Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties

Autores
Luque, Gisela Carina; Moya, Melissa; Picchio, Matías Luis; Bagnarello, Vanessa; Valerio, Idalia; Balaños, José; Gamboa, Sue H.; Tomé, Liliana C.; Minari, Roque Javier; Mecerreyes, David
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
There is an actual need for developing materials for wound healing applications with anti-inflammatory, antioxidant, or antibacterial properties in order to improve the healing performance. In this work, we report the preparation and characterization of soft and bioactive iongel materials for patches, based on polymeric poly(vinyl alcohol) (PVA) and four ionic liquids containing the cholinium cation and different phenolic acid anions, namely cholinium salicylate ([Ch][Sal]), cholinium gallate ([Ch][Ga]), cholinium vanillate ([Ch][Van]), and cholinium caffeate ([Ch][Caff]). Within the iongels, the phenolic motif in the ionic liquids plays a dual role, acting as a PVA crosslinker and a bioactive compound. The obtained iongels are flexible, elastic, ionic conducting, and thermoreversible materials. Moreover, the iongels demonstrated high biocompatibility, non-hemolytic activity, and non-agglutination in mice blood, which are key-sought material specifications in wound healing applications. All the iongels have shown antibacterial properties, being PVA-[Ch][Sal], the one with higher inhibition halo for Escherichia Coli. The iongels also revealed high values of antioxidant activity due to the presence of the polyphenol, with the PVA-[Ch][Van] iongel having the highest activity. Finally, the iongels show a decrease in NO production in LPS-stimulated macrophages, with the PVA-[Ch][Sal] iongel displaying the best anti-inflammatory activity (>63% at 200 µg/mL).
Fil: Luque, Gisela Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Moya, Melissa. Universidad de Ciencias Médicas; Costa Rica
Fil: Picchio, Matías Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad del País Vasco. Polymat; España
Fil: Bagnarello, Vanessa. Universidad de Ciencias Médicas; Costa Rica
Fil: Valerio, Idalia. Universidad de Ciencias Médicas; Costa Rica
Fil: Balaños, José. Universidad de Ciencias Médicas; Costa Rica
Fil: Gamboa, Sue H.. Universidad de Ciencias Médicas; Costa Rica
Fil: Tomé, Liliana C.. Universidade Nova de Lisboa; Portugal
Fil: Minari, Roque Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina
Fil: Mecerreyes, David. Ikerbasque; España. Universidad del País Vasco. Polymat; España
Materia
BIOCOMPATIBLE IONIC LIQUIDS
IONGELS
WOUND HEALING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/225639
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/225639
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory PropertiesLuque, Gisela CarinaMoya, MelissaPicchio, Matías LuisBagnarello, VanessaValerio, IdaliaBalaños, JoséGamboa, Sue H.Tomé, Liliana C.Minari, Roque JavierMecerreyes, DavidBIOCOMPATIBLE IONIC LIQUIDSIONGELSWOUND HEALINGhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2There is an actual need for developing materials for wound healing applications with anti-inflammatory, antioxidant, or antibacterial properties in order to improve the healing performance. In this work, we report the preparation and characterization of soft and bioactive iongel materials for patches, based on polymeric poly(vinyl alcohol) (PVA) and four ionic liquids containing the cholinium cation and different phenolic acid anions, namely cholinium salicylate ([Ch][Sal]), cholinium gallate ([Ch][Ga]), cholinium vanillate ([Ch][Van]), and cholinium caffeate ([Ch][Caff]). Within the iongels, the phenolic motif in the ionic liquids plays a dual role, acting as a PVA crosslinker and a bioactive compound. The obtained iongels are flexible, elastic, ionic conducting, and thermoreversible materials. Moreover, the iongels demonstrated high biocompatibility, non-hemolytic activity, and non-agglutination in mice blood, which are key-sought material specifications in wound healing applications. All the iongels have shown antibacterial properties, being PVA-[Ch][Sal], the one with higher inhibition halo for Escherichia Coli. The iongels also revealed high values of antioxidant activity due to the presence of the polyphenol, with the PVA-[Ch][Van] iongel having the highest activity. Finally, the iongels show a decrease in NO production in LPS-stimulated macrophages, with the PVA-[Ch][Sal] iongel displaying the best anti-inflammatory activity (>63% at 200 µg/mL).Fil: Luque, Gisela Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Moya, Melissa. Universidad de Ciencias Médicas; Costa RicaFil: Picchio, Matías Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad del País Vasco. Polymat; EspañaFil: Bagnarello, Vanessa. Universidad de Ciencias Médicas; Costa RicaFil: Valerio, Idalia. Universidad de Ciencias Médicas; Costa RicaFil: Balaños, José. Universidad de Ciencias Médicas; Costa RicaFil: Gamboa, Sue H.. Universidad de Ciencias Médicas; Costa RicaFil: Tomé, Liliana C.. Universidade Nova de Lisboa; PortugalFil: Minari, Roque Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química; ArgentinaFil: Mecerreyes, David. Ikerbasque; España. Universidad del País Vasco. Polymat; EspañaMultidisciplinary Digital Publishing Institute2023-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/225639Luque, Gisela Carina; Moya, Melissa; Picchio, Matías Luis; Bagnarello, Vanessa; Valerio, Idalia; et al.; Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties; Multidisciplinary Digital Publishing Institute; Polymers; 15; 5; 3-2023; 1-162073-4360CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/polym15051076info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4360/15/5/1076info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:13:50Zoai:ri.conicet.gov.ar:11336/225639instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:13:50.346CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties
title Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties
spellingShingle Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties
Luque, Gisela Carina
BIOCOMPATIBLE IONIC LIQUIDS
IONGELS
WOUND HEALING
title_short Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties
title_full Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties
title_fullStr Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties
title_full_unstemmed Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties
title_sort Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties
dc.creator.none.fl_str_mv Luque, Gisela Carina
Moya, Melissa
Picchio, Matías Luis
Bagnarello, Vanessa
Valerio, Idalia
Balaños, José
Gamboa, Sue H.
