Characterization of andean blueberry in bioactive compounds, evaluation of biological properties, and in vitro bioaccessibility

Autores
Baenas, Nieves; Ruales, Jenny; Moreno, Diego A.; Barrio, Daniel Alejandro; Stinco, Carla M.; Martínez Cifuentes, Gabriela; Meléndez Martínez, Antonio J.; García Ruiz, Almudena
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this study was to evaluate Andean blueberries (Vaccinium floribundum Kunth) from Ecuador as a potential functional ingredient for the food and pharmaceutical industries. The analysis of bioactive compounds by HPLC–DAD–MSn determined a high content of (poly)phenols, mainly anthocyanins, and the presence of the carotenoid lutein. Regarding its biological properties, Andean blueberry did not show toxicity by the zebrafish embryogenesis test, showing also a lack of the antinutrients lectins. Moreover, the results of in vitro and in vivo antioxidant capacity evaluation suggested its possibility to be used as natural antioxidant. This fruit also exhibited antimicrobial activity toward Staphylococcus aureus and Escherichia coli in low doses. Finally, in vitro gastrointestinal (GI) digestion showed a partial bioaccessibility of (poly) phenols (~50% at the final step), showing high antioxidant capacity in the different GI phases. These results revealed Andean blueberry as an interesting candidate for being used as a functional ingredient and the development of further in vivo and clinical assays.
Fil: Baenas, Nieves. Universidad de Murcia; España
Fil: Ruales, Jenny. Escuela Politécnica Nacional; Ecuador
Fil: Moreno, Diego A.. Consejo Superior de Investigaciones Científicas. Centro de Edafología y Biología Aplicada del Segura; España
Fil: Barrio, Daniel Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Río Negro. Sede Viedma del Centro de Investigaciones y Transferencia de Río Negro | Universidad Nacional de Río Negro. Centro de Investigaciones y Transferencia de Río Negro. Sede Viedma del Centro de Investigaciones y Transferencia de Río Negro; Argentina
Fil: Stinco, Carla M.. Universidad de Sevilla; España
Fil: Martínez Cifuentes, Gabriela. Escuela Politécnica Nacional; Ecuador
Fil: Meléndez Martínez, Antonio J.. Universidad de Sevilla; España
Fil: García Ruiz, Almudena. Escuela Politécnica Nacional; Ecuador. Instituto Imdea Energia; España. Consejo Superior de Investigaciones Científicas; España
Materia
ANTHOCYANINS
ANTIMICROBIAL
ANTIOXIDANT
HPLC–MS/MS
MORTIÑO
TOXICITY
VACCINIUM FLORIBUNDUM
ZEBRAFISH
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/153643
Acceder
id CONICETDig_e3c80ecb38c376f6f7834e27161751a1
oai_identifier_str oai:ri.conicet.gov.ar:11336/153643
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Characterization of andean blueberry in bioactive compounds, evaluation of biological properties, and in vitro bioaccessibilityBaenas, NievesRuales, JennyMoreno, Diego A.Barrio, Daniel AlejandroStinco, Carla M.Martínez Cifuentes, GabrielaMeléndez Martínez, Antonio J.García Ruiz, AlmudenaANTHOCYANINSANTIMICROBIALANTIOXIDANTHPLC–MS/MSMORTIÑOTOXICITYVACCINIUM FLORIBUNDUMZEBRAFISHhttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2The aim of this study was to evaluate Andean blueberries (Vaccinium floribundum Kunth) from Ecuador as a potential functional ingredient for the food and pharmaceutical industries. The analysis of bioactive compounds by HPLC–DAD–MSn determined a high content of (poly)phenols, mainly anthocyanins, and the presence of the carotenoid lutein. Regarding its biological properties, Andean blueberry did not show toxicity by the zebrafish embryogenesis test, showing also a lack of the antinutrients lectins. Moreover, the results of in vitro and in vivo antioxidant capacity evaluation suggested its possibility to be used as natural antioxidant. This fruit also exhibited antimicrobial activity toward Staphylococcus