Evaluation of a lyophilized crispr-cas12 assay for a sensitive, specific, and rapid detection of sars-cov-2
- Autores
- Curti, Lucía Ana; Primost, Ivana; Valla, Sofía Aylén; Ibañez Alegre, Daiana Macarena; Olguin Perglione, Cecilia; Repizo, Guillermo Daniel; Lara, María Julia; Parcerisa, Ivana Lorna; Palacios, Antonela Rocio; Llases, María Eugenia; Rinflerch, Adriana Raquel; Barrios, Melanie; Pereyra Bonnet, Federico Alberto; Giménez, Carla Alejandra; Marcone, Débora Natalia
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- We evaluated a lyophilized CRISPR-Cas12 assay for SARS-CoV-2 detection (Lyo-CRISPR SARS-CoV-2 kit) based on reverse transcription, isothermal amplification, and CRISPR-Cas12 reaction. From a total of 210 RNA samples extracted from nasopharyngeal swabs using spin columns, the LyoCRISPR SARS-CoV-2 kit detected 105/105 (100%; 95% confidence interval (CI): 96.55–100) positive samples and 104/105 (99.05%; 95% CI: 94.81–99.97) negative samples that were previously tested using commercial RT-qPCR. The estimated overall Kappa index was 0.991, reflecting an almost perfect concordance level between the two diagnostic tests. An initial validation test was also performed on 30 nasopharyngeal samples collected in lysis buffer, in which the Lyo-CRISPR SARS-CoV-2 kit detected 20/21 (95.24%; 95% CI: 76.18–99.88) positive samples and 9/9 (100%; 95% CI: 66.37–100) negative samples. The estimated Kappa index was 0.923, indicating a strong concordance between the test procedures. The Lyo-CRISPR SARS-CoV-2 kit was suitable for detecting a wide range of RT-qPCR-positive samples (cycle threshold range: 11.45–36.90) and dilutions of heat-inactivated virus (range: 2.5–100 copies/µL); no cross-reaction was observed with the other respiratory pathogens tested. We demonstrated that the performance of the Lyo-CRISPR SARS-CoV-2 kit was similar to that of commercial RT-qPCR, as the former was highly sensitive and specific, timesaving (1.5 h), inexpensive, and did not require sophisticated equipment. The use of this kit would reduce the time taken for diagnosis and facilitate molecular diagnosis in low-resource laboratories.
Fil: Curti, Lucía Ana. Caspr Biotech; Estados Unidos
Fil: Primost, Ivana. Municipalidad de Malvinas Argentinas (buenos Aires). Hospital Municipal de Trauma y Emergencias Doctor Federico Abete.; Argentina
Fil: Valla, Sofía Aylén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Ibañez Alegre, Daiana Macarena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina
Fil: Olguin Perglione, Cecilia. Instituto Nacional de Tecnología Agropecuaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Repizo, Guillermo Daniel. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lara, María Julia. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Parcerisa, Ivana Lorna. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Palacios, Antonela Rocio. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Llases, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Caspr Biotech; Estados Unidos
Fil: Rinflerch, Adriana Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina
Fil: Barrios, Melanie. Instituto de Producción Agropecuaria; Argentina
Fil: Pereyra Bonnet, Federico Alberto. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Giménez, Carla Alejandra. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marcone, Débora Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
COVID-19
CRISPR
DIAGNOSIS
FLUORESCENCE DETECTION
LYSIS BUFFER
SARS-COV-2 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/135603
Ver los metadatos del registro completo
