Ultrasonic-assisted extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae) using ethanol-water mixtures

Autores
Barrera Vazquez, Maria Fernanda; Comini, Laura Raquel; Martini, Raquel Evangelina; Núñez Montoya, Susana Carolina; Bottini, Susana Beatriz; Cabrera, Jose Luis
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this study, ultrasound-assisted extraction (UAE) was evaluated as an easier and more efficient alternative method for the isolation of anthraquinones (AQs) from Heterophyllaea pustulata Hook f. (Rubiaceae), compared with conventional extraction techniques. The extraction was performed using an ethanol-water solution as solvent. The influence of different operating conditions, as temperature, time, solvent composition and solvent/sample ratio and its relationship with ultrasonic techniques was analyzed. For this purpose and to achieve global optimization of the ultrasound-assisted extraction of H. pustulata, Taguchi experimental design with a L9 orthogonal array was applied. The results showed that the yield obtained with the ultrasound assisted extraction is approximately twice higher than the traditional Soxhlet technique, and Taguchi analysis demonstrated that the most influential factor is solvent concentration, followed by time, temperature and solvent/sample ratio. The solvent composition effect is directly related to cavitation process, and the effect of solvent physical properties on it. The optimal combination of these factors on the ultrasound assisted extraction is a solvent composition 60% v/v of ethanol, a solvent/sample ratio equal to 20:1, a temperature of 55 ºC and an extraction time of 30 min.
Fil: Barrera Vazquez, Maria Fernanda. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Planta Piloto de Ingenieria Quimica (i). Grupo Vinculado Al Plapiqui - Investigación y Desarrollo en Tecnologia Quimica; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Comini, Laura Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Martini, Raquel Evangelina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Planta Piloto de Ingenieria Quimica (i). Grupo Vinculado Al Plapiqui - Investigación y Desarrollo en Tecnologia Quimica; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Núñez Montoya, Susana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Bottini, Susana Beatriz. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Planta Piloto de Ingenieria Quimica (i). Grupo Vinculado Al Plapiqui - Investigación y Desarrollo en Tecnologia Quimica; Argentina
Fil: Cabrera, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Materia
Ultrasound-Assisted Extraction
Anthraquinone
Optimization
Taguchi Experimental Desing
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15768
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Ultrasonic-assisted extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae) using ethanol-water mixturesBarrera Vazquez, Maria FernandaComini, Laura RaquelMartini, Raquel EvangelinaNúñez Montoya, Susana CarolinaBottini, Susana BeatrizCabrera, Jose LuisUltrasound-Assisted ExtractionAnthraquinoneOptimizationTaguchi Experimental Desinghttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2In this study, ultrasound-assisted extraction (UAE) was evaluated as an easier and more efficient alternative method for the isolation of anthraquinones (AQs) from Heterophyllaea pustulata Hook f. (Rubiaceae), compared with conventional extraction techniques. The extraction was performed using an ethanol-water solution as solvent. The influence of different operating conditions, as temperature, time, solvent composition and solvent/sample ratio and its relationship with ultrasonic techniques was analyzed. For this purpose and to achieve global optimization of the ultrasound-assisted extraction of H. pustulata, Taguchi experimental design with a L9 orthogonal array was applied. The results showed that the yield obtained with the ultrasound assisted extraction is approximately twice higher than the traditional Soxhlet technique, and Taguchi analysis demonstrated that the most influential factor is solvent concentration, followed by time, temperature and solvent/sample ratio. The solvent composition effect is directly related to cavitation process, and the effect of solvent physical properties on it. The optimal combination of these factors on the ultrasound assisted extraction is a solvent composition 60% v/v of ethanol, a solvent/sample ratio equal to 20:1, a temperature of 55 ºC and an extraction time of 30 min.Fil: Barrera Vazquez, Maria Fernanda. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Planta Piloto de Ingenieria Quimica (i). Grupo Vinculado Al Plapiqui - Investigación y Desarrollo en Tecnologia Quimica; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Comini, Laura Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Martini, Raquel Evangelina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Planta Piloto de Ingenieria Quimica (i). Grupo Vinculado Al Plapiqui - Investigación y Desarrollo en Tecnologia Quimica; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Núñez Montoya, Susana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Bottini, Susana Beatriz. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Planta Piloto de Ingenieria Quimica (i). Grupo Vinculado Al Plapiqui - Investigación y Desarrollo en Tecnologia Quimica; ArgentinaFil: Cabrera, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaElsevier Science2015-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15768Barrera Vazquez, Maria Fernanda; Comini, Laura Raquel; Martini, Raquel Evangelina; Núñez Montoya, Susana Carolina; Bottini, Susana Beatriz; et al.; Ultrasonic-assisted extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae) using ethanol-water mixtures; Elsevier Science; Industrial Crops And Products; 69; 2-2015; 278-2830926-6690enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0926669015000679info:eu-repo/semantics/altIdentifier/doi/10.1016/j.indcrop.2015.01.065info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:56Zoai:ri.conicet.gov.ar:11336/15768instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:57.832CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ultrasonic-assisted extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae) using ethanol-water mixtures
title Ultrasonic-assisted extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae) using ethanol-water mixtures
