Stromal cell expression of caveolin-1 predicts outcome in breast cancer

Autores
Sloan, Erica K.; Ciocca, Daniel Ramon; Pouliot, Normand; Natoli, Anthony; Restall, Christina; Henderson, Michael A.; Fanelli, Mariel Andrea; Cuello Carrión, Fernando Darío; Gago, Francisco E.; Anderson, Robin L.
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Caveolin-1 has been linked to tumor progression and clinical outcome in breast cancer, but a clear resolution of its role as a prognostic marker is lacking. We assessed caveolin-1 levels in normal breast tissue and two breast cancer cohorts for which outcome data were available. We found that caveolin-1 was not expressed in normal breast luminal epithelium but was present in the epithelial compartment of some tumors. We found no association between caveolin-1 expression in the epithelial compartment and clinical outcome. However, high levels of caveolin-1 in the stromal tissue surrounding the tumor, rather than within tumor cells, associated strongly with reduced metastasis and improved survival (P < 0.0001). The onset of mammary tumors driven by Her2/neu overexpression was accelerated in mice lacking caveolin-1, thereby supporting the observation that the presence of caveolin-1 in the tumor microenvironment modulates tumor development. These studies suggest that stromal caveolin-1 expression may be a potential therapeutic target and a valuable prognostic indicator of breast cancer progression.
Fil: Sloan, Erica K.. Peter Maccallum Cancer Centre; Australia
Fil: Ciocca, Daniel Ramon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Fundación Argentina para la Investigación del Cáncer; Argentina
Fil: Pouliot, Normand. Peter Maccallum Cancer Centre; Australia. University of Melbourne; Australia
Fil: Natoli, Anthony. Peter Maccallum Cancer Centre; Australia
Fil: Restall, Christina. Peter Maccallum Cancer Centre; Australia
Fil: Henderson, Michael A.. Peter Maccallum Cancer Centre; Australia
Fil: Fanelli, Mariel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Fundación Argentina para la Investigación del Cáncer;; Argentina
Fil: Cuello Carrión, Fernando Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Fundación Argentina para la Investigación del Cáncer;; Argentina
Fil: Gago, Francisco E.. Universidad Nacional de Cuyo; Argentina
Fil: Anderson, Robin L.. Peter Maccallum Cancer Centre; Australia
Materia
Caveolin-1
Breast Cancer
Stromal Expression
Prognostic Factor
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/82326
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/82326
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Stromal cell expression of caveolin-1 predicts outcome in breast cancerSloan, Erica K.Ciocca, Daniel RamonPouliot, NormandNatoli, AnthonyRestall, ChristinaHenderson, Michael A.Fanelli, Mariel AndreaCuello Carrión, Fernando DaríoGago, Francisco E.Anderson, Robin L.Caveolin-1Breast CancerStromal ExpressionPrognostic Factorhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Caveolin-1 has been linked to tumor progression and clinical outcome in breast cancer, but a clear resolution of its role as a prognostic marker is lacking. We assessed caveolin-1 levels in normal breast tissue and two breast cancer cohorts for which outcome data were available. We found that caveolin-1 was not expressed in normal breast luminal epithelium but was present in the epithelial compartment of some tumors. We found no association between caveolin-1 expression in the epithelial compartment and clinical outcome. However, high levels of caveolin-1 in the stromal tissue surrounding the tumor, rather than within tumor cells, associated strongly with reduced metastasis and improved survival (P < 0.0001). The onset of mammary tumors driven by Her2/neu overexpression was accelerated in mice lacking caveolin-1, thereby supporting the observation that the presence of caveolin-1 in the tumor microenvironment modulates tumor development. These studies suggest that stromal caveolin-1 expression may be a potential therapeutic target and a valuable prognostic indicator of breast cancer progression.Fil: Sloan, Erica K.. Peter Maccallum Cancer Centre; AustraliaFil: Ciocca, Daniel Ramon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Fundación Argentina para la Investigación del Cáncer; ArgentinaFil: Pouliot, Normand. Peter Maccallum Cancer Centre; Australia. University of Melbourne; AustraliaFil: Natoli, Anthony. Peter Maccallum Cancer Centre; AustraliaFil: Restall, Christina. Peter Maccallum Cancer Centre; AustraliaFil: Henderson, Michael A.. Peter Maccallum Cancer Centre; AustraliaFil: Fanelli, Mariel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Fundación Argentina para la Investigación del Cáncer;; ArgentinaFil: Cuello Carrión, Fernando Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Fundación Argentina para la Investigación del Cáncer;; ArgentinaFil: Gago, Francisco E.. Universidad Nacional de Cuyo; ArgentinaFil: Anderson, Robin L.. Peter Maccallum Cancer Centre; AustraliaElsevier2009-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/82326Sloan, Erica K.; Ciocca, Daniel Ramon; Pouliot, Normand; Natoli, Anthony; Restall, Christina; et al.; Stromal cell expression of caveolin-1 predicts outcome in breast cancer; Elsevier; American Journal Of Pathology; 174; 6; 6-2009; 2035-20430002-9440CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2353/ajpath.2009.080924info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0002944010610632info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:36:52Zoai:ri.conicet.gov.ar:11336/82326instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:36:53.065CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Stromal cell expression of caveolin-1 predicts outcome in breast cancer
title Stromal cell expression of caveolin-1 predicts outcome in breast cancer
spellingShingle Stromal cell expression of caveolin-1 predicts outcome in breast cancer
Sloan, Erica K.
Caveolin-1
Breast Cancer
Stromal Expression
Prognostic Factor
title_short Stromal cell expression of caveolin-1 predicts outcome in breast cancer
title_full Stromal cell expression of caveolin-1 predicts outcome in breast cancer
title_fullStr Stromal cell expression of caveolin-1 predicts outcome in breast cancer
title_full_unstemmed Stromal cell expression of caveolin-1 predicts outcome in breast cancer
title_sort Stromal cell expression of caveolin-1 predicts outcome in breast cancer
dc.creator.none.fl_str_mv Sloan, Erica K.
Ciocca, Daniel Ramon
Pouliot, Normand
Natoli, Anthony
Restall, Christina
Henderson, Michael A.
Fanelli, Mariel Andrea
Cuello Carrión, Fernando Darío
Gago, Francisco E.
Anderson, Robin L.
author Sloan, Erica K.
author_facet Sloan, Erica K.
Ciocca, Daniel Ramon
Pouliot, Normand
Natoli, Anthony
Restall, Christina
Henderson, Michael A.
Fanelli, Mariel Andrea
Cuello Carrión, Fernando Darío
Gago, Francisco E.
Anderson, Robin L.
author_role author
author2 Ciocca, Daniel Ramon
Pouliot, Normand
Natoli, Anthony
Restall, Christina
Henderson, Michael A.
Fanelli, Mariel Andrea
Cuello Carrión, Fernando Darío
Gago, Francisco E.
Anderson, Robin L.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Caveolin-1
Breast Cancer
Stromal Expression
Prognostic Factor
topic Caveolin-1
Breast Cancer
Stromal Expression
Prognostic Factor
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Caveolin-1 has been linked to tumor progression and clinical outcome in breast cancer, but a clear resolution of its role as a prognostic marker is lacking. We assessed caveolin-1 levels in normal breast tissue and two breast cancer cohorts for which outcome data were available. We found that caveolin-1 was not expressed in normal breast luminal epithelium but was present in the epithelial compartment of some tumors. We found no association between caveolin-1 expression in the epithelial compartment and clinical outcome. However, high levels of caveolin-1 in the stromal tissue surrounding the tumor, rather than within tumor cells, associated strongly with reduced metastasis and improved survival (P < 0.0001). The onset of mammary tumors driven by Her2/neu overexpression was accelerated in mice lacking caveolin-1, thereby supporting the observation that the presence of caveolin-1 in the tumor microenvironment modulates tumor development. These studies suggest that stromal caveolin-1 expression may be a potential therapeutic target and a valuable prognostic indicator of breast cancer progression.
Fil: Sloan, Erica K.. Peter Maccallum Cancer Centre; Australia
Fil: Ciocca, Daniel Ramon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Fundación Argentina para la Investigación del Cáncer; Argentina
Fil: Pouliot, Normand. Peter Maccallum Cancer Centre; Australia. University of Melbourne; Australia
Fil: Natoli, Anthony. Peter Maccallum Cancer Centre; Australia
Fil: Restall, Christina. Peter Maccallum Cancer Centre; Australia
Fil: Henderson, Michael A.. Peter Maccallum Cancer Centre; Australia
Fil: Fanelli, Mariel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Fundación Argentina para la Investigación del Cáncer;; Argentina
Fil: Cuello Carrión, Fernando Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Fundación Argentina para la Investigación del Cáncer;; Argentina
Fil: Gago, Francisco E.. Universidad Nacional de Cuyo; Argentina
Fil: Anderson, Robin L.. Peter Maccallum Cancer Centre; Australia
description Caveolin-1 has been linked to tumor progression and clinical outcome in breast cancer, but a clear resolution of its role as a prognostic marker is lacking. We assessed caveolin-1 levels in normal breast tissue and two breast cancer cohorts for which outcome data were available. We found that caveolin-1 was not expressed in normal breast luminal epithelium but was present in the epithelial compartment of some tumors. We found no association between caveolin-1 expression in the epithelial compartment and clinical outcome. However, high levels of caveolin-1 in the stromal tissue surrounding the tumor, rather than within tumor cells, associated strongly with reduced metastasis and improved survival (P < 0.0001). The onset of mammary tumors driven by Her2/neu overexpression was accelerated in mice lacking caveolin-1, thereby supporting the observation that the presence of caveolin-1 in the tumor microenvironment modulates tumor development. These studies suggest that stromal caveolin-1 expression may be a potential therapeutic target and a valuable prognostic indicator of breast cancer progression.
publishDate 2009
dc.date.none.fl_str_mv 2009-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/82326
Sloan, Erica K.; Ciocca, Daniel Ramon; Pouliot, Normand; Natoli, Anthony; Restall, Christina; et al.; Stromal cell expression of caveolin-1 predicts outcome in breast cancer; Elsevier; American Journal Of Pathology; 174; 6; 6-2009; 2035-2043
0002-9440
CONICET Digital
CONICET
url http://hdl.handle.net/11336/82326
identifier_str_mv Sloan, Erica K.; Ciocca, Daniel Ramon; Pouliot, Normand; Natoli, Anthony; Restall, Christina; et al.; Stromal cell expression of caveolin-1 predicts outcome in breast cancer; Elsevier; American Journal Of Pathology; 174; 6; 6-2009; 2035-2043
0002-9440
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2353/ajpath.2009.080924
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0002944010610632
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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