Rhodococcus oleaginous as a chassis for adipose protein expression and in vivo effect on growth and lipid metabolism

Autores
Herrera, Yanina; Villalba, María Soledad; Alvarado, Cecilia Viviana; Alvarez, Hector Manuel; Hernández, María de Los Angeles
Año de publicación
2021
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Oleaginous Rhodococcus are powerful biological systems for the production of several compounds of biotechnological interest, including neutral lipids such as triacylglycerols (TAG) and fatty acids (FA). These bacteria also possess a robust metabolism which in turn permits them to growth from a high range of carbon sources and under diverse stress conditions. Based on these properties, these bacteria are promising chassis for the production of several compounds via both, expression of native proteins as well as proteins from other biological systems. In this work, we demonstrate that these oleaginous bacteria can be used as an alternative host for protein expression from a complex system, such as adipocytes.
Fil: Herrera, Yanina. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Comodoro. Departamento de Bioquímica; Argentina
Fil: Villalba, María Soledad. Universidad Nacional de la Patagonia "San Juan Bosco". Instituto de Biociencias de la Patagonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Biociencias de la Patagonia; Argentina
Fil: Alvarado, Cecilia Viviana. Universidad Nacional de la Patagonia Austral. Centro de Investigaciones y Transferencia Golfo San Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia Golfo San Jorge. Universidad Nacional de la Patagonia "San Juan Bosco". Centro de Investigaciones y Transferencia Golfo San Jorge; Argentina
Fil: Alvarez, Hector Manuel. Universidad Nacional de la Patagonia "San Juan Bosco". Instituto de Biociencias de la Patagonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Biociencias de la Patagonia; Argentina
Fil: Hernández, María de Los Angeles. Universidad Nacional de la Patagonia "San Juan Bosco". Instituto de Biociencias de la Patagonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Biociencias de la Patagonia; Argentina
LVII Annual Meeting of the Argentine Society for Biochemistry and Molecular Biology Research; XVI Annual Meeting of the Argentinean Society for General Microbiology
Mendoza
Argentina
Sociedad Argentina de Investigación Bioquímica
Sociedad Argentina de Microbiología General
Materia
RHODOCOCCUS
FABP4
ADIPOSE PROTEIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/181698
Acceder
id CONICETDig_ea9539338ba8f2bb3543e86c8b11ab9d
oai_identifier_str oai:ri.conicet.gov.ar:11336/181698
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Rhodococcus oleaginous as a chassis for adipose protein expression and in vivo effect on growth and lipid metabolismHerrera, YaninaVillalba, María SoledadAlvarado, Cecilia VivianaAlvarez, Hector ManuelHernández, María de Los AngelesRHODOCOCCUSFABP4ADIPOSE PROTEINhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Oleaginous Rhodococcus are powerful biological systems for the production of several compounds of biotechnological interest, including neutral lipids such as triacylglycerols (TAG) and fatty acids (FA). These bacteria also possess a robust metabolism which in turn permits them to growth from a high range of carbon sources and under diverse stress conditions. Based on these properties, these bacteria are promising chassis for the production of several compounds via both, expression of native proteins as well as proteins from other biological systems. In this work, we demonstrate that these oleaginous bacteria can be used as an alternative host for protein expression from a complex system, such as adipocytes.Fil: Herrera, Yanina. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Comodoro. Departamento de Bioquímica; ArgentinaFil: Villalba, María Soledad. Universidad Nacional de la Patagonia "San Juan Bosco". Instituto de Biociencias de la Patagonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Biociencias de la Patagonia; ArgentinaFil: Alvarado, Cecilia Viviana. Universidad Nacional de la Patagonia Austral. Centro de Investigaciones y Transferencia Golfo San Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia Golfo San Jorge. Universidad Nacional de la Patagonia "San Juan Bosco". Centro de Investigaciones y Transferencia Golfo San Jorge; ArgentinaFil: Alvarez, Hector Manuel. Universidad Nacional de la Patagonia "San Juan Bosco". Instituto de Biociencias de la Patagonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Biociencias de la Patagonia; ArgentinaFil: Hernández, María de Los Angeles. Universidad Nacional de la Patagonia "San Juan Bosco". Instituto de Biociencias de la Patagonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Biociencias de la Patagonia; ArgentinaLVII Annual Meeting of the Argentine Society for Biochemistry and Molecular Biology Research; XVI Annual Meeting of the Argentinean Society for General MicrobiologyMendozaArgentinaSociedad Argentina de Investigación BioquímicaSociedad Argentina de Microbiología GeneralTech Science Press2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/181698Rhodococcus oleaginous as a chassis for adipose protein expression and in vivo effect on growth and lipid metabolism; LVII Annual Meeting of the Argentine Society for Biochemistry and Molecular Biology Research; XVI Annual Meeting of the Argentinean Society for General Microbiology; Mendoza; Argentina; 2021; 119-1190327-95451667-5746CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://samige.org.ar//wp-content/uploads/2022/10/Libro-de-resumenes-2021-Biocell.pdfInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:43:28Zoai:ri.conicet.gov.ar:11336/181698instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:43:29.21CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Rhodococcus oleaginous as a chassis for adipose protein expression and in vivo effect on growth and lipid metabolism
