Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucrose

Autores
Culleré, Marcela Elena; Spear, Norman E.; Molina, Juan Carlos
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Late prenatal exposure to ethanol recruits sensory processing of the drug and of its motivational properties, an experience that leads to heightened ethanol affinity. Recent studies indicate common sensory and neurobiological substrates between this drug and sweet tastants. Using a recently developed operant conditioning technique for infant rats, we examined the effects of prenatal ethanol history upon sucrose self-administration (postnatal days, PDs 14-17). Prior to the last conditioning session, a low (0.5g/kg) or a high (2.5g/kg) ethanol dose were paired with sucrose. The intention was to determine if ethanol would inflate or devalue the reinforcing capability of the tastant and if these effects are dependent upon prenatal ethanol history. Male and female pups prenatally exposed to ethanol (2.0g/kg) responded more when reinforced with sucrose than pups lacking this antenatal experience. Independently of prenatal status, a low ethanol dose (0.5g/kg) enhanced the reinforcing capability of sucrose while the highest dose (2.5g/kg) seemed to ameliorate the motivational properties of the tastant. During extinction (PD 18), two factors were critical in determining persistence of responding despite reinforcement omission. Pups prenatally exposed to ethanol that subsequently experienced the low ethanol dose paired with sucrose, showed higher resistance to extinction. The effects here reported were not associated with differential blood alcohol levels across prenatal treatments. These results indicate that fetal ethanol experience promotes affinity for a natural sweet reinforcer and that low doses of ethanol are also capable of enhancing the positive motivational consequences of sucrose when ethanol and sucrose are paired during infancy.
Fil: Culleré, Marcela Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Spear, Norman E.. University of Binghamton; Estados Unidos
Fil: Molina, Juan Carlos. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. University of Binghamton; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Materia
ETHANOL
FETUS
INFANT
OPERANT CONDITIONING
SECOND ORDER CONDITIONING
SUCROSE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/185727
Acceder
id CONICETDig_1b584dc81e1edc47eac75082e82e268e
oai_identifier_str oai:ri.conicet.gov.ar:11336/185727
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucroseCulleré, Marcela ElenaSpear, Norman E.Molina, Juan CarlosETHANOLFETUSINFANTOPERANT CONDITIONINGSECOND ORDER CONDITIONINGSUCROSEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Late prenatal exposure to ethanol recruits sensory processing of the drug and of its motivational properties, an experience that leads to heightened ethanol affinity. Recent studies indicate common sensory and neurobiological substrates between this drug and sweet tastants. Using a recently developed operant conditioning technique for infant rats, we examined the effects of prenatal ethanol history upon sucrose self-administration (postnatal days, PDs 14-17). Prior to the last conditioning session, a low (0.5g/kg) or a high (2.5g/kg) ethanol dose were paired with sucrose. The intention was to determine if ethanol would inflate or devalue the reinforcing capability of the tastant and if these effects are dependent upon prenatal ethanol history. Male and female pups prenatally exposed to ethanol (2.0g/kg) responded more when reinforced with sucrose than pups lacking this antenatal experience. Independently of prenatal status, a low ethanol dose (0.5g/kg) enhanced the reinforcing capability of sucrose while the highest dose (2.5g/kg) seemed to ameliorate the motivational properties of the tastant. During extinction (PD 18), two factors were critical in determining persistence of responding despite reinforcement omission. Pups prenatally exposed to ethanol that subsequently experienced the low ethanol dose paired with sucrose, showed higher resistance to extinction. The effects here reported were not associated with differential blood alcohol levels across prenatal treatments. These results indicate that fetal ethanol experience promotes affinity for a natural sweet reinforcer and that low doses of ethanol are also capable of enhancing the positive motivational consequences of sucrose when ethanol and sucrose are paired during infancy.Fil: Culleré, Marcela Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Spear, Norman E.. University of Binghamton; Estados UnidosFil: Molina, Juan Carlos. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. University of Binghamton; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaElsevier Science Inc.2014-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/185727Culleré, Marcela Elena; Spear, Norman E.; Molina, Juan Carlos; Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucrose; Elsevier Science Inc.; Alcohol; 48; 1; 2-2014; 25-330741-83291873-6823CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0741832913002085info:eu-repo/semantics/altIdentifier/doi/10.1016/j.alcohol.2013.11.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:01:03Zoai:ri.conicet.gov.ar:11336/185727instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:01:04.225CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucrose
title Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucrose
spellingShingle Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucrose
Culleré, Marcela Elena
ETHANOL
FETUS
INFANT
OPERANT CONDITIONING
SECOND ORDER CONDITIONING
SUCROSE
title_short Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucrose
title_full Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucrose
title_fullStr Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucrose
title_full_unstemmed Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucrose
title_sort Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucrose
dc.creator.none.fl_str_mv Culleré, Marcela Elena
Spear, Norman E.
