Angiogenesis at Different Stage of Pregnancy in Goat Placenta

Autores
Díaz, Tomás; Merkis, Cecilia Inés; Cots, Debora Soledad; Sanchis, Eva Gabriela; Cristofolini, Andrea Lorena; Romanini, María Cristina; Bozzo, A.; Rolando, Alicia Nelida
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The increase intransplacental exchange depends primarily on the great development of the placental vascular bed. The aim of this study was to evaluate the pattern of placental vascular development at day 50 and 100 of pregnancyin goats and the relationship with the vascular endothelial growth factor (VEGF) immunolocalization. The placental morphometric variables:capillary area density, capillary perimeter density, capillary number density and average capillary perimeter of the caruncular (CAR)and cotyledonary (COT) tissues were measured at day 50 (n = 5) and 100 (n = 5) of gestation. Also, the immunolocalization ofVEGF was performed. In the CAR and COT tissues a significant increase of capillary area density and capillary perimeter density at day 100 of the gestation was observed. In the COT tissue, this was due to the increase in the capillary number density; however in the CAR tissue this was due to the increase in the capillary size. We can conclude that in both tissues there were different strategies to increase the capillary area and, thereby, the nutrients exchange. The immunolocalization of VEGF in the COT tissue showed the endothelial cells of blood vessels and trophoblastcells surrounding the villi intensely inmunostained, which would indicate the involvement of VEGF in the placental vascular development.
Fil: Díaz, Tomás. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina
Fil: Merkis, Cecilia Inés. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Cots, Debora Soledad. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina
Fil: Sanchis, Eva Gabriela. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Cristofolini, Andrea Lorena. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Romanini, María Cristina. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina
Fil: Bozzo, A.. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina
Fil: Rolando, Alicia Nelida. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina
Materia
Angiogenesis
Placenta
Goat
Vegf
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/70805
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/70805
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Angiogenesis at Different Stage of Pregnancy in Goat PlacentaDíaz, TomásMerkis, Cecilia InésCots, Debora SoledadSanchis, Eva GabrielaCristofolini, Andrea LorenaRomanini, María CristinaBozzo, A.Rolando, Alicia NelidaAngiogenesisPlacentaGoatVegfhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The increase intransplacental exchange depends primarily on the great development of the placental vascular bed. The aim of this study was to evaluate the pattern of placental vascular development at day 50 and 100 of pregnancyin goats and the relationship with the vascular endothelial growth factor (VEGF) immunolocalization. The placental morphometric variables:capillary area density, capillary perimeter density, capillary number density and average capillary perimeter of the caruncular (CAR)and cotyledonary (COT) tissues were measured at day 50 (n = 5) and 100 (n = 5) of gestation. Also, the immunolocalization ofVEGF was performed. In the CAR and COT tissues a significant increase of capillary area density and capillary perimeter density at day 100 of the gestation was observed. In the COT tissue, this was due to the increase in the capillary number density; however in the CAR tissue this was due to the increase in the capillary size. We can conclude that in both tissues there were different strategies to increase the capillary area and, thereby, the nutrients exchange. The immunolocalization of VEGF in the COT tissue showed the endothelial cells of blood vessels and trophoblastcells surrounding the villi intensely inmunostained, which would indicate the involvement of VEGF in the placental vascular development.Fil: Díaz, Tomás. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; ArgentinaFil: Merkis, Cecilia Inés. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; ArgentinaFil: Cots, Debora Soledad. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; ArgentinaFil: Sanchis, Eva Gabriela. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; ArgentinaFil: Cristofolini, Andrea Lorena. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; ArgentinaFil: Romanini, María Cristina. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; ArgentinaFil: Bozzo, A.. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; ArgentinaFil: Rolando, Alicia Nelida. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; ArgentinaRoyal Netherlands Soc Agr Sci2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/70805Díaz, Tomás; Merkis, Cecilia Inés; Cots, Debora Soledad; Sanchis, Eva Gabriela; Cristofolini, Andrea Lorena; et al.; Angiogenesis at Different Stage of Pregnancy in Goat Placenta; Royal Netherlands Soc Agr Sci; Njas - Wageningen Journal of Life Sciences; 9; 9-2015; 391-3981573-5214CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.davidpublisher.com/index.php/Home/Article/indexinfo:eu-repo/semantics/altIdentifier/doi/10.17265/1934-7391/2015.08.007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:31Zoai:ri.conicet.gov.ar:11336/70805instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:31.792CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Angiogenesis at Different Stage of Pregnancy in Goat Placenta
title Angiogenesis at Different Stage of Pregnancy in Goat Placenta
spellingShingle Angiogenesis at Different Stage of Pregnancy in Goat Placenta
Díaz, Tomás
Angiogenesis
Placenta
Goat
Vegf
title_short Angiogenesis at Different Stage of Pregnancy in Goat Placenta
title_full Angiogenesis at Different Stage of Pregnancy in Goat Placenta
title_fullStr Angiogenesis at Different Stage of Pregnancy in Goat Placenta
title_full_unstemmed Angiogenesis at Different Stage of Pregnancy in Goat Placenta
title_sort Angiogenesis at Different Stage of Pregnancy in Goat Placenta
dc.creator.none.fl_str_mv Díaz, Tomás
Merkis, Cecilia Inés
Cots, Debora Soledad
Sanchis, Eva Gabriela
Cristofolini, Andrea Lorena
Romanini, María Cristina
Bozzo, A.
