Eff ect of the Treatment with Alpha-Macroglobulin on the Development of Experimental Pancreatitis

Autores
Di Loreto, Verónica Elina; Roma, Stella Maris; Rigalli, Alfredo
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Alpha-macroglobulins are proteinase inhibitors. Monofl uorophosphate increases alpha-macroglobulin levels in plasma, inducing a higher survival rate and lower pancreatic damage in rats with pancreatitis. The aim of this study was to evaluate the eff ect of alpha-macroglobulin on the development of pancreatitis. Pancreatitis was surgically induced in Sprague-Dawley rats divided into groups of 16 rats each and subjected to the following intravenous treatments for 3 days: Controls: pancreatitis without treatment, Enriched plasma: pancreatitis + alpha-macroglobulin-enriched plasma, Normal plasma: pancreatitis + plasma with normal levels of alpha-macroglobulin, Saline Solution: pancreatitis + saline solution, Purifi ed alpha-macroglobulin: pancreatitis + purifi ed alpha-macroglobulin. After 14 days pancreatic damage was assessed using a score that measures: edema, fi brin, neutrophils, mononuclear leukocytes, necrosis, vascular congestion, thrombosis, hemorrhage and fi brosis. Pancreatic damage decreased and the percentage of animals with pancreatitis was lower in enrichedplasma and purifi ed alpha-macroglobulin groups. We conclude that the intravenous administration of alpha-macroglobulins causes a reduction in the histological damage produced by pancreatitis.
Fil: Di Loreto, Verónica Elina. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Roma, Stella Maris. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rigalli, Alfredo. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Macroglobulin
Monofluorophosphate
Mfp
Pancreas
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/21253
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/21253
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Eff ect of the Treatment with Alpha-Macroglobulin on the Development of Experimental PancreatitisDi Loreto, Verónica ElinaRoma, Stella MarisRigalli, AlfredoMacroglobulinMonofluorophosphateMfpPancreashttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Alpha-macroglobulins are proteinase inhibitors. Monofl uorophosphate increases alpha-macroglobulin levels in plasma, inducing a higher survival rate and lower pancreatic damage in rats with pancreatitis. The aim of this study was to evaluate the eff ect of alpha-macroglobulin on the development of pancreatitis. Pancreatitis was surgically induced in Sprague-Dawley rats divided into groups of 16 rats each and subjected to the following intravenous treatments for 3 days: Controls: pancreatitis without treatment, Enriched plasma: pancreatitis + alpha-macroglobulin-enriched plasma, Normal plasma: pancreatitis + plasma with normal levels of alpha-macroglobulin, Saline Solution: pancreatitis + saline solution, Purifi ed alpha-macroglobulin: pancreatitis + purifi ed alpha-macroglobulin. After 14 days pancreatic damage was assessed using a score that measures: edema, fi brin, neutrophils, mononuclear leukocytes, necrosis, vascular congestion, thrombosis, hemorrhage and fi brosis. Pancreatic damage decreased and the percentage of animals with pancreatitis was lower in enrichedplasma and purifi ed alpha-macroglobulin groups. We conclude that the intravenous administration of alpha-macroglobulins causes a reduction in the histological damage produced by pancreatitis.Fil: Di Loreto, Verónica Elina. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Roma, Stella Maris. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rigalli, Alfredo. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaGeorg Thieme Verlag Kg2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/21253Di Loreto, Verónica Elina; Roma, Stella Maris; Rigalli, Alfredo; Eff ect of the Treatment with Alpha-Macroglobulin on the Development of Experimental Pancreatitis; Georg Thieme Verlag Kg; Drug Research; 63; 2; -1-2013; 90-932194-9379CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1055/s-0032-1333227info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/DOI/DOI?10.1055/s-0032-1333227info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:14Zoai:ri.conicet.gov.ar:11336/21253instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:14.422CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Eff ect of the Treatment with Alpha-Macroglobulin on the Development of Experimental Pancreatitis
title Eff ect of the Treatment with Alpha-Macroglobulin on the Development of Experimental Pancreatitis
spellingShingle Eff ect of the Treatment with Alpha-Macroglobulin on the Development of Experimental Pancreatitis
Di Loreto, Verónica Elina
Macroglobulin
Monofluorophosphate
Mfp
Pancreas
