Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration
- Autores
- Pautassi, Ricardo Marcos; Nizhnikov, Michael Eduard; Spear, Norman E.
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A recent study found appetitive reinforcement in infant rats given 1.0 but not 2.0 g/kg ethanol and only when ethanol was delivered intragastrically (i.g., but not if intraperitoneally, i.p.; Nizhnikov, Pautassi, Truxell and Spear, 2009). Corticosterone release could modulate ethanol’s motivational effects. The goal of this study was to replicate the differential capability of i.g vs. i.p. ethanol to induce conditioning and to find hormonal correlates underlying this phenomenon. Experiment 1 confirmed that 1.0 g/kg ethanol induced conditioned preference in infant rats when given i.g. but not i.p. In Experiment 2 corticosterone was assessed at 20, 40, 60 or 120 min after ethanol (0.0, 0.5, 1.0 and 2.0 g/kg, i.g. or i.p.). Route of administration failed to alter corticosterone release. The 2.0 g/kg, but not 0.5 or 1.0 g/kg, ethanol dose evoked heightened corticosterone release. The results confirm the differing motivational effects associated with i.g and i.p. ethanol. These effects do not seem to be related to differential corticosterone responsiveness.
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Nizhnikov, Michael Eduard. University of Binghamton; Estados Unidos
Fil: Spear, Norman E.. University of Binghamton; Estados Unidos - Materia
-
corticosterone
infant rat
ethanol
route of administration
appetitive conditioning - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/268637
Ver los metadatos del registro completo
id |
CONICETDig_e7c07bd83854c7abea7c7bb37a359e70 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/268637 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administrationPautassi, Ricardo MarcosNizhnikov, Michael EduardSpear, Norman E.corticosteroneinfant ratethanolroute of administrationappetitive conditioninghttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3A recent study found appetitive reinforcement in infant rats given 1.0 but not 2.0 g/kg ethanol and only when ethanol was delivered intragastrically (i.g., but not if intraperitoneally, i.p.; Nizhnikov, Pautassi, Truxell and Spear, 2009). Corticosterone release could modulate ethanol’s motivational effects. The goal of this study was to replicate the differential capability of i.g vs. i.p. ethanol to induce conditioning and to find hormonal correlates underlying this phenomenon. Experiment 1 confirmed that 1.0 g/kg ethanol induced conditioned preference in infant rats when given i.g. but not i.p. In Experiment 2 corticosterone was assessed at 20, 40, 60 or 120 min after ethanol (0.0, 0.5, 1.0 and 2.0 g/kg, i.g. or i.p.). Route of administration failed to alter corticosterone release. The 2.0 g/kg, but not 0.5 or 1.0 g/kg, ethanol dose evoked heightened corticosterone release. The results confirm the differing motivational effects associated with i.g and i.p. ethanol. These effects do not seem to be related to differential corticosterone responsiveness.Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Nizhnikov, Michael Eduard. University of Binghamton; Estados UnidosFil: Spear, Norman E.. University of Binghamton; Estados UnidosJohn Wiley & Sons2011-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/268637Pautassi, Ricardo Marcos; Nizhnikov, Michael Eduard; Spear, Norman E.; Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration; John Wiley & Sons; Developmental Psychobiology; 54; 1; 5-2011; 98-1040012-1630CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/dev.20567info:eu-repo/semantics/altIdentifier/doi/10.1002/dev.20567info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:03Zoai:ri.conicet.gov.ar:11336/268637instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:03.639CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration |
title |
Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration |
spellingShingle |
Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration Pautassi, Ricardo Marcos corticosterone infant rat ethanol route of administration appetitive conditioning |
title_short |
Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration |
title_full |
Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration |
title_fullStr |
Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration |
title_full_unstemmed |
Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration |
title_sort |
Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration |
dc.creator.none.fl_str_mv |
Pautassi, Ricardo Marcos Nizhnikov, Michael Eduard Spear, Norman E. |
author |
Pautassi, Ricardo Marcos |
author_facet |
Pautassi, Ricardo Marcos Nizhnikov, Michael Eduard Spear, Norman E. |
author_role |
author |
author2 |
Nizhnikov, Michael Eduard Spear, Norman E. |
author2_role |
author author |
dc.subject.none.fl_str_mv |
corticosterone infant rat ethanol route of administration appetitive conditioning |
topic |
corticosterone infant rat ethanol route of administration appetitive conditioning |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
A recent study found appetitive reinforcement in infant rats given 1.0 but not 2.0 g/kg ethanol and only when ethanol was delivered intragastrically (i.g., but not if intraperitoneally, i.p.; Nizhnikov, Pautassi, Truxell and Spear, 2009). Corticosterone release could modulate ethanol’s motivational effects. The goal of this study was to replicate the differential capability of i.g vs. i.p. ethanol to induce conditioning and to find hormonal correlates underlying this phenomenon. Experiment 1 confirmed that 1.0 g/kg ethanol induced conditioned preference in infant rats when given i.g. but not i.p. In Experiment 2 corticosterone was assessed at 20, 40, 60 or 120 min after ethanol (0.0, 0.5, 1.0 and 2.0 g/kg, i.g. or i.p.). Route of administration failed to alter corticosterone release. The 2.0 g/kg, but not 0.5 or 1.0 g/kg, ethanol dose evoked heightened corticosterone release. The results confirm the differing motivational effects associated with i.g and i.p. ethanol. These effects do not seem to be related to differential corticosterone responsiveness. Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina Fil: Nizhnikov, Michael Eduard. University of Binghamton; Estados Unidos Fil: Spear, Norman E.. University of Binghamton; Estados Unidos |
description |
A recent study found appetitive reinforcement in infant rats given 1.0 but not 2.0 g/kg ethanol and only when ethanol was delivered intragastrically (i.g., but not if intraperitoneally, i.p.; Nizhnikov, Pautassi, Truxell and Spear, 2009). Corticosterone release could modulate ethanol’s motivational effects. The goal of this study was to replicate the differential capability of i.g vs. i.p. ethanol to induce conditioning and to find hormonal correlates underlying this phenomenon. Experiment 1 confirmed that 1.0 g/kg ethanol induced conditioned preference in infant rats when given i.g. but not i.p. In Experiment 2 corticosterone was assessed at 20, 40, 60 or 120 min after ethanol (0.0, 0.5, 1.0 and 2.0 g/kg, i.g. or i.p.). Route of administration failed to alter corticosterone release. The 2.0 g/kg, but not 0.5 or 1.0 g/kg, ethanol dose evoked heightened corticosterone release. The results confirm the differing motivational effects associated with i.g and i.p. ethanol. These effects do not seem to be related to differential corticosterone responsiveness. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/268637 Pautassi, Ricardo Marcos; Nizhnikov, Michael Eduard; Spear, Norman E.; Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration; John Wiley & Sons; Developmental Psychobiology; 54; 1; 5-2011; 98-104 0012-1630 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/268637 |
identifier_str_mv |
Pautassi, Ricardo Marcos; Nizhnikov, Michael Eduard; Spear, Norman E.; Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration; John Wiley & Sons; Developmental Psychobiology; 54; 1; 5-2011; 98-104 0012-1630 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/dev.20567 info:eu-repo/semantics/altIdentifier/doi/10.1002/dev.20567 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
John Wiley & Sons |
publisher.none.fl_str_mv |
John Wiley & Sons |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844614102096281600 |
score |
13.070432 |