Cytotoxic effect of polyvinyl alcohol-magnetite composite

Autores
Baca Ramos, Karla; Olivas Armendáriz, Imelda; Chapa González, Christian; Alvarez, Vera Alejandra; García Casillas, Perla E.
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Polymeric hydrogel is a promising candidate for drug delivery applications due to its ability to encapsulate and release drugs. Incorporating magnetic particles enables controlled and specific release, providing sustained and targeted delivery. This study aimed to assess the cytotoxicity of the magnetite-polyvinyl alcohol (MPVA) hydrogel, specifically its magnetite content, using 3T3 fibroblast cells. The findings indicate that the MPVA hydrogel with magnetite nanoparticles was compatible with the cells and did not induce cell death. Incorporating magnetite nanoparticles into the PVA hydrogel improved its thermal stability and degradation temperature, disrupting the chain order, decreasing melting behavior, and fractional crystallinity of the hydrogel. The MPVA hydrogel demonstrated a higher gel fraction and crosslink density compared to the PVA hydrogel due to the presence of magnetite nanoparticles. The interaction between PVA and magnetite nanoparticles occurred through non-covalent forces, allowing for reversible interactions and dispersion of the nanoparticles within the PVA matrix. Although the cytotoxicity of the MPVA gel was similar to that of the PVA gel, the viability of fibroblast cells within the MPVA gel varied depending on the concentration. The MPVA hydrogel exhibited stronger attachment and induced irregular changes on the cell surface compared to the PVA hydrogel. Furthermore, the MPVA gel displayed paramagnetic behavior and controllable magnetization, as demonstrated by the hysteresis loop. These magnetic properties make the MPVA gel suitable for potential biomedical applications, including drug delivery, tissue engineering, and magnetic resonance imaging (MRI) contrast agents.
Fil: Baca Ramos, Karla. Universidad Auonoma de Ciudad Juarez; México
Fil: Olivas Armendáriz, Imelda. Universidad Auonoma de Ciudad Juarez; México
Fil: Chapa González, Christian. Universidad Auonoma de Ciudad Juarez; México
Fil: Alvarez, Vera Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: García Casillas, Perla E.. Centro de Investigación en Química Aplicada; México
Materia
Cytotoxicity
Hydrogel
Magnetite
Cell interaction
Polyvinyl Alcohol
Composite
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/278315
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/278315
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cytotoxic effect of polyvinyl alcohol-magnetite compositeBaca Ramos, KarlaOlivas Armendáriz, ImeldaChapa González, ChristianAlvarez, Vera AlejandraGarcía Casillas, Perla E.CytotoxicityHydrogelMagnetiteCell interactionPolyvinyl AlcoholCompositehttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Polymeric hydrogel is a promising candidate for drug delivery applications due to its ability to encapsulate and release drugs. Incorporating magnetic particles enables controlled and specific release, providing sustained and targeted delivery. This study aimed to assess the cytotoxicity of the magnetite-polyvinyl alcohol (MPVA) hydrogel, specifically its magnetite content, using 3T3 fibroblast cells. The findings indicate that the MPVA hydrogel with magnetite nanoparticles was compatible with the cells and did not induce cell death. Incorporating magnetite nanoparticles into the PVA hydrogel improved its thermal stability and degradation temperature, disrupting the chain order, decreasing melting behavior, and fractional crystallinity of the hydrogel. The MPVA hydrogel demonstrated a higher gel fraction and crosslink density compared to the PVA hydrogel due to the presence of magnetite nanoparticles. The interaction between PVA and magnetite nanoparticles occurred through non-covalent forces, allowing for reversible interactions and dispersion of the nanoparticles within the PVA matrix. Although the cytotoxicity of the MPVA gel was similar to that of the PVA gel, the viability of fibroblast cells within the MPVA gel varied depending on the concentration. The MPVA hydrogel exhibited stronger attachment and induced irregular changes on the cell surface compared to the PVA hydrogel. Furthermore, the MPVA gel displayed paramagnetic behavior and controllable magnetization, as demonstrated by the hysteresis loop. These magnetic properties make the MPVA gel suitable for potential biomedical applications, including drug delivery, tissue engineering, and magnetic resonance imaging (MRI) contrast agents.Fil: Baca Ramos, Karla. Universidad Auonoma de Ciudad Juarez; MéxicoFil: Olivas Armendáriz, Imelda. Universidad Auonoma de Ciudad Juarez; MéxicoFil: Chapa González, Christian. Universidad Auonoma de Ciudad Juarez; MéxicoFil: Alvarez, Vera Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: García Casillas, Perla E.. Centro de Investigación en Química Aplicada; MéxicoNature2023-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/278315Baca Ramos, Karla; Olivas Armendáriz, Imelda; Chapa González, Christian; Alvarez, Vera Alejandra; García Casillas, Perla E.; Cytotoxic effect of polyvinyl alcohol-magnetite composite; Nature; SN Applied Sciences; 5; 9; 8-2023; 1-102523-3971CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s42452-023-05454-0info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s42452-023-05454-0info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-01-08T12:57:43Zoai:ri.conicet.gov.ar:11336/278315instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-01-08 12:57:43.883CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cytotoxic effect of polyvinyl alcohol-magnetite composite
title Cytotoxic effect of polyvinyl alcohol-magnetite composite
spellingShingle Cytotoxic effect of polyvinyl alcohol-magnetite composite
Baca Ramos, Karla
Cytotoxicity
Hydrogel
Magnetite
Cell interaction
Polyvinyl Alcohol
Composite
title_short Cytotoxic effect of polyvinyl alcohol-magnetite composite
title_full Cytotoxic effect of polyvinyl alcohol-magnetite composite
title_fullStr Cytotoxic effect of polyvinyl alcohol-magnetite composite
title_full_unstemmed Cytotoxic effect of polyvinyl alcohol-magnetite composite
title_sort Cytotoxic effect of polyvinyl alcohol-magnetite composite
dc.creator.none.fl_str_mv Baca Ramos, Karla
Olivas Armendáriz, Imelda
Chapa González, Christian
Alvarez, Vera Alejandra
García Casillas, Perla E.