Molina, Juan Carlos
author Culleré, Marcela Elena
author_facet Culleré, Marcela Elena
Spear, Norman E.
Molina, Juan Carlos
author_role author
author2 Spear, Norman E.
Molina, Juan Carlos
author2_role author
author
dc.subject.none.fl_str_mv ETHANOL
FETUS
INFANT
OPERANT CONDITIONING
SECOND ORDER CONDITIONING
SUCROSE
topic ETHANOL
FETUS
INFANT
OPERANT CONDITIONING
SECOND ORDER CONDITIONING
SUCROSE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Late prenatal exposure to ethanol recruits sensory processing of the drug and of its motivational properties, an experience that leads to heightened ethanol affinity. Recent studies indicate common sensory and neurobiological substrates between this drug and sweet tastants. Using a recently developed operant conditioning technique for infant rats, we examined the effects of prenatal ethanol history upon sucrose self-administration (postnatal days, PDs 14-17). Prior to the last conditioning session, a low (0.5g/kg) or a high (2.5g/kg) ethanol dose were paired with sucrose. The intention was to determine if ethanol would inflate or devalue the reinforcing capability of the tastant and if these effects are dependent upon prenatal ethanol history. Male and female pups prenatally exposed to ethanol (2.0g/kg) responded more when reinforced with sucrose than pups lacking this antenatal experience. Independently of prenatal status, a low ethanol dose (0.5g/kg) enhanced the reinforcing capability of sucrose while the highest dose (2.5g/kg) seemed to ameliorate the motivational properties of the tastant. During extinction (PD 18), two factors were critical in determining persistence of responding despite reinforcement omission. Pups prenatally exposed to ethanol that subsequently experienced the low ethanol dose paired with sucrose, showed higher resistance to extinction. The effects here reported were not associated with differential blood alcohol levels across prenatal treatments. These results indicate that fetal ethanol experience promotes affinity for a natural sweet reinforcer and that low doses of ethanol are also capable of enhancing the positive motivational consequences of sucrose when ethanol and sucrose are paired during infancy.
Fil: Culleré, Marcela Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Spear, Norman E.. University of Binghamton; Estados Unidos
Fil: Molina, Juan Carlos. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. University of Binghamton; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
description Late prenatal exposure to ethanol recruits sensory processing of the drug and of its motivational properties, an experience that leads to heightened ethanol affinity. Recent studies indicate common sensory and neurobiological substrates between this drug and sweet tastants. Using a recently developed operant conditioning technique for infant rats, we examined the effects of prenatal ethanol history upon sucrose self-administration (postnatal days, PDs 14-17). Prior to the last conditioning session, a low (0.5g/kg) or a high (2.5g/kg) ethanol dose were paired with sucrose. The intention was to determine if ethanol would inflate or devalue the reinforcing capability of the tastant and if these effects are dependent upon prenatal ethanol history. Male and female pups prenatally exposed to ethanol (2.0g/kg) responded more when reinforced with sucrose than pups lacking this antenatal experience. Independently of prenatal status, a low ethanol dose (0.5g/kg) enhanced the reinforcing capability of sucrose while the highest dose (2.5g/kg) seemed to ameliorate the motivational properties of the tastant. During extinction (PD 18), two factors were critical in determining persistence of responding despite reinforcement omission. Pups prenatally exposed to ethanol that subsequently experienced the low ethanol dose paired with sucrose, showed higher resistance to extinction. The effects here reported were not associated with differential blood alcohol levels across prenatal treatments. These results indicate that fetal ethanol experience promotes affinity for a natural sweet reinforcer and that low doses of ethanol are also capable of enhancing the positive motivational consequences of sucrose when ethanol and sucrose are paired during infancy.
publishDate 2014
dc.date.none.fl_str_mv 2014-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/185727
Culleré, Marcela Elena; Spear, Norman E.; Molina, Juan Carlos; Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucrose; Elsevier Science Inc.; Alcohol; 48; 1; 2-2014; 25-33
0741-8329
1873-6823
CONICET Digital
CONICET
url http://hdl.handle.net/11336/185727
identifier_str_mv Culleré, Marcela Elena; Spear, Norman E.; Molina, Juan Carlos; Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucrose; Elsevier Science Inc.; Alcohol; 48; 1; 2-2014; 25-33
0741-8329
1873-6823
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0741832913002085
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.alcohol.2013.11.003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc.
publisher.none.fl_str_mv Elsevier Science Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083150555381760
score 13.22299

Publicaciones similares