Hybrid Nanogel‐Wrapped Anisotropic Gold Nanoparticles Feature Enhanced Photothermal Stability

Autores
Esporrín Ubieto, David; Huck Iriart, Cristián; Picco, Agustin Silvio; Beloqui, Ana; Calderón, Marcelo
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Anisotropic gold nanoparticles (AuNPs) are renowned for their uniqueproperties – including localized surface plasmon resonance (LSPR) andadjustable optical responses to light exposure – that enable the conversion of light into heat and make them a promising tool in cancer therapy.Nonetheless, their tendency to aggregate and consequently lose theirphotothermal conversion capacity during prolonged irradiation periodsrepresents a central challenge in developing anisotropic AuNPs for clinicaluse. To overcome this issue, an innovative approach that facilitates theencapsulation of individual anisotropic AuNPs within thin nanogels, forming hybrid nanomaterials that mirror the inorganic core’s morphology while introducing a negligible (2–8 nm) increase in overall diameter is proposed. The encapsulation of rod- and star-shaped anisotropic AuNPs within poly-acrylamide (pAA) or poly-(N-isopropylacrylamide) (pNIPAM) nanogels is successfully demonstrated. The ultrathin polymeric layers display remarkable durability, significantly enhancing the photothermal stability of anisotropic AuNPs during their interaction with near-infrared light and effectively boosting their photothermal capacities for extended irradiation periods. The outcomes of the research thus support the development of more stable and reliable AuNPs as hybrid nanomaterials, positioning them as promising nanomedicinal platforms.
Fil: Esporrín Ubieto, David. Universidad del Pais Vasco. Polymat.; España
Fil: Huck Iriart, Cristián. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Tecnologias Emergentes y Ciencias Aplicadas. - Universidad Nacional de San Martin. Instituto de Tecnologias Emergentes y Ciencias Aplicadas.; Argentina
Fil: Picco, Agustin Silvio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Beloqui, Ana. Universidad del Pais Vasco. Polymat.; España
Fil: Calderón, Marcelo. Universidad del Pais Vasco. Polymat.; España
Materia
gold nanoparticle
photostability
nanogel
pNIPAM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/258508
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/258508
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hybrid Nanogel‐Wrapped Anisotropic Gold Nanoparticles Feature Enhanced Photothermal StabilityEsporrín Ubieto, DavidHuck Iriart, CristiánPicco, Agustin SilvioBeloqui, AnaCalderón, Marcelogold nanoparticlephotostabilitynanogelpNIPAMhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Anisotropic gold nanoparticles (AuNPs) are renowned for their uniqueproperties – including localized surface plasmon resonance (LSPR) andadjustable optical responses to light exposure – that enable the conversion of light into heat and make them a promising tool in cancer therapy.Nonetheless, their tendency to aggregate and consequently lose theirphotothermal conversion capacity during prolonged irradiation periodsrepresents a central challenge in developing anisotropic AuNPs for clinicaluse. To overcome this issue, an innovative approach that facilitates theencapsulation of individual anisotropic AuNPs within thin nanogels, forming hybrid nanomaterials that mirror the inorganic core’s morphology while introducing a negligible (2–8 nm) increase in overall diameter is proposed. The encapsulation of rod- and star-shaped anisotropic AuNPs within poly-acrylamide (pAA) or poly-(N-isopropylacrylamide) (pNIPAM) nanogels is successfully demonstrated. The ultrathin polymeric layers display remarkable durability, significantly enhancing the photothermal stability of anisotropic AuNPs during their interaction with near-infrared light and effectively boosting their photothermal capacities for extended irradiation periods. The outcomes of the research thus support the development of more stable and reliable AuNPs as hybrid nanomaterials, positioning them as promising nanomedicinal platforms.Fil: Esporrín Ubieto, David. Universidad del Pais Vasco. Polymat.; EspañaFil: Huck Iriart, Cristián. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Tecnologias Emergentes y Ciencias Aplicadas. - Universidad Nacional de San Martin. Instituto de Tecnologias Emergentes y Ciencias Aplicadas.; ArgentinaFil: Picco, Agustin Silvio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Beloqui, Ana. Universidad del Pais Vasco. Polymat.; EspañaFil: Calderón, Marcelo. Universidad del Pais Vasco. Polymat.; EspañaWiley VCH Verlag2024-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/258508Esporrín Ubieto, David; Huck Iriart, Cristián; Picco, Agustin Silvio; Beloqui, Ana; Calderón, Marcelo; Hybrid Nanogel‐Wrapped Anisotropic Gold Nanoparticles Feature Enhanced Photothermal Stability; Wiley VCH Verlag; Small; 20; 48; 9-2024; 1-121613-6810CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/smll.202404097info:eu-repo/semantics/altIdentifier/doi/10.1002/smll.202404097info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:05Zoai:ri.conicet.gov.ar:11336/258508instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:05.681CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hybrid Nanogel‐Wrapped Anisotropic Gold Nanoparticles Feature Enhanced Photothermal Stability
title Hybrid Nanogel‐Wrapped Anisotropic Gold Nanoparticles Feature Enhanced Photothermal Stability
spellingShingle Hybrid Nanogel‐Wrapped Anisotropic Gold Nanoparticles Feature Enhanced Photothermal Stability
