Phantom percepts: Tinnitus and pain as persisting aversive memory networks

Autores
De Ridder, Dirk; Elgoyhen, Ana Belen; Romo, Ranulfo; Langguth, Berthold
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Phantomperception refers to the conscious awareness of a percept in the absence of an external stimulus. On the basis of basic neuroscience on perception and clinical research in phantom pain and phantom sound, we propose a working model for their origin. Sensory deafferentation results in high-frequency, gamma band, synchronized neuronal activity in the sensory cortex. This activity becomes a conscious percept only if it is connected to larger coactivated "(self-)awareness" and "salience" brain networks. Through the involvement of learning mechanisms, the phantom percept becomes associated to distress, which in turn is reflected by a simultaneously coactivated nonspecific distress network consisting of the anterior cingulate cortex, anterior insula, and amygdala. Memory mechanisms play a role in the persistence of the awareness of the phantom percept, as well as in the reinforcement of the associated distress. Thus, different dynamic overlapping brain networks should be considered as targets for the treatment of this disorder.
Fil: De Ridder, Dirk. University Hospital Antwerp; Bélgica
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Romo, Ranulfo. Universidad Nacional Autónoma de México; México
Fil: Langguth, Berthold. Universitat Regensburg; Alemania
Materia
Tinnitus
Perception
Phantoms
Pain
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79433
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Phantom percepts: Tinnitus and pain as persisting aversive memory networksDe Ridder, DirkElgoyhen, Ana BelenRomo, RanulfoLangguth, BertholdTinnitusPerceptionPhantomsPainhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Phantomperception refers to the conscious awareness of a percept in the absence of an external stimulus. On the basis of basic neuroscience on perception and clinical research in phantom pain and phantom sound, we propose a working model for their origin. Sensory deafferentation results in high-frequency, gamma band, synchronized neuronal activity in the sensory cortex. This activity becomes a conscious percept only if it is connected to larger coactivated "(self-)awareness" and "salience" brain networks. Through the involvement of learning mechanisms, the phantom percept becomes associated to distress, which in turn is reflected by a simultaneously coactivated nonspecific distress network consisting of the anterior cingulate cortex, anterior insula, and amygdala. Memory mechanisms play a role in the persistence of the awareness of the phantom percept, as well as in the reinforcement of the associated distress. Thus, different dynamic overlapping brain networks should be considered as targets for the treatment of this disorder.Fil: De Ridder, Dirk. University Hospital Antwerp; BélgicaFil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Romo, Ranulfo. Universidad Nacional Autónoma de México; MéxicoFil: Langguth, Berthold. Universitat Regensburg; AlemaniaNational Academy of Sciences2011-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79433De Ridder, Dirk; Elgoyhen, Ana Belen; Romo, Ranulfo; Langguth, Berthold; Phantom percepts: Tinnitus and pain as persisting aversive memory networks; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 108; 20; 5-2011; 8075-80800027-8424CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.1018466108info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/content/108/20/8075info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:06:13Zoai:ri.conicet.gov.ar:11336/79433instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:06:14.181CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Phantom percepts: Tinnitus and pain as persisting aversive memory networks
title Phantom percepts: Tinnitus and pain as persisting aversive memory networks
spellingShingle Phantom percepts: Tinnitus and pain as persisting aversive memory networks
De Ridder, Dirk
Tinnitus
Perception
Phantoms
Pain
title_short Phantom percepts: Tinnitus and pain as persisting aversive memory networks
title_full Phantom percepts: Tinnitus and pain as persisting aversive memory networks
title_fullStr Phantom percepts: Tinnitus and pain as persisting aversive memory networks
title_full_unstemmed Phantom percepts: Tinnitus and pain as persisting aversive memory networks
title_sort Phantom percepts: Tinnitus and pain as persisting aversive memory networks
dc.creator.none.fl_str_mv De Ridder, Dirk
Elgoyhen, Ana Belen
Romo, Ranulfo
Langguth, Berthold
author De Ridder, Dirk
author_facet De Ridder, Dirk
Elgoyhen, Ana Belen
Romo, Ranulfo
Langguth, Berthold
author_role author
author2 Elgoyhen, Ana Belen
Romo, Ranulfo
Langguth, Berthold
author2_role author
author
author
dc.subject.none.fl_str_mv Tinnitus
Perception
Phantoms
Pain
topic Tinnitus
Perception
Phantoms
Pain
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Phantomperception refers to the conscious awareness of a percept in the absence of an external stimulus. On the basis of basic neuroscience on perception and clinical research in phantom pain and phantom sound, we propose a working model for their origin. Sensory deafferentation results in high-frequency, gamma band, synchronized neuronal activity in the sensory cortex. This activity becomes a conscious percept only if it is connected to larger coactivated "(self-)awareness" and "salience" brain networks. Through the involvement of learning mechanisms, the phantom percept becomes associated to distress, which in turn is reflected by a simultaneously coactivated nonspecific distress network consisting of the anterior cingulate cortex, anterior insula, and amygdala. Memory mechanisms play a role in the persistence of the awareness of the phantom percept, as well as in the reinforcement of the associated distress. Thus, different dynamic overlapping brain networks should be considered as targets for the treatment of this disorder.
Fil: De Ridder, Dirk. University Hospital Antwerp; Bélgica
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Romo, Ranulfo. Universidad Nacional Autónoma de México; México
Fil: Langguth, Berthold. Universitat Regensburg; Alemania
description Phantomperception refers to the conscious awareness of a percept in the absence of an external stimulus. On the basis of basic neuroscience on perception and clinical research in phantom pain and phantom sound, we propose a working model for their origin. Sensory deafferentation results in high-frequency, gamma band, synchronized neuronal activity in the sensory cortex. This activity becomes a conscious percept only if it is connected to larger coactivated "(self-)awareness" and "salience" brain networks. Through the involvement of learning mechanisms, the phantom percept becomes associated to distress, which in turn is reflected by a simultaneously coactivated nonspecific distress network consisting of the anterior cingulate cortex, anterior insula, and amygdala. Memory mechanisms play a role in the persistence of the awareness of the phantom percept, as well as in the reinforcement of the associated distress. Thus, different dynamic overlapping brain networks should be considered as targets for the treatment of this disorder.
publishDate 2011
dc.date.none.fl_str_mv 2011-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79433
De Ridder, Dirk; Elgoyhen, Ana Belen; Romo, Ranulfo; Langguth, Berthold; Phantom percepts: Tinnitus and pain as persisting aversive memory networks; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 108; 20; 5-2011; 8075-8080
0027-8424
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79433
identifier_str_mv De Ridder, Dirk; Elgoyhen, Ana Belen; Romo, Ranulfo; Langguth, Berthold; Phantom percepts: Tinnitus and pain as persisting aversive memory networks; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 108; 20; 5-2011; 8075-8080
0027-8424
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.1018466108
info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/content/108/20/8075
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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