Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database

Autores
Quarracino, Cecilia; Capani, Francisco; Otero losada, Matilde Estela; Rodríguez, G. E.; Perez Lloret, Santiago
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose: To explore the frequency of orthostatic hypotension (OH) in a large sample of amyotrophic lateral sclerosis patients (ALS).Methods: From the PRO-ACT database, data of 1,240 ALS patients were analyzed, focusing on blood pressure and heart rate before and after standing. OH was defined as a drop in systolic/diastolic blood pressure > 20/10 mm Hg within 3 min of standing. Neurogenic OH was diagnosed when the heart rate increase was below 15 bpm in patients not taking medications that could affect this response.Results: At baseline, 138 (11.1%) patients showed OH, 76.1% of whom had neurogenic OH. At follow-up, 163 patients (13.1%) had OH, 71.2% with neurogenic OH. Only 22.5% of the patients with OH at baseline had OH at follow-up.Conclusion: In a large sample of ALS patients, OH occurred in 11–13%, pointing to a subgroup that might require special care to avoid related complications.
Fil: Quarracino, Cecilia. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Capani, Francisco. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Otero losada, Matilde Estela. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rodríguez, G. E.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Perez Lloret, Santiago. Facultad de Medicina ; Instituto Universitario de Ciencias de la Salud - Fundacion H. A Barcelo; . Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Cátedra de Fisiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
orthostatic hypotension
Pooled Resource Open-Access ALS
Clinical Trials database
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/273097
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/273097
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials databaseQuarracino, CeciliaCapani, FranciscoOtero losada, Matilde EstelaRodríguez, G. E.Perez Lloret, Santiagoorthostatic hypotensionPooled Resource Open-Access ALSClinical Trials databasehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Purpose: To explore the frequency of orthostatic hypotension (OH) in a large sample of amyotrophic lateral sclerosis patients (ALS).Methods: From the PRO-ACT database, data of 1,240 ALS patients were analyzed, focusing on blood pressure and heart rate before and after standing. OH was defined as a drop in systolic/diastolic blood pressure > 20/10 mm Hg within 3 min of standing. Neurogenic OH was diagnosed when the heart rate increase was below 15 bpm in patients not taking medications that could affect this response.Results: At baseline, 138 (11.1%) patients showed OH, 76.1% of whom had neurogenic OH. At follow-up, 163 patients (13.1%) had OH, 71.2% with neurogenic OH. Only 22.5% of the patients with OH at baseline had OH at follow-up.Conclusion: In a large sample of ALS patients, OH occurred in 11–13%, pointing to a subgroup that might require special care to avoid related complications.Fil: Quarracino, Cecilia. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Capani, Francisco. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Otero losada, Matilde Estela. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rodríguez, G. E.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Perez Lloret, Santiago. Facultad de Medicina ; Instituto Universitario de Ciencias de la Salud - Fundacion H. A Barcelo; . Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Cátedra de Fisiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFrontiers Media2025-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/273097Quarracino, Cecilia; Capani, Francisco; Otero losada, Matilde Estela; Rodríguez, G. E.; Perez Lloret, Santiago; Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database; Frontiers Media; Frontiers in Neurology; 16; 1-2025; 1-51664-2295CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fneur.2025.1512357/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2025.1512357info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:24:18Zoai:ri.conicet.gov.ar:11336/273097instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:24:18.481CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database
title Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database
spellingShingle Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database
Quarracino, Cecilia
orthostatic hypotension
Pooled Resource Open-Access ALS
Clinical Trials database
title_short Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database
title_full Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database
title_fullStr Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database
title_full_unstemmed Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database
title_sort Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database
dc.creator.none.fl_str_mv Quarracino, Cecilia
Capani, Francisco
Otero losada, Matilde Estela
Rodríguez, G. E.
Perez Lloret, Santiago
author Quarracino, Cecilia
author_facet Quarracino, Cecilia
Capani, Francisco
Otero losada, Matilde Estela
Rodríguez, G. E.
Perez Lloret, Santiago
author_role author
author2 Capani, Francisco
Otero losada, Matilde Estela
Rodríguez, G. E.
Perez Lloret, Santiago
author2_role author
author
author
author
dc.subject.none.fl_str_mv orthostatic hypotension
Pooled Resource Open-Access ALS
Clinical Trials database
topic orthostatic hypotension
Pooled Resource Open-Access ALS
Clinical Trials database
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Purpose: To explore the frequency of orthostatic hypotension (OH) in a large sample of amyotrophic lateral sclerosis patients (ALS).Methods: From the PRO-ACT database, data of 1,240 ALS patients were analyzed, focusing on blood pressure and heart rate before and after standing. OH was defined as a drop in systolic/diastolic blood pressure > 20/10 mm Hg within 3 min of standing. Neurogenic OH was diagnosed when the heart rate increase was below 15 bpm in patients not taking medications that could affect this response.Results: At baseline, 138 (11.1%) patients showed OH, 76.1% of whom had neurogenic OH. At follow-up, 163 patients (13.1%) had OH, 71.2% with neurogenic OH. Only 22.5% of the patients with OH at baseline had OH at follow-up.Conclusion: In a large sample of ALS patients, OH occurred in 11–13%, pointing to a subgroup that might require special care to avoid related complications.
Fil: Quarracino, Cecilia. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Capani, Francisco. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Otero losada, Matilde Estela. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rodríguez, G. E.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Perez Lloret, Santiago. Facultad de Medicina ; Instituto Universitario de Ciencias de la Salud - Fundacion H. A Barcelo; . Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Cátedra de Fisiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Purpose: To explore the frequency of orthostatic hypotension (OH) in a large sample of amyotrophic lateral sclerosis patients (ALS).Methods: From the PRO-ACT database, data of 1,240 ALS patients were analyzed, focusing on blood pressure and heart rate before and after standing. OH was defined as a drop in systolic/diastolic blood pressure > 20/10 mm Hg within 3 min of standing. Neurogenic OH was diagnosed when the heart rate increase was below 15 bpm in patients not taking medications that could affect this response.Results: At baseline, 138 (11.1%) patients showed OH, 76.1% of whom had neurogenic OH. At follow-up, 163 patients (13.1%) had OH, 71.2% with neurogenic OH. Only 22.5% of the patients with OH at baseline had OH at follow-up.Conclusion: In a large sample of ALS patients, OH occurred in 11–13%, pointing to a subgroup that might require special care to avoid related complications.
publishDate 2025
dc.date.none.fl_str_mv 2025-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/273097
Quarracino, Cecilia; Capani, Francisco; Otero losada, Matilde Estela; Rodríguez, G. E.; Perez Lloret, Santiago; Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database; Frontiers Media; Frontiers in Neurology; 16; 1-2025; 1-5
1664-2295
CONICET Digital
CONICET
url http://hdl.handle.net/11336/273097
identifier_str_mv Quarracino, Cecilia; Capani, Francisco; Otero losada, Matilde Estela; Rodríguez, G. E.; Perez Lloret, Santiago; Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database; Frontiers Media; Frontiers in Neurology; 16; 1-2025; 1-5
1664-2295
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fneur.2025.1512357/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2025.1512357
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082663568375808
score 13.22299

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