Cardiac mitochondria function and tissue remodeling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive rats

Autores
Piotrkowski, Barbara; Koch, Osvaldo Raul; Cavanagh, Elena M. V. de; Fraga, César Guillermo
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Renal and cardiac benefits of renin-angiotensin system inhibition exceed blood pressure (BP) reduction and seem to involve mitochondrial function. It has been shown that RAS inhibition prevented mitochondrial dysfunction in spontaneously hypertensive rats (SHR) kidneys. Here, it is investigated whether a non-antihypertensive enalapril dose protects cardiac tissue and mitochondria function. Three-month-old SHR received water containing enalapril (10 mg/kg/day, SHR+Enal) or no additions (SHR-C) for 5 months. Wistar-Kyoto rats (WKY) were normotensive controls. At month 5, BP was similar in SHR+Enal and SHR-C. In SHR+Enal and WKY, heart weight and myocardial fibrosis were lower than in SHR-C. Matrix metalloprotease-2 activity was lower in SHR+Enal with respect to SHR-C and WKY. In SHR+Enal and WKY, NADH/cytochrome c oxidoreductase activity, eNOS protein and activity and mtNOS activity were higher and Mn-SOD activity was lower than in SHR-C. In summary, enalapril at a non-antihypertensive dose prevented cardiac hypertrophy and modifies parameters of cardiac mitochondrial dysfunction in SHR
Fil: Piotrkowski, Barbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina
Fil: Koch, Osvaldo Raul. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cavanagh, Elena M. V. de. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina
Fil: Fraga, César Guillermo. University of California; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina
Materia
Hypertension
Antioxidants
Mitochondria
Heart
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25482
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/25482
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cardiac mitochondria function and tissue remodeling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive ratsPiotrkowski, BarbaraKoch, Osvaldo RaulCavanagh, Elena M. V. deFraga, César GuillermoHypertensionAntioxidantsMitochondriaHearthttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Renal and cardiac benefits of renin-angiotensin system inhibition exceed blood pressure (BP) reduction and seem to involve mitochondrial function. It has been shown that RAS inhibition prevented mitochondrial dysfunction in spontaneously hypertensive rats (SHR) kidneys. Here, it is investigated whether a non-antihypertensive enalapril dose protects cardiac tissue and mitochondria function. Three-month-old SHR received water containing enalapril (10 mg/kg/day, SHR+Enal) or no additions (SHR-C) for 5 months. Wistar-Kyoto rats (WKY) were normotensive controls. At month 5, BP was similar in SHR+Enal and SHR-C. In SHR+Enal and WKY, heart weight and myocardial fibrosis were lower than in SHR-C. Matrix metalloprotease-2 activity was lower in SHR+Enal with respect to SHR-C and WKY. In SHR+Enal and WKY, NADH/cytochrome c oxidoreductase activity, eNOS protein and activity and mtNOS activity were higher and Mn-SOD activity was lower than in SHR-C. In summary, enalapril at a non-antihypertensive dose prevented cardiac hypertrophy and modifies parameters of cardiac mitochondrial dysfunction in SHRFil: Piotrkowski, Barbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; ArgentinaFil: Koch, Osvaldo Raul. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cavanagh, Elena M. V. de. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; ArgentinaFil: Fraga, César Guillermo. University of California; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; ArgentinaTaylor & Francis Ltd2009-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25482Piotrkowski, Barbara; Koch, Osvaldo Raul; Cavanagh, Elena M. V. de; Fraga, César Guillermo; Cardiac mitochondria function and tissue remodeling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive rats; Taylor & Francis Ltd; Free Radical Research; 43; 4; 4-2009; 390-3991071-57621029-2470CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1080/10715760902801517info:eu-repo/semantics/altIdentifier/doi/10.1080/10715760902801517info:eu-repo/semantics/altIdentifier/pmid/19296328info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:01:58Zoai:ri.conicet.gov.ar:11336/25482instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:01:59.265CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cardiac mitochondria function and tissue remodeling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive rats
title Cardiac mitochondria function and tissue remodeling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive rats
spellingShingle Cardiac mitochondria function and tissue remodeling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive rats
Piotrkowski, Barbara
