypoxic rats. These data are consistent with the western blot analysis that showed an increment in ubiquitination levels in the synapses of severe hypoxic rat. We did observe any alterations neither in synaptic structure nor in ubiquitinization in mild asphyctic rats. These data suggest that hypoxia might cause early misfolding and aggregation of synaptic proteins in severe anoxic animas that could induce long-term neurodegeneration.
Fil: Grimaldi, M.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: Romer, I.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: González de Apodaca, M. T.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: Iturbe, L.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: Catania, I. D.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: González, J.. Pontificia Universidad Javeriana; Colombia
Fil: Kolliker Fres, R.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: Barreto, G.. Pontificia Universidad Javeriana; Colombia
Fil: Capani, Francisco. Universidad Argentina "John F. Kennedy"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina - Materia
-
Neostriatum
Post-Synaptic Density
Rat
Synapse
Ubiquitination - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/67339
Ver los metadatos del registro completo
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Early changes in the synapses of the neostriatum induced by perinatal asphyxiaGrimaldi, M.Romer, I.González de Apodaca, M. T.Iturbe, L.Catania, I. D.González, J.Kolliker Fres, R.Barreto, G.Capani, FranciscoNeostriatumPost-Synaptic DensityRatSynapseUbiquitinationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Perinatal asphyxia (PA) is a medical condition associated with a high short-term morbimortality and different long-term neurological diseases. In previous work we have observed at 6 months post-synaptic densities (PSDs) alterations compatible with neurodegeneration highly correlated with the increment in the ubiquitination. Although alterations in the synaptic organization and function have been related with neuronal death after hypoxia, little is known about the synaptic changes in young animals exposed to PA. The main aim of this work is to study the PSDs changes in striatum of 30-day-old rats subjected to PA. Using two-dimensional electron microscopic analyses of synapses staining with ethanolic phosphotungstic acid we observed an increment of PSD thickness in severe hypoxic rats. These data are consistent with the western blot analysis that showed an increment in ubiquitination levels in the synapses of severe hypoxic rat. We did observe any alterations neither in synaptic structure nor in ubiquitinization in mild asphyctic rats. These data suggest that hypoxia might cause early misfolding and aggregation of synaptic proteins in severe anoxic animas that could induce long-term neurodegeneration.Fil: Grimaldi, M.. Universidad Argentina "John F. Kennedy"; ArgentinaFil: Romer, I.. Universidad Argentina "John F. Kennedy"; ArgentinaFil: González de Apodaca, M. T.. Universidad Argentina "John F. Kennedy"; ArgentinaFil: Iturbe, L.. Universidad Argentina "John F. Kennedy"; ArgentinaFil: Catania, I. D.. Universidad Argentina "John F. Kennedy"; ArgentinaFil: González, J.. Pontificia Universidad Javeriana; ColombiaFil: Kolliker Fres, R.. Universidad Argentina "John F. Kennedy"; ArgentinaFil: Barreto, G.. Pontificia Universidad Javeriana; ColombiaFil: Capani, Francisco. Universidad Argentina "John F. Kennedy"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaTaylor & Francis2012-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67339Grimaldi, M.; Romer, I.; González de Apodaca, M. T.; Iturbe, L.; Catania, I. D.; et al.; Early changes in the synapses of the neostriatum induced by perinatal asphyxia; Taylor & Francis; Nutritional Neuroscience; 15; 3; 5-2012; 103-1101028-415XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1179/1476830511Y.0000000026info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1179/1476830511Y.0000000026info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:41:31Zoai:ri.conicet.gov.ar:11336/67339instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:41:31.48CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Early changes in the synapses of the neostriatum induced by perinatal asphyxia |
title |
Early changes in the synapses of the neostriatum induced by perinatal asphyxia |
spellingShingle |
Early changes in the synapses of the neostriatum induced by perinatal asphyxia Grimaldi, M. Neostriatum Post-Synaptic Density Rat Synapse Ubiquitination |
title_short |
Early changes in the synapses of the neostriatum induced by perinatal asphyxia |
title_full |
Early changes in the synapses of the neostriatum induced by perinatal asphyxia |
title_fullStr |
Early changes in the synapses of the neostriatum induced by perinatal asphyxia |
title_full_unstemmed |
Early changes in the synapses of the neostriatum induced by perinatal asphyxia |
