Photophysical, photochemical and photobiological properties of anthraquinones isolated from a phototoxic vegetal species: Heterophyllaea pustulata

Autores
Comini, Laura Raquel; Núñez Montoya, Susana Carolina; Argüello, Gustavo A.; Cabrera, Jose Luis
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Studies undertaken on isolated photosensitizing agents from Heterophyllaea pustulata, a photo-toxic plant, which natural habitat is the North-western part of Argentina, are presented here. The carried out work involved several steps that were initiated with the chemical-structural study of their most important secondary metabolites. As a result, three flavonoids, one iridoid glycoside (asperuloside) and ten aglycone anthraquinones were identified. Through the study of the photo-physical, photochemical and photobiological properties of the anthraquinone derivatives, we concluded that they show good photosensitizing (type I and type II) characteristics. The performed toxicological assays in vivo showed a direct cause-effect relation between these metabolites and the reported phototoxicity for H. pustulata. Finally, a few words about the potential application of these photsensitizing compounds as antibacterial agents will be given.
Fil: Comini, Laura Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Núñez Montoya, Susana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Argüello, Gustavo A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Cabrera, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Materia
Photosensitizers
Reactive Oxygen Species
Anthraquinones
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/71665
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Photophysical, photochemical and photobiological properties of anthraquinones isolated from a phototoxic vegetal species: Heterophyllaea pustulataComini, Laura RaquelNúñez Montoya, Susana CarolinaArgüello, Gustavo A.Cabrera, Jose LuisPhotosensitizersReactive Oxygen SpeciesAnthraquinoneshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Studies undertaken on isolated photosensitizing agents from Heterophyllaea pustulata, a photo-toxic plant, which natural habitat is the North-western part of Argentina, are presented here. The carried out work involved several steps that were initiated with the chemical-structural study of their most important secondary metabolites. As a result, three flavonoids, one iridoid glycoside (asperuloside) and ten aglycone anthraquinones were identified. Through the study of the photo-physical, photochemical and photobiological properties of the anthraquinone derivatives, we concluded that they show good photosensitizing (type I and type II) characteristics. The performed toxicological assays in vivo showed a direct cause-effect relation between these metabolites and the reported phototoxicity for H. pustulata. Finally, a few words about the potential application of these photsensitizing compounds as antibacterial agents will be given.Fil: Comini, Laura Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Núñez Montoya, Susana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Argüello, Gustavo A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Cabrera, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaResearch Trends2010-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/71665Comini, Laura Raquel; Núñez Montoya, Susana Carolina; Argüello, Gustavo A.; Cabrera, Jose Luis; Photophysical, photochemical and photobiological properties of anthraquinones isolated from a phototoxic vegetal species: Heterophyllaea pustulata; Research Trends; Trends in photochemistry and Photobiology; 12; 2-2010; 17-360972-4532CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.researchtrends.net/tia/title_issue.asp?id=15&in=0&vn=12&type=3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:03Zoai:ri.conicet.gov.ar:11336/71665instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:04.039CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Photophysical, photochemical and photobiological properties of anthraquinones isolated from a phototoxic vegetal species: Heterophyllaea pustulata
title Photophysical, photochemical and photobiological properties of anthraquinones isolated from a phototoxic vegetal species: Heterophyllaea pustulata
spellingShingle Photophysical, photochemical and photobiological properties of anthraquinones isolated from a phototoxic vegetal species: Heterophyllaea pustulata
Comini, Laura Raquel
Photosensitizers
Reactive Oxygen Species
Anthraquinones
title_short Photophysical, photochemical and photobiological properties of anthraquinones isolated from a phototoxic vegetal species: Heterophyllaea pustulata
title_full Photophysical, photochemical and photobiological properties of anthraquinones isolated from a phototoxic vegetal species: Heterophyllaea pustulata
title_fullStr Photophysical, photochemical and photobiological properties of anthraquinones isolated from a phototoxic vegetal species: Heterophyllaea pustulata
title_full_unstemmed Photophysical, photochemical and photobiological properties of anthraquinones isolated from a phototoxic vegetal species: Heterophyllaea pustulata
title_sort Photophysical, photochemical and photobiological properties of anthraquinones isolated from a phototoxic vegetal species: Heterophyllaea pustulata
dc.creator.none.fl_str_mv Comini, Laura Raquel
Núñez Montoya, Susana Carolina
Argüello, Gustavo A.
Cabrera, Jose Luis
author Comini, Laura Raquel
author_facet Comini, Laura Raquel
Núñez Montoya, Susana Carolina
Argüello, Gustavo A.
Cabrera, Jose Luis
author_role author
author2 Núñez Montoya, Susana Carolina
Argüello, Gustavo A.
Cabrera, Jose Luis
author2_role author
author
author
dc.subject.none.fl_str_mv Photosensitizers
Reactive Oxygen Species
Anthraquinones
topic Photosensitizers
Reactive Oxygen Species
Anthraquinones
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Studies undertaken on isolated photosensitizing agents from Heterophyllaea pustulata, a photo-toxic plant, which natural habitat is the North-western part of Argentina, are presented here. The carried out work involved several steps that were initiated with the chemical-structural study of their most important secondary metabolites. As a result, three flavonoids, one iridoid glycoside (asperuloside) and ten aglycone anthraquinones were identified. Through the study of the photo-physical, photochemical and photobiological properties of the anthraquinone derivatives, we concluded that they show good photosensitizing (type I and type II) characteristics. The performed toxicological assays in vivo showed a direct cause-effect relation between these metabolites and the reported phototoxicity for H. pustulata. Finally, a few words about the potential application of these photsensitizing compounds as antibacterial agents will be given.
Fil: Comini, Laura Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Núñez Montoya, Susana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Argüello, Gustavo A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Cabrera, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
description Studies undertaken on isolated photosensitizing agents from Heterophyllaea pustulata, a photo-toxic plant, which natural habitat is the North-western part of Argentina, are presented here. The carried out work involved several steps that were initiated with the chemical-structural study of their most important secondary metabolites. As a result, three flavonoids, one iridoid glycoside (asperuloside) and ten aglycone anthraquinones were identified. Through the study of the photo-physical, photochemical and photobiological properties of the anthraquinone derivatives, we concluded that they show good photosensitizing (type I and type II) characteristics. The performed toxicological assays in vivo showed a direct cause-effect relation between these metabolites and the reported phototoxicity for H. pustulata. Finally, a few words about the potential application of these photsensitizing compounds as antibacterial agents will be given.
publishDate 2010
dc.date.none.fl_str_mv 2010-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/71665
Comini, Laura Raquel; Núñez Montoya, Susana Carolina; Argüello, Gustavo A.; Cabrera, Jose Luis; Photophysical, photochemical and photobiological properties of anthraquinones isolated from a phototoxic vegetal species: Heterophyllaea pustulata; Research Trends; Trends in photochemistry and Photobiology; 12; 2-2010; 17-36
0972-4532
CONICET Digital
CONICET
url http://hdl.handle.net/11336/71665
identifier_str_mv Comini, Laura Raquel; Núñez Montoya, Susana Carolina; Argüello, Gustavo A.; Cabrera, Jose Luis; Photophysical, photochemical and photobiological properties of anthraquinones isolated from a phototoxic vegetal species: Heterophyllaea pustulata; Research Trends; Trends in photochemistry and Photobiology; 12; 2-2010; 17-36
0972-4532
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.researchtrends.net/tia/title_issue.asp?id=15&in=0&vn=12&type=3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Research Trends
publisher.none.fl_str_mv Research Trends
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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