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Evaluation of a lyophilized crispr-cas12 assay for a sensitive, specific, and rapid detection of sars-cov-2Curti, Lucía AnaPrimost, IvanaValla, Sofía AylénIbañez Alegre, Daiana MacarenaOlguin Perglione, CeciliaRepizo, Guillermo DanielLara, María JuliaParcerisa, Ivana LornaPalacios, Antonela RocioLlases, María EugeniaRinflerch, Adriana RaquelBarrios, MelaniePereyra Bonnet, Federico AlbertoGiménez, Carla AlejandraMarcone, Débora NataliaCOVID-19CRISPRDIAGNOSISFLUORESCENCE DETECTIONLYSIS BUFFERSARS-COV-2https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We evaluated a lyophilized CRISPR-Cas12 assay for SARS-CoV-2 detection (Lyo-CRISPR SARS-CoV-2 kit) based on reverse transcription, isothermal amplification, and CRISPR-Cas12 reaction. From a total of 210 RNA samples extracted from nasopharyngeal swabs using spin columns, the LyoCRISPR SARS-CoV-2 kit detected 105/105 (100%; 95% confidence interval (CI): 96.55–100) positive samples and 104/105 (99.05%; 95% CI: 94.81–99.97) negative samples that were previously tested using commercial RT-qPCR. The estimated overall Kappa index was 0.991, reflecting an almost perfect concordance level between the two diagnostic tests. An initial validation test was also performed on 30 nasopharyngeal samples collected in lysis buffer, in which the Lyo-CRISPR SARS-CoV-2 kit detected 20/21 (95.24%; 95% CI: 76.18–99.88) positive samples and 9/9 (100%; 95% CI: 66.37–100) negative samples. The estimated Kappa index was 0.923, indicating a strong concordance between the test procedures. The Lyo-CRISPR SARS-CoV-2 kit was suitable for detecting a wide range of RT-qPCR-positive samples (cycle threshold range: 11.45–36.90) and dilutions of heat-inactivated virus (range: 2.5–100 copies/µL); no cross-reaction was observed with the other respiratory pathogens tested. We demonstrated that the performance of the Lyo-CRISPR SARS-CoV-2 kit was similar to that of commercial RT-qPCR, as the former was highly sensitive and specific, timesaving (1.5 h), inexpensive, and did not require sophisticated equipment. The use of this kit would reduce the time taken for diagnosis and facilitate molecular diagnosis in low-resource laboratories.Fil: Curti, Lucía Ana. Caspr Biotech; Estados UnidosFil: Primost, Ivana. Municipalidad de Malvinas Argentinas (buenos Aires). Hospital Municipal de Trauma y Emergencias Doctor Federico Abete.; ArgentinaFil: Valla, Sofía Aylén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; ArgentinaFil: Ibañez Alegre, Daiana Macarena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; ArgentinaFil: Olguin Perglione, Cecilia. Instituto Nacional de Tecnología Agropecuaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Repizo, Guillermo Daniel. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lara, María Julia. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Parcerisa, Ivana Lorna. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Palacios, Antonela Rocio. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Llases, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Caspr Biotech; Estados UnidosFil: Rinflerch, Adriana Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; ArgentinaFil: Barrios, Melanie. Instituto de Producción Agropecuaria; ArgentinaFil: Pereyra Bonnet, Federico Alberto. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Giménez, Carla Alejandra. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Marcone, Débora Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMultidisciplinary Digital Publishing Institute2021-03-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/135603Curti, Lucía Ana; Primost, Ivana; Valla, Sofía Aylén; Ibañez Alegre, Daiana Macarena; Olguin Perglione, Cecilia; et al.; Evaluation of a lyophilized crispr-cas12 assay for a sensitive, specific, and rapid detection of sars-cov-2; Multidisciplinary Digital Publishing Institute; Viruses; 13; 3; 5-3-2021; 1-91999-4915CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4915/13/3/420info:eu-repo/semantics/altIdentifier/doi/10.3390/v13030420info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:04:06Zoai:ri.conicet.gov.ar:11336/135603instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:04:06.871CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Evaluation of a lyophilized crispr-cas12 assay for a sensitive, specific, and rapid detection of sars-cov-2 |
title |
Evaluation of a lyophilized crispr-cas12 assay for a sensitive, specific, and rapid detection of sars-cov-2 |
spellingShingle |
Evaluation of a lyophilized crispr-cas12 assay for a sensitive, specific, and rapid detection of sars-cov-2 Curti, Lucía Ana COVID-19 CRISPR DIAGNOSIS FLUORESCENCE DETECTION LYSIS BUFFER SARS-COV-2 |
title_short |
Evaluation of a lyophilized crispr-cas12 assay for a sensitive, specific, and rapid detection of sars-cov-2 |
title_full |
Evaluation of a lyophilized crispr-cas12 assay for a sensitive, specific, and rapid detection of sars-cov-2 |
title_fullStr |
Evaluation of a lyophilized crispr-cas12 assay for a sensitive, specific, and rapid detection of sars-cov-2 |
title_full_unstemmed |
Evaluation of a lyophilized crispr-cas12 assay for a sensitive, specific, and rapid detection of sars-cov-2 |
title_sort |
Evaluation of a lyophilized crispr-cas12 assay for a sensitive, specific, and rapid detection of sars-cov-2 |
dc.creator.none.fl_str_mv |
Curti, Lucía Ana Primost, Ivana Valla, Sofía Aylén Ibañez Alegre, Daiana Macarena Olguin Perglione, Cecilia Repizo, Guillermo Daniel Lara, María Julia Parcerisa, Ivana Lorna Palacios, Antonela Rocio Llases, María Eugenia Rinflerch, Adriana Raquel Barrios, Melanie Pereyra Bonnet, Federico Alberto Giménez, Carla Alejandra Marcone, Débora Natalia |
author |
Curti, Lucía Ana |
author_facet |
Curti, Lucía Ana Primost, Ivana Valla, Sofía Aylén Ibañez Alegre, Daiana Macarena Olguin Perglione, Cecilia Repizo, Guillermo Daniel Lara, María Julia Parcerisa, Ivana Lorna Palacios, Antonela Rocio Llases, María Eugenia Rinflerch, Adriana Raquel Barrios, Melanie Pereyra Bonnet, Federico Alberto Giménez, Carla Alejandra Marcone, Débora Natalia |
author_role |
author |
author2 |
Primost, Ivana Valla, Sofía Aylén Ibañez Alegre, Daiana Macarena Olguin Perglione, Cecilia Repizo, Guillermo Daniel Lara, María Julia Parcerisa, Ivana Lorna Palacios, Antonela Rocio Llases, María Eugenia Rinflerch, Adriana Raquel Barrios, Melanie Pereyra Bonnet, Federico Alberto Giménez, Carla Alejandra Marcone, Débora Natalia |
author2_role |
author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
COVID-19 CRISPR DIAGNOSIS FLUORESCENCE DETECTION LYSIS BUFFER SARS-COV-2 |
topic |
COVID-19 CRISPR DIAGNOSIS FLUORESCENCE DETECTION LYSIS BUFFER SARS-COV-2 |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
We evaluated a lyophilized CRISPR-Cas12 assay for SARS-CoV-2 detection (Lyo-CRISPR SARS-CoV-2 kit) based on reverse transcription, isothermal amplification, and CRISPR-Cas12 reaction. From a total of 210 RNA samples extracted from nasopharyngeal swabs using spin columns, the LyoCRISPR SARS-CoV-2 kit detected 105/105 (100%; 95% confidence interval (CI): 96.55–100) positive samples and 104/105 (99.05%; 95% CI: 94.81–99.97) negative samples that were previously tested using commercial RT-qPCR. The estimated overall Kappa index was 0.991, reflecting an almost perfect concordance level between the two diagnostic tests. An initial validation test was also performed on 30 nasopharyngeal samples collected in lysis buffer, in which the Lyo-CRISPR SARS-CoV-2 kit detected 20/21 (95.24%; 95% CI: 76.18–99.88) positive samples and 9/9 (100%; 95% CI: 66.37–100) negative samples. The estimated Kappa index was 0.923, indicating a strong concordance between the test procedures. The Lyo-CRISPR SARS-CoV-2 kit was suitable for detecting a wide range of RT-qPCR-positive samples (cycle threshold range: 11.45–36.90) and dilutions of heat-inactivated virus (range: 2.5–100 copies/µL); no cross-reaction was observed with the other respiratory pathogens tested. We demonstrated that the performance of the Lyo-CRISPR SARS-CoV-2 kit was similar to that of commercial RT-qPCR, as the former was highly sensitive and specific, timesaving (1.5 h), inexpensive, and did not require sophisticated equipment. The use of this kit would reduce the time taken for diagnosis and facilitate molecular diagnosis in low-resource laboratories. Fil: Curti, Lucía Ana. Caspr Biotech; Estados Unidos Fil: Primost, Ivana. Municipalidad de Malvinas Argentinas (buenos Aires). Hospital Municipal de Trauma y Emergencias Doctor Federico Abete.; Argentina Fil: Valla, Sofía Aylén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina Fil: Ibañez Alegre, Daiana Macarena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina Fil: Olguin Perglione, Cecilia. Instituto Nacional de Tecnología Agropecuaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Repizo, Guillermo Daniel. