Which are important targets in development of S.aureus mastitis vaccine?

Autores
Scali, F.; Camussone, Cecilia María; Calvinho, L. F.; Cipolla, M.; Zecconi, A.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Staphylococcus aureus represents one of the leading causes of mastitis in dairy cows worldwide. S. aureus IMI have variable outcomes due to virulence of the strain involved, immune defenses of the host, and by antibiotic resistance. The difficulty in eradication and the increasing concerns on antibiotics usages underscore the interest in developing new tools to control S. aureus mastitis. Vaccination represents one of the most studied of these tools but, so far, no vaccine seems to provide reliable protection. This review summarizes current knowledge on the major vaccine targets, including surface proteins, capsular polysaccharides, biofilm, and toxins. Finally, the present status of vaccination against S. aureus and the future of vaccines design were discussed,includi ng how differences among in vivo models may influence vaccines development.
Fil: Scali, F.. Universita Degli Studi Di Milano; Italia
Fil: Camussone, Cecilia María. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Calvinho, L. F.. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Cipolla, M.. Universita Degli Studi Di Milano; Italia
Fil: Zecconi, A.. Universita Degli Studi Di Milano; Italia
Materia
Staphylococcus Aureus
Mastitis
Vaccine
Virulence Factors
Immune Response
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/17307
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Which are important targets in development of S.aureus mastitis vaccine?Scali, F.Camussone, Cecilia MaríaCalvinho, L. F.Cipolla, M.Zecconi, A.Staphylococcus AureusMastitisVaccineVirulence FactorsImmune Responsehttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Staphylococcus aureus represents one of the leading causes of mastitis in dairy cows worldwide. S. aureus IMI have variable outcomes due to virulence of the strain involved, immune defenses of the host, and by antibiotic resistance. The difficulty in eradication and the increasing concerns on antibiotics usages underscore the interest in developing new tools to control S. aureus mastitis. Vaccination represents one of the most studied of these tools but, so far, no vaccine seems to provide reliable protection. This review summarizes current knowledge on the major vaccine targets, including surface proteins, capsular polysaccharides, biofilm, and toxins. Finally, the present status of vaccination against S. aureus and the future of vaccines design were discussed,includi ng how differences among in vivo models may influence vaccines development.Fil: Scali, F.. Universita Degli Studi Di Milano; ItaliaFil: Camussone, Cecilia María. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Calvinho, L. F.. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Cipolla, M.. Universita Degli Studi Di Milano; ItaliaFil: Zecconi, A.. Universita Degli Studi Di Milano; ItaliaElsevier2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/17307Scali, F.; Camussone, Cecilia María; Calvinho, L. F.; Cipolla, M.; Zecconi, A.; Which are important targets in development of S.aureus mastitis vaccine?; Elsevier; Research In Veterinary Science; 100; 3-2015; 88-990034-5288enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.rvsc.2015.03.019info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0034528815000934?via%3Dihubinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:35:20Zoai:ri.conicet.gov.ar:11336/17307instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:35:20.507CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Which are important targets in development of S.aureus mastitis vaccine?
title Which are important targets in development of S.aureus mastitis vaccine?
spellingShingle Which are important targets in development of S.aureus mastitis vaccine?
Scali, F.
Staphylococcus Aureus
Mastitis
Vaccine
Virulence Factors
Immune Response
title_short Which are important targets in development of S.aureus mastitis vaccine?
title_full Which are important targets in development of S.aureus mastitis vaccine?
title_fullStr Which are important targets in development of S.aureus mastitis vaccine?
title_full_unstemmed Which are important targets in development of S.aureus mastitis vaccine?
title_sort Which are important targets in development of S.aureus mastitis vaccine?
dc.creator.none.fl_str_mv Scali, F.
Camussone, Cecilia María
Calvinho, L. F.
Cipolla, M.
Zecconi, A.
author Scali, F.
author_facet Scali, F.
Camussone, Cecilia María
Calvinho, L. F.
Cipolla, M.
Zecconi, A.
author_role author
author2 Camussone, Cecilia María
Calvinho, L. F.
Cipolla, M.
Zecconi, A.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Staphylococcus Aureus
Mastitis
Vaccine
Virulence Factors
Immune Response
topic Staphylococcus Aureus
Mastitis
Vaccine
Virulence Factors
Immune Response
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Staphylococcus aureus represents one of the leading causes of mastitis in dairy cows worldwide. S. aureus IMI have variable outcomes due to virulence of the strain involved, immune defenses of the host, and by antibiotic resistance. The difficulty in eradication and the increasing concerns on antibiotics usages underscore the interest in developing new tools to control S. aureus mastitis. Vaccination represents one of the most studied of these tools but, so far, no vaccine seems to provide reliable protection. This review summarizes current knowledge on the major vaccine targets, including surface proteins, capsular polysaccharides, biofilm, and toxins. Finally, the present status of vaccination against S. aureus and the future of vaccines design were discussed,includi ng how differences among in vivo models may influence vaccines development.
Fil: Scali, F.. Universita Degli Studi Di Milano; Italia
Fil: Camussone, Cecilia María. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Calvinho, L. F.. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Cipolla, M.. Universita Degli Studi Di Milano; Italia
Fil: Zecconi, A.. Universita Degli Studi Di Milano; Italia
description Staphylococcus aureus represents one of the leading causes of mastitis in dairy cows worldwide. S. aureus IMI have variable outcomes due to virulence of the strain involved, immune defenses of the host, and by antibiotic resistance. The difficulty in eradication and the increasing concerns on antibiotics usages underscore the interest in developing new tools to control S. aureus mastitis. Vaccination represents one of the most studied of these tools but, so far, no vaccine seems to provide reliable protection. This review summarizes current knowledge on the major vaccine targets, including surface proteins, capsular polysaccharides, biofilm, and toxins. Finally, the present status of vaccination against S. aureus and the future of vaccines design were discussed,includi ng how differences among in vivo models may influence vaccines development.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/17307
Scali, F.; Camussone, Cecilia María; Calvinho, L. F.; Cipolla, M.; Zecconi, A.; Which are important targets in development of S.aureus mastitis vaccine?; Elsevier; Research In Veterinary Science; 100; 3-2015; 88-99
0034-5288
url http://hdl.handle.net/11336/17307
identifier_str_mv Scali, F.; Camussone, Cecilia María; Calvinho, L. F.; Cipolla, M.; Zecconi, A.; Which are important targets in development of S.aureus mastitis vaccine?; Elsevier; Research In Veterinary Science; 100; 3-2015; 88-99
0034-5288
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.rvsc.2015.03.019
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0034528815000934?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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