Respiratory failure and death in vulnerable premature children with lower respiratory tract illness

Autores
Ofman, Gaston; Pradarelli, Brad; Caballero, Mauricio Tomás; Bianchi, Alejandra; Grimaldi, Luciano Alva; Sancilio, Andrea; Duenas, Karina; Rodriguez, Andrea; Ferrero, Fernando; Ferretti, Adrian; Coviello, Silvina Andrea; Ferolla, Fausto Martín; Acosta, Patricio Leandro; Bergel, Eduardo; Libster, Romina Paula; Polack, Fernando Pedro
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background. Efforts to better understand the risk factors associated with respiratory failure (RF) and fatal lower respiratory tract infection (LRTI) in premature children in developing countries are necessary to elaborate evidenced-based preventive interventions. We aim to characterize the burden of respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) LRTI in premature children and determine risk factors for RF and fatal illness in a vulnerable population. Methods. This is a prospective, population-based, cross-sectional study. Subjects with severe LRTI were enrolled during respiratory season. Risk factors for RF and death in premature infants were investigated. Results. A total of 664 premature children participated. Infant's hospitalization rate due to LRTI was 82.6/1000 (95% confidence interval [CI], 68.6-96.7/1000). Infant's RSV and hMPV rates were 40.9/1000 (95% CI, 36.3-45.6/1000) and 6.6/1000 (95% CI, 3.9- 9.2/1000), respectively. The RF rate was 8.2/1000 (95% CI, 4.9-11.5/1000). The LRTI mortality was 2.2/1000 (95% CI, 0.7-3.7/1000); for RSV, the rate was 0.8/1000 (95% CI, 0-1.7/1000) with a case-fatality ratio of 1.8%. Never breastfeeding, malnutrition, younger than 6 months, congenital heart disease, and lower hematocrit were risk factors for RF. Experiencing pneumonia, pneumothorax, sepsis, or apnea were clinical determinants of poor outcomes. Conclusions. Premature children under 2 years old in vulnerable environments experience RF and death more often than term counterparts. Modifiable risk factors associated with poor outcomes should prompt evidence-based interventions.
Fil: Ofman, Gaston. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Pradarelli, Brad. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Caballero, Mauricio Tomás. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bianchi, Alejandra. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Grimaldi, Luciano Alva. Gobierno de la Provincia de Buenos Aires. Hospital Zonal General de Agudos Doctor Lucio Melendez.; Argentina
Fil: Sancilio, Andrea. Gobierno de la Provincia de Buenos Aires. Hospital Interzonal de Agudos Evita; Argentina
Fil: Duenas, Karina. Gobierno de la Provincia de Buenos Aires. Hospital Interzonal de Agudos Evita; Argentina
Fil: Rodriguez, Andrea. Gobierno de la Provincia de Buenos Aires. Hospital Provincial Evita Pueblo.; Argentina
Fil: Ferrero, Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Ferretti, Adrian. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Coviello, Silvina Andrea. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferolla, Fausto Martín. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Acosta, Patricio Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Bergel, Eduardo. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Libster, Romina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Polack, Fernando Pedro. Fundacion de Endocrinologia Infantil.; Argentina
Materia
PREMATURITY
RESPIRATORY FAILURE
RESPIRATORY INFECTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/168167
Acceder
id CONICETDig_b3112acdf0ba26c44d92297ab60765d9
oai_identifier_str oai:ri.conicet.gov.ar:11336/168167
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Respiratory failure and death in vulnerable premature children with lower respiratory tract illnessOfman, GastonPradarelli, BradCaballero, Mauricio TomásBianchi, AlejandraGrimaldi, Luciano AlvaSancilio, AndreaDuenas, KarinaRodriguez, AndreaFerrero, FernandoFerretti, AdrianCoviello, Silvina AndreaFerolla, Fausto MartínAcosta, Patricio LeandroBergel, EduardoLibster, Romina PaulaPolack, Fernando PedroPREMATURITYRESPIRATORY FAILURERESPIRATORY INFECTIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background. Efforts to better understand the risk factors associated with respiratory failure (RF) and fatal lower respiratory tract infection (LRTI) in premature children in developing countries are necessary to elaborate evidenced-based preventive interventions. We aim to characterize the burden of respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) LRTI in premature children and determine risk factors for RF and fatal illness in a vulnerable population. Methods. This is a prospective, population-based, cross-sectional study. Subjects with severe LRTI were enrolled during respiratory season. Risk factors for RF and death in premature infants were investigated. Results. A total of 664 premature children participated. Infant's hospitalization rate due to LRTI was 82.6/1000 (95% confidence interval [CI], 68.6-96.7/1000). Infant's RSV and hMPV rates were 40.9/1000 (95% CI, 36.3-45.6/1000) and 6.6/1000 (95% CI, 3.9- 9.2/1000), respectively. The RF rate was 8.2/1000 (95% CI, 4.9-11.5/1000). The LRTI mortality was 2.2/1000 (95% CI, 0.7-3.7/1000); for RSV, the rate was 0.8/1000 (95% CI, 0-1.7/1000) with a case-fatality ratio of 1.8%. Never breastfeeding, malnutrition, younger than 6 months, congenital heart disease, and lower hematocrit were risk factors for RF. Experiencing pneumonia, pneumothorax, sepsis, or apnea were clinical determinants of poor outcomes. Conclusions. Premature children under 2 years old in vulnerable environments experience RF and death more often than term counterparts. Modifiable risk factors associated with poor outcomes should prompt evidence-based interventions.Fil: Ofman, Gaston. Fundacion de Endocrinologia Infantil.; ArgentinaFil: Pradarelli, Brad. Fundacion de Endocrinologia Infantil.; ArgentinaFil: Caballero, Mauricio Tomás. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bianchi, Alejandra. Fundacion de Endocrinologia Infantil.; ArgentinaFil: Grimaldi, Luciano Alva. Gobierno de la Provincia de Buenos Aires. Hospital Zonal General de Agudos Doctor Lucio Melendez.; ArgentinaFil: Sancilio, Andrea. Gobierno de la Provincia de Buenos Aires. Hospital Interzonal de Agudos Evita; ArgentinaFil: Duenas, Karina. Gobierno de la Provincia de Buenos Aires. Hospital Interzonal de Agudos Evita; ArgentinaFil: Rodriguez, Andrea. Gobierno de la Provincia de Buenos Aires. Hospital Provincial Evita Pueblo.; ArgentinaFil: Ferrero, Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Ferretti, Adrian. Fundacion de Endocrinologia Infantil.; ArgentinaFil: Coviello, Silvina Andrea. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ferolla, Fausto Martín. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Acosta, Patricio Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundacion de Endocrinologia Infantil.; ArgentinaFil: Bergel, Eduardo. Fundacion de Endocrinologia Infantil.; ArgentinaFil: Libster, Romina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundacion de Endocrinologia Infantil.; ArgentinaFil: Polack, Fernando Pedro. Fundacion de Endocrinologia Infantil.; ArgentinaUniversity of Chicago Press2020-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/168167Ofman, Gaston; Pradarelli, Brad; Caballero, Mauricio Tomás; Bianchi, Alejandra; Grimaldi, Luciano Alva; et al.; Respiratory failure and death in vulnerable premature children with lower respiratory tract illness; University of Chicago Press; Journal Of Infectious Diseases; 222; 7; 2-2020; 1129-11370022-1899CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiaa046/5719603info:eu-repo/semantics/altIdentifier/doi/10.1093/infdis/jiaa046info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:24:57Zoai:ri.conicet.gov.ar:11336/168167instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:24:57.747CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Respiratory failure and death in vulnerable premature children with lower respiratory tract illness
title Respiratory failure and death in vulnerable premature children with lower respiratory tract illness
spellingShingle Respiratory failure and death in vulnerable premature children with lower respiratory tract illness
Ofman, Gaston
PREMATURITY
RESPIRATORY FAILURE
RESPIRATORY INFECTION
title_short Respiratory failure and death in vulnerable premature children with lower respiratory tract illness
title_full Respiratory failure and death in vulnerable premature children with lower respiratory tract illness
title_fullStr Respiratory failure and death in vulnerable premature children with lower respiratory tract illness
title_full_unstemmed Respiratory failure and death in vulnerable premature children with lower respiratory tract illness
title_sort Respiratory failure and death in vulnerable premature children with lower respiratory tract illness
dc.creator.none.fl_str_mv Ofman, Gaston
Pradarelli, Brad
Caballero, Mauricio Tomás
Bianchi, Alejandra
Grimaldi, Luciano Alva
Sancilio, Andrea
Duenas, Karina
Rodriguez, Andrea
Ferrero, Fernando
Ferretti, Adrian
Coviello, Silvina Andrea
Ferolla, Fausto Martín
Acosta, Patricio Leandro
Bergel, Eduardo
Libster, Romina Paula
Polack, Fernando Pedro
author Ofman, Gaston
author_facet Ofman, Gaston
Pradarelli, Brad
Caballero, Mauricio Tomás
Bianchi, Alejandra
Grimaldi, Luciano Alva
Sancilio, Andrea
Duenas, Karina
Rodriguez, Andrea
Ferrero, Fernando
Ferretti, Adrian
Coviello, Silvina Andrea
Ferolla, Fausto Martín
Acosta, Patricio Leandro
Bergel, Eduardo
Libster, Romina Paula
Polack, Fernando Pedro
author_role author
author2 Pradarelli, Brad
Caballero, Mauricio Tomás
Bianchi, Alejandra
Grimaldi, Luciano Alva
Sancilio, Andrea
Duenas, Karina
Rodriguez, Andrea
Ferrero, Fernando
Ferretti, Adrian
Coviello, Silvina Andrea
Ferolla, Fausto Martín
Acosta, Patricio Leandro
Bergel, Eduardo
Libster, Romina Paula
Polack, Fernando Pedro
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv PREMATURITY
RESPIRATORY FAILURE
RESPIRATORY INFECTION
topic PREMATURITY
RESPIRATORY FAILURE
RESPIRATORY INFECTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background. Efforts to better understand the risk factors associated with respiratory failure (RF) and fatal lower respiratory tract infection (LRTI) in premature children in developing countries are necessary to elaborate evidenced-based preventive interventions. We aim to characterize the burden of respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) LRTI in premature children and determine risk factors for RF and fatal illness in a vulnerable population. Methods. This is a prospective, population-based, cross-sectional study. Subjects with severe LRTI were enrolled during respiratory season. Risk factors for RF and death in premature infants were investigated. Results. A total of 664 premature children participated. Infant's hospitalization rate due to LRTI was 82.6/1000 (95% confidence interval [CI], 68.6-96.7/1000). Infant's RSV and hMPV rates were 40.9/1000 (95% CI, 36.3-45.6/1000) and 6.6/1000 (95% CI, 3.9- 9.2/1000), respectively. The RF rate was 8.2/1000 (95% CI, 4.9-11.5/1000). The LRTI mortality was 2.2/1000 (95% CI, 0.7-3.7/1000); for RSV, the rate was 0.8/1000 (95% CI, 0-1.7/1000) with a case-fatality ratio of 1.8%. Never breastfeeding, malnutrition, younger than 6 months, congenital heart disease, and lower hematocrit were risk factors for RF. Experiencing pneumonia, pneumothorax, sepsis, or apnea were clinical determinants of poor outcomes. Conclusions. Premature children under 2 years old in vulnerable environments experience RF and death more often than term counterparts. Modifiable risk factors associated with poor outcomes should prompt evidence-based interventions.
Fil: Ofman, Gaston. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Pradarelli, Brad. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Caballero, Mauricio Tomás. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bianchi, Alejandra. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Grimaldi, Luciano Alva. Gobierno de la Provincia de Buenos Aires. Hospital Zonal General de Agudos Doctor Lucio Melendez.; Argentina
Fil: Sancilio, Andrea. Gobierno de la Provincia de Buenos Aires. Hospital Interzonal de Agudos Evita; Argentina
Fil: Duenas, Karina. Gobierno de la Provincia de Buenos Aires. Hospital Interzonal de Agudos Evita; Argentina
Fil: Rodriguez, Andrea. Gobierno de la Provincia de Buenos Aires. Hospital Provincial Evita Pueblo.; Argentina
Fil: Ferrero, Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Ferretti, Adrian. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Coviello, Silvina Andrea. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferolla, Fausto Martín. Fundacion de Endocrinologia Infantil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Acosta, Patricio Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Bergel, Eduardo. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Libster, Romina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundacion de Endocrinologia Infantil.; Argentina
Fil: Polack, Fernando Pedro. Fundacion de Endocrinologia Infantil.; Argentina
description Background. Efforts to better understand the risk factors associated with respiratory failure (RF) and fatal lower respiratory tract infection (LRTI) in premature children in developing countries are necessary to elaborate evidenced-based preventive interventions. We aim to characterize the burden of respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) LRTI in premature children and determine risk factors for RF and fatal illness in a vulnerable population. Methods. This is a prospective, population-based, cross-sectional study. Subjects with severe LRTI were enrolled during respiratory season. Risk factors for RF and death in premature infants were investigated. Results. A total of 664 premature children participated. Infant's hospitalization rate due to LRTI was 82.6/1000 (95% confidence interval [CI], 68.6-96.7/1000). Infant's RSV and hMPV rates were 40.9/1000 (95% CI, 36.3-45.6/1000) and 6.6/1000 (95% CI, 3.9- 9.2/1000), respectively. The RF rate was 8.2/1000 (95% CI, 4.9-11.5/1000). The LRTI mortality was 2.2/1000 (95% CI, 0.7-3.7/1000); for RSV, the rate was 0.8/1000 (95% CI, 0-1.7/1000) with a case-fatality ratio of 1.8%. Never breastfeeding, malnutrition, younger than 6 months, congenital heart disease, and lower hematocrit were risk factors for RF. Experiencing pneumonia, pneumothorax, sepsis, or apnea were clinical determinants of poor outcomes. Conclusions. Premature children under 2 years old in vulnerable environments experience RF and death more often than term counterparts. Modifiable risk factors associated with poor outcomes should prompt evidence-based interventions.
publishDate 2020
dc.date.none.fl_str_mv 2020-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/168167
Ofman, Gaston; Pradarelli, Brad; Caballero, Mauricio Tomás; Bianchi, Alejandra; Grimaldi, Luciano Alva; et al.; Respiratory failure and death in vulnerable premature children with lower respiratory tract illness; University of Chicago Press; Journal Of Infectious Diseases; 222; 7; 2-2020; 1129-1137
0022-1899
CONICET Digital
CONICET
url http://hdl.handle.net/11336/168167
identifier_str_mv Ofman, Gaston; Pradarelli, Brad; Caballero, Mauricio Tomás; Bianchi, Alejandra; Grimaldi, Luciano Alva; et al.; Respiratory failure and death in vulnerable premature children with lower respiratory tract illness; University of Chicago Press; Journal Of Infectious Diseases; 222; 7; 2-2020; 1129-1137
0022-1899
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiaa046/5719603
info:eu-repo/semantics/altIdentifier/doi/10.1093/infdis/jiaa046
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv University of Chicago Press
publisher.none.fl_str_mv University of Chicago Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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