aureus and Escherichia coli in low doses. Finally, in vitro gastrointestinal (GI) digestion showed a partial bioaccessibility of (poly) phenols (~50% at the final step), showing high antioxidant capacity in the different GI phases. These results revealed Andean blueberry as an interesting candidate for being used as a functional ingredient and the development of further in vivo and clinical assays.Fil: Baenas, Nieves. Universidad de Murcia; EspañaFil: Ruales, Jenny. Escuela Politécnica Nacional; EcuadorFil: Moreno, Diego A.. Consejo Superior de Investigaciones Científicas. Centro de Edafología y Biología Aplicada del Segura; EspañaFil: Barrio, Daniel Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Río Negro. Sede Viedma del Centro de Investigaciones y Transferencia de Río Negro | Universidad Nacional de Río Negro. Centro de Investigaciones y Transferencia de Río Negro. Sede Viedma del Centro de Investigaciones y Transferencia de Río Negro; ArgentinaFil: Stinco, Carla M.. Universidad de Sevilla; EspañaFil: Martínez Cifuentes, Gabriela. Escuela Politécnica Nacional; EcuadorFil: Meléndez Martínez, Antonio J.. Universidad de Sevilla; EspañaFil: García Ruiz, Almudena. Escuela Politécnica Nacional; Ecuador. Instituto Imdea Energia; España. Consejo Superior de Investigaciones Científicas; EspañaMultidisciplinary Digital Publishing Institute2020-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/153643Baenas, Nieves; Ruales, Jenny; Moreno, Diego A.; Barrio, Daniel Alejandro; Stinco, Carla M.; et al.; Characterization of andean blueberry in bioactive compounds, evaluation of biological properties, and in vitro bioaccessibility; Multidisciplinary Digital Publishing Institute; Foods; 9; 10; 10-2020; 1-162304-8158CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2304-8158/9/10/1483info:eu-repo/semantics/altIdentifier/doi/10.3390/foods9101483info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:19Zoai:ri.conicet.gov.ar:11336/153643instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:19.964CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Characterization of andean blueberry in bioactive compounds, evaluation of biological properties, and in vitro bioaccessibility
title Characterization of andean blueberry in bioactive compounds, evaluation of biological properties, and in vitro bioaccessibility
spellingShingle Characterization of andean blueberry in bioactive compounds, evaluation of biological properties, and in vitro bioaccessibility
Baenas, Nieves
ANTHOCYANINS
ANTIMICROBIAL
ANTIOXIDANT
HPLC–MS/MS
MORTIÑO
TOXICITY
VACCINIUM FLORIBUNDUM
ZEBRAFISH
title_short Characterization of andean blueberry in bioactive compounds, evaluation of biological properties, and in vitro bioaccessibility
title_full Characterization of andean blueberry in bioactive compounds, evaluation of biological properties, and in vitro bioaccessibility
title_fullStr Characterization of andean blueberry in bioactive compounds, evaluation of biological properties, and in vitro bioaccessibility
title_full_unstemmed Characterization of andean blueberry in bioactive compounds, evaluation of biological properties, and in vitro bioaccessibility
title_sort Characterization of andean blueberry in bioactive compounds, evaluation of biological properties, and in vitro bioaccessibility
dc.creator.none.fl_str_mv Baenas, Nieves
Ruales, Jenny
Moreno, Diego A.
Barrio, Daniel Alejandro
Stinco, Carla M.
Martínez Cifuentes, Gabriela
Meléndez Martínez, Antonio J.
García Ruiz, Almudena
author Baenas, Nieves
author_facet Baenas, Nieves
Ruales, Jenny
Moreno, Diego A.
Barrio, Daniel Alejandro
Stinco, Carla M.
Martínez Cifuentes, Gabriela
Meléndez Martínez, Antonio J.
García Ruiz, Almudena
author_role author
author2 Ruales, Jenny
Moreno, Diego A.
Barrio, Daniel Alejandro
Stinco, Carla M.
Martínez Cifuentes, Gabriela
Meléndez Martínez, Antonio J.
