Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review
- Autores
- Pinazo, Maria Jesús; Thomas Carazo, María del Carmen; Bua, Jacqueline Elena; Perrone, Alina Elizabeth; Schijman, Alejandro Gabriel; Viotti, Rodolfo Jorge; Ramsey, Janine; Ribeiro, Isabela; Sosa-estani, Sergio Alejandro; López, Manuel Carlos; Gascon, Joaquim
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The most neglected aspects of Chagas disease (CD) have been patient care and treatment. Despite recent progress in the development of potentially improved drugs, there is no consensus among different research groups on the lack of therapeutic response markers to evaluate efficacy of newly proposed drugs early after treatment. A systematic review of current evidence regarding molecules which are potential biomarkers for therapeutic response has been conducted using quality assessment and target responses as primary criteria. The review provides a panorama of the cumulative evidence and specific needs for development of a battery of complementary biomarkers which together fulfill ideal or acceptable criteria to evaluate early responses to treatment for chronic CD. There are several marker candidates which together may fulfill acceptable criteria to indicate the efficacy of a trypanocidal treatment. Data from ongoing studies are considered essential to improve assessment of existing markers and to identify those for early follow-up of treated patients.
Fil: Pinazo, Maria Jesús. Universidad de Barcelona; España
Fil: Thomas Carazo, María del Carmen. Consejo Superior de Investigaciones Científicas; España
Fil: Bua, Jacqueline Elena. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Perrone, Alina Elizabeth. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Viotti, Rodolfo Jorge. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Ramsey, Janine. Instituto Nacional de Salud Pública. Centro Regional de Investigación en Salud Pública; México
Fil: Ribeiro, Isabela. Drugs for Neglected Diseases Initiative; Suiza
Fil: Sosa-estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: López, Manuel Carlos. Consejo Superior de Investigaciones Científicas; España
Fil: Gascon, Joaquim. Universidad de Barcelona; España - Materia
-
Biological Marker
Biomarker
Chagas Disease
Cure Marker
Humoral And Cellular Immune Response
Pcr
Treatment
Trypanosoma Cruzi - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/33330
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
spelling |
Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic reviewPinazo, Maria JesúsThomas Carazo, María del CarmenBua, Jacqueline ElenaPerrone, Alina ElizabethSchijman, Alejandro GabrielViotti, Rodolfo JorgeRamsey, JanineRibeiro, IsabelaSosa-estani, Sergio AlejandroLópez, Manuel CarlosGascon, JoaquimBiological MarkerBiomarkerChagas DiseaseCure MarkerHumoral And Cellular Immune ResponsePcrTreatmentTrypanosoma Cruzihttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The most neglected aspects of Chagas disease (CD) have been patient care and treatment. Despite recent progress in the development of potentially improved drugs, there is no consensus among different research groups on the lack of therapeutic response markers to evaluate efficacy of newly proposed drugs early after treatment. A systematic review of current evidence regarding molecules which are potential biomarkers for therapeutic response has been conducted using quality assessment and target responses as primary criteria. The review provides a panorama of the cumulative evidence and specific needs for development of a battery of complementary biomarkers which together fulfill ideal or acceptable criteria to evaluate early responses to treatment for chronic CD. There are several marker candidates which together may fulfill acceptable criteria to indicate the efficacy of a trypanocidal treatment. Data from ongoing studies are considered essential to improve assessment of existing markers and to identify those for early follow-up of treated patients.Fil: Pinazo, Maria Jesús. Universidad de Barcelona; EspañaFil: Thomas Carazo, María del Carmen. Consejo Superior de Investigaciones Científicas; EspañaFil: Bua, Jacqueline Elena. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Perrone, Alina Elizabeth. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Viotti, Rodolfo Jorge. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Ramsey, Janine. Instituto Nacional de Salud Pública. Centro Regional de Investigación en Salud Pública; MéxicoFil: Ribeiro, Isabela. Drugs for Neglected Diseases Initiative; SuizaFil: Sosa-estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: López, Manuel Carlos. Consejo Superior de Investigaciones Científicas; EspañaFil: Gascon, Joaquim. Universidad de Barcelona; EspañaTaylor & Francis2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/33330Pinazo, Maria Jesús; Thomas Carazo, María del Carmen; Bua, Jacqueline Elena; Perrone, Alina Elizabeth; Schijman, Alejandro Gabriel; et al.; Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review; Taylor & Francis; Expert Review of Anti-infective Therapy; 12; 4; 3-2014; 479-4961478-7210CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1586/14787210.2014.899150info:eu-repo/semantics/altIdentifier/doi/10.1586/14787210.2014.899150info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:35:28Zoai:ri.conicet.gov.ar:11336/33330instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:35:28.614CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review |
title |
Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review |
spellingShingle |
Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review Pinazo, Maria Jesús Biological Marker Biomarker Chagas Disease Cure Marker Humoral And Cellular Immune Response Pcr Treatment Trypanosoma Cruzi |
