Boron compounds used in the first clinical trials in patients with intracranial tumours in the USA

Autores
Portu, Agustina Mariana; Olivera, María Silvina
Año de publicación
2023
Idioma
inglés
Tipo de recurso
parte de libro
Estado
versión publicada
Descripción
A summary of the first clinical trials of BNCT for patients with intracranial tumour1 in the USA from 1951 to 1961 is presented, describing the boron compounds used. Among a considerable amount of boron compounds studied both experimentally and in biodistributions, Sodium tetraborate, sodium pentaborate, p-carboxyphenylboronic acid (PCPB) and sodium closodecahydrodecaborate (GB-10) were chosen for clinical trials. The number of patients, the route of administration, the facility and the clinical outcome are reported.
Fil: Portu, Agustina Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Area de Aplicaciones de la Tecnología Nuclear. Gerencia de Radiobiología (Centro Atómico Constituyentes); Argentina
Fil: Olivera, María Silvina. Comisión Nacional de Energía Atómica; Argentina
Materia
BNCT
FIRST CLINICAL TRIALS
BORON COMPOUNDS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/271531
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/271531
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Boron compounds used in the first clinical trials in patients with intracranial tumours in the USAPortu, Agustina MarianaOlivera, María SilvinaBNCTFIRST CLINICAL TRIALSBORON COMPOUNDShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A summary of the first clinical trials of BNCT for patients with intracranial tumour1 in the USA from 1951 to 1961 is presented, describing the boron compounds used. Among a considerable amount of boron compounds studied both experimentally and in biodistributions, Sodium tetraborate, sodium pentaborate, p-carboxyphenylboronic acid (PCPB) and sodium closodecahydrodecaborate (GB-10) were chosen for clinical trials. The number of patients, the route of administration, the facility and the clinical outcome are reported.Fil: Portu, Agustina Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Area de Aplicaciones de la Tecnología Nuclear. Gerencia de Radiobiología (Centro Atómico Constituyentes); ArgentinaFil: Olivera, María Silvina. Comisión Nacional de Energía Atómica; ArgentinaInternational Atomic Energy AgencySwainson, Ian2023info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookParthttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/271531Portu, Agustina Mariana; Olivera, María Silvina; Boron compounds used in the first clinical trials in patients with intracranial tumours in the USA; International Atomic Energy Agency; 2023; 343-347978-92-0-132623-2CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.iaea.org/publications/15339/advances-in-boron-neutron-capture-therapyinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:55:40Zoai:ri.conicet.gov.ar:11336/271531instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:55:41.157CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Boron compounds used in the first clinical trials in patients with intracranial tumours in the USA
title Boron compounds used in the first clinical trials in patients with intracranial tumours in the USA
spellingShingle Boron compounds used in the first clinical trials in patients with intracranial tumours in the USA
Portu, Agustina Mariana
BNCT
FIRST CLINICAL TRIALS
BORON COMPOUNDS
title_short Boron compounds used in the first clinical trials in patients with intracranial tumours in the USA
title_full Boron compounds used in the first clinical trials in patients with intracranial tumours in the USA
title_fullStr Boron compounds used in the first clinical trials in patients with intracranial tumours in the USA
title_full_unstemmed Boron compounds used in the first clinical trials in patients with intracranial tumours in the USA
title_sort Boron compounds used in the first clinical trials in patients with intracranial tumours in the USA
dc.creator.none.fl_str_mv Portu, Agustina Mariana
Olivera, María Silvina
author Portu, Agustina Mariana
author_facet Portu, Agustina Mariana
Olivera, María Silvina
author_role author
author2 Olivera, María Silvina
author2_role author
dc.contributor.none.fl_str_mv Swainson, Ian
dc.subject.none.fl_str_mv BNCT
FIRST CLINICAL TRIALS
BORON COMPOUNDS
topic BNCT
FIRST CLINICAL TRIALS
BORON COMPOUNDS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A summary of the first clinical trials of BNCT for patients with intracranial tumour1 in the USA from 1951 to 1961 is presented, describing the boron compounds used. Among a considerable amount of boron compounds studied both experimentally and in biodistributions, Sodium tetraborate, sodium pentaborate, p-carboxyphenylboronic acid (PCPB) and sodium closodecahydrodecaborate (GB-10) were chosen for clinical trials. The number of patients, the route of administration, the facility and the clinical outcome are reported.
Fil: Portu, Agustina Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Area de Aplicaciones de la Tecnología Nuclear. Gerencia de Radiobiología (Centro Atómico Constituyentes); Argentina
Fil: Olivera, María Silvina. Comisión Nacional de Energía Atómica; Argentina
description A summary of the first clinical trials of BNCT for patients with intracranial tumour1 in the USA from 1951 to 1961 is presented, describing the boron compounds used. Among a considerable amount of boron compounds studied both experimentally and in biodistributions, Sodium tetraborate, sodium pentaborate, p-carboxyphenylboronic acid (PCPB) and sodium closodecahydrodecaborate (GB-10) were chosen for clinical trials. The number of patients, the route of administration, the facility and the clinical outcome are reported.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/bookPart
http://purl.org/coar/resource_type/c_3248
info:ar-repo/semantics/parteDeLibro
status_str publishedVersion
format bookPart
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/271531
Portu, Agustina Mariana; Olivera, María Silvina; Boron compounds used in the first clinical trials in patients with intracranial tumours in the USA; International Atomic Energy Agency; 2023; 343-347
978-92-0-132623-2
CONICET Digital
CONICET
url http://hdl.handle.net/11336/271531
identifier_str_mv Portu, Agustina Mariana; Olivera, María Silvina; Boron compounds used in the first clinical trials in patients with intracranial tumours in the USA; International Atomic Energy Agency; 2023; 343-347
978-92-0-132623-2
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.iaea.org/publications/15339/advances-in-boron-neutron-capture-therapy
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv International Atomic Energy Agency
publisher.none.fl_str_mv International Atomic Energy Agency
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613676820070400
score 13.070432

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