Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis

Autores
Closs, Cecilia Inés; Ackerman, Marianela; Masson, Walter; Lobo, Martin; Molinero, Graciela; Lavalle Cobo, Augusto; Béliard, Sophie; Mourre, Florian; Valéro, René; Nogueira, Juan Patricio
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Obesity and its co-morbidities, including type 2 diabetes (T2DM) and dyslipidemia, are accompanied by excess cardiovascular morbi-mortality. Aside from excess low density lipoprotein-cholesterol (LDL-C), atherogenic dyslipidemia (AD), mainly characterized by elevated triglycerides and decreased high density lipoprotein-cholesterol (HDL-C) levels, is often present in T2DM obese patients. Bariatric surgery, such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), has become a reference treatment in that population. However, the respective effects of RYGB vs SG on lipid metabolism in T2DM patients have been rarely studied. Methods: A meta-analysis of randomized controlled trials, comparing the effects of RGYBG vs SG on lipid metabolism 12 months after surgery in T2DM patients, was performed. Results: Four studies including a total of 298 patients (151 patients in the RYGB and 147 patients in the SG group) were examined. Despite a greater decrease in body mass index and greater improvement in glycemic control in RYGB compared to SG. RYGB vs SG was more effective in reducing total cholesterol, LDL-C, and non-HDL-C levels (mean difference [MD] −26.10 mg/dL, 95 % CI −38.88 to −13.50, p<0.00001; [MD] −20.10 mg/dL, 95 % CI −27.90 to −12.20, p<0.00001 and MD 31.90 mg/dl, 95 % CI −46.90 to −16.80, p<0.00001, respectively). Conclusions: The superiority of RYGB vs SG in reducing LDL-C, with an effect comparable to a moderate-intensity statin, suggests RYBG should be favored in hypercholesterolemic T2DM patients in order to further reduce cardiovascular risk.
Fil: Closs, Cecilia Inés. Centro Medico Melian; Argentina
Fil: Ackerman, Marianela. No especifíca;
Fil: Masson, Walter. Hospital Italiano; Argentina
Fil: Lobo, Martin. Sociedad Argentina de Cardiología; Argentina
Fil: Molinero, Graciela. Sociedad Argentina de Cardiología; Argentina
Fil: Lavalle Cobo, Augusto. Sociedad Argentina de Cardiología; Argentina
Fil: Béliard, Sophie. Inserm; Francia
Fil: Mourre, Florian. Inserm; Francia
Fil: Valéro, René. Inserm; Francia
Fil: Nogueira, Juan Patricio. Universidad Nacional de Formosa. Facultad de Ciencias de la Salud. Centro de Investigacion En Endocrinologia, Nutricion y Metabolismo.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
Materia
BARIATRIC SURGERY
HDL-CHOLESTEROL
LDL-CHOLESTEROL
LIPIDS
ROUX-EN-Y GASTRIC BYPASS
SLEEVE GASTRECTOMY
TRIGLYCERIDES
TYPE 2 DIABETES MELLITUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/216489

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oai_identifier_str oai:ri.conicet.gov.ar:11336/216489
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysisCloss, Cecilia InésAckerman, MarianelaMasson, WalterLobo, MartinMolinero, GracielaLavalle Cobo, AugustoBéliard, SophieMourre, FlorianValéro, RenéNogueira, Juan PatricioBARIATRIC SURGERYHDL-CHOLESTEROLLDL-CHOLESTEROLLIPIDSROUX-EN-Y GASTRIC BYPASSSLEEVE GASTRECTOMYTRIGLYCERIDESTYPE 2 DIABETES MELLITUShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Introduction: Obesity and its co-morbidities, including type 2 diabetes (T2DM) and dyslipidemia, are accompanied by excess cardiovascular morbi-mortality. Aside from excess low density lipoprotein-cholesterol (LDL-C), atherogenic dyslipidemia (AD), mainly characterized by elevated triglycerides and decreased high density lipoprotein-cholesterol (HDL-C) levels, is often present in T2DM obese patients. Bariatric surgery, such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), has become a reference treatment in that population. However, the respective effects of RYGB vs SG on lipid metabolism in T2DM patients have been rarely studied. Methods: A meta-analysis of randomized controlled trials, comparing the effects of RGYBG vs SG on lipid metabolism 12 months after surgery in T2DM patients, was performed. Results: Four studies including a total of 298 patients (151 patients in the RYGB and 147 patients in the SG group) were examined. Despite a greater decrease in body mass index and greater improvement in glycemic control in RYGB compared to SG. RYGB vs SG was more effective in reducing total cholesterol, LDL-C, and non-HDL-C levels (mean difference [MD] −26.10 mg/dL, 95 % CI −38.88 to −13.50, p<0.00001; [MD] −20.10 mg/dL, 95 % CI −27.90 to −12.20, p<0.00001 and MD 31.90 mg/dl, 95 % CI −46.90 to −16.80, p<0.00001, respectively). Conclusions: The superiority of RYGB vs SG in reducing