Early changes in the synapses of the neostriatum induced by perinatal asphyxia

Autores
Grimaldi, M.; Romer, I.; González de Apodaca, M. T.; Iturbe, L.; Catania, I. D.; González, J.; Kolliker Fres, R.; Barreto, G.; Capani, Francisco
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Perinatal asphyxia (PA) is a medical condition associated with a high short-term morbimortality and different long-term neurological diseases. In previous work we have observed at 6 months post-synaptic densities (PSDs) alterations compatible with neurodegeneration highly correlated with the increment in the ubiquitination. Although alterations in the synaptic organization and function have been related with neuronal death after hypoxia, little is known about the synaptic changes in young animals exposed to PA. The main aim of this work is to study the PSDs changes in striatum of 30-day-old rats subjected to PA. Using two-dimensional electron microscopic analyses of synapses staining with ethanolic phosphotungstic acid we observed an increment of PSD thickness in severe hypoxic rats. These data are consistent with the western blot analysis that showed an increment in ubiquitination levels in the synapses of severe hypoxic rat. We did observe any alterations neither in synaptic structure nor in ubiquitinization in mild asphyctic rats. These data suggest that hypoxia might cause early misfolding and aggregation of synaptic proteins in severe anoxic animas that could induce long-term neurodegeneration.
Fil: Grimaldi, M.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: Romer, I.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: González de Apodaca, M. T.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: Iturbe, L.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: Catania, I. D.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: González, J.. Pontificia Universidad Javeriana; Colombia
Fil: Kolliker Fres, R.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: Barreto, G.. Pontificia Universidad Javeriana; Colombia
Fil: Capani, Francisco. Universidad Argentina "John F. Kennedy"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Materia
Neostriatum
Post-Synaptic Density
Rat
Synapse
Ubiquitination
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67339
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Early changes in the synapses of the neostriatum induced by perinatal asphyxiaGrimaldi, M.Romer, I.González de Apodaca, M. T.Iturbe, L.Catania, I. D.González, J.Kolliker Fres, R.Barreto, G.Capani, FranciscoNeostriatumPost-Synaptic DensityRatSynapseUbiquitinationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Perinatal asphyxia (PA) is a medical condition associated with a high short-term morbimortality and different long-term neurological diseases. In previous work we have observed at 6 months post-synaptic densities (PSDs) alterations compatible with neurodegeneration highly correlated with the increment in the ubiquitination. Although alterations in the synaptic organization and function have been related with neuronal death after hypoxia, little is known about the synaptic changes in young animals exposed to PA. The main aim of this work is to study the PSDs changes in striatum of 30-day-old rats subjected to PA. Using two-dimensional electron microscopic analyses of synapses staining with ethanolic phosphotungstic acid we observed an increment of PSD thickness in severe hypoxic rats. These data are consistent with the western blot analysis that showed an increment in ubiquitination levels in the synapses of severe hypoxic rat. We did observe any alterations neither in synaptic structure nor in ubiquitinization in mild asphyctic rats. These data suggest that hypoxia might cause early misfolding and aggregation of synaptic proteins in severe anoxic animas that could induce long-term neurodegeneration.Fil: Grimaldi, M.. Universidad Argentina "John F. Kennedy"; ArgentinaFil: Romer, I.. Universidad Argentina "John F. Kennedy"; ArgentinaFil: González de Apodaca, M. T.. Universidad Argentina "John F. Kennedy"; ArgentinaFil: Iturbe, L.. Universidad Argentina "John F. Kennedy"; ArgentinaFil: Catania, I. D.. Universidad Argentina "John F. Kennedy"; ArgentinaFil: González, J.. Pontificia Universidad Javeriana; ColombiaFil: Kolliker Fres, R.. Universidad Argentina "John F. Kennedy"; ArgentinaFil: Barreto, G.. Pontificia Universidad Javeriana; ColombiaFil: Capani, Francisco. Universidad Argentina "John F. Kennedy"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaTaylor & Francis2012-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67339Grimaldi, M.; Romer, I.; González de Apodaca, M. T.; Iturbe, L.; Catania, I. D.; et al.; Early changes in the synapses of the neostriatum induced by perinatal asphyxia; Taylor & Francis; Nutritional Neuroscience; 15; 3; 5-2012; 103-1101028-415XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1179/1476830511Y.0000000026info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1179/1476830511Y.0000000026info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:14:08Zoai:ri.conicet.gov.ar:11336/67339instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:14:08.804CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Early changes in the synapses of the neostriatum induced by perinatal asphyxia
title Early changes in the synapses of the neostriatum induced by perinatal asphyxia
spellingShingle Early changes in the synapses of the neostriatum induced by perinatal asphyxia
Grimaldi, M.
