Regulation of Expression and Latency in BLV and HTLV

Autores
Pluta, Aneta; Jaworski, Juan Pablo; Douville, Renée N.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Human T-lymphotrophic virus type 1 (HTLV-1) and Bovine leukemia virus (BLV) belong to the Deltaretrovirus genus. HTLV-1 is the etiologic agent of the highly aggressive and currently incurable cancer adult T-cell leukemia (ATL) and a neurological disease HTLV-1-associated myelopathy (HAM)/tropical spastic paraparesis (TSP). BLV causes neoplastic proliferation of B cells in cattle: enzootic bovine leucosis (EBL). Despite the severity of these conditions, infection by HTLV-1 and BLV appear in most cases clinically asymptomatic. These viruses can undergo latency in their hosts. The silencing of proviral gene expression and maintenance of latency are central for the establishment of persistent infection, as well as for pathogenesis in vivo. In this review, we will present the mechanisms that control proviral activation and retroviral latency in deltaretroviruses, in comparison with other exogenous retroviruses. The 50 long terminal repeats (50-LTRs) play a main role in controlling viral gene expression. While the regulation of transcription initiation is a major mechanism of silencing, we discuss topics that include (i) the epigenetic control of the provirus, (ii) the cis-elements present in the LTR, (iii) enhancers with cell-type specific regulatory functions, (iv) the role of virally-encoded transactivator proteins, (v) the role of repressors in transcription and silencing, (vi) the effect of hormonal signaling, (vii) implications of LTR variability on transcription and latency, and (viii) the regulatory role of non-coding RNAs. Finally, we discuss how a better understanding of these mechanisms may allow for the development of more effective treatments against Deltaretroviruses.
Fil: Pluta, Aneta. National Veterinary Research Institute; Polonia
Fil: Jaworski, Juan Pablo. Instituto Nacional de Tecnologia Agropecuaria. Centro de Investigacion En Ciencias Veterinarias y Agronomicas. Instituto de Virologia E Innovaciones Tecnologicas. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Pque. Centenario. Instituto de Virologia E Innovaciones Tecnologicas.; Argentina
Fil: Douville, Renée N.. University of Manitoba; Canadá
Materia
BOVINE LEUKEMIA VIRUS (BLV)
DELTARETROVIRUS
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1)
HUMAN T-LYMPHOTROPHIC VIRUS TYPE 1 (HTLV-1)
LATENCY
LONG TERMINAL REPEAT (LTR)
RETROVIRUS
TRANSCRIPTION
VIRAL GENE REGULATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/145963
Acceder
id CONICETDig_e3144a2555238f235cefd09b064b9b98
oai_identifier_str oai:ri.conicet.gov.ar:11336/145963
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Regulation of Expression and Latency in BLV and HTLVPluta, AnetaJaworski, Juan PabloDouville, Renée N.BOVINE LEUKEMIA VIRUS (BLV)DELTARETROVIRUSHUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1)HUMAN T-LYMPHOTROPHIC VIRUS TYPE 1 (HTLV-1)LATENCYLONG TERMINAL REPEAT (LTR)RETROVIRUSTRANSCRIPTIONVIRAL GENE REGULATIONhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Human T-lymphotrophic virus type 1 (HTLV-1) and Bovine leukemia virus (BLV) belong to the Deltaretrovirus genus. HTLV-1 is the etiologic agent of the highly aggressive and currently incurable cancer adult T-cell leukemia (ATL) and a neurological disease HTLV-1-associated myelopathy (HAM)/tropical spastic paraparesis (TSP). BLV causes neoplastic proliferation of B cells in cattle: enzootic bovine leucosis (EBL). Despite the severity of these conditions, infection by HTLV-1 and BLV appear in most cases clinically asymptomatic. These viruses can undergo latency in their hosts. The silencing of proviral gene expression and maintenance of latency are central for the establishment of persistent infection, as well as for pathogenesis in vivo. In this review, we will present the mechanisms that control proviral activation and retroviral latency in deltaretroviruses, in comparison with other exogenous retroviruses. The 50 long terminal repeats (50-LTRs) play a main role in controlling viral gene expression. While the regulation of transcription initiation is a major mechanism of silencing, we discuss topics that include (i) the epigenetic control of the provirus, (ii) the cis-elements present in the LTR, (iii) enhancers with cell-type specific regulatory functions, (iv) the role of virally-encoded transactivator proteins, (v) the role of repressors in transcription and silencing, (vi) the effect of hormonal signaling, (vii) implications of LTR variability on transcription and latency, and (viii) the regulatory role of non-coding RNAs. Finally, we discuss how a better understanding of these mechanisms may allow for the development of more effective treatments against Deltaretroviruses.Fil: Pluta, Aneta. National Veterinary Research Institute; PoloniaFil: Jaworski, Juan Pablo. Instituto Nacional de Tecnologia Agropecuaria. Centro de Investigacion En Ciencias Veterinarias y Agronomicas. Instituto de Virologia E Innovaciones Tecnologicas. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Pque. Centenario. Instituto de Virologia E Innovaciones Tecnologicas.; ArgentinaFil: Douville, Renée N.. University of Manitoba; CanadáMolecular Diversity Preservation International2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/145963Pluta, Aneta; Jaworski, Juan Pablo; Douville, Renée N.; Regulation of Expression and Latency in BLV and HTLV; Molecular Diversity Preservation International; Viruses; 12; 10; 9-2020; 1-311999-4915CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4915/12/10/1079info:eu-repo/semantics/altIdentifier/doi/10.3390/v12101079info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:11:41Zoai:ri.conicet.gov.ar:11336/145963instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:11:42.161CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Regulation of Expression and Latency in BLV and HTLV
title Regulation of Expression and Latency in BLV and HTLV
spellingShingle Regulation of Expression and Latency in BLV and HTLV
Pluta, Aneta
BOVINE LEUKEMIA VIRUS (BLV)
DELTARETROVIRUS
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1)
HUMAN T-LYMPHOTROPHIC VIRUS TYPE 1 (HTLV-1)
LATENCY
LONG TERMINAL REPEAT (LTR)
RETROVIRUS
TRANSCRIPTION
VIRAL GENE REGULATION
title_short Regulation of Expression and Latency in BLV and HTLV
title_full Regulation of Expression and Latency in BLV and HTLV
title_fullStr Regulation of Expression and Latency in BLV and HTLV
title_full_unstemmed Regulation of Expression and Latency in BLV and HTLV
title_sort Regulation of Expression and Latency in BLV and HTLV
dc.creator.none.fl_str_mv Pluta, Aneta
Jaworski, Juan Pablo
Douville, Renée N.
author Pluta, Aneta
author_facet Pluta, Aneta
Jaworski, Juan Pablo
Douville, Renée N.
author_role author
author2 Jaworski, Juan Pablo
Douville, Renée N.
