Mathematical model for the homeostasis of alpha-macroglobulins in the rat

Autores
Aguirre, Maria Cristina; Armendariz, Mirta Noemi; Lupo, Maela; Rigalli, Alfredo
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Alpha-macroglobulins (AM) are proteins that inactivate proteinases. Sodium monofluorophosphate (MFP) binds to AM and transiently changes AM plasma levels. As a consequence MFP is useful to modify AM homeostasis. A mathematical model to study the homeostasis of AM is proposed in this paper. The model describes changes in plasma concentration of AM, MFP concentration in the gastrointestinal tract, MFP plasma concentration, plasma concentration of AMMFP and includes rate constants of the processes involved in AM homeostasis. Estimation of the rate constants values was achieved using experimental and mathematical resources. The homeostasis of AM after an oral dose of 80 ìmole of MFP was analyzed with a simulation tool. Experimental conditions that modify the homeostasis of AM had been simulated and validated using specific drugs that change some parameter of the system. The mathematical model describes accurately the behavior of the biological model. The results allow concluding that the simplifications made did not underestimate the main processes involved in the homeostasis and, also that the assumptions made were correct.
Fil: Aguirre, Maria Cristina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Armendariz, Mirta Noemi. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Lupo, Maela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Escuela de Ciencias médicas. Cátedra de Química Biologica; Argentina
Fil: Rigalli, Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Escuela de Ciencias médicas. Cátedra de Química Biologica; Argentina
Materia
ALPHA-MACROGLOBULIN
HOMEOSTASIS
RAT
MONOFLUOROPHOSPHATE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/268256
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mathematical model for the homeostasis of alpha-macroglobulins in the ratAguirre, Maria CristinaArmendariz, Mirta NoemiLupo, MaelaRigalli, AlfredoALPHA-MACROGLOBULINHOMEOSTASISRATMONOFLUOROPHOSPHATEhttps://purl.org/becyt/ford/1.1https://purl.org/becyt/ford/1Alpha-macroglobulins (AM) are proteins that inactivate proteinases. Sodium monofluorophosphate (MFP) binds to AM and transiently changes AM plasma levels. As a consequence MFP is useful to modify AM homeostasis. A mathematical model to study the homeostasis of AM is proposed in this paper. The model describes changes in plasma concentration of AM, MFP concentration in the gastrointestinal tract, MFP plasma concentration, plasma concentration of AMMFP and includes rate constants of the processes involved in AM homeostasis. Estimation of the rate constants values was achieved using experimental and mathematical resources. The homeostasis of AM after an oral dose of 80 ìmole of MFP was analyzed with a simulation tool. Experimental conditions that modify the homeostasis of AM had been simulated and validated using specific drugs that change some parameter of the system. The mathematical model describes accurately the behavior of the biological model. The results allow concluding that the simplifications made did not underestimate the main processes involved in the homeostasis and, also that the assumptions made were correct.Fil: Aguirre, Maria Cristina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Armendariz, Mirta Noemi. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Lupo, Maela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Escuela de Ciencias médicas. Cátedra de Química Biologica; ArgentinaFil: Rigalli, Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Escuela de Ciencias médicas. Cátedra de Química Biologica; ArgentinaElsevier Science Inc.2011-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/268256Aguirre, Maria Cristina; Armendariz, Mirta Noemi; Lupo, Maela; Rigalli, Alfredo; Mathematical model for the homeostasis of alpha-macroglobulins in the rat; Elsevier Science Inc.; Mathematical Biosciences; 234; 1; 11-2011; 17-240025-5564CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0025556411001179info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mbs.2011.08.002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:31Zoai:ri.conicet.gov.ar:11336/268256instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:32.135CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mathematical model for the homeostasis of alpha-macroglobulins in the rat
title Mathematical model for the homeostasis of alpha-macroglobulins in the rat
spellingShingle Mathematical model for the homeostasis of alpha-macroglobulins in the rat
Aguirre, Maria Cristina
ALPHA-MACROGLOBULIN
HOMEOSTASIS
RAT
MONOFLUOROPHOSPHATE