author Baca Ramos, Karla
author_facet Baca Ramos, Karla
Olivas Armendáriz, Imelda
Chapa González, Christian
Alvarez, Vera Alejandra
García Casillas, Perla E.
author_role author
author2 Olivas Armendáriz, Imelda
Chapa González, Christian
Alvarez, Vera Alejandra
García Casillas, Perla E.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Cytotoxicity
Hydrogel
Magnetite
Cell interaction
Polyvinyl Alcohol
Composite
topic Cytotoxicity
Hydrogel
Magnetite
Cell interaction
Polyvinyl Alcohol
Composite
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Polymeric hydrogel is a promising candidate for drug delivery applications due to its ability to encapsulate and release drugs. Incorporating magnetic particles enables controlled and specific release, providing sustained and targeted delivery. This study aimed to assess the cytotoxicity of the magnetite-polyvinyl alcohol (MPVA) hydrogel, specifically its magnetite content, using 3T3 fibroblast cells. The findings indicate that the MPVA hydrogel with magnetite nanoparticles was compatible with the cells and did not induce cell death. Incorporating magnetite nanoparticles into the PVA hydrogel improved its thermal stability and degradation temperature, disrupting the chain order, decreasing melting behavior, and fractional crystallinity of the hydrogel. The MPVA hydrogel demonstrated a higher gel fraction and crosslink density compared to the PVA hydrogel due to the presence of magnetite nanoparticles. The interaction between PVA and magnetite nanoparticles occurred through non-covalent forces, allowing for reversible interactions and dispersion of the nanoparticles within the PVA matrix. Although the cytotoxicity of the MPVA gel was similar to that of the PVA gel, the viability of fibroblast cells within the MPVA gel varied depending on the concentration. The MPVA hydrogel exhibited stronger attachment and induced irregular changes on the cell surface compared to the PVA hydrogel. Furthermore, the MPVA gel displayed paramagnetic behavior and controllable magnetization, as demonstrated by the hysteresis loop. These magnetic properties make the MPVA gel suitable for potential biomedical applications, including drug delivery, tissue engineering, and magnetic resonance imaging (MRI) contrast agents.
Fil: Baca Ramos, Karla. Universidad Auonoma de Ciudad Juarez; México
Fil: Olivas Armendáriz, Imelda. Universidad Auonoma de Ciudad Juarez; México
Fil: Chapa González, Christian. Universidad Auonoma de Ciudad Juarez; México
Fil: Alvarez, Vera Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: García Casillas, Perla E.. Centro de Investigación en Química Aplicada; México
description Polymeric hydrogel is a promising candidate for drug delivery applications due to its ability to encapsulate and release drugs. Incorporating magnetic particles enables controlled and specific release, providing sustained and targeted delivery. This study aimed to assess the cytotoxicity of the magnetite-polyvinyl alcohol (MPVA) hydrogel, specifically its magnetite content, using 3T3 fibroblast cells. The findings indicate that the MPVA hydrogel with magnetite nanoparticles was compatible with the cells and did not induce cell death. Incorporating magnetite nanoparticles into the PVA hydrogel improved its thermal stability and degradation temperature, disrupting the chain order, decreasing melting behavior, and fractional crystallinity of the hydrogel. The MPVA hydrogel demonstrated a higher gel fraction and crosslink density compared to the PVA hydrogel due to the presence of magnetite nanoparticles. The interaction between PVA and magnetite nanoparticles occurred through non-covalent forces, allowing for reversible interactions and dispersion of the nanoparticles within the PVA matrix. Although the cytotoxicity of the MPVA gel was similar to that of the PVA gel, the viability of fibroblast cells within the MPVA gel varied depending on the concentration. The MPVA hydrogel exhibited stronger attachment and induced irregular changes on the cell surface compared to the PVA hydrogel. Furthermore, the MPVA gel displayed paramagnetic behavior and controllable magnetization, as demonstrated by the hysteresis loop. These magnetic properties make the MPVA gel suitable for potential biomedical applications, including drug delivery, tissue engineering, and magnetic resonance imaging (MRI) contrast agents.
publishDate 2023
dc.date.none.fl_str_mv 2023-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/278315
Baca Ramos, Karla; Olivas Armendáriz, Imelda; Chapa González, Christian; Alvarez, Vera Alejandra; García Casillas, Perla E.; Cytotoxic effect of polyvinyl alcohol-magnetite composite; Nature; SN Applied Sciences; 5; 9; 8-2023; 1-10
2523-3971
CONICET Digital
CONICET
url http://hdl.handle.net/11336/278315
identifier_str_mv Baca Ramos, Karla; Olivas Armendáriz, Imelda; Chapa González, Christian; Alvarez, Vera Alejandra; García Casillas, Perla E.; Cytotoxic effect of polyvinyl alcohol-magnetite composite; Nature; SN Applied Sciences; 5; 9; 8-2023; 1-10
2523-3971
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s42452-023-05454-0
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s42452-023-05454-0
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.747614

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