Association between genomic instability and evolutionary chromosomal rearrangements in neotropical primates

Autores
Puntieri, Fiona; Andrioli, Nancy Beatriz; Nieves, Mariela
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
During the last decades, the mammalian genome has been proposed to have regions prone to breakage and reorganization concentrated in certain chromosomal bands that seem to correspond to evolutionary breakpoints. These bands are likely to be involved in chromosome fragility or instability. In Primates, some biomarkers of genetic damage may be associated with various degrees of genomic instability. Here, we investigated the usefulness of Sister Chromatid Exchange as abiomarker of potential sites of frequent chromosome breakage and rearrangement in Alouatta caraya, Ateles chamek, Ateles paniscus, and Cebus cay. These Neotropical species have particular genomic and chromosomal features allowing the analysis of genomic instability for comparative purposes. We determined the frequency of spontaneous induction of Sister Chromatid Exchanges and assessed the relationship between these and structural rearrangements implicated in the evolution of the primates of interest. Overall, A. caraya and C. cay presenteda lowproportionof statistically significant unstablebands, suggesting fairly stablegenomes andtheexistenceof somekind of protection against endogenous damage. In contrast, Ateles showed a highly significant proportion of unstable bands; thesewere mainly found in the rearranged regions, which is consistent with the numerous genomic reorganizations thatmight have occurred during the evolution of this genus.
Fil: Puntieri, Fiona. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución. Grupo de Investigación de Biología Evolutiva; Argentina
Fil: Andrioli, Nancy Beatriz. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución. Grupo de Investigación de Biología Evolutiva; Argentina
Fil: Nieves, Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución. Grupo de Investigación de Biología Evolutiva; Argentina
Materia
CHROMOSOME EVOLUTION
PLATYRRHINI
SISTER CHROMATID EXCHANGE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/182490
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Association between genomic instability and evolutionary chromosomal rearrangements in neotropical primatesPuntieri, FionaAndrioli, Nancy BeatrizNieves, MarielaCHROMOSOME EVOLUTIONPLATYRRHINISISTER CHROMATID EXCHANGEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1During the last decades, the mammalian genome has been proposed to have regions prone to breakage and reorganization concentrated in certain chromosomal bands that seem to correspond to evolutionary breakpoints. These bands are likely to be involved in chromosome fragility or instability. In Primates, some biomarkers of genetic damage may be associated with various degrees of genomic instability. Here, we investigated the usefulness of Sister Chromatid Exchange as abiomarker of potential sites of frequent chromosome breakage and rearrangement in Alouatta caraya, Ateles chamek, Ateles paniscus, and Cebus cay. These Neotropical species have particular genomic and chromosomal features allowing the analysis of genomic instability for comparative purposes. We determined the frequency of spontaneous induction of Sister Chromatid Exchanges and assessed the relationship between these and structural rearrangements implicated in the evolution of the primates of interest. Overall, A. caraya and C. cay presenteda lowproportionof statistically significant unstablebands, suggesting fairly stablegenomes andtheexistenceof somekind of protection against endogenous damage. In contrast, Ateles showed a highly significant proportion of unstable bands; thesewere mainly found in the rearranged regions, which is consistent with the numerous genomic reorganizations thatmight have occurred during the evolution of this genus.Fil: Puntieri, Fiona. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución. Grupo de Investigación de Biología Evolutiva; ArgentinaFil: Andrioli, Nancy Beatriz. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución. Grupo de Investigación de Biología Evolutiva; ArgentinaFil: Nieves, Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución. Grupo de Investigación de Biología Evolutiva; ArgentinaOxford University Press2018-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/182490Puntieri, Fiona; Andrioli, Nancy Beatriz; Nieves, Mariela; Association between genomic instability and evolutionary chromosomal rearrangements in neotropical primates; Oxford University Press; Genome Biology and Evolution; 10; 7; 7-2018; 1647-16561759-6653CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/gbe/evy119info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/gbe/article/10/7/1647/5037821info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:59Zoai:ri.conicet.gov.ar:11336/182490instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:59.671CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Association between genomic instability and evolutionary chromosomal rearrangements in neotropical primates
title Association between genomic instability and evolutionary chromosomal rearrangements in neotropical primates
spellingShingle Association between genomic instability and evolutionary chromosomal rearrangements in neotropical primates
