Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light

Autores
Katz, Maximiliano Javier; Simonetta, Sergio Hernan; Ralph, Martin R.; Golombek, Diego Andrés
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
PP2B is a Ca2+/calmodulin-dependent protein phosphatase that is ubiquitously expressed in mammals. Among other actions, it is an effector mechanism in NMDA-mediated glutamate neurotransmission as well as a regulator of GSK3beta and MAPK signaling cascades. Because all of these mechanisms have demonstrable roles in the control of circadian rhythyms, we hypothesized that PP2B would be a key regulator of rhythm generation and entrainment, and that through inhibition of its phosphatase activity, the circadian system would be affected by immunosuppressant drug therapy. We report here that immunosuppressant drugs (cyclosporin A, FK506) (1) block the circadian responses to light that underlie photic entrainment; (2) produce circadian phase shifts with a characteristic nonphotic profile; and (3) disrupt circadian rhythm expression when applied chronically. These results indicate a role for PP2B in circadian rhythm generation and entrainment. In addition, because rhythm disturbance has been implicated in impairment of both physical and mental health, we suggest that the use of immunosuppressants would be safer and more efficacious if their impacts on circadian rhythmicity were taken into account
Fil: Katz, Maximiliano Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Simonetta, Sergio Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Ralph, Martin R.. University of Toronto; Canadá
Fil: Golombek, Diego Andrés. Universidad Nacional de Quilmes; Argentina
Materia
Calcineurin
Tacrolimus
Circadian
Entrainment
Cyclosporin A
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/29378
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/29378
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to lightKatz, Maximiliano JavierSimonetta, Sergio HernanRalph, Martin R.Golombek, Diego AndrésCalcineurinTacrolimusCircadianEntrainmentCyclosporin Ahttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1PP2B is a Ca2+/calmodulin-dependent protein phosphatase that is ubiquitously expressed in mammals. Among other actions, it is an effector mechanism in NMDA-mediated glutamate neurotransmission as well as a regulator of GSK3beta and MAPK signaling cascades. Because all of these mechanisms have demonstrable roles in the control of circadian rhythyms, we hypothesized that PP2B would be a key regulator of rhythm generation and entrainment, and that through inhibition of its phosphatase activity, the circadian system would be affected by immunosuppressant drug therapy. We report here that immunosuppressant drugs (cyclosporin A, FK506) (1) block the circadian responses to light that underlie photic entrainment; (2) produce circadian phase shifts with a characteristic nonphotic profile; and (3) disrupt circadian rhythm expression when applied chronically. These results indicate a role for PP2B in circadian rhythm generation and entrainment. In addition, because rhythm disturbance has been implicated in impairment of both physical and mental health, we suggest that the use of immunosuppressants would be safer and more efficacious if their impacts on circadian rhythmicity were taken into accountFil: Katz, Maximiliano Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad Nacional de Quilmes; ArgentinaFil: Simonetta, Sergio Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad Nacional de Quilmes; ArgentinaFil: Ralph, Martin R.. University of Toronto; CanadáFil: Golombek, Diego Andrés. Universidad Nacional de Quilmes; ArgentinaElsevier2008-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/29378Katz, Maximiliano Javier; Simonetta, Sergio Hernan; Ralph, Martin R.; Golombek, Diego Andrés; Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light; Elsevier; Pharmacology Biochemistry and Behavior; 90; 4; 10-2008; 763-7680091-30571873-5177CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0091305708002074info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pbb.2008.05.017info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:03Zoai:ri.conicet.gov.ar:11336/29378instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:03.315CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light
title Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light
spellingShingle Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light
Katz, Maximiliano Javier
Calcineurin
Tacrolimus
Circadian
Entrainment
Cyclosporin A
title_short Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light
title_full Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light
title_fullStr Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light
title_full_unstemmed Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light
title_sort Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light
dc.creator.none.fl_str_mv Katz, Maximiliano Javier
Simonetta, Sergio Hernan
Ralph, Martin R.
Golombek, Diego Andrés
author Katz, Maximiliano Javier
author_facet Katz, Maximiliano Javier
Simonetta, Sergio Hernan
Ralph, Martin R.
Golombek, Diego Andrés
author_role author
author2 Simonetta, Sergio Hernan
Ralph, Martin R.
Golombek, Diego Andrés
author2_role author
author
author
dc.subject.none.fl_str_mv Calcineurin
Tacrolimus
Circadian
Entrainment
Cyclosporin A
topic Calcineurin
Tacrolimus
Circadian
Entrainment
Cyclosporin A
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv PP2B is a Ca2+/calmodulin-dependent protein phosphatase that is ubiquitously expressed in mammals. Among other actions, it is an effector mechanism in NMDA-mediated glutamate neurotransmission as well as a regulator of GSK3beta and MAPK signaling cascades. Because all of these mechanisms have demonstrable roles in the control of circadian rhythyms, we hypothesized that PP2B would be a key regulator of rhythm generation and entrainment, and that through inhibition of its phosphatase activity, the circadian system would be affected by immunosuppressant drug therapy. We report here that immunosuppressant drugs (cyclosporin A, FK506) (1) block the circadian responses to light that underlie photic entrainment; (2) produce circadian phase shifts with a characteristic nonphotic profile; and (3) disrupt circadian rhythm expression when applied chronically. These results indicate a role for PP2B in circadian rhythm generation and entrainment. In addition, because rhythm disturbance has been implicated in impairment of both physical and mental health, we suggest that the use of immunosuppressants would be safer and more efficacious if their impacts on circadian rhythmicity were taken into account
Fil: Katz, Maximiliano Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Simonetta, Sergio Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Ralph, Martin R.. University of Toronto; Canadá
Fil: Golombek, Diego Andrés. Universidad Nacional de Quilmes; Argentina
description PP2B is a Ca2+/calmodulin-dependent protein phosphatase that is ubiquitously expressed in mammals. Among other actions, it is an effector mechanism in NMDA-mediated glutamate neurotransmission as well as a regulator of GSK3beta and MAPK signaling cascades. Because all of these mechanisms have demonstrable roles in the control of circadian rhythyms, we hypothesized that PP2B would be a key regulator of rhythm generation and entrainment, and that through inhibition of its phosphatase activity, the circadian system would be affected by immunosuppressant drug therapy. We report here that immunosuppressant drugs (cyclosporin A, FK506) (1) block the circadian responses to light that underlie photic entrainment; (2) produce circadian phase shifts with a characteristic nonphotic profile; and (3) disrupt circadian rhythm expression when applied chronically. These results indicate a role for PP2B in circadian rhythm generation and entrainment. In addition, because rhythm disturbance has been implicated in impairment of both physical and mental health, we suggest that the use of immunosuppressants would be safer and more efficacious if their impacts on circadian rhythmicity were taken into account
publishDate 2008
dc.date.none.fl_str_mv 2008-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/29378
Katz, Maximiliano Javier; Simonetta, Sergio Hernan; Ralph, Martin R.; Golombek, Diego Andrés; Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light; Elsevier; Pharmacology Biochemistry and Behavior; 90; 4; 10-2008; 763-768
0091-3057
1873-5177
CONICET Digital
CONICET
url http://hdl.handle.net/11336/29378
identifier_str_mv Katz, Maximiliano Javier; Simonetta, Sergio Hernan; Ralph, Martin R.; Golombek, Diego Andrés; Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light; Elsevier; Pharmacology Biochemistry and Behavior; 90; 4; 10-2008; 763-768
0091-3057
1873-5177
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0091305708002074
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pbb.2008.05.017
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269261219758080
score 13.13397

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