title_short |
Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review |
title_full |
Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review |
title_fullStr |
Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review |
title_full_unstemmed |
Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review |
title_sort |
Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review |
dc.creator.none.fl_str_mv |
Pinazo, Maria Jesús Thomas Carazo, María del Carmen Bua, Jacqueline Elena Perrone, Alina Elizabeth Schijman, Alejandro Gabriel Viotti, Rodolfo Jorge Ramsey, Janine Ribeiro, Isabela Sosa-estani, Sergio Alejandro López, Manuel Carlos Gascon, Joaquim |
author |
Pinazo, Maria Jesús |
author_facet |
Pinazo, Maria Jesús Thomas Carazo, María del Carmen Bua, Jacqueline Elena Perrone, Alina Elizabeth Schijman, Alejandro Gabriel Viotti, Rodolfo Jorge Ramsey, Janine Ribeiro, Isabela Sosa-estani, Sergio Alejandro López, Manuel Carlos Gascon, Joaquim |
author_role |
author |
author2 |
Thomas Carazo, María del Carmen Bua, Jacqueline Elena Perrone, Alina Elizabeth Schijman, Alejandro Gabriel Viotti, Rodolfo Jorge Ramsey, Janine Ribeiro, Isabela Sosa-estani, Sergio Alejandro López, Manuel Carlos Gascon, Joaquim |
author2_role |
author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Biological Marker Biomarker Chagas Disease Cure Marker Humoral And Cellular Immune Response Pcr Treatment Trypanosoma Cruzi |
topic |
Biological Marker Biomarker Chagas Disease Cure Marker Humoral And Cellular Immune Response Pcr Treatment Trypanosoma Cruzi |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The most neglected aspects of Chagas disease (CD) have been patient care and treatment. Despite recent progress in the development of potentially improved drugs, there is no consensus among different research groups on the lack of therapeutic response markers to evaluate efficacy of newly proposed drugs early after treatment. A systematic review of current evidence regarding molecules which are potential biomarkers for therapeutic response has been conducted using quality assessment and target responses as primary criteria. The review provides a panorama of the cumulative evidence and specific needs for development of a battery of complementary biomarkers which together fulfill ideal or acceptable criteria to evaluate early responses to treatment for chronic CD. There are several marker candidates which together may fulfill acceptable criteria to indicate the efficacy of a trypanocidal treatment. Data from ongoing studies are considered essential to improve assessment of existing markers and to identify those for early follow-up of treated patients. Fil: Pinazo, Maria Jesús. Universidad de Barcelona; España Fil: Thomas Carazo, María del Carmen. Consejo Superior de Investigaciones Científicas; España Fil: Bua, Jacqueline Elena. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Perrone, Alina Elizabeth. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Viotti, Rodolfo Jorge. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina Fil: Ramsey, Janine. Instituto Nacional de Salud Pública. Centro Regional de Investigación en Salud Pública; México Fil: Ribeiro, Isabela. Drugs for Neglected Diseases Initiative; Suiza Fil: Sosa-estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: López, Manuel Carlos. Consejo Superior de Investigaciones Científicas; España Fil: Gascon, Joaquim. Universidad de Barcelona; España |
description |
The most neglected aspects of Chagas disease (CD) have been patient care and treatment. Despite recent progress in the development of potentially improved drugs, there is no consensus among different research groups on the lack of therapeutic response markers to evaluate efficacy of newly proposed drugs early after treatment. A systematic review of current evidence regarding molecules which are potential biomarkers for therapeutic response has been conducted using quality assessment and target responses as primary criteria. The review provides a panorama of the cumulative evidence and specific needs for development of a battery of complementary biomarkers which together fulfill ideal or acceptable criteria to evaluate early responses to treatment for chronic CD. There are several marker candidates which together may fulfill acceptable criteria to indicate the efficacy of a trypanocidal treatment. Data from ongoing studies are considered essential to improve assessment of existing markers and to identify those for early follow-up of treated patients. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/33330 Pinazo, Maria Jesús; Thomas Carazo, María del Carmen; Bua, Jacqueline Elena; Perrone, Alina Elizabeth; Schijman, Alejandro Gabriel; et al.; Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review; Taylor & Francis; Expert Review of Anti-infective Therapy; 12; 4; 3-2014; 479-496 1478-7210 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/33330 |
identifier_str_mv |
Pinazo, Maria Jesús; Thomas Carazo, María del Carmen; Bua, Jacqueline Elena; Perrone, Alina Elizabeth; Schijman, Alejandro Gabriel; et al.; Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review; Taylor & Francis; Expert Review of Anti-infective Therapy; 12; 4; 3-2014; 479-496 1478-7210 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1586/14787210.2014.899150 info:eu-repo/semantics/altIdentifier/doi/10.1586/14787210.2014.899150 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Taylor & Francis |
publisher.none.fl_str_mv |
Taylor & Francis |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613105296867328 |
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13.070432 |