Rolando, Alicia Nelida
author Díaz, Tomás
author_facet Díaz, Tomás
Merkis, Cecilia Inés
Cots, Debora Soledad
Sanchis, Eva Gabriela
Cristofolini, Andrea Lorena
Romanini, María Cristina
Bozzo, A.
Rolando, Alicia Nelida
author_role author
author2 Merkis, Cecilia Inés
Cots, Debora Soledad
Sanchis, Eva Gabriela
Cristofolini, Andrea Lorena
Romanini, María Cristina
Bozzo, A.
Rolando, Alicia Nelida
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Angiogenesis
Placenta
Goat
Vegf
topic Angiogenesis
Placenta
Goat
Vegf
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The increase intransplacental exchange depends primarily on the great development of the placental vascular bed. The aim of this study was to evaluate the pattern of placental vascular development at day 50 and 100 of pregnancyin goats and the relationship with the vascular endothelial growth factor (VEGF) immunolocalization. The placental morphometric variables:capillary area density, capillary perimeter density, capillary number density and average capillary perimeter of the caruncular (CAR)and cotyledonary (COT) tissues were measured at day 50 (n = 5) and 100 (n = 5) of gestation. Also, the immunolocalization ofVEGF was performed. In the CAR and COT tissues a significant increase of capillary area density and capillary perimeter density at day 100 of the gestation was observed. In the COT tissue, this was due to the increase in the capillary number density; however in the CAR tissue this was due to the increase in the capillary size. We can conclude that in both tissues there were different strategies to increase the capillary area and, thereby, the nutrients exchange. The immunolocalization of VEGF in the COT tissue showed the endothelial cells of blood vessels and trophoblastcells surrounding the villi intensely inmunostained, which would indicate the involvement of VEGF in the placental vascular development.
Fil: Díaz, Tomás. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina
Fil: Merkis, Cecilia Inés. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Cots, Debora Soledad. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina
Fil: Sanchis, Eva Gabriela. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Cristofolini, Andrea Lorena. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Romanini, María Cristina. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina
Fil: Bozzo, A.. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina
Fil: Rolando, Alicia Nelida. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina
description The increase intransplacental exchange depends primarily on the great development of the placental vascular bed. The aim of this study was to evaluate the pattern of placental vascular development at day 50 and 100 of pregnancyin goats and the relationship with the vascular endothelial growth factor (VEGF) immunolocalization. The placental morphometric variables:capillary area density, capillary perimeter density, capillary number density and average capillary perimeter of the caruncular (CAR)and cotyledonary (COT) tissues were measured at day 50 (n = 5) and 100 (n = 5) of gestation. Also, the immunolocalization ofVEGF was performed. In the CAR and COT tissues a significant increase of capillary area density and capillary perimeter density at day 100 of the gestation was observed. In the COT tissue, this was due to the increase in the capillary number density; however in the CAR tissue this was due to the increase in the capillary size. We can conclude that in both tissues there were different strategies to increase the capillary area and, thereby, the nutrients exchange. The immunolocalization of VEGF in the COT tissue showed the endothelial cells of blood vessels and trophoblastcells surrounding the villi intensely inmunostained, which would indicate the involvement of VEGF in the placental vascular development.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/70805
Díaz, Tomás; Merkis, Cecilia Inés; Cots, Debora Soledad; Sanchis, Eva Gabriela; Cristofolini, Andrea Lorena; et al.; Angiogenesis at Different Stage of Pregnancy in Goat Placenta; Royal Netherlands Soc Agr Sci; Njas - Wageningen Journal of Life Sciences; 9; 9-2015; 391-398
1573-5214
CONICET Digital
CONICET
url http://hdl.handle.net/11336/70805
identifier_str_mv Díaz, Tomás; Merkis, Cecilia Inés; Cots, Debora Soledad; Sanchis, Eva Gabriela; Cristofolini, Andrea Lorena; et al.; Angiogenesis at Different Stage of Pregnancy in Goat Placenta; Royal Netherlands Soc Agr Sci; Njas - Wageningen Journal of Life Sciences; 9; 9-2015; 391-398
1573-5214
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.davidpublisher.com/index.php/Home/Article/index
info:eu-repo/semantics/altIdentifier/doi/10.17265/1934-7391/2015.08.007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Netherlands Soc Agr Sci
publisher.none.fl_str_mv Royal Netherlands Soc Agr Sci
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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