author2_role author
author
dc.subject.none.fl_str_mv BOVINE LEUKEMIA VIRUS (BLV)
DELTARETROVIRUS
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1)
HUMAN T-LYMPHOTROPHIC VIRUS TYPE 1 (HTLV-1)
LATENCY
LONG TERMINAL REPEAT (LTR)
RETROVIRUS
TRANSCRIPTION
VIRAL GENE REGULATION
topic BOVINE LEUKEMIA VIRUS (BLV)
DELTARETROVIRUS
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1)
HUMAN T-LYMPHOTROPHIC VIRUS TYPE 1 (HTLV-1)
LATENCY
LONG TERMINAL REPEAT (LTR)
RETROVIRUS
TRANSCRIPTION
VIRAL GENE REGULATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Human T-lymphotrophic virus type 1 (HTLV-1) and Bovine leukemia virus (BLV) belong to the Deltaretrovirus genus. HTLV-1 is the etiologic agent of the highly aggressive and currently incurable cancer adult T-cell leukemia (ATL) and a neurological disease HTLV-1-associated myelopathy (HAM)/tropical spastic paraparesis (TSP). BLV causes neoplastic proliferation of B cells in cattle: enzootic bovine leucosis (EBL). Despite the severity of these conditions, infection by HTLV-1 and BLV appear in most cases clinically asymptomatic. These viruses can undergo latency in their hosts. The silencing of proviral gene expression and maintenance of latency are central for the establishment of persistent infection, as well as for pathogenesis in vivo. In this review, we will present the mechanisms that control proviral activation and retroviral latency in deltaretroviruses, in comparison with other exogenous retroviruses. The 50 long terminal repeats (50-LTRs) play a main role in controlling viral gene expression. While the regulation of transcription initiation is a major mechanism of silencing, we discuss topics that include (i) the epigenetic control of the provirus, (ii) the cis-elements present in the LTR, (iii) enhancers with cell-type specific regulatory functions, (iv) the role of virally-encoded transactivator proteins, (v) the role of repressors in transcription and silencing, (vi) the effect of hormonal signaling, (vii) implications of LTR variability on transcription and latency, and (viii) the regulatory role of non-coding RNAs. Finally, we discuss how a better understanding of these mechanisms may allow for the development of more effective treatments against Deltaretroviruses.
Fil: Pluta, Aneta. National Veterinary Research Institute; Polonia
Fil: Jaworski, Juan Pablo. Instituto Nacional de Tecnologia Agropecuaria. Centro de Investigacion En Ciencias Veterinarias y Agronomicas. Instituto de Virologia E Innovaciones Tecnologicas. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Pque. Centenario. Instituto de Virologia E Innovaciones Tecnologicas.; Argentina
Fil: Douville, Renée N.. University of Manitoba; Canadá
description Human T-lymphotrophic virus type 1 (HTLV-1) and Bovine leukemia virus (BLV) belong to the Deltaretrovirus genus. HTLV-1 is the etiologic agent of the highly aggressive and currently incurable cancer adult T-cell leukemia (ATL) and a neurological disease HTLV-1-associated myelopathy (HAM)/tropical spastic paraparesis (TSP). BLV causes neoplastic proliferation of B cells in cattle: enzootic bovine leucosis (EBL). Despite the severity of these conditions, infection by HTLV-1 and BLV appear in most cases clinically asymptomatic. These viruses can undergo latency in their hosts. The silencing of proviral gene expression and maintenance of latency are central for the establishment of persistent infection, as well as for pathogenesis in vivo. In this review, we will present the mechanisms that control proviral activation and retroviral latency in deltaretroviruses, in comparison with other exogenous retroviruses. The 50 long terminal repeats (50-LTRs) play a main role in controlling viral gene expression. While the regulation of transcription initiation is a major mechanism of silencing, we discuss topics that include (i) the epigenetic control of the provirus, (ii) the cis-elements present in the LTR, (iii) enhancers with cell-type specific regulatory functions, (iv) the role of virally-encoded transactivator proteins, (v) the role of repressors in transcription and silencing, (vi) the effect of hormonal signaling, (vii) implications of LTR variability on transcription and latency, and (viii) the regulatory role of non-coding RNAs. Finally, we discuss how a better understanding of these mechanisms may allow for the development of more effective treatments against Deltaretroviruses.
publishDate 2020
dc.date.none.fl_str_mv 2020-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/145963
Pluta, Aneta; Jaworski, Juan Pablo; Douville, Renée N.; Regulation of Expression and Latency in BLV and HTLV; Molecular Diversity Preservation International; Viruses; 12; 10; 9-2020; 1-31
1999-4915
CONICET Digital
CONICET
url http://hdl.handle.net/11336/145963
identifier_str_mv Pluta, Aneta; Jaworski, Juan Pablo; Douville, Renée N.; Regulation of Expression and Latency in BLV and HTLV; Molecular Diversity Preservation International; Viruses; 12; 10; 9-2020; 1-31
1999-4915
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4915/12/10/1079
info:eu-repo/semantics/altIdentifier/doi/10.3390/v12101079
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270168694128640
score 13.13397

Publicaciones similares