Tomé, Liliana C.
Minari, Roque Javier
Mecerreyes, David
author Luque, Gisela Carina
author_facet Luque, Gisela Carina
Moya, Melissa
Picchio, Matías Luis
Bagnarello, Vanessa
Valerio, Idalia
Balaños, José
Gamboa, Sue H.
Tomé, Liliana C.
Minari, Roque Javier
Mecerreyes, David
author_role author
author2 Moya, Melissa
Picchio, Matías Luis
Bagnarello, Vanessa
Valerio, Idalia
Balaños, José
Gamboa, Sue H.
Tomé, Liliana C.
Minari, Roque Javier
Mecerreyes, David
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BIOCOMPATIBLE IONIC LIQUIDS
IONGELS
WOUND HEALING
topic BIOCOMPATIBLE IONIC LIQUIDS
IONGELS
WOUND HEALING
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv There is an actual need for developing materials for wound healing applications with anti-inflammatory, antioxidant, or antibacterial properties in order to improve the healing performance. In this work, we report the preparation and characterization of soft and bioactive iongel materials for patches, based on polymeric poly(vinyl alcohol) (PVA) and four ionic liquids containing the cholinium cation and different phenolic acid anions, namely cholinium salicylate ([Ch][Sal]), cholinium gallate ([Ch][Ga]), cholinium vanillate ([Ch][Van]), and cholinium caffeate ([Ch][Caff]). Within the iongels, the phenolic motif in the ionic liquids plays a dual role, acting as a PVA crosslinker and a bioactive compound. The obtained iongels are flexible, elastic, ionic conducting, and thermoreversible materials. Moreover, the iongels demonstrated high biocompatibility, non-hemolytic activity, and non-agglutination in mice blood, which are key-sought material specifications in wound healing applications. All the iongels have shown antibacterial properties, being PVA-[Ch][Sal], the one with higher inhibition halo for Escherichia Coli. The iongels also revealed high values of antioxidant activity due to the presence of the polyphenol, with the PVA-[Ch][Van] iongel having the highest activity. Finally, the iongels show a decrease in NO production in LPS-stimulated macrophages, with the PVA-[Ch][Sal] iongel displaying the best anti-inflammatory activity (>63% at 200 µg/mL).
Fil: Luque, Gisela Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Moya, Melissa. Universidad de Ciencias Médicas; Costa Rica
Fil: Picchio, Matías Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad del País Vasco. Polymat; España
Fil: Bagnarello, Vanessa. Universidad de Ciencias Médicas; Costa Rica
Fil: Valerio, Idalia. Universidad de Ciencias Médicas; Costa Rica
Fil: Balaños, José. Universidad de Ciencias Médicas; Costa Rica
Fil: Gamboa, Sue H.. Universidad de Ciencias Médicas; Costa Rica
Fil: Tomé, Liliana C.. Universidade Nova de Lisboa; Portugal
Fil: Minari, Roque Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina
Fil: Mecerreyes, David. Ikerbasque; España. Universidad del País Vasco. Polymat; España
description There is an actual need for developing materials for wound healing applications with anti-inflammatory, antioxidant, or antibacterial properties in order to improve the healing performance. In this work, we report the preparation and characterization of soft and bioactive iongel materials for patches, based on polymeric poly(vinyl alcohol) (PVA) and four ionic liquids containing the cholinium cation and different phenolic acid anions, namely cholinium salicylate ([Ch][Sal]), cholinium gallate ([Ch][Ga]), cholinium vanillate ([Ch][Van]), and cholinium caffeate ([Ch][Caff]). Within the iongels, the phenolic motif in the ionic liquids plays a dual role, acting as a PVA crosslinker and a bioactive compound. The obtained iongels are flexible, elastic, ionic conducting, and thermoreversible materials. Moreover, the iongels demonstrated high biocompatibility, non-hemolytic activity, and non-agglutination in mice blood, which are key-sought material specifications in wound healing applications. All the iongels have shown antibacterial properties, being PVA-[Ch][Sal], the one with higher inhibition halo for Escherichia Coli. The iongels also revealed high values of antioxidant activity due to the presence of the polyphenol, with the PVA-[Ch][Van] iongel having the highest activity. Finally, the iongels show a decrease in NO production in LPS-stimulated macrophages, with the PVA-[Ch][Sal] iongel displaying the best anti-inflammatory activity (>63% at 200 µg/mL).
publishDate 2023
dc.date.none.fl_str_mv 2023-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/225639
Luque, Gisela Carina; Moya, Melissa; Picchio, Matías Luis; Bagnarello, Vanessa; Valerio, Idalia; et al.; Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties; Multidisciplinary Digital Publishing Institute; Polymers; 15; 5; 3-2023; 1-16
2073-4360
CONICET Digital
CONICET
url http://hdl.handle.net/11336/225639
identifier_str_mv Luque, Gisela Carina; Moya, Melissa; Picchio, Matías Luis; Bagnarello, Vanessa; Valerio, Idalia; et al.; Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties; Multidisciplinary Digital Publishing Institute; Polymers; 15; 5; 3-2023; 1-16
2073-4360
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/polym15051076
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4360/15/5/1076
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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