Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis
- Autores
- Closs, Cecilia Inés; Ackerman, Marianela; Masson, Walter; Lobo, Martin; Molinero, Graciela; Lavalle Cobo, Augusto; Béliard, Sophie; Mourre, Florian; Valéro, René; Nogueira, Juan Patricio
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Introduction: Obesity and its co-morbidities, including type 2 diabetes (T2DM) and dyslipidemia, are accompanied by excess cardiovascular morbi-mortality. Aside from excess low density lipoprotein-cholesterol (LDL-C), atherogenic dyslipidemia (AD), mainly characterized by elevated triglycerides and decreased high density lipoprotein-cholesterol (HDL-C) levels, is often present in T2DM obese patients. Bariatric surgery, such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), has become a reference treatment in that population. However, the respective effects of RYGB vs SG on lipid metabolism in T2DM patients have been rarely studied. Methods: A meta-analysis of randomized controlled trials, comparing the effects of RGYBG vs SG on lipid metabolism 12 months after surgery in T2DM patients, was performed. Results: Four studies including a total of 298 patients (151 patients in the RYGB and 147 patients in the SG group) were examined. Despite a greater decrease in body mass index and greater improvement in glycemic control in RYGB compared to SG. RYGB vs SG was more effective in reducing total cholesterol, LDL-C, and non-HDL-C levels (mean difference [MD] −26.10 mg/dL, 95 % CI −38.88 to −13.50, p<0.00001; [MD] −20.10 mg/dL, 95 % CI −27.90 to −12.20, p<0.00001 and MD 31.90 mg/dl, 95 % CI −46.90 to −16.80, p<0.00001, respectively). Conclusions: The superiority of RYGB vs SG in reducing LDL-C, with an effect comparable to a moderate-intensity statin, suggests RYBG should be favored in hypercholesterolemic T2DM patients in order to further reduce cardiovascular risk.
Fil: Closs, Cecilia Inés. Centro Medico Melian; Argentina
Fil: Ackerman, Marianela. No especifíca;
Fil: Masson, Walter. Hospital Italiano; Argentina
Fil: Lobo, Martin. Sociedad Argentina de Cardiología; Argentina
Fil: Molinero, Graciela. Sociedad Argentina de Cardiología; Argentina
Fil: Lavalle Cobo, Augusto. Sociedad Argentina de Cardiología; Argentina
Fil: Béliard, Sophie. Inserm; Francia
Fil: Mourre, Florian. Inserm; Francia
Fil: Valéro, René. Inserm; Francia
Fil: Nogueira, Juan Patricio. Universidad Nacional de Formosa. Facultad de Ciencias de la Salud. Centro de Investigacion En Endocrinologia, Nutricion y Metabolismo.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina - Materia
-
BARIATRIC SURGERY
HDL-CHOLESTEROL
LDL-CHOLESTEROL
LIPIDS
ROUX-EN-Y GASTRIC BYPASS
SLEEVE GASTRECTOMY
TRIGLYCERIDES
TYPE 2 DIABETES MELLITUS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/216489
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CONICET Digital (CONICET) |
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Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysisCloss, Cecilia InésAckerman, MarianelaMasson, WalterLobo, MartinMolinero, GracielaLavalle Cobo, AugustoBéliard, SophieMourre, FlorianValéro, RenéNogueira, Juan PatricioBARIATRIC SURGERYHDL-CHOLESTEROLLDL-CHOLESTEROLLIPIDSROUX-EN-Y GASTRIC BYPASSSLEEVE GASTRECTOMYTRIGLYCERIDESTYPE 2 DIABETES MELLITUShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Introduction: Obesity and its co-morbidities, including type 2 diabetes (T2DM) and dyslipidemia, are accompanied by excess cardiovascular morbi-mortality. Aside from excess low density lipoprotein-cholesterol (LDL-C), atherogenic dyslipidemia (AD), mainly characterized by elevated triglycerides and decreased high density lipoprotein-cholesterol (HDL-C) levels, is often present in T2DM obese patients. Bariatric surgery, such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), has become a reference treatment in that population. However, the respective effects of RYGB vs SG on lipid metabolism in T2DM patients have been rarely studied. Methods: A meta-analysis of randomized controlled trials, comparing the effects of RGYBG vs SG on lipid metabolism 12 months after surgery in T2DM patients, was performed. Results: Four studies including a total of 298 patients (151 patients