title_short Eff ect of the Treatment with Alpha-Macroglobulin on the Development of Experimental Pancreatitis
title_full Eff ect of the Treatment with Alpha-Macroglobulin on the Development of Experimental Pancreatitis
title_fullStr Eff ect of the Treatment with Alpha-Macroglobulin on the Development of Experimental Pancreatitis
title_full_unstemmed Eff ect of the Treatment with Alpha-Macroglobulin on the Development of Experimental Pancreatitis
title_sort Eff ect of the Treatment with Alpha-Macroglobulin on the Development of Experimental Pancreatitis
dc.creator.none.fl_str_mv Di Loreto, Verónica Elina
Roma, Stella Maris
Rigalli, Alfredo
author Di Loreto, Verónica Elina
author_facet Di Loreto, Verónica Elina
Roma, Stella Maris
Rigalli, Alfredo
author_role author
author2 Roma, Stella Maris
Rigalli, Alfredo
author2_role author
author
dc.subject.none.fl_str_mv Macroglobulin
Monofluorophosphate
Mfp
Pancreas
topic Macroglobulin
Monofluorophosphate
Mfp
Pancreas
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Alpha-macroglobulins are proteinase inhibitors. Monofl uorophosphate increases alpha-macroglobulin levels in plasma, inducing a higher survival rate and lower pancreatic damage in rats with pancreatitis. The aim of this study was to evaluate the eff ect of alpha-macroglobulin on the development of pancreatitis. Pancreatitis was surgically induced in Sprague-Dawley rats divided into groups of 16 rats each and subjected to the following intravenous treatments for 3 days: Controls: pancreatitis without treatment, Enriched plasma: pancreatitis + alpha-macroglobulin-enriched plasma, Normal plasma: pancreatitis + plasma with normal levels of alpha-macroglobulin, Saline Solution: pancreatitis + saline solution, Purifi ed alpha-macroglobulin: pancreatitis + purifi ed alpha-macroglobulin. After 14 days pancreatic damage was assessed using a score that measures: edema, fi brin, neutrophils, mononuclear leukocytes, necrosis, vascular congestion, thrombosis, hemorrhage and fi brosis. Pancreatic damage decreased and the percentage of animals with pancreatitis was lower in enrichedplasma and purifi ed alpha-macroglobulin groups. We conclude that the intravenous administration of alpha-macroglobulins causes a reduction in the histological damage produced by pancreatitis.
Fil: Di Loreto, Verónica Elina. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Roma, Stella Maris. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rigalli, Alfredo. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Alpha-macroglobulins are proteinase inhibitors. Monofl uorophosphate increases alpha-macroglobulin levels in plasma, inducing a higher survival rate and lower pancreatic damage in rats with pancreatitis. The aim of this study was to evaluate the eff ect of alpha-macroglobulin on the development of pancreatitis. Pancreatitis was surgically induced in Sprague-Dawley rats divided into groups of 16 rats each and subjected to the following intravenous treatments for 3 days: Controls: pancreatitis without treatment, Enriched plasma: pancreatitis + alpha-macroglobulin-enriched plasma, Normal plasma: pancreatitis + plasma with normal levels of alpha-macroglobulin, Saline Solution: pancreatitis + saline solution, Purifi ed alpha-macroglobulin: pancreatitis + purifi ed alpha-macroglobulin. After 14 days pancreatic damage was assessed using a score that measures: edema, fi brin, neutrophils, mononuclear leukocytes, necrosis, vascular congestion, thrombosis, hemorrhage and fi brosis. Pancreatic damage decreased and the percentage of animals with pancreatitis was lower in enrichedplasma and purifi ed alpha-macroglobulin groups. We conclude that the intravenous administration of alpha-macroglobulins causes a reduction in the histological damage produced by pancreatitis.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/21253
Di Loreto, Verónica Elina; Roma, Stella Maris; Rigalli, Alfredo; Eff ect of the Treatment with Alpha-Macroglobulin on the Development of Experimental Pancreatitis; Georg Thieme Verlag Kg; Drug Research; 63; 2; -1-2013; 90-93
2194-9379
CONICET Digital
CONICET
url http://hdl.handle.net/11336/21253
identifier_str_mv Di Loreto, Verónica Elina; Roma, Stella Maris; Rigalli, Alfredo; Eff ect of the Treatment with Alpha-Macroglobulin on the Development of Experimental Pancreatitis; Georg Thieme Verlag Kg; Drug Research; 63; 2; -1-2013; 90-93
2194-9379
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0032-1333227
info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/DOI/DOI?10.1055/s-0032-1333227
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Georg Thieme Verlag Kg
publisher.none.fl_str_mv Georg Thieme Verlag Kg
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269845751595008
score 13.13397

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