Comorbidity and high viral load linked to clinical presentation of respiratory human bocavirus infection

Autores
Ghietto, Lucía María; Majul, Diego; Ferreyra Soaje, Patricia; Baumeister, Elsa; Avaro, Martín; Insfran, Constanza; Mosca, Liliana; Cámara, Alicia; Moreno, Laura Beatriz; Adamo, Maria Pilar
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Human bocavirus (HBoV) is a new parvovirus associated with acute respiratory tract infection (ARTI). In order to evaluate HBoV significance as an agent of acute respiratory disease, we screened 1,135 respiratory samples from children and adults with and without symptoms during two complete calendar years. HBoV1 prevalence in patients with ARTI was 6.33 % in 2011 and 11.64 % in 2012, including neonatal and adult patients. HBoV1 was also detected in 3.77 % of asymptomatic individuals. The co-detection rate was 78.1 %. Among children, 87 % were clinically diagnosed with lower respiratory infection (no significant differences between patients with and without coinfection), and 31 % exhibited comorbidities. Pediatric patients with comorbidities were significantly older than patients without comorbidities. Patients with ARTI had either high or low viral load, while controls had only low viral load, but there were no clinical differences between patients with high or low viral load. In conclusion, we present evidence of the pathogenic potential of HBoV1 in young children with ARTI. Since patients with HBoV1-single infection are not significantly different from those with coinfection with respect to clinical features, the virus can be as pathogenic by itself as other respiratory agents are. Furthermore, an association between high HBoV1 load and disease could not be demonstrated in this study, but all asymptomatic individuals had low viral loads. Also, children with comorbidities are susceptible to HBoV1 infection at older ages than previously healthy children. Thus, the clinical presentation of infection may occur depending on both viral load and the particular interaction between the HBoV1 and the host.
Fil: Ghietto, Lucía María. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología ; Argentina
Fil: Majul, Diego. Universidad Nacional de Cordoba. Hospital de Niños; Argentina
Fil: Ferreyra Soaje, Patricia. Universidad Nacional de Cordoba. Hospital de Niños; Argentina
Fil: Baumeister, Elsa. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorios e Instituto de Salud ; Argentina
Fil: Avaro, Martín. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorios e Instituto de Salud ; Argentina
Fil: Insfran, Constanza. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología ; Argentina
Fil: Mosca, Liliana. Universidad Nacional de Cordoba. Hospital de Niños; Argentina
Fil: Cámara, Alicia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología ; Argentina
Fil: Moreno, Laura Beatriz. Universidad Nacional de Cordoba. Hospital de Niños; Argentina
Fil: Adamo, Maria Pilar. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología ; Argentina
Materia
Human Bocavirus
Respiratory Infection
Viral Load
Co-Morbidity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/59828
Acceder
id CONICETDig_ea8eccd55110e294af5fbea1eb4e7f14
oai_identifier_str oai:ri.conicet.gov.ar:11336/59828
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Comorbidity and high viral load linked to clinical presentation of respiratory human bocavirus infectionGhietto, Lucía MaríaMajul, DiegoFerreyra Soaje, PatriciaBaumeister, ElsaAvaro, MartínInsfran, ConstanzaMosca, LilianaCámara, AliciaMoreno, Laura BeatrizAdamo, Maria PilarHuman BocavirusRespiratory InfectionViral LoadCo-Morbidityhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Human bocavirus (HBoV) is a new parvovirus associated with acute respiratory tract infection (ARTI). In order to evaluate HBoV significance as an agent of acute respiratory disease, we screened 1,135 respiratory samples from children and adults with and without symptoms during two complete calendar years. HBoV1 prevalence in patients with ARTI was 6.33 % in 2011 and 11.64 % in 2012, including neonatal and adult patients. HBoV1 was also detected in 3.77 % of asymptomatic individuals. The co-detection rate was 78.1 %. Among children, 87 % were clinically diagnosed with lower respiratory infection (no significant differences between patients with and without coinfection), and 31 % exhibited comorbidities. Pediatric patients with comorbidities were significantly older than patients without comorbidities. Patients with ARTI had either high or low viral load, while controls had only low viral load, but there were no clinical differences between patients with high or low viral load. In conclusion, we present evidence of the pathogenic potential of HBoV1 in young children with ARTI. Since patients with HBoV1-single infection are not significantly different from those with coinfection with respect to clinical features, the virus can be as pathogenic by itself as other respiratory agents are. Furthermore, an association between high HBoV1 load and disease could not be demonstrated in this study, but all asymptomatic individuals had low viral loads. Also, children with comorbidities are susceptible to HBoV1 infection at older ages than previously healthy children. Thus, the clinical presentation of infection may occur depending on both viral load and the particular interaction between the HBoV1 and the host.Fil: Ghietto, Lucía María. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología ; ArgentinaFil: Majul, Diego. Universidad Nacional de Cordoba. Hospital de Niños; ArgentinaFil: Ferreyra Soaje, Patricia. Universidad Nacional de Cordoba. Hospital de Niños; ArgentinaFil: Baumeister, Elsa. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorios e Instituto de Salud ; ArgentinaFil: Avaro, Martín. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorios e Instituto de Salud ; ArgentinaFil: Insfran, Constanza. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología ; ArgentinaFil: Mosca, Liliana. Universidad Nacional de Cordoba. Hospital de Niños; ArgentinaFil: Cámara, Alicia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología ; ArgentinaFil: Moreno, Laura Beatriz. Universidad Nacional de Cordoba. Hospital de Niños; ArgentinaFil: Adamo, Maria Pilar. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología ; ArgentinaSpringer Wien2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/59828Ghietto, Lucía María; Majul, Diego; Ferreyra Soaje, Patricia; Baumeister, Elsa; Avaro, Martín; et al.; Comorbidity and high viral load linked to clinical presentation of respiratory human bocavirus infection; Springer Wien; Archives of Virology; 160; 1; 1-2015; 117-1270304-86081432-8798CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs00705-014-2238-5info:eu-repo/semantics/altIdentifier/doi/10.1007/s00705-014-2238-5info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:55:41Zoai:ri.conicet.gov.ar:11336/59828instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:55:41.869CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Comorbidity and high viral load linked to clinical presentation of respiratory human bocavirus infection
title Comorbidity and high viral load linked to clinical presentation of respiratory human bocavirus infection
spellingShingle Comorbidity and high viral load linked to clinical presentation of respiratory human bocavirus infection
Ghietto, Lucía María
Human Bocavirus
Respiratory Infection
Viral Load
Co-Morbidity
title_short Comorbidity and high viral load linked to clinical presentation of respiratory human bocavirus infection
title_full Comorbidity and high viral load linked to clinical presentation of respiratory human bocavirus infection
title_fullStr Comorbidity and high viral load linked to clinical presentation of respiratory human bocavirus infection
title_full_unstemmed Comorbidity and high viral load linked to clinical presentation of respiratory human bocavirus infection
title_sort Comorbidity and high viral load linked to clinical presentation of respiratory human bocavirus infection
dc.creator.none.fl_str_mv Ghietto, Lucía María
Majul, Diego
Ferreyra Soaje, Patricia
Baumeister, Elsa
Avaro, Martín
Insfran, Constanza
Mosca, Liliana
Cámara, Alicia
Moreno, Laura Beatriz
Adamo, Maria Pilar
author Ghietto, Lucía María
author_facet Ghietto, Lucía María
Majul, Diego
Ferreyra Soaje, Patricia
Baumeister, Elsa
Avaro, Martín
Insfran, Constanza
Mosca, Liliana
Cámara, Alicia
Moreno, Laura Beatriz
Adamo, Maria Pilar
author_role author
author2 Majul, Diego
Ferreyra Soaje, Patricia
Baumeister, Elsa
Avaro, Martín
Insfran, Constanza
Mosca, Liliana
Cámara, Alicia
Moreno, Laura Beatriz
Adamo, Maria Pilar
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Human Bocavirus
Respiratory Infection
Viral Load
Co-Morbidity
topic Human Bocavirus
Respiratory Infection
Viral Load
Co-Morbidity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Human bocavirus (HBoV) is a new parvovirus associated with acute respiratory tract infection (ARTI). In order to evaluate HBoV significance as an agent of acute respiratory disease, we screened 1,135 respiratory samples from children and adults with and without symptoms during two complete calendar years. HBoV1 prevalence in patients with ARTI was 6.33 % in 2011 and 11.64 % in 2012, including neonatal and adult patients. HBoV1 was also detected in 3.77 % of asymptomatic individuals. The co-detection rate was 78.1 %. Among children, 87 % were clinically diagnosed with lower respiratory infection (no significant differences between patients with and without coinfection), and 31 % exhibited comorbidities. Pediatric patients with comorbidities were significantly older than patients without comorbidities. Patients with ARTI had either high or low viral load, while controls had only low viral load, but there were no clinical differences between patients with high or low viral load. In conclusion, we present evidence of the pathogenic potential of HBoV1 in young children with ARTI. Since patients with HBoV1-single infection are not significantly different from those with coinfection with respect to clinical features, the virus can be as pathogenic by itself as other respiratory agents are. Furthermore, an association between high HBoV1 load and disease could not be demonstrated in this study, but all asymptomatic individuals had low viral loads. Also, children with comorbidities are susceptible to HBoV1 infection at older ages than previously healthy children. Thus, the clinical presentation of infection may occur depending on both viral load and the particular interaction between the HBoV1 and the host.