spellingShingle Ultrasonic-assisted extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae) using ethanol-water mixtures
Barrera Vazquez, Maria Fernanda
Ultrasound-Assisted Extraction
Anthraquinone
Optimization
Taguchi Experimental Desing
title_short Ultrasonic-assisted extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae) using ethanol-water mixtures
title_full Ultrasonic-assisted extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae) using ethanol-water mixtures
title_fullStr Ultrasonic-assisted extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae) using ethanol-water mixtures
title_full_unstemmed Ultrasonic-assisted extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae) using ethanol-water mixtures
title_sort Ultrasonic-assisted extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae) using ethanol-water mixtures
dc.creator.none.fl_str_mv Barrera Vazquez, Maria Fernanda
Comini, Laura Raquel
Martini, Raquel Evangelina
Núñez Montoya, Susana Carolina
Bottini, Susana Beatriz
Cabrera, Jose Luis
author Barrera Vazquez, Maria Fernanda
author_facet Barrera Vazquez, Maria Fernanda
Comini, Laura Raquel
Martini, Raquel Evangelina
Núñez Montoya, Susana Carolina
Bottini, Susana Beatriz
Cabrera, Jose Luis
author_role author
author2 Comini, Laura Raquel
Martini, Raquel Evangelina
Núñez Montoya, Susana Carolina
Bottini, Susana Beatriz
Cabrera, Jose Luis
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ultrasound-Assisted Extraction
Anthraquinone
Optimization
Taguchi Experimental Desing
topic Ultrasound-Assisted Extraction
Anthraquinone
Optimization
Taguchi Experimental Desing
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv In this study, ultrasound-assisted extraction (UAE) was evaluated as an easier and more efficient alternative method for the isolation of anthraquinones (AQs) from Heterophyllaea pustulata Hook f. (Rubiaceae), compared with conventional extraction techniques. The extraction was performed using an ethanol-water solution as solvent. The influence of different operating conditions, as temperature, time, solvent composition and solvent/sample ratio and its relationship with ultrasonic techniques was analyzed. For this purpose and to achieve global optimization of the ultrasound-assisted extraction of H. pustulata, Taguchi experimental design with a L9 orthogonal array was applied. The results showed that the yield obtained with the ultrasound assisted extraction is approximately twice higher than the traditional Soxhlet technique, and Taguchi analysis demonstrated that the most influential factor is solvent concentration, followed by time, temperature and solvent/sample ratio. The solvent composition effect is directly related to cavitation process, and the effect of solvent physical properties on it. The optimal combination of these factors on the ultrasound assisted extraction is a solvent composition 60% v/v of ethanol, a solvent/sample ratio equal to 20:1, a temperature of 55 ºC and an extraction time of 30 min.
Fil: Barrera Vazquez, Maria Fernanda. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Planta Piloto de Ingenieria Quimica (i). Grupo Vinculado Al Plapiqui - Investigación y Desarrollo en Tecnologia Quimica; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Comini, Laura Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Martini, Raquel Evangelina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Planta Piloto de Ingenieria Quimica (i). Grupo Vinculado Al Plapiqui - Investigación y Desarrollo en Tecnologia Quimica; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Núñez Montoya, Susana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Bottini, Susana Beatriz. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Planta Piloto de Ingenieria Quimica (i). Grupo Vinculado Al Plapiqui - Investigación y Desarrollo en Tecnologia Quimica; Argentina
Fil: Cabrera, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
description In this study, ultrasound-assisted extraction (UAE) was evaluated as an easier and more efficient alternative method for the isolation of anthraquinones (AQs) from Heterophyllaea pustulata Hook f. (Rubiaceae), compared with conventional extraction techniques. The extraction was performed using an ethanol-water solution as solvent. The influence of different operating conditions, as temperature, time, solvent composition and solvent/sample ratio and its relationship with ultrasonic techniques was analyzed. For this purpose and to achieve global optimization of the ultrasound-assisted extraction of H. pustulata, Taguchi experimental design with a L9 orthogonal array was applied. The results showed that the yield obtained with the ultrasound assisted extraction is approximately twice higher than the traditional Soxhlet technique, and Taguchi analysis demonstrated that the most influential factor is solvent concentration, followed by time, temperature and solvent/sample ratio. The solvent composition effect is directly related to cavitation process, and the effect of solvent physical properties on it. The optimal combination of these factors on the ultrasound assisted extraction is a solvent composition 60% v/v of ethanol, a solvent/sample ratio equal to 20:1, a temperature of 55 ºC and an extraction time of 30 min.
publishDate 2015
dc.date.none.fl_str_mv 2015-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15768
Barrera Vazquez, Maria Fernanda; Comini, Laura Raquel; Martini, Raquel Evangelina; Núñez Montoya, Susana Carolina; Bottini, Susana Beatriz; et al.; Ultrasonic-assisted extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae) using ethanol-water mixtures; Elsevier Science; Industrial Crops And Products; 69; 2-2015; 278-283
0926-6690
url http://hdl.handle.net/11336/15768
identifier_str_mv Barrera Vazquez, Maria Fernanda; Comini, Laura Raquel; Martini, Raquel Evangelina; Núñez Montoya, Susana Carolina; Bottini, Susana Beatriz; et al.; Ultrasonic-assisted extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae) using ethanol-water mixtures; Elsevier Science; Industrial Crops And Products; 69; 2-2015; 278-283
0926-6690
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0926669015000679
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.indcrop.2015.01.065
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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