LDL-C, with an effect comparable to a moderate-intensity statin, suggests RYBG should be favored in hypercholesterolemic T2DM patients in order to further reduce cardiovascular risk.Fil: Closs, Cecilia Inés. Centro Medico Melian; ArgentinaFil: Ackerman, Marianela. No especifíca;Fil: Masson, Walter. Hospital Italiano; ArgentinaFil: Lobo, Martin. Sociedad Argentina de Cardiología; ArgentinaFil: Molinero, Graciela. Sociedad Argentina de Cardiología; ArgentinaFil: Lavalle Cobo, Augusto. Sociedad Argentina de Cardiología; ArgentinaFil: Béliard, Sophie. Inserm; FranciaFil: Mourre, Florian. Inserm; FranciaFil: Valéro, René. Inserm; FranciaFil: Nogueira, Juan Patricio. Universidad Nacional de Formosa. Facultad de Ciencias de la Salud. Centro de Investigacion En Endocrinologia, Nutricion y Metabolismo.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; ArgentinaSpringer2022-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/216489Closs, Cecilia Inés; Ackerman, Marianela; Masson, Walter; Lobo, Martin; Molinero, Graciela; et al.; Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis; Springer; Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract.; 26; 8; 5-2022; 1575-15841091-255XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s11605-022-05338-5info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:09:10Zoai:ri.conicet.gov.ar:11336/216489instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:09:11.201CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis
title Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis
spellingShingle Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis
Closs, Cecilia Inés
BARIATRIC SURGERY
HDL-CHOLESTEROL
LDL-CHOLESTEROL
LIPIDS
ROUX-EN-Y GASTRIC BYPASS
SLEEVE GASTRECTOMY
TRIGLYCERIDES
TYPE 2 DIABETES MELLITUS
title_short Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis
title_full Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis
title_fullStr Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis
title_full_unstemmed Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis
title_sort Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis
dc.creator.none.fl_str_mv Closs, Cecilia Inés
Ackerman, Marianela
Masson, Walter
Lobo, Martin
Molinero, Graciela
Lavalle Cobo, Augusto
Béliard, Sophie
Mourre, Florian
Valéro, René
Nogueira, Juan Patricio
author Closs, Cecilia Inés
author_facet Closs, Cecilia Inés
Ackerman, Marianela
Masson, Walter
Lobo, Martin
Molinero, Graciela
Lavalle Cobo, Augusto
Béliard, Sophie
Mourre, Florian
Valéro, René
Nogueira, Juan Patricio
author_role author
author2 Ackerman, Marianela
Masson, Walter
Lobo, Martin
Molinero, Graciela
Lavalle Cobo, Augusto
Béliard, Sophie
Mourre, Florian
Valéro, René
Nogueira, Juan Patricio
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BARIATRIC SURGERY
HDL-CHOLESTEROL
LDL-CHOLESTEROL
LIPIDS
ROUX-EN-Y GASTRIC BYPASS
SLEEVE GASTRECTOMY
TRIGLYCERIDES
TYPE 2 DIABETES MELLITUS
topic BARIATRIC SURGERY
HDL-CHOLESTEROL
LDL-CHOLESTEROL
LIPIDS
ROUX-EN-Y GASTRIC BYPASS
SLEEVE GASTRECTOMY
TRIGLYCERIDES
TYPE 2 DIABETES MELLITUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Obesity and its co-morbidities, including type 2 diabetes (T2DM) and dyslipidemia, are accompanied by excess cardiovascular morbi-mortality. Aside from excess low density lipoprotein-cholesterol (LDL-C), atherogenic dyslipidemia (AD), mainly characterized by elevated triglycerides and decreased high density lipoprotein-cholesterol (HDL-C) levels, is often present in T2DM obese patients. Bariatric surgery, such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), has become a reference treatment in that population. However, the respective effects of RYGB vs SG on lipid metabolism in T2DM patients have been rarely studied. Methods: A meta-analysis of randomized controlled trials, comparing the effects of RGYBG vs SG on lipid metabolism 12 months after surgery in T2DM patients, was performed. Results: Four studies including a total of 298 patients (151 patients in the RYGB and 147 patients in the SG group) were examined. Despite a greater decrease in body mass index and greater improvement in glycemic control in RYGB compared to SG. RYGB vs SG was more effective in reducing total cholesterol, LDL-C, and non-HDL-C levels (mean difference [MD] −26.10 mg/dL, 95 % CI −38.88 to −13.50, p<0.00001; [MD] −20.10 mg/dL, 95 % CI −27.90 to −12.20, p<0.00001 and MD 31.90 mg/dl, 95 % CI −46.90 to −16.80, p<0.00001, respectively). Conclusions: The superiority of RYGB vs SG in reducing LDL-C, with an effect comparable to a moderate-intensity statin, suggests RYBG should be favored in hypercholesterolemic T2DM patients in order to further reduce cardiovascular risk.