in the RYGB and 147 patients in the SG group) were examined. Despite a greater decrease in body mass index and greater improvement in glycemic control in RYGB compared to SG. RYGB vs SG was more effective in reducing total cholesterol, LDL-C, and non-HDL-C levels (mean difference [MD] −26.10 mg/dL, 95 % CI −38.88 to −13.50, p<0.00001; [MD] −20.10 mg/dL, 95 % CI −27.90 to −12.20, p<0.00001 and MD 31.90 mg/dl, 95 % CI −46.90 to −16.80, p<0.00001, respectively). Conclusions: The superiority of RYGB vs SG in reducing LDL-C, with an effect comparable to a moderate-intensity statin, suggests RYBG should be favored in hypercholesterolemic T2DM patients in order to further reduce cardiovascular risk.Fil: Closs, Cecilia Inés. Centro Medico Melian; ArgentinaFil: Ackerman, Marianela. No especifíca;Fil: Masson, Walter. Hospital Italiano; ArgentinaFil: Lobo, Martin. Sociedad Argentina de Cardiología; ArgentinaFil: Molinero, Graciela. Sociedad Argentina de Cardiología; ArgentinaFil: Lavalle Cobo, Augusto. Sociedad Argentina de Cardiología; ArgentinaFil: Béliard, Sophie. Inserm; FranciaFil: Mourre, Florian. Inserm; FranciaFil: Valéro, René. Inserm; FranciaFil: Nogueira, Juan Patricio. Universidad Nacional de Formosa. Facultad de Ciencias de la Salud. Centro de Investigacion En Endocrinologia, Nutricion y Metabolismo.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; ArgentinaSpringer2022-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/216489Closs, Cecilia Inés; Ackerman, Marianela; Masson, Walter; Lobo, Martin; Molinero, Graciela; et al.; Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis; Springer; Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract.; 26; 8; 5-2022; 1575-15841091-255XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s11605-022-05338-5info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:09:10Zoai:ri.conicet.gov.ar:11336/216489instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:09:11.201CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis |
title |
Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis |
spellingShingle |
Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis Closs, Cecilia Inés BARIATRIC SURGERY HDL-CHOLESTEROL LDL-CHOLESTEROL LIPIDS ROUX-EN-Y GASTRIC BYPASS SLEEVE GASTRECTOMY TRIGLYCERIDES TYPE 2 DIABETES MELLITUS |
title_short |
Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis |
title_full |
Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis |
title_fullStr |
Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis |
title_full_unstemmed |
Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis |
title_sort |
Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis |
dc.creator.none.fl_str_mv |
Closs, Cecilia Inés Ackerman, Marianela Masson, Walter Lobo, Martin Molinero, Graciela Lavalle Cobo, Augusto Béliard, Sophie Mourre, Florian Valéro, René Nogueira, Juan Patricio |
author |
Closs, Cecilia Inés |
author_facet |
Closs, Cecilia Inés Ackerman, Marianela Masson, Walter Lobo, Martin Molinero, Graciela Lavalle Cobo, Augusto Béliard, Sophie Mourre, Florian Valéro, René Nogueira, Juan Patricio |
author_role |
author |
author2 |
Ackerman, Marianela Masson, Walter Lobo, Martin Molinero, Graciela Lavalle Cobo, Augusto Béliard, Sophie Mourre, Florian Valéro, René Nogueira, Juan Patricio |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
BARIATRIC SURGERY HDL-CHOLESTEROL LDL-CHOLESTEROL LIPIDS ROUX-EN-Y GASTRIC BYPASS SLEEVE GASTRECTOMY TRIGLYCERIDES TYPE 2 DIABETES MELLITUS |
topic |
BARIATRIC SURGERY HDL-CHOLESTEROL LDL-CHOLESTEROL LIPIDS ROUX-EN-Y GASTRIC BYPASS SLEEVE GASTRECTOMY TRIGLYCERIDES TYPE 2 DIABETES MELLITUS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Introduction: Obesity and its co-morbidities, including type 2 diabetes (T2DM) and dyslipidemia, are accompanied by excess cardiovascular morbi-mortality. Aside from excess low density lipoprotein-cholesterol (LDL-C), atherogenic dyslipidemia (AD), mainly characterized by elevated triglycerides and decreased high density lipoprotein-cholesterol (HDL-C) levels, is often present in T2DM obese patients. Bariatric surgery, such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), has become a reference treatment in that