Endometrial CD16(+) and CD16(-) NK cell count in fertility and unexplained infertility

Autores
Junovich, Gisela Yael; Azpiroz, Maria Agustina; Incera, Maria Eugenia; Ferrer, Maria Constanza; Pasqualini, Rodolfo Agustin; Gutierrez, Gabriela Lidia
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Problem: Peripheral counts of CD16+ NK cells have been well characterized in reproductive failure. However, not enough case-control clinical studies have been conducted to establish normal or abnormal CD16+/- values in the endometrium. Method of Study: Peripheral and endometrial NK cell counts by FACS, IL-6 and VEGF cytokines levels by ELISA were characterized in fertile women and unexplained infertility patients with implantation failures (UI-IF) during implantation window. ROC and correlation analysis were performed. Results: ROC analysis revealed endometrial CD16+ NK cells, IL-6 and VEGF as good diagnostic parameters for unexplained infertility. Almost half of UI-FI patients showed increased total and CD16+ NK cell counts correlating with decreased levels of endometrial IL-6 and VEGF. No correlation was found with peripheral blood values. Conclusions: Increased CD16+ NK cells were associated to IL-6 and VEGF deficiency in a high proportion of UI-IF patients. Testing for these immunomarkers could be a potential tool in infertility diagnosis.
Fil: Junovich, Gisela Yael. Halitus Instituto Medico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Azpiroz, Maria Agustina. Halitus Instituto Medico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Incera, Maria Eugenia. Halitus Instituto Medico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferrer, Maria Constanza. Centro de Investigación de la Fundación Repro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pasqualini, Rodolfo Agustin. Halitus Instituto Medico; Argentina
Fil: Gutierrez, Gabriela Lidia. Centro de Investigación de la Fundación Repro; Argentina. Halitus Instituto Medico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Endometrium
Nk
Implantation
Infertility
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/26595
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/26595
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Endometrial CD16(+) and CD16(-) NK cell count in fertility and unexplained infertilityJunovich, Gisela YaelAzpiroz, Maria AgustinaIncera, Maria EugeniaFerrer, Maria ConstanzaPasqualini, Rodolfo AgustinGutierrez, Gabriela LidiaEndometriumNkImplantationInfertilityhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Problem: Peripheral counts of CD16+ NK cells have been well characterized in reproductive failure. However, not enough case-control clinical studies have been conducted to establish normal or abnormal CD16+/- values in the endometrium. Method of Study: Peripheral and endometrial NK cell counts by FACS, IL-6 and VEGF cytokines levels by ELISA were characterized in fertile women and unexplained infertility patients with implantation failures (UI-IF) during implantation window. ROC and correlation analysis were performed. Results: ROC analysis revealed endometrial CD16+ NK cells, IL-6 and VEGF as good diagnostic parameters for unexplained infertility. Almost half of UI-FI patients showed increased total and CD16+ NK cell counts correlating with decreased levels of endometrial IL-6 and VEGF. No correlation was found with peripheral blood values. Conclusions: Increased CD16+ NK cells were associated to IL-6 and VEGF deficiency in a high proportion of UI-IF patients. Testing for these immunomarkers could be a potential tool in infertility diagnosis.Fil: Junovich, Gisela Yael. Halitus Instituto Medico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Azpiroz, Maria Agustina. Halitus Instituto Medico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Incera, Maria Eugenia. Halitus Instituto Medico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ferrer, Maria Constanza. Centro de Investigación de la Fundación Repro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pasqualini, Rodolfo Agustin. Halitus Instituto Medico; ArgentinaFil: Gutierrez, Gabriela Lidia. Centro de Investigación de la Fundación Repro; Argentina. Halitus Instituto Medico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley2013-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/26595Junovich, Gisela Yael; Azpiroz, Maria Agustina; Incera, Maria Eugenia; Ferrer, Maria Constanza; Pasqualini, Rodolfo Agustin; et al.; Endometrial CD16(+) and CD16(-) NK cell count in fertility and unexplained infertility; Wiley; American Journal of Reproductive Immunology; 70; 3; 5-2013; 282-2898755-89201600-0897CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/aji.12132/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1111/aji.12132info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:11:51Zoai:ri.conicet.gov.ar:11336/26595instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:11:51.657CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Endometrial CD16(+) and CD16(-) NK cell count in fertility and unexplained infertility
title Endometrial CD16(+) and CD16(-) NK cell count in fertility and unexplained infertility