Puntieri, Fiona
CHROMOSOME EVOLUTION
PLATYRRHINI
SISTER CHROMATID EXCHANGE
title_short Association between genomic instability and evolutionary chromosomal rearrangements in neotropical primates
title_full Association between genomic instability and evolutionary chromosomal rearrangements in neotropical primates
title_fullStr Association between genomic instability and evolutionary chromosomal rearrangements in neotropical primates
title_full_unstemmed Association between genomic instability and evolutionary chromosomal rearrangements in neotropical primates
title_sort Association between genomic instability and evolutionary chromosomal rearrangements in neotropical primates
dc.creator.none.fl_str_mv Puntieri, Fiona
Andrioli, Nancy Beatriz
Nieves, Mariela
author Puntieri, Fiona
author_facet Puntieri, Fiona
Andrioli, Nancy Beatriz
Nieves, Mariela
author_role author
author2 Andrioli, Nancy Beatriz
Nieves, Mariela
author2_role author
author
dc.subject.none.fl_str_mv CHROMOSOME EVOLUTION
PLATYRRHINI
SISTER CHROMATID EXCHANGE
topic CHROMOSOME EVOLUTION
PLATYRRHINI
SISTER CHROMATID EXCHANGE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv During the last decades, the mammalian genome has been proposed to have regions prone to breakage and reorganization concentrated in certain chromosomal bands that seem to correspond to evolutionary breakpoints. These bands are likely to be involved in chromosome fragility or instability. In Primates, some biomarkers of genetic damage may be associated with various degrees of genomic instability. Here, we investigated the usefulness of Sister Chromatid Exchange as abiomarker of potential sites of frequent chromosome breakage and rearrangement in Alouatta caraya, Ateles chamek, Ateles paniscus, and Cebus cay. These Neotropical species have particular genomic and chromosomal features allowing the analysis of genomic instability for comparative purposes. We determined the frequency of spontaneous induction of Sister Chromatid Exchanges and assessed the relationship between these and structural rearrangements implicated in the evolution of the primates of interest. Overall, A. caraya and C. cay presenteda lowproportionof statistically significant unstablebands, suggesting fairly stablegenomes andtheexistenceof somekind of protection against endogenous damage. In contrast, Ateles showed a highly significant proportion of unstable bands; thesewere mainly found in the rearranged regions, which is consistent with the numerous genomic reorganizations thatmight have occurred during the evolution of this genus.
Fil: Puntieri, Fiona. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución. Grupo de Investigación de Biología Evolutiva; Argentina
Fil: Andrioli, Nancy Beatriz. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución. Grupo de Investigación de Biología Evolutiva; Argentina
Fil: Nieves, Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución. Grupo de Investigación de Biología Evolutiva; Argentina
description During the last decades, the mammalian genome has been proposed to have regions prone to breakage and reorganization concentrated in certain chromosomal bands that seem to correspond to evolutionary breakpoints. These bands are likely to be involved in chromosome fragility or instability. In Primates, some biomarkers of genetic damage may be associated with various degrees of genomic instability. Here, we investigated the usefulness of Sister Chromatid Exchange as abiomarker of potential sites of frequent chromosome breakage and rearrangement in Alouatta caraya, Ateles chamek, Ateles paniscus, and Cebus cay. These Neotropical species have particular genomic and chromosomal features allowing the analysis of genomic instability for comparative purposes. We determined the frequency of spontaneous induction of Sister Chromatid Exchanges and assessed the relationship between these and structural rearrangements implicated in the evolution of the primates of interest. Overall, A. caraya and C. cay presenteda lowproportionof statistically significant unstablebands, suggesting fairly stablegenomes andtheexistenceof somekind of protection against endogenous damage. In contrast, Ateles showed a highly significant proportion of unstable bands; thesewere mainly found in the rearranged regions, which is consistent with the numerous genomic reorganizations thatmight have occurred during the evolution of this genus.
publishDate 2018
dc.date.none.fl_str_mv 2018-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/182490
Puntieri, Fiona; Andrioli, Nancy Beatriz; Nieves, Mariela; Association between genomic instability and evolutionary chromosomal rearrangements in neotropical primates; Oxford University Press; Genome Biology and Evolution; 10; 7; 7-2018; 1647-1656
1759-6653
CONICET Digital
CONICET
url http://hdl.handle.net/11336/182490
identifier_str_mv Puntieri, Fiona; Andrioli, Nancy Beatriz; Nieves, Mariela; Association between genomic instability and evolutionary chromosomal rearrangements in neotropical primates; Oxford University Press; Genome Biology and Evolution; 10; 7; 7-2018; 1647-1656
1759-6653
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/gbe/evy119
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/gbe/article/10/7/1647/5037821
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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