Hypertension
Antioxidants
Mitochondria
Heart
title_short Cardiac mitochondria function and tissue remodeling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive rats
title_full Cardiac mitochondria function and tissue remodeling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive rats
title_fullStr Cardiac mitochondria function and tissue remodeling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive rats
title_full_unstemmed Cardiac mitochondria function and tissue remodeling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive rats
title_sort Cardiac mitochondria function and tissue remodeling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive rats
dc.creator.none.fl_str_mv Piotrkowski, Barbara
Koch, Osvaldo Raul
Cavanagh, Elena M. V. de
Fraga, César Guillermo
author Piotrkowski, Barbara
author_facet Piotrkowski, Barbara
Koch, Osvaldo Raul
Cavanagh, Elena M. V. de
Fraga, César Guillermo
author_role author
author2 Koch, Osvaldo Raul
Cavanagh, Elena M. V. de
Fraga, César Guillermo
author2_role author
author
author
dc.subject.none.fl_str_mv Hypertension
Antioxidants
Mitochondria
Heart
topic Hypertension
Antioxidants
Mitochondria
Heart
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Renal and cardiac benefits of renin-angiotensin system inhibition exceed blood pressure (BP) reduction and seem to involve mitochondrial function. It has been shown that RAS inhibition prevented mitochondrial dysfunction in spontaneously hypertensive rats (SHR) kidneys. Here, it is investigated whether a non-antihypertensive enalapril dose protects cardiac tissue and mitochondria function. Three-month-old SHR received water containing enalapril (10 mg/kg/day, SHR+Enal) or no additions (SHR-C) for 5 months. Wistar-Kyoto rats (WKY) were normotensive controls. At month 5, BP was similar in SHR+Enal and SHR-C. In SHR+Enal and WKY, heart weight and myocardial fibrosis were lower than in SHR-C. Matrix metalloprotease-2 activity was lower in SHR+Enal with respect to SHR-C and WKY. In SHR+Enal and WKY, NADH/cytochrome c oxidoreductase activity, eNOS protein and activity and mtNOS activity were higher and Mn-SOD activity was lower than in SHR-C. In summary, enalapril at a non-antihypertensive dose prevented cardiac hypertrophy and modifies parameters of cardiac mitochondrial dysfunction in SHR
Fil: Piotrkowski, Barbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina
Fil: Koch, Osvaldo Raul. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cavanagh, Elena M. V. de. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina
Fil: Fraga, César Guillermo. University of California; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina
description Renal and cardiac benefits of renin-angiotensin system inhibition exceed blood pressure (BP) reduction and seem to involve mitochondrial function. It has been shown that RAS inhibition prevented mitochondrial dysfunction in spontaneously hypertensive rats (SHR) kidneys. Here, it is investigated whether a non-antihypertensive enalapril dose protects cardiac tissue and mitochondria function. Three-month-old SHR received water containing enalapril (10 mg/kg/day, SHR+Enal) or no additions (SHR-C) for 5 months. Wistar-Kyoto rats (WKY) were normotensive controls. At month 5, BP was similar in SHR+Enal and SHR-C. In SHR+Enal and WKY, heart weight and myocardial fibrosis were lower than in SHR-C. Matrix metalloprotease-2 activity was lower in SHR+Enal with respect to SHR-C and WKY. In SHR+Enal and WKY, NADH/cytochrome c oxidoreductase activity, eNOS protein and activity and mtNOS activity were higher and Mn-SOD activity was lower than in SHR-C. In summary, enalapril at a non-antihypertensive dose prevented cardiac hypertrophy and modifies parameters of cardiac mitochondrial dysfunction in SHR
publishDate 2009
dc.date.none.fl_str_mv 2009-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25482
Piotrkowski, Barbara; Koch, Osvaldo Raul; Cavanagh, Elena M. V. de; Fraga, César Guillermo; Cardiac mitochondria function and tissue remodeling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive rats; Taylor & Francis Ltd; Free Radical Research; 43; 4; 4-2009; 390-399
1071-5762
1029-2470
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25482
identifier_str_mv Piotrkowski, Barbara; Koch, Osvaldo Raul; Cavanagh, Elena M. V. de; Fraga, César Guillermo; Cardiac mitochondria function and tissue remodeling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive rats; Taylor & Francis Ltd; Free Radical Research; 43; 4; 4-2009; 390-399
1071-5762
1029-2470
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1080/10715760902801517
info:eu-repo/semantics/altIdentifier/doi/10.1080/10715760902801517
info:eu-repo/semantics/altIdentifier/pmid/19296328
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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