title_sort |
Early changes in the synapses of the neostriatum induced by perinatal asphyxia |
dc.creator.none.fl_str_mv |
Grimaldi, M. Romer, I. González de Apodaca, M. T. Iturbe, L. Catania, I. D. González, J. Kolliker Fres, R. Barreto, G. Capani, Francisco |
author |
Grimaldi, M. |
author_facet |
Grimaldi, M. Romer, I. González de Apodaca, M. T. Iturbe, L. Catania, I. D. González, J. Kolliker Fres, R. Barreto, G. Capani, Francisco |
author_role |
author |
author2 |
Romer, I. González de Apodaca, M. T. Iturbe, L. Catania, I. D. González, J. Kolliker Fres, R. Barreto, G. Capani, Francisco |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Neostriatum Post-Synaptic Density Rat Synapse Ubiquitination |
topic |
Neostriatum Post-Synaptic Density Rat Synapse Ubiquitination |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Perinatal asphyxia (PA) is a medical condition associated with a high short-term morbimortality and different long-term neurological diseases. In previous work we have observed at 6 months post-synaptic densities (PSDs) alterations compatible with neurodegeneration highly correlated with the increment in the ubiquitination. Although alterations in the synaptic organization and function have been related with neuronal death after hypoxia, little is known about the synaptic changes in young animals exposed to PA. The main aim of this work is to study the PSDs changes in striatum of 30-day-old rats subjected to PA. Using two-dimensional electron microscopic analyses of synapses staining with ethanolic phosphotungstic acid we observed an increment of PSD thickness in severe hypoxic rats. These data are consistent with the western blot analysis that showed an increment in ubiquitination levels in the synapses of severe hypoxic rat. We did observe any alterations neither in synaptic structure nor in ubiquitinization in mild asphyctic rats. These data suggest that hypoxia might cause early misfolding and aggregation of synaptic proteins in severe anoxic animas that could induce long-term neurodegeneration. Fil: Grimaldi, M.. Universidad Argentina "John F. Kennedy"; Argentina Fil: Romer, I.. Universidad Argentina "John F. Kennedy"; Argentina Fil: González de Apodaca, M. T.. Universidad Argentina "John F. Kennedy"; Argentina Fil: Iturbe, L.. Universidad Argentina "John F. Kennedy"; Argentina Fil: Catania, I. D.. Universidad Argentina "John F. Kennedy"; Argentina Fil: González, J.. Pontificia Universidad Javeriana; Colombia Fil: Kolliker Fres, R.. Universidad Argentina "John F. Kennedy"; Argentina Fil: Barreto, G.. Pontificia Universidad Javeriana; Colombia Fil: Capani, Francisco. Universidad Argentina "John F. Kennedy"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina |
description |
Perinatal asphyxia (PA) is a medical condition associated with a high short-term morbimortality and different long-term neurological diseases. In previous work we have observed at 6 months post-synaptic densities (PSDs) alterations compatible with neurodegeneration highly correlated with the increment in the ubiquitination. Although alterations in the synaptic organization and function have been related with neuronal death after hypoxia, little is known about the synaptic changes in young animals exposed to PA. The main aim of this work is to study the PSDs changes in striatum of 30-day-old rats subjected to PA. Using two-dimensional electron microscopic analyses of synapses staining with ethanolic phosphotungstic acid we observed an increment of PSD thickness in severe hypoxic rats. These data are consistent with the western blot analysis that showed an increment in ubiquitination levels in the synapses of severe hypoxic rat. We did observe any alterations neither in synaptic structure nor in ubiquitinization in mild asphyctic rats. These data suggest that hypoxia might cause early misfolding and aggregation of synaptic proteins in severe anoxic animas that could induce long-term neurodegeneration. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/67339 Grimaldi, M.; Romer, I.; González de Apodaca, M. T.; Iturbe, L.; Catania, I. D.; et al.; Early changes in the synapses of the neostriatum induced by perinatal asphyxia; Taylor & Francis; Nutritional Neuroscience; 15; 3; 5-2012; 103-110 1028-415X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/67339 |
identifier_str_mv |
Grimaldi, M.; Romer, I.; González de Apodaca, M. T.; Iturbe, L.; Catania, I. D.; et al.; Early changes in the synapses of the neostriatum induced by perinatal asphyxia; Taylor & Francis; Nutritional Neuroscience; 15; 3; 5-2012; 103-110 1028-415X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1179/1476830511Y.0000000026 info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1179/1476830511Y.0000000026 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Taylor & Francis |
publisher.none.fl_str_mv |
Taylor & Francis |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614446236827648 |
score |
13.070432 |