Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration

Autores
Pautassi, Ricardo Marcos; Nizhnikov, Michael Eduard; Spear, Norman E.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A recent study found appetitive reinforcement in infant rats given 1.0 but not 2.0 g/kg ethanol and only when ethanol was delivered intragastrically (i.g., but not if intraperitoneally, i.p.; Nizhnikov, Pautassi, Truxell and Spear, 2009). Corticosterone release could modulate ethanol’s motivational effects. The goal of this study was to replicate the differential capability of i.g vs. i.p. ethanol to induce conditioning and to find hormonal correlates underlying this phenomenon. Experiment 1 confirmed that 1.0 g/kg ethanol induced conditioned preference in infant rats when given i.g. but not i.p. In Experiment 2 corticosterone was assessed at 20, 40, 60 or 120 min after ethanol (0.0, 0.5, 1.0 and 2.0 g/kg, i.g. or i.p.). Route of administration failed to alter corticosterone release. The 2.0 g/kg, but not 0.5 or 1.0 g/kg, ethanol dose evoked heightened corticosterone release. The results confirm the differing motivational effects associated with i.g and i.p. ethanol. These effects do not seem to be related to differential corticosterone responsiveness.
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Nizhnikov, Michael Eduard. University of Binghamton; Estados Unidos
Fil: Spear, Norman E.. University of Binghamton; Estados Unidos
Materia
corticosterone
infant rat
ethanol
route of administration
appetitive conditioning
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/268637

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spelling Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administrationPautassi, Ricardo MarcosNizhnikov, Michael EduardSpear, Norman E.corticosteroneinfant ratethanolroute of administrationappetitive conditioninghttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3A recent study found appetitive reinforcement in infant rats given 1.0 but not 2.0 g/kg ethanol and only when ethanol was delivered intragastrically (i.g., but not if intraperitoneally, i.p.; Nizhnikov, Pautassi, Truxell and Spear, 2009). Corticosterone release could modulate ethanol’s motivational effects. The goal of this study was to replicate the differential capability of i.g vs. i.p. ethanol to induce conditioning and to find hormonal correlates underlying this phenomenon. Experiment 1 confirmed that 1.0 g/kg ethanol induced conditioned preference in infant rats when given i.g. but not i.p. In Experiment 2 corticosterone was assessed at 20, 40, 60 or 120 min after ethanol (0.0, 0.5, 1.0 and 2.0 g/kg, i.g. or i.p.). Route of administration failed to alter corticosterone release. The 2.0 g/kg, but not 0.5 or 1.0 g/kg, ethanol dose evoked heightened corticosterone release. The results confirm the differing motivational effects associated with i.g and i.p. ethanol. These effects do not seem to be related to differential corticosterone responsiveness.Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Nizhnikov, Michael Eduard. University of Binghamton; Estados UnidosFil: Spear, Norman E.. University of Binghamton; Estados UnidosJohn Wiley & Sons2011-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/268637Pautassi, Ricardo Marcos; Nizhnikov, Michael Eduard; Spear, Norman E.; Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration; John Wiley & Sons; Developmental Psychobiology; 54; 1; 5-2011; 98-1040012-1630CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/dev.20567info:eu-repo/semantics/altIdentifier/doi/10.1002/dev.20567info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:03Zoai:ri.conicet.gov.ar:11336/268637instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:03.639CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration
title Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration
spellingShingle Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration
Pautassi, Ricardo Marcos
corticosterone
infant rat
ethanol
route of administration
appetitive conditioning
title_short Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration
title_full Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration
title_fullStr Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration
title_full_unstemmed Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration
title_sort Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration
dc.creator.none.fl_str_mv Pautassi, Ricardo Marcos
Nizhnikov, Michael Eduard
Spear, Norman E.
author Pautassi, Ricardo Marcos
author_facet Pautassi, Ricardo Marcos
Nizhnikov, Michael Eduard
Spear, Norman E.
author_role author
author2 Nizhnikov, Michael Eduard
Spear, Norman E.
author2_role author
author
dc.subject.none.fl_str_mv corticosterone
infant rat
ethanol
route of administration
appetitive conditioning
topic corticosterone
infant rat
ethanol
route of administration
appetitive conditioning
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv A recent study found appetitive reinforcement in infant rats given 1.0 but not 2.0 g/kg ethanol and only when ethanol was delivered intragastrically (i.g., but not if intraperitoneally, i.p.; Nizhnikov, Pautassi, Truxell and Spear, 2009). Corticosterone release could modulate ethanol’s motivational effects. The goal of this study was to replicate the differential capability of i.g vs. i.p. ethanol to induce conditioning and to find hormonal correlates underlying this phenomenon. Experiment 1 confirmed that 1.0 g/kg ethanol induced conditioned preference in infant rats when given i.g. but not i.p. In Experiment 2 corticosterone was assessed at 20, 40, 60 or 120 min after ethanol (0.0, 0.5, 1.0 and 2.0 g/kg, i.g. or i.p.). Route of administration failed to alter corticosterone release. The 2.0 g/kg, but not 0.5 or 1.0 g/kg, ethanol dose evoked heightened corticosterone release. The results confirm the differing motivational effects associated with i.g and i.p. ethanol. These effects do not seem to be related to differential corticosterone responsiveness.
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Nizhnikov, Michael Eduard. University of Binghamton; Estados Unidos
Fil: Spear, Norman E.. University of Binghamton; Estados Unidos
description A recent study found appetitive reinforcement in infant rats given 1.0 but not 2.0 g/kg ethanol and only when ethanol was delivered intragastrically (i.g., but not if intraperitoneally, i.p.; Nizhnikov, Pautassi, Truxell and Spear, 2009). Corticosterone release could modulate ethanol’s motivational effects. The goal of this study was to replicate the differential capability of i.g vs. i.p. ethanol to induce conditioning and to find hormonal correlates underlying this phenomenon. Experiment 1 confirmed that 1.0 g/kg ethanol induced conditioned preference in infant rats when given i.g. but not i.p. In Experiment 2 corticosterone was assessed at 20, 40, 60 or 120 min after ethanol (0.0, 0.5, 1.0 and 2.0 g/kg, i.g. or i.p.). Route of administration failed to alter corticosterone release. The 2.0 g/kg, but not 0.5 or 1.0 g/kg, ethanol dose evoked heightened corticosterone release. The results confirm the differing motivational effects associated with i.g and i.p. ethanol. These effects do not seem to be related to differential corticosterone responsiveness.
publishDate 2011
dc.date.none.fl_str_mv 2011-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/268637
Pautassi, Ricardo Marcos; Nizhnikov, Michael Eduard; Spear, Norman E.; Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration; John Wiley & Sons; Developmental Psychobiology; 54; 1; 5-2011; 98-104
0012-1630
CONICET Digital
CONICET
url http://hdl.handle.net/11336/268637
identifier_str_mv Pautassi, Ricardo Marcos; Nizhnikov, Michael Eduard; Spear, Norman E.; Ethanol‐mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration; John Wiley & Sons; Developmental Psychobiology; 54; 1; 5-2011; 98-104
0012-1630
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/dev.20567
info:eu-repo/semantics/altIdentifier/doi/10.1002/dev.20567
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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