title Rhodococcus oleaginous as a chassis for adipose protein expression and in vivo effect on growth and lipid metabolism
spellingShingle Rhodococcus oleaginous as a chassis for adipose protein expression and in vivo effect on growth and lipid metabolism
Herrera, Yanina
RHODOCOCCUS
FABP4
ADIPOSE PROTEIN
title_short Rhodococcus oleaginous as a chassis for adipose protein expression and in vivo effect on growth and lipid metabolism
title_full Rhodococcus oleaginous as a chassis for adipose protein expression and in vivo effect on growth and lipid metabolism
title_fullStr Rhodococcus oleaginous as a chassis for adipose protein expression and in vivo effect on growth and lipid metabolism
title_full_unstemmed Rhodococcus oleaginous as a chassis for adipose protein expression and in vivo effect on growth and lipid metabolism
title_sort Rhodococcus oleaginous as a chassis for adipose protein expression and in vivo effect on growth and lipid metabolism
dc.creator.none.fl_str_mv Herrera, Yanina
Villalba, María Soledad
Alvarado, Cecilia Viviana
Alvarez, Hector Manuel
Hernández, María de Los Angeles
author Herrera, Yanina
author_facet Herrera, Yanina
Villalba, María Soledad
Alvarado, Cecilia Viviana
Alvarez, Hector Manuel
Hernández, María de Los Angeles
author_role author
author2 Villalba, María Soledad
Alvarado, Cecilia Viviana
Alvarez, Hector Manuel
Hernández, María de Los Angeles
author2_role author
author
author
author
dc.subject.none.fl_str_mv RHODOCOCCUS
FABP4
ADIPOSE PROTEIN
topic RHODOCOCCUS
FABP4
ADIPOSE PROTEIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Oleaginous Rhodococcus are powerful biological systems for the production of several compounds of biotechnological interest, including neutral lipids such as triacylglycerols (TAG) and fatty acids (FA). These bacteria also possess a robust metabolism which in turn permits them to growth from a high range of carbon sources and under diverse stress conditions. Based on these properties, these bacteria are promising chassis for the production of several compounds via both, expression of native proteins as well as proteins from other biological systems. In this work, we demonstrate that these oleaginous bacteria can be used as an alternative host for protein expression from a complex system, such as adipocytes.
Fil: Herrera, Yanina. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Comodoro. Departamento de Bioquímica; Argentina
Fil: Villalba, María Soledad. Universidad Nacional de la Patagonia "San Juan Bosco". Instituto de Biociencias de la Patagonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Biociencias de la Patagonia; Argentina
Fil: Alvarado, Cecilia Viviana. Universidad Nacional de la Patagonia Austral. Centro de Investigaciones y Transferencia Golfo San Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia Golfo San Jorge. Universidad Nacional de la Patagonia "San Juan Bosco". Centro de Investigaciones y Transferencia Golfo San Jorge; Argentina
Fil: Alvarez, Hector Manuel. Universidad Nacional de la Patagonia "San Juan Bosco". Instituto de Biociencias de la Patagonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Biociencias de la Patagonia; Argentina
Fil: Hernández, María de Los Angeles. Universidad Nacional de la Patagonia "San Juan Bosco". Instituto de Biociencias de la Patagonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Biociencias de la Patagonia; Argentina
LVII Annual Meeting of the Argentine Society for Biochemistry and Molecular Biology Research; XVI Annual Meeting of the Argentinean Society for General Microbiology
Mendoza
Argentina
Sociedad Argentina de Investigación Bioquímica
Sociedad Argentina de Microbiología General
description Oleaginous Rhodococcus are powerful biological systems for the production of several compounds of biotechnological interest, including neutral lipids such as triacylglycerols (TAG) and fatty acids (FA). These bacteria also possess a robust metabolism which in turn permits them to growth from a high range of carbon sources and under diverse stress conditions. Based on these properties, these bacteria are promising chassis for the production of several compounds via both, expression of native proteins as well as proteins from other biological systems. In this work, we demonstrate that these oleaginous bacteria can be used as an alternative host for protein expression from a complex system, such as adipocytes.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/181698
Rhodococcus oleaginous as a chassis for adipose protein expression and in vivo effect on growth and lipid metabolism; LVII Annual Meeting of the Argentine Society for Biochemistry and Molecular Biology Research; XVI Annual Meeting of the Argentinean Society for General Microbiology; Mendoza; Argentina; 2021; 119-119
0327-9545
1667-5746
CONICET Digital
CONICET
url http://hdl.handle.net/11336/181698
identifier_str_mv Rhodococcus oleaginous as a chassis for adipose protein expression and in vivo effect on growth and lipid metabolism; LVII Annual Meeting of the Argentine Society for Biochemistry and Molecular Biology Research; XVI Annual Meeting of the Argentinean Society for General Microbiology; Mendoza; Argentina; 2021; 119-119
0327-9545
1667-5746
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://samige.org.ar//wp-content/uploads/2022/10/Libro-de-resumenes-2021-Biocell.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Tech Science Press
publisher.none.fl_str_mv Tech Science Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614470155894784
score 13.069144

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