spellingShingle Endometrial CD16(+) and CD16(-) NK cell count in fertility and unexplained infertility
Junovich, Gisela Yael
Endometrium
Nk
Implantation
Infertility
title_short Endometrial CD16(+) and CD16(-) NK cell count in fertility and unexplained infertility
title_full Endometrial CD16(+) and CD16(-) NK cell count in fertility and unexplained infertility
title_fullStr Endometrial CD16(+) and CD16(-) NK cell count in fertility and unexplained infertility
title_full_unstemmed Endometrial CD16(+) and CD16(-) NK cell count in fertility and unexplained infertility
title_sort Endometrial CD16(+) and CD16(-) NK cell count in fertility and unexplained infertility
dc.creator.none.fl_str_mv Junovich, Gisela Yael
Azpiroz, Maria Agustina
Incera, Maria Eugenia
Ferrer, Maria Constanza
Pasqualini, Rodolfo Agustin
Gutierrez, Gabriela Lidia
author Junovich, Gisela Yael
author_facet Junovich, Gisela Yael
Azpiroz, Maria Agustina
Incera, Maria Eugenia
Ferrer, Maria Constanza
Pasqualini, Rodolfo Agustin
Gutierrez, Gabriela Lidia
author_role author
author2 Azpiroz, Maria Agustina
Incera, Maria Eugenia
Ferrer, Maria Constanza
Pasqualini, Rodolfo Agustin
Gutierrez, Gabriela Lidia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Endometrium
Nk
Implantation
Infertility
topic Endometrium
Nk
Implantation
Infertility
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Problem: Peripheral counts of CD16+ NK cells have been well characterized in reproductive failure. However, not enough case-control clinical studies have been conducted to establish normal or abnormal CD16+/- values in the endometrium. Method of Study: Peripheral and endometrial NK cell counts by FACS, IL-6 and VEGF cytokines levels by ELISA were characterized in fertile women and unexplained infertility patients with implantation failures (UI-IF) during implantation window. ROC and correlation analysis were performed. Results: ROC analysis revealed endometrial CD16+ NK cells, IL-6 and VEGF as good diagnostic parameters for unexplained infertility. Almost half of UI-FI patients showed increased total and CD16+ NK cell counts correlating with decreased levels of endometrial IL-6 and VEGF. No correlation was found with peripheral blood values. Conclusions: Increased CD16+ NK cells were associated to IL-6 and VEGF deficiency in a high proportion of UI-IF patients. Testing for these immunomarkers could be a potential tool in infertility diagnosis.
Fil: Junovich, Gisela Yael. Halitus Instituto Medico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Azpiroz, Maria Agustina. Halitus Instituto Medico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Incera, Maria Eugenia. Halitus Instituto Medico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferrer, Maria Constanza. Centro de Investigación de la Fundación Repro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pasqualini, Rodolfo Agustin. Halitus Instituto Medico; Argentina
Fil: Gutierrez, Gabriela Lidia. Centro de Investigación de la Fundación Repro; Argentina. Halitus Instituto Medico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Problem: Peripheral counts of CD16+ NK cells have been well characterized in reproductive failure. However, not enough case-control clinical studies have been conducted to establish normal or abnormal CD16+/- values in the endometrium. Method of Study: Peripheral and endometrial NK cell counts by FACS, IL-6 and VEGF cytokines levels by ELISA were characterized in fertile women and unexplained infertility patients with implantation failures (UI-IF) during implantation window. ROC and correlation analysis were performed. Results: ROC analysis revealed endometrial CD16+ NK cells, IL-6 and VEGF as good diagnostic parameters for unexplained infertility. Almost half of UI-FI patients showed increased total and CD16+ NK cell counts correlating with decreased levels of endometrial IL-6 and VEGF. No correlation was found with peripheral blood values. Conclusions: Increased CD16+ NK cells were associated to IL-6 and VEGF deficiency in a high proportion of UI-IF patients. Testing for these immunomarkers could be a potential tool in infertility diagnosis.
publishDate 2013
dc.date.none.fl_str_mv 2013-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/26595
Junovich, Gisela Yael; Azpiroz, Maria Agustina; Incera, Maria Eugenia; Ferrer, Maria Constanza; Pasqualini, Rodolfo Agustin; et al.; Endometrial CD16(+) and CD16(-) NK cell count in fertility and unexplained infertility; Wiley; American Journal of Reproductive Immunology; 70; 3; 5-2013; 282-289
8755-8920
1600-0897
CONICET Digital
CONICET
url http://hdl.handle.net/11336/26595
identifier_str_mv Junovich, Gisela Yael; Azpiroz, Maria Agustina; Incera, Maria Eugenia; Ferrer, Maria Constanza; Pasqualini, Rodolfo Agustin; et al.; Endometrial CD16(+) and CD16(-) NK cell count in fertility and unexplained infertility; Wiley; American Journal of Reproductive Immunology; 70; 3; 5-2013; 282-289
8755-8920
1600-0897
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/aji.12132/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1111/aji.12132
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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