Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review

Autores
Pinazo, Maria Jesús; Thomas Carazo, María del Carmen; Bua, Jacqueline Elena; Perrone, Alina Elizabeth; Schijman, Alejandro Gabriel; Viotti, Rodolfo Jorge; Ramsey, Janine; Ribeiro, Isabela; Sosa-estani, Sergio Alejandro; López, Manuel Carlos; Gascon, Joaquim
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The most neglected aspects of Chagas disease (CD) have been patient care and treatment. Despite recent progress in the development of potentially improved drugs, there is no consensus among different research groups on the lack of therapeutic response markers to evaluate efficacy of newly proposed drugs early after treatment. A systematic review of current evidence regarding molecules which are potential biomarkers for therapeutic response has been conducted using quality assessment and target responses as primary criteria. The review provides a panorama of the cumulative evidence and specific needs for development of a battery of complementary biomarkers which together fulfill ideal or acceptable criteria to evaluate early responses to treatment for chronic CD. There are several marker candidates which together may fulfill acceptable criteria to indicate the efficacy of a trypanocidal treatment. Data from ongoing studies are considered essential to improve assessment of existing markers and to identify those for early follow-up of treated patients.
Fil: Pinazo, Maria Jesús. Universidad de Barcelona; España
Fil: Thomas Carazo, María del Carmen. Consejo Superior de Investigaciones Científicas; España
Fil: Bua, Jacqueline Elena. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Perrone, Alina Elizabeth. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Viotti, Rodolfo Jorge. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Ramsey, Janine. Instituto Nacional de Salud Pública. Centro Regional de Investigación en Salud Pública; México
Fil: Ribeiro, Isabela. Drugs for Neglected Diseases Initiative; Suiza
Fil: Sosa-estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: López, Manuel Carlos. Consejo Superior de Investigaciones Científicas; España
Fil: Gascon, Joaquim. Universidad de Barcelona; España
Materia
Biological Marker
Biomarker
Chagas Disease
Cure Marker
Humoral And Cellular Immune Response
Pcr
Treatment
Trypanosoma Cruzi
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/33330
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/33330
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic reviewPinazo, Maria JesúsThomas Carazo, María del CarmenBua, Jacqueline ElenaPerrone, Alina ElizabethSchijman, Alejandro GabrielViotti, Rodolfo JorgeRamsey, JanineRibeiro, IsabelaSosa-estani, Sergio AlejandroLópez, Manuel CarlosGascon, JoaquimBiological MarkerBiomarkerChagas DiseaseCure MarkerHumoral And Cellular Immune ResponsePcrTreatmentTrypanosoma Cruzihttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The most neglected aspects of Chagas disease (CD) have been patient care and treatment. Despite recent progress in the development of potentially improved drugs, there is no consensus among different research groups on the lack of therapeutic response markers to evaluate efficacy of newly proposed drugs early after treatment. A systematic review of current evidence regarding molecules which are potential biomarkers for therapeutic response has been conducted using quality assessment and target responses as primary criteria. The review provides a panorama of the cumulative evidence and specific needs for development of a battery of complementary biomarkers which together fulfill ideal or acceptable criteria to evaluate early responses to treatment for chronic CD. There are several marker candidates which together may fulfill acceptable criteria to indicate the efficacy of a trypanocidal treatment. Data from ongoing studies are considered essential to improve assessment of existing markers and to identify those for early follow-up of treated patients.Fil: Pinazo, Maria Jesús. Universidad de Barcelona; EspañaFil: Thomas Carazo, María del Carmen. Consejo Superior de Investigaciones Científicas; EspañaFil: Bua, Jacqueline Elena. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Perrone, Alina Elizabeth. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Viotti, Rodolfo Jorge. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Ramsey, Janine. Instituto Nacional de Salud Pública. Centro Regional de Investigación en Salud Pública; MéxicoFil: Ribeiro, Isabela. Drugs for Neglected Diseases Initiative; SuizaFil: Sosa-estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: López, Manuel Carlos. Consejo Superior de Investigaciones Científicas; EspañaFil: Gascon, Joaquim. Universidad de Barcelona; EspañaTaylor & Francis2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/33330Pinazo, Maria Jesús; Thomas Carazo, María del Carmen; Bua, Jacqueline Elena; Perrone, Alina Elizabeth; Schijman, Alejandro Gabriel; et al.; Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review; Taylor & Francis; Expert Review of Anti-infective Therapy; 12; 4; 3-2014; 479-4961478-7210CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1586/14787210.2014.899150info:eu-repo/semantics/altIdentifier/doi/10.1586/14787210.2014.899150info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:03:31Zoai:ri.conicet.gov.ar:11336/33330instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:03:31.905CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review
title Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review
spellingShingle Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review
Pinazo, Maria Jesús
Biological Marker
Biomarker
Chagas Disease
Cure Marker
Humoral And Cellular Immune Response
Pcr
Treatment
Trypanosoma Cruzi
title_short Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review
title_full Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review
title_fullStr Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review
title_full_unstemmed Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review
title_sort Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review
dc.creator.none.fl_str_mv Pinazo, Maria Jesús
Thomas Carazo, María del Carmen
Bua, Jacqueline Elena
Perrone, Alina Elizabeth
Schijman, Alejandro Gabriel
Viotti, Rodolfo Jