GATA believe it: new essential regulators of pancreas development

Autores
Rodríguez Seguí, Santiago Andrés; Akerman, Ildem; Ferrer, Jorge
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Understanding the transcriptional mechanisms that underlie pancreas formation is central to the efforts to develop novel regenerative therapies for type 1 diabetes. Recently, mutations in the transcription factor GATA6 were unexpectedly shown to be the most common cause of human pancreas agenesis. In this issue of the JCI, Carrasco et al. and Xuan et al. investigate the role of Gata6 and its paralogue Gata4 in mouse embryonic pancreas and show that GATA factors are essential regulators of the proliferation, morphogenesis, and differentiation of multipotent pancreatic progenitors.
Fil: Rodríguez Seguí, Santiago Andrés. Institut d’Investigacions Biomèdiques August Pi I Sunyer; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Akerman, Ildem. Institut d’Investigacions Biomèdiques August Pi I Sunyer; España
Fil: Ferrer, Jorge. Institut d’Investigacions Biomèdiques August Pi I Sunyer; España
Materia
Pancreas
Development
GATA6
Transcription factor
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20278
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/20278
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling GATA believe it: new essential regulators of pancreas developmentRodríguez Seguí, Santiago AndrésAkerman, IldemFerrer, JorgePancreasDevelopmentGATA6Transcription factorhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Understanding the transcriptional mechanisms that underlie pancreas formation is central to the efforts to develop novel regenerative therapies for type 1 diabetes. Recently, mutations in the transcription factor GATA6 were unexpectedly shown to be the most common cause of human pancreas agenesis. In this issue of the JCI, Carrasco et al. and Xuan et al. investigate the role of Gata6 and its paralogue Gata4 in mouse embryonic pancreas and show that GATA factors are essential regulators of the proliferation, morphogenesis, and differentiation of multipotent pancreatic progenitors.Fil: Rodríguez Seguí, Santiago Andrés. Institut d’Investigacions Biomèdiques August Pi I Sunyer; España. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Akerman, Ildem. Institut d’Investigacions Biomèdiques August Pi I Sunyer; EspañaFil: Ferrer, Jorge. Institut d’Investigacions Biomèdiques August Pi I Sunyer; EspañaAmer Soc Clinical Investigation Inc2012-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20278Rodríguez Seguí, Santiago Andrés; Akerman, Ildem; Ferrer, Jorge; GATA believe it: new essential regulators of pancreas development; Amer Soc Clinical Investigation Inc; Journal Of Clinical Investigation; 122; 10; 9-2012; 3469-34710021-9738CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1172/JCI65751info:eu-repo/semantics/altIdentifier/url/http://www.jci.org/articles/view/65751info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461932/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:56:56Zoai:ri.conicet.gov.ar:11336/20278instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:56:56.408CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv GATA believe it: new essential regulators of pancreas development
title GATA believe it: new essential regulators of pancreas development
spellingShingle GATA believe it: new essential regulators of pancreas development
Rodríguez Seguí, Santiago Andrés
Pancreas
Development
GATA6
Transcription factor
title_short GATA believe it: new essential regulators of pancreas development
title_full GATA believe it: new essential regulators of pancreas development
title_fullStr GATA believe it: new essential regulators of pancreas development
title_full_unstemmed GATA believe it: new essential regulators of pancreas development
title_sort GATA believe it: new essential regulators of pancreas development
dc.creator.none.fl_str_mv Rodríguez Seguí, Santiago Andrés
Akerman, Ildem
Ferrer, Jorge
author Rodríguez Seguí, Santiago Andrés
author_facet Rodríguez Seguí, Santiago Andrés
Akerman, Ildem
Ferrer, Jorge
author_role author
author2 Akerman, Ildem
Ferrer, Jorge
author2_role author
author
dc.subject.none.fl_str_mv Pancreas
Development
GATA6
Transcription factor
topic Pancreas
Development
GATA6
Transcription factor
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Understanding the transcriptional mechanisms that underlie pancreas formation is central to the efforts to develop novel regenerative therapies for type 1 diabetes. Recently, mutations in the transcription factor GATA6 were unexpectedly shown to be the most common cause of human pancreas agenesis. In this issue of the JCI, Carrasco et al. and Xuan et al. investigate the role of Gata6 and its paralogue Gata4 in mouse embryonic pancreas and show that GATA factors are essential regulators of the proliferation, morphogenesis, and differentiation of multipotent pancreatic progenitors.
Fil: Rodríguez Seguí, Santiago Andrés. Institut d’Investigacions Biomèdiques August Pi I Sunyer; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Akerman, Ildem. Institut d’Investigacions Biomèdiques August Pi I Sunyer; España
Fil: Ferrer, Jorge. Institut d’Investigacions Biomèdiques August Pi I Sunyer; España
description Understanding the transcriptional mechanisms that underlie pancreas formation is central to the efforts to develop novel regenerative therapies for type 1 diabetes. Recently, mutations in the transcription factor GATA6 were unexpectedly shown to be the most common cause of human pancreas agenesis. In this issue of the JCI, Carrasco et al. and Xuan et al. investigate the role of Gata6 and its paralogue Gata4 in mouse embryonic pancreas and show that GATA factors are essential regulators of the proliferation, morphogenesis, and differentiation of multipotent pancreatic progenitors.
publishDate 2012
dc.date.none.fl_str_mv 2012-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20278
Rodríguez Seguí, Santiago Andrés; Akerman, Ildem; Ferrer, Jorge; GATA believe it: new essential regulators of pancreas development; Amer Soc Clinical Investigation Inc; Journal Of Clinical Investigation; 122; 10; 9-2012; 3469-3471
0021-9738
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20278
identifier_str_mv Rodríguez Seguí, Santiago Andrés; Akerman, Ildem; Ferrer, Jorge; GATA believe it: new essential regulators of pancreas development; Amer Soc Clinical Investigation Inc; Journal Of Clinical Investigation; 122; 10; 9-2012; 3469-3471
0021-9738
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1172/JCI65751
info:eu-repo/semantics/altIdentifier/url/http://www.jci.org/articles/view/65751
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461932/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Amer Soc Clinical Investigation Inc
publisher.none.fl_str_mv Amer Soc Clinical Investigation Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613706945658880
score 13.070432

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