García Ruiz, Almudena
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTHOCYANINS
ANTIMICROBIAL
ANTIOXIDANT
HPLC–MS/MS
MORTIÑO
TOXICITY
VACCINIUM FLORIBUNDUM
ZEBRAFISH
topic ANTHOCYANINS
ANTIMICROBIAL
ANTIOXIDANT
HPLC–MS/MS
MORTIÑO
TOXICITY
VACCINIUM FLORIBUNDUM
ZEBRAFISH
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The aim of this study was to evaluate Andean blueberries (Vaccinium floribundum Kunth) from Ecuador as a potential functional ingredient for the food and pharmaceutical industries. The analysis of bioactive compounds by HPLC–DAD–MSn determined a high content of (poly)phenols, mainly anthocyanins, and the presence of the carotenoid lutein. Regarding its biological properties, Andean blueberry did not show toxicity by the zebrafish embryogenesis test, showing also a lack of the antinutrients lectins. Moreover, the results of in vitro and in vivo antioxidant capacity evaluation suggested its possibility to be used as natural antioxidant. This fruit also exhibited antimicrobial activity toward Staphylococcus aureus and Escherichia coli in low doses. Finally, in vitro gastrointestinal (GI) digestion showed a partial bioaccessibility of (poly) phenols (~50% at the final step), showing high antioxidant capacity in the different GI phases. These results revealed Andean blueberry as an interesting candidate for being used as a functional ingredient and the development of further in vivo and clinical assays.
Fil: Baenas, Nieves. Universidad de Murcia; España
Fil: Ruales, Jenny. Escuela Politécnica Nacional; Ecuador
Fil: Moreno, Diego A.. Consejo Superior de Investigaciones Científicas. Centro de Edafología y Biología Aplicada del Segura; España
Fil: Barrio, Daniel Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Río Negro. Sede Viedma del Centro de Investigaciones y Transferencia de Río Negro | Universidad Nacional de Río Negro. Centro de Investigaciones y Transferencia de Río Negro. Sede Viedma del Centro de Investigaciones y Transferencia de Río Negro; Argentina
Fil: Stinco, Carla M.. Universidad de Sevilla; España
Fil: Martínez Cifuentes, Gabriela. Escuela Politécnica Nacional; Ecuador
Fil: Meléndez Martínez, Antonio J.. Universidad de Sevilla; España
Fil: García Ruiz, Almudena. Escuela Politécnica Nacional; Ecuador. Instituto Imdea Energia; España. Consejo Superior de Investigaciones Científicas; España
description The aim of this study was to evaluate Andean blueberries (Vaccinium floribundum Kunth) from Ecuador as a potential functional ingredient for the food and pharmaceutical industries. The analysis of bioactive compounds by HPLC–DAD–MSn determined a high content of (poly)phenols, mainly anthocyanins, and the presence of the carotenoid lutein. Regarding its biological properties, Andean blueberry did not show toxicity by the zebrafish embryogenesis test, showing also a lack of the antinutrients lectins. Moreover, the results of in vitro and in vivo antioxidant capacity evaluation suggested its possibility to be used as natural antioxidant. This fruit also exhibited antimicrobial activity toward Staphylococcus aureus and Escherichia coli in low doses. Finally, in vitro gastrointestinal (GI) digestion showed a partial bioaccessibility of (poly) phenols (~50% at the final step), showing high antioxidant capacity in the different GI phases. These results revealed Andean blueberry as an interesting candidate for being used as a functional ingredient and the development of further in vivo and clinical assays.
publishDate 2020
dc.date.none.fl_str_mv 2020-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/153643
Baenas, Nieves; Ruales, Jenny; Moreno, Diego A.; Barrio, Daniel Alejandro; Stinco, Carla M.; et al.; Characterization of andean blueberry in bioactive compounds, evaluation of biological properties, and in vitro bioaccessibility; Multidisciplinary Digital Publishing Institute; Foods; 9; 10; 10-2020; 1-16
2304-8158
CONICET Digital
CONICET
url http://hdl.handle.net/11336/153643
identifier_str_mv Baenas, Nieves; Ruales, Jenny; Moreno, Diego A.; Barrio, Daniel Alejandro; Stinco, Carla M.; et al.; Characterization of andean blueberry in bioactive compounds, evaluation of biological properties, and in vitro bioaccessibility; Multidisciplinary Digital Publishing Institute; Foods; 9; 10; 10-2020; 1-16
2304-8158
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2304-8158/9/10/1483
info:eu-repo/semantics/altIdentifier/doi/10.3390/foods9101483
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268918440263680
score 13.13397

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