title_short Mathematical model for the homeostasis of alpha-macroglobulins in the rat
title_full Mathematical model for the homeostasis of alpha-macroglobulins in the rat
title_fullStr Mathematical model for the homeostasis of alpha-macroglobulins in the rat
title_full_unstemmed Mathematical model for the homeostasis of alpha-macroglobulins in the rat
title_sort Mathematical model for the homeostasis of alpha-macroglobulins in the rat
dc.creator.none.fl_str_mv Aguirre, Maria Cristina
Armendariz, Mirta Noemi
Lupo, Maela
Rigalli, Alfredo
author Aguirre, Maria Cristina
author_facet Aguirre, Maria Cristina
Armendariz, Mirta Noemi
Lupo, Maela
Rigalli, Alfredo
author_role author
author2 Armendariz, Mirta Noemi
Lupo, Maela
Rigalli, Alfredo
author2_role author
author
author
dc.subject.none.fl_str_mv ALPHA-MACROGLOBULIN
HOMEOSTASIS
RAT
MONOFLUOROPHOSPHATE
topic ALPHA-MACROGLOBULIN
HOMEOSTASIS
RAT
MONOFLUOROPHOSPHATE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.1
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Alpha-macroglobulins (AM) are proteins that inactivate proteinases. Sodium monofluorophosphate (MFP) binds to AM and transiently changes AM plasma levels. As a consequence MFP is useful to modify AM homeostasis. A mathematical model to study the homeostasis of AM is proposed in this paper. The model describes changes in plasma concentration of AM, MFP concentration in the gastrointestinal tract, MFP plasma concentration, plasma concentration of AMMFP and includes rate constants of the processes involved in AM homeostasis. Estimation of the rate constants values was achieved using experimental and mathematical resources. The homeostasis of AM after an oral dose of 80 ìmole of MFP was analyzed with a simulation tool. Experimental conditions that modify the homeostasis of AM had been simulated and validated using specific drugs that change some parameter of the system. The mathematical model describes accurately the behavior of the biological model. The results allow concluding that the simplifications made did not underestimate the main processes involved in the homeostasis and, also that the assumptions made were correct.
Fil: Aguirre, Maria Cristina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Armendariz, Mirta Noemi. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Lupo, Maela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Escuela de Ciencias médicas. Cátedra de Química Biologica; Argentina
Fil: Rigalli, Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Escuela de Ciencias médicas. Cátedra de Química Biologica; Argentina
description Alpha-macroglobulins (AM) are proteins that inactivate proteinases. Sodium monofluorophosphate (MFP) binds to AM and transiently changes AM plasma levels. As a consequence MFP is useful to modify AM homeostasis. A mathematical model to study the homeostasis of AM is proposed in this paper. The model describes changes in plasma concentration of AM, MFP concentration in the gastrointestinal tract, MFP plasma concentration, plasma concentration of AMMFP and includes rate constants of the processes involved in AM homeostasis. Estimation of the rate constants values was achieved using experimental and mathematical resources. The homeostasis of AM after an oral dose of 80 ìmole of MFP was analyzed with a simulation tool. Experimental conditions that modify the homeostasis of AM had been simulated and validated using specific drugs that change some parameter of the system. The mathematical model describes accurately the behavior of the biological model. The results allow concluding that the simplifications made did not underestimate the main processes involved in the homeostasis and, also that the assumptions made were correct.
publishDate 2011
dc.date.none.fl_str_mv 2011-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/268256
Aguirre, Maria Cristina; Armendariz, Mirta Noemi; Lupo, Maela; Rigalli, Alfredo; Mathematical model for the homeostasis of alpha-macroglobulins in the rat; Elsevier Science Inc.; Mathematical Biosciences; 234; 1; 11-2011; 17-24
0025-5564
CONICET Digital
CONICET
url http://hdl.handle.net/11336/268256
identifier_str_mv Aguirre, Maria Cristina; Armendariz, Mirta Noemi; Lupo, Maela; Rigalli, Alfredo; Mathematical model for the homeostasis of alpha-macroglobulins in the rat; Elsevier Science Inc.; Mathematical Biosciences; 234; 1; 11-2011; 17-24
0025-5564
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0025556411001179
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mbs.2011.08.002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc.
publisher.none.fl_str_mv Elsevier Science Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270123163910144
score 13.13397

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