Neostriatum
Post-Synaptic Density
Rat
Synapse
Ubiquitination
title_short Early changes in the synapses of the neostriatum induced by perinatal asphyxia
title_full Early changes in the synapses of the neostriatum induced by perinatal asphyxia
title_fullStr Early changes in the synapses of the neostriatum induced by perinatal asphyxia
title_full_unstemmed Early changes in the synapses of the neostriatum induced by perinatal asphyxia
title_sort Early changes in the synapses of the neostriatum induced by perinatal asphyxia
dc.creator.none.fl_str_mv Grimaldi, M.
Romer, I.
González de Apodaca, M. T.
Iturbe, L.
Catania, I. D.
González, J.
Kolliker Fres, R.
Barreto, G.
Capani, Francisco
author Grimaldi, M.
author_facet Grimaldi, M.
Romer, I.
González de Apodaca, M. T.
Iturbe, L.
Catania, I. D.
González, J.
Kolliker Fres, R.
Barreto, G.
Capani, Francisco
author_role author
author2 Romer, I.
González de Apodaca, M. T.
Iturbe, L.
Catania, I. D.
González, J.
Kolliker Fres, R.
Barreto, G.
Capani, Francisco
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neostriatum
Post-Synaptic Density
Rat
Synapse
Ubiquitination
topic Neostriatum
Post-Synaptic Density
Rat
Synapse
Ubiquitination
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Perinatal asphyxia (PA) is a medical condition associated with a high short-term morbimortality and different long-term neurological diseases. In previous work we have observed at 6 months post-synaptic densities (PSDs) alterations compatible with neurodegeneration highly correlated with the increment in the ubiquitination. Although alterations in the synaptic organization and function have been related with neuronal death after hypoxia, little is known about the synaptic changes in young animals exposed to PA. The main aim of this work is to study the PSDs changes in striatum of 30-day-old rats subjected to PA. Using two-dimensional electron microscopic analyses of synapses staining with ethanolic phosphotungstic acid we observed an increment of PSD thickness in severe hypoxic rats. These data are consistent with the western blot analysis that showed an increment in ubiquitination levels in the synapses of severe hypoxic rat. We did observe any alterations neither in synaptic structure nor in ubiquitinization in mild asphyctic rats. These data suggest that hypoxia might cause early misfolding and aggregation of synaptic proteins in severe anoxic animas that could induce long-term neurodegeneration.
Fil: Grimaldi, M.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: Romer, I.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: González de Apodaca, M. T.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: Iturbe, L.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: Catania, I. D.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: González, J.. Pontificia Universidad Javeriana; Colombia
Fil: Kolliker Fres, R.. Universidad Argentina "John F. Kennedy"; Argentina
Fil: Barreto, G.. Pontificia Universidad Javeriana; Colombia
Fil: Capani, Francisco. Universidad Argentina "John F. Kennedy"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
description Perinatal asphyxia (PA) is a medical condition associated with a high short-term morbimortality and different long-term neurological diseases. In previous work we have observed at 6 months post-synaptic densities (PSDs) alterations compatible with neurodegeneration highly correlated with the increment in the ubiquitination. Although alterations in the synaptic organization and function have been related with neuronal death after hypoxia, little is known about the synaptic changes in young animals exposed to PA. The main aim of this work is to study the PSDs changes in striatum of 30-day-old rats subjected to PA. Using two-dimensional electron microscopic analyses of synapses staining with ethanolic phosphotungstic acid we observed an increment of PSD thickness in severe hypoxic rats. These data are consistent with the western blot analysis that showed an increment in ubiquitination levels in the synapses of severe hypoxic rat. We did observe any alterations neither in synaptic structure nor in ubiquitinization in mild asphyctic rats. These data suggest that hypoxia might cause early misfolding and aggregation of synaptic proteins in severe anoxic animas that could induce long-term neurodegeneration.
publishDate 2012
dc.date.none.fl_str_mv 2012-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67339
Grimaldi, M.; Romer, I.; González de Apodaca, M. T.; Iturbe, L.; Catania, I. D.; et al.; Early changes in the synapses of the neostriatum induced by perinatal asphyxia; Taylor & Francis; Nutritional Neuroscience; 15; 3; 5-2012; 103-110
1028-415X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67339
identifier_str_mv Grimaldi, M.; Romer, I.; González de Apodaca, M. T.; Iturbe, L.; Catania, I. D.; et al.; Early changes in the synapses of the neostriatum induced by perinatal asphyxia; Taylor & Francis; Nutritional Neuroscience; 15; 3; 5-2012; 103-110
1028-415X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1179/1476830511Y.0000000026
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1179/1476830511Y.0000000026
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782547689734144
score 12.982451

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