Influence of proline and β-Cyclodextrin in ketoconazole physicochemical and microbiological performance
- Autores
- Zoppi, Ariana; Buhlman, Natalia; Cerutti, Juan Pablo; Longhi, Marcela Raquel; Aiassa, Virginia
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This investigation presents the characterization and evaluation of the physicochemical and microbiological properties of a new multicomponent complex of ketoconazole. Complex formation of the drug, with proline and β-cyclodextrin, was evaluated using nuclear magnetic resonance and phase solubility studies. The complex, in solid state, was prepared through kneading and physical mixture and then characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry and scanning electron microscopy. By means of confocal laser scanning microscopy, the effect of proline on the morphology of Candida albicans was evaluated. Microbiological assays were performed to evaluate the antifungal activity of the complex against C. albicans. The results obtained from phase solubility assays showed that the complexation of ketoconazole is an effective strategy to enhance its solubility. Confocal laser scanning microscopy demonstrated that proline severely affected Candida morphology, and microbiological studies established high antifungal activity for the complex, signifying an advantage, and therefore, a potential improvement in its application areas.
Fil: Zoppi, Ariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Buhlman, Natalia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Fil: Cerutti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Aiassa, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina - Materia
-
46 Β-CYCLODEXTRIN (PUBCHEM CID: 444041)
ANTIFUNGAL ACTIVITY
KETOCONAZOLE
KETOCONAZOLE (PUBCHEM CID: 47576)
L-PROLINE (PUBCHEM CID: 145742)
MULTICOMPONENT COMPLEX
SOLUBILITY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/126690
Ver los metadatos del registro completo
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spelling |
Influence of proline and β-Cyclodextrin in ketoconazole physicochemical and microbiological performanceZoppi, ArianaBuhlman, NataliaCerutti, Juan PabloLonghi, Marcela RaquelAiassa, Virginia46 Β-CYCLODEXTRIN (PUBCHEM CID: 444041)ANTIFUNGAL ACTIVITYKETOCONAZOLEKETOCONAZOLE (PUBCHEM CID: 47576)L-PROLINE (PUBCHEM CID: 145742)MULTICOMPONENT COMPLEXSOLUBILITYhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2This investigation presents the characterization and evaluation of the physicochemical and microbiological properties of a new multicomponent complex of ketoconazole. Complex formation of the drug, with proline and β-cyclodextrin, was evaluated using nuclear magnetic resonance and phase solubility studies. The complex, in solid state, was prepared through kneading and physical mixture and then characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry and scanning electron microscopy. By means of confocal laser scanning microscopy, the effect of proline on the morphology of Candida albicans was evaluated. Microbiological assays were performed to evaluate the antifungal activity of the complex against C. albicans. The results obtained from phase solubility assays showed that the complexation of ketoconazole is an effective strategy to enhance its solubility. Confocal laser scanning microscopy demonstrated that proline severely affected Candida morphology, and microbiological studies established high antifungal activity for the complex, signifying an advantage, and therefore, a potential improvement in its application areas.Fil: Zoppi, Ariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Buhlman, Natalia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaFil: Cerutti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Aiassa, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaElsevier Science2019-01-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/126690Zoppi, Ariana; Buhlman, Natalia; Cerutti, Juan Pablo; Longhi, Marcela Raquel; Aiassa, Virginia; Influence of proline and β-Cyclodextrin in ketoconazole physicochemical and microbiological performance; Elsevier Science; Journal of Molecular Structure; 1176; 15-1-2019; 470-4770022-2860CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0022286018310433info:eu-repo/semantics/altIdentifier/doi/10.1016/j.molstruc.2018.08.094info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:05Zoai:ri.conicet.gov.ar:11336/126690instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:05.419CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Influence of proline and β-Cyclodextrin in ketoconazole physicochemical and microbiological performance |
title |
Influence of proline and β-Cyclodextrin in ketoconazole physicochemical and microbiological performance |
spellingShingle |
Influence of proline and β-Cyclodextrin in ketoconazole physicochemical and microbiological performance Zoppi, Ariana 46 Β-CYCLODEXTRIN (PUBCHEM CID: 444041) ANTIFUNGAL ACTIVITY KETOCONAZOLE KETOCONAZOLE (PUBCHEM CID: 47576) L-PROLINE (PUBCHEM CID: 145742) MULTICOMPONENT COMPLEX SOLUBILITY |