population. However, the respective effects of RYGB vs SG on lipid metabolism in T2DM patients have been rarely studied. Methods: A meta-analysis of randomized controlled trials, comparing the effects of RGYBG vs SG on lipid metabolism 12 months after surgery in T2DM patients, was performed. Results: Four studies including a total of 298 patients (151 patients in the RYGB and 147 patients in the SG group) were examined. Despite a greater decrease in body mass index and greater improvement in glycemic control in RYGB compared to SG. RYGB vs SG was more effective in reducing total cholesterol, LDL-C, and non-HDL-C levels (mean difference [MD] −26.10 mg/dL, 95 % CI −38.88 to −13.50, p<0.00001; [MD] −20.10 mg/dL, 95 % CI −27.90 to −12.20, p<0.00001 and MD 31.90 mg/dl, 95 % CI −46.90 to −16.80, p<0.00001, respectively). Conclusions: The superiority of RYGB vs SG in reducing LDL-C, with an effect comparable to a moderate-intensity statin, suggests RYBG should be favored in hypercholesterolemic T2DM patients in order to further reduce cardiovascular risk. Fil: Closs, Cecilia Inés. Centro Medico Melian; Argentina Fil: Ackerman, Marianela. No especifíca; Fil: Masson, Walter. Hospital Italiano; Argentina Fil: Lobo, Martin. Sociedad Argentina de Cardiología; Argentina Fil: Molinero, Graciela. Sociedad Argentina de Cardiología; Argentina Fil: Lavalle Cobo, Augusto. Sociedad Argentina de Cardiología; Argentina Fil: Béliard, Sophie. Inserm; Francia Fil: Mourre, Florian. Inserm; Francia Fil: Valéro, René. Inserm; Francia Fil: Nogueira, Juan Patricio. Universidad Nacional de Formosa. Facultad de Ciencias de la Salud. Centro de Investigacion En Endocrinologia, Nutricion y Metabolismo.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina |
description |
Introduction: Obesity and its co-morbidities, including type 2 diabetes (T2DM) and dyslipidemia, are accompanied by excess cardiovascular morbi-mortality. Aside from excess low density lipoprotein-cholesterol (LDL-C), atherogenic dyslipidemia (AD), mainly characterized by elevated triglycerides and decreased high density lipoprotein-cholesterol (HDL-C) levels, is often present in T2DM obese patients. Bariatric surgery, such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), has become a reference treatment in that population. However, the respective effects of RYGB vs SG on lipid metabolism in T2DM patients have been rarely studied. Methods: A meta-analysis of randomized controlled trials, comparing the effects of RGYBG vs SG on lipid metabolism 12 months after surgery in T2DM patients, was performed. Results: Four studies including a total of 298 patients (151 patients in the RYGB and 147 patients in the SG group) were examined. Despite a greater decrease in body mass index and greater improvement in glycemic control in RYGB compared to SG. RYGB vs SG was more effective in reducing total cholesterol, LDL-C, and non-HDL-C levels (mean difference [MD] −26.10 mg/dL, 95 % CI −38.88 to −13.50, p<0.00001; [MD] −20.10 mg/dL, 95 % CI −27.90 to −12.20, p<0.00001 and MD 31.90 mg/dl, 95 % CI −46.90 to −16.80, p<0.00001, respectively). Conclusions: The superiority of RYGB vs SG in reducing LDL-C, with an effect comparable to a moderate-intensity statin, suggests RYBG should be favored in hypercholesterolemic T2DM patients in order to further reduce cardiovascular risk. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/216489 Closs, Cecilia Inés; Ackerman, Marianela; Masson, Walter; Lobo, Martin; Molinero, Graciela; et al.; Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis; Springer; Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract.; 26; 8; 5-2022; 1575-1584 1091-255X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/216489 |
identifier_str_mv |
Closs, Cecilia Inés; Ackerman, Marianela; Masson, Walter; Lobo, Martin; Molinero, Graciela; et al.; Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis; Springer; Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract.; 26; 8; 5-2022; 1575-1584 1091-255X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1007/s11605-022-05338-5 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613967393062912 |
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13.070432 |