Fil: Ghietto, Lucía María. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología ; Argentina
Fil: Majul, Diego. Universidad Nacional de Cordoba. Hospital de Niños; Argentina
Fil: Ferreyra Soaje, Patricia. Universidad Nacional de Cordoba. Hospital de Niños; Argentina
Fil: Baumeister, Elsa. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorios e Instituto de Salud ; Argentina
Fil: Avaro, Martín. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorios e Instituto de Salud ; Argentina
Fil: Insfran, Constanza. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología ; Argentina
Fil: Mosca, Liliana. Universidad Nacional de Cordoba. Hospital de Niños; Argentina
Fil: Cámara, Alicia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología ; Argentina
Fil: Moreno, Laura Beatriz. Universidad Nacional de Cordoba. Hospital de Niños; Argentina
Fil: Adamo, Maria Pilar. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología ; Argentina
description Human bocavirus (HBoV) is a new parvovirus associated with acute respiratory tract infection (ARTI). In order to evaluate HBoV significance as an agent of acute respiratory disease, we screened 1,135 respiratory samples from children and adults with and without symptoms during two complete calendar years. HBoV1 prevalence in patients with ARTI was 6.33 % in 2011 and 11.64 % in 2012, including neonatal and adult patients. HBoV1 was also detected in 3.77 % of asymptomatic individuals. The co-detection rate was 78.1 %. Among children, 87 % were clinically diagnosed with lower respiratory infection (no significant differences between patients with and without coinfection), and 31 % exhibited comorbidities. Pediatric patients with comorbidities were significantly older than patients without comorbidities. Patients with ARTI had either high or low viral load, while controls had only low viral load, but there were no clinical differences between patients with high or low viral load. In conclusion, we present evidence of the pathogenic potential of HBoV1 in young children with ARTI. Since patients with HBoV1-single infection are not significantly different from those with coinfection with respect to clinical features, the virus can be as pathogenic by itself as other respiratory agents are. Furthermore, an association between high HBoV1 load and disease could not be demonstrated in this study, but all asymptomatic individuals had low viral loads. Also, children with comorbidities are susceptible to HBoV1 infection at older ages than previously healthy children. Thus, the clinical presentation of infection may occur depending on both viral load and the particular interaction between the HBoV1 and the host.
publishDate 2015
dc.date.none.fl_str_mv 2015-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/59828
Ghietto, Lucía María; Majul, Diego; Ferreyra Soaje, Patricia; Baumeister, Elsa; Avaro, Martín; et al.; Comorbidity and high viral load linked to clinical presentation of respiratory human bocavirus infection; Springer Wien; Archives of Virology; 160; 1; 1-2015; 117-127
0304-8608
1432-8798
CONICET Digital
CONICET
url http://hdl.handle.net/11336/59828
identifier_str_mv Ghietto, Lucía María; Majul, Diego; Ferreyra Soaje, Patricia; Baumeister, Elsa; Avaro, Martín; et al.; Comorbidity and high viral load linked to clinical presentation of respiratory human bocavirus infection; Springer Wien; Archives of Virology; 160; 1; 1-2015; 117-127
0304-8608
1432-8798
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs00705-014-2238-5
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00705-014-2238-5
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Wien
publisher.none.fl_str_mv Springer Wien
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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