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Lara, María Julia. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Parcerisa, Ivana Lorna. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Palacios, Antonela Rocio. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Llases, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Caspr Biotech; Estados Unidos Fil: Rinflerch, Adriana Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina Fil: Barrios, Melanie. Instituto de Producción Agropecuaria; Argentina Fil: Pereyra Bonnet, Federico Alberto. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Giménez, Carla Alejandra. Caspr Biotech; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Marcone, Débora Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
We evaluated a lyophilized CRISPR-Cas12 assay for SARS-CoV-2 detection (Lyo-CRISPR SARS-CoV-2 kit) based on reverse transcription, isothermal amplification, and CRISPR-Cas12 reaction. From a total of 210 RNA samples extracted from nasopharyngeal swabs using spin columns, the LyoCRISPR SARS-CoV-2 kit detected 105/105 (100%; 95% confidence interval (CI): 96.55–100) positive samples and 104/105 (99.05%; 95% CI: 94.81–99.97) negative samples that were previously tested using commercial RT-qPCR. The estimated overall Kappa index was 0.991, reflecting an almost perfect concordance level between the two diagnostic tests. An initial validation test was also performed on 30 nasopharyngeal samples collected in lysis buffer, in which the Lyo-CRISPR SARS-CoV-2 kit detected 20/21 (95.24%; 95% CI: 76.18–99.88) positive samples and 9/9 (100%; 95% CI: 66.37–100) negative samples. The estimated Kappa index was 0.923, indicating a strong concordance between the test procedures. The Lyo-CRISPR SARS-CoV-2 kit was suitable for detecting a wide range of RT-qPCR-positive samples (cycle threshold range: 11.45–36.90) and dilutions of heat-inactivated virus (range: 2.5–100 copies/µL); no cross-reaction was observed with the other respiratory pathogens tested. We demonstrated that the performance of the Lyo-CRISPR SARS-CoV-2 kit was similar to that of commercial RT-qPCR, as the former was highly sensitive and specific, timesaving (1.5 h), inexpensive, and did not require sophisticated equipment. The use of this kit would reduce the time taken for diagnosis and facilitate molecular diagnosis in low-resource laboratories. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/135603 Curti, Lucía Ana; Primost, Ivana; Valla, Sofía Aylén; Ibañez Alegre, Daiana Macarena; Olguin Perglione, Cecilia; et al.; Evaluation of a lyophilized crispr-cas12 assay for a sensitive, specific, and rapid detection of sars-cov-2; Multidisciplinary Digital Publishing Institute; Viruses; 13; 3; 5-3-2021; 1-9 1999-4915 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/135603 |
identifier_str_mv |
Curti, Lucía Ana; Primost, Ivana; Valla, Sofía Aylén; Ibañez Alegre, Daiana Macarena; Olguin Perglione, Cecilia; et al.; Evaluation of a lyophilized crispr-cas12 assay for a sensitive, specific, and rapid detection of sars-cov-2; Multidisciplinary Digital Publishing Institute; Viruses; 13; 3; 5-3-2021; 1-9 1999-4915 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4915/13/3/420 info:eu-repo/semantics/altIdentifier/doi/10.3390/v13030420 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613864712306688 |
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13.070432 |