Esporrín Ubieto, David
gold nanoparticle
photostability
nanogel
pNIPAM
title_short Hybrid Nanogel‐Wrapped Anisotropic Gold Nanoparticles Feature Enhanced Photothermal Stability
title_full Hybrid Nanogel‐Wrapped Anisotropic Gold Nanoparticles Feature Enhanced Photothermal Stability
title_fullStr Hybrid Nanogel‐Wrapped Anisotropic Gold Nanoparticles Feature Enhanced Photothermal Stability
title_full_unstemmed Hybrid Nanogel‐Wrapped Anisotropic Gold Nanoparticles Feature Enhanced Photothermal Stability
title_sort Hybrid Nanogel‐Wrapped Anisotropic Gold Nanoparticles Feature Enhanced Photothermal Stability
dc.creator.none.fl_str_mv Esporrín Ubieto, David
Huck Iriart, Cristián
Picco, Agustin Silvio
Beloqui, Ana
Calderón, Marcelo
author Esporrín Ubieto, David
author_facet Esporrín Ubieto, David
Huck Iriart, Cristián
Picco, Agustin Silvio
Beloqui, Ana
Calderón, Marcelo
author_role author
author2 Huck Iriart, Cristián
Picco, Agustin Silvio
Beloqui, Ana
Calderón, Marcelo
author2_role author
author
author
author
dc.subject.none.fl_str_mv gold nanoparticle
photostability
nanogel
pNIPAM
topic gold nanoparticle
photostability
nanogel
pNIPAM
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Anisotropic gold nanoparticles (AuNPs) are renowned for their uniqueproperties – including localized surface plasmon resonance (LSPR) andadjustable optical responses to light exposure – that enable the conversion of light into heat and make them a promising tool in cancer therapy.Nonetheless, their tendency to aggregate and consequently lose theirphotothermal conversion capacity during prolonged irradiation periodsrepresents a central challenge in developing anisotropic AuNPs for clinicaluse. To overcome this issue, an innovative approach that facilitates theencapsulation of individual anisotropic AuNPs within thin nanogels, forming hybrid nanomaterials that mirror the inorganic core’s morphology while introducing a negligible (2–8 nm) increase in overall diameter is proposed. The encapsulation of rod- and star-shaped anisotropic AuNPs within poly-acrylamide (pAA) or poly-(N-isopropylacrylamide) (pNIPAM) nanogels is successfully demonstrated. The ultrathin polymeric layers display remarkable durability, significantly enhancing the photothermal stability of anisotropic AuNPs during their interaction with near-infrared light and effectively boosting their photothermal capacities for extended irradiation periods. The outcomes of the research thus support the development of more stable and reliable AuNPs as hybrid nanomaterials, positioning them as promising nanomedicinal platforms.
Fil: Esporrín Ubieto, David. Universidad del Pais Vasco. Polymat.; España
Fil: Huck Iriart, Cristián. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Tecnologias Emergentes y Ciencias Aplicadas. - Universidad Nacional de San Martin. Instituto de Tecnologias Emergentes y Ciencias Aplicadas.; Argentina
Fil: Picco, Agustin Silvio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Beloqui, Ana. Universidad del Pais Vasco. Polymat.; España
Fil: Calderón, Marcelo. Universidad del Pais Vasco. Polymat.; España
description Anisotropic gold nanoparticles (AuNPs) are renowned for their uniqueproperties – including localized surface plasmon resonance (LSPR) andadjustable optical responses to light exposure – that enable the conversion of light into heat and make them a promising tool in cancer therapy.Nonetheless, their tendency to aggregate and consequently lose theirphotothermal conversion capacity during prolonged irradiation periodsrepresents a central challenge in developing anisotropic AuNPs for clinicaluse. To overcome this issue, an innovative approach that facilitates theencapsulation of individual anisotropic AuNPs within thin nanogels, forming hybrid nanomaterials that mirror the inorganic core’s morphology while introducing a negligible (2–8 nm) increase in overall diameter is proposed. The encapsulation of rod- and star-shaped anisotropic AuNPs within poly-acrylamide (pAA) or poly-(N-isopropylacrylamide) (pNIPAM) nanogels is successfully demonstrated. The ultrathin polymeric layers display remarkable durability, significantly enhancing the photothermal stability of anisotropic AuNPs during their interaction with near-infrared light and effectively boosting their photothermal capacities for extended irradiation periods. The outcomes of the research thus support the development of more stable and reliable AuNPs as hybrid nanomaterials, positioning them as promising nanomedicinal platforms.
publishDate 2024
dc.date.none.fl_str_mv 2024-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/258508
Esporrín Ubieto, David; Huck Iriart, Cristián; Picco, Agustin Silvio; Beloqui, Ana; Calderón, Marcelo; Hybrid Nanogel‐Wrapped Anisotropic Gold Nanoparticles Feature Enhanced Photothermal Stability; Wiley VCH Verlag; Small; 20; 48; 9-2024; 1-12
1613-6810
CONICET Digital
CONICET
url http://hdl.handle.net/11336/258508
identifier_str_mv Esporrín Ubieto, David; Huck Iriart, Cristián; Picco, Agustin Silvio; Beloqui, Ana; Calderón, Marcelo; Hybrid Nanogel‐Wrapped Anisotropic Gold Nanoparticles Feature Enhanced Photothermal Stability; Wiley VCH Verlag; Small; 20; 48; 9-2024; 1-12
1613-6810
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/smll.202404097
info:eu-repo/semantics/altIdentifier/doi/10.1002/smll.202404097
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269560619663360
score 13.13397

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