Fil: Closs, Cecilia Inés. Centro Medico Melian; Argentina
Fil: Ackerman, Marianela. No especifíca;
Fil: Masson, Walter. Hospital Italiano; Argentina
Fil: Lobo, Martin. Sociedad Argentina de Cardiología; Argentina
Fil: Molinero, Graciela. Sociedad Argentina de Cardiología; Argentina
Fil: Lavalle Cobo, Augusto. Sociedad Argentina de Cardiología; Argentina
Fil: Béliard, Sophie. Inserm; Francia
Fil: Mourre, Florian. Inserm; Francia
Fil: Valéro, René. Inserm; Francia
Fil: Nogueira, Juan Patricio. Universidad Nacional de Formosa. Facultad de Ciencias de la Salud. Centro de Investigacion En Endocrinologia, Nutricion y Metabolismo.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
description Introduction: Obesity and its co-morbidities, including type 2 diabetes (T2DM) and dyslipidemia, are accompanied by excess cardiovascular morbi-mortality. Aside from excess low density lipoprotein-cholesterol (LDL-C), atherogenic dyslipidemia (AD), mainly characterized by elevated triglycerides and decreased high density lipoprotein-cholesterol (HDL-C) levels, is often present in T2DM obese patients. Bariatric surgery, such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), has become a reference treatment in that population. However, the respective effects of RYGB vs SG on lipid metabolism in T2DM patients have been rarely studied. Methods: A meta-analysis of randomized controlled trials, comparing the effects of RGYBG vs SG on lipid metabolism 12 months after surgery in T2DM patients, was performed. Results: Four studies including a total of 298 patients (151 patients in the RYGB and 147 patients in the SG group) were examined. Despite a greater decrease in body mass index and greater improvement in glycemic control in RYGB compared to SG. RYGB vs SG was more effective in reducing total cholesterol, LDL-C, and non-HDL-C levels (mean difference [MD] −26.10 mg/dL, 95 % CI −38.88 to −13.50, p<0.00001; [MD] −20.10 mg/dL, 95 % CI −27.90 to −12.20, p<0.00001 and MD 31.90 mg/dl, 95 % CI −46.90 to −16.80, p<0.00001, respectively). Conclusions: The superiority of RYGB vs SG in reducing LDL-C, with an effect comparable to a moderate-intensity statin, suggests RYBG should be favored in hypercholesterolemic T2DM patients in order to further reduce cardiovascular risk.
publishDate 2022
dc.date.none.fl_str_mv 2022-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/216489
Closs, Cecilia Inés; Ackerman, Marianela; Masson, Walter; Lobo, Martin; Molinero, Graciela; et al.; Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis; Springer; Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract.; 26; 8; 5-2022; 1575-1584
1091-255X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/216489
identifier_str_mv Closs, Cecilia Inés; Ackerman, Marianela; Masson, Walter; Lobo, Martin; Molinero, Graciela; et al.; Effectiveness of Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy on Lipid Levels in Type 2 Diabetes: a Meta-analysis; Springer; Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract.; 26; 8; 5-2022; 1575-1584
1091-255X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s11605-022-05338-5
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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