title_short |
Influence of proline and β-Cyclodextrin in ketoconazole physicochemical and microbiological performance |
title_full |
Influence of proline and β-Cyclodextrin in ketoconazole physicochemical and microbiological performance |
title_fullStr |
Influence of proline and β-Cyclodextrin in ketoconazole physicochemical and microbiological performance |
title_full_unstemmed |
Influence of proline and β-Cyclodextrin in ketoconazole physicochemical and microbiological performance |
title_sort |
Influence of proline and β-Cyclodextrin in ketoconazole physicochemical and microbiological performance |
dc.creator.none.fl_str_mv |
Zoppi, Ariana Buhlman, Natalia Cerutti, Juan Pablo Longhi, Marcela Raquel Aiassa, Virginia |
author |
Zoppi, Ariana |
author_facet |
Zoppi, Ariana Buhlman, Natalia Cerutti, Juan Pablo Longhi, Marcela Raquel Aiassa, Virginia |
author_role |
author |
author2 |
Buhlman, Natalia Cerutti, Juan Pablo Longhi, Marcela Raquel Aiassa, Virginia |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
46 Β-CYCLODEXTRIN (PUBCHEM CID: 444041) ANTIFUNGAL ACTIVITY KETOCONAZOLE KETOCONAZOLE (PUBCHEM CID: 47576) L-PROLINE (PUBCHEM CID: 145742) MULTICOMPONENT COMPLEX SOLUBILITY |
topic |
46 Β-CYCLODEXTRIN (PUBCHEM CID: 444041) ANTIFUNGAL ACTIVITY KETOCONAZOLE KETOCONAZOLE (PUBCHEM CID: 47576) L-PROLINE (PUBCHEM CID: 145742) MULTICOMPONENT COMPLEX SOLUBILITY |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.10 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
This investigation presents the characterization and evaluation of the physicochemical and microbiological properties of a new multicomponent complex of ketoconazole. Complex formation of the drug, with proline and β-cyclodextrin, was evaluated using nuclear magnetic resonance and phase solubility studies. The complex, in solid state, was prepared through kneading and physical mixture and then characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry and scanning electron microscopy. By means of confocal laser scanning microscopy, the effect of proline on the morphology of Candida albicans was evaluated. Microbiological assays were performed to evaluate the antifungal activity of the complex against C. albicans. The results obtained from phase solubility assays showed that the complexation of ketoconazole is an effective strategy to enhance its solubility. Confocal laser scanning microscopy demonstrated that proline severely affected Candida morphology, and microbiological studies established high antifungal activity for the complex, signifying an advantage, and therefore, a potential improvement in its application areas. Fil: Zoppi, Ariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Buhlman, Natalia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina Fil: Cerutti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Aiassa, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina |
description |
This investigation presents the characterization and evaluation of the physicochemical and microbiological properties of a new multicomponent complex of ketoconazole. Complex formation of the drug, with proline and β-cyclodextrin, was evaluated using nuclear magnetic resonance and phase solubility studies. The complex, in solid state, was prepared through kneading and physical mixture and then characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry and scanning electron microscopy. By means of confocal laser scanning microscopy, the effect of proline on the morphology of Candida albicans was evaluated. Microbiological assays were performed to evaluate the antifungal activity of the complex against C. albicans. The results obtained from phase solubility assays showed that the complexation of ketoconazole is an effective strategy to enhance its solubility. Confocal laser scanning microscopy demonstrated that proline severely affected Candida morphology, and microbiological studies established high antifungal activity for the complex, signifying an advantage, and therefore, a potential improvement in its application areas. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-15 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/126690 Zoppi, Ariana; Buhlman, Natalia; Cerutti, Juan Pablo; Longhi, Marcela Raquel; Aiassa, Virginia; Influence of proline and β-Cyclodextrin in ketoconazole physicochemical and microbiological performance; Elsevier Science; Journal of Molecular Structure; 1176; 15-1-2019; 470-477 0022-2860 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/126690 |
identifier_str_mv |
Zoppi, Ariana; Buhlman, Natalia; Cerutti, Juan Pablo; Longhi, Marcela Raquel; Aiassa, Virginia; Influence of proline and β-Cyclodextrin in ketoconazole physicochemical and microbiological performance; Elsevier Science; Journal of Molecular Structure; 1176; 15-1-2019; 470-477 0022-2860 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0022286018310433 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.molstruc.2018.08.094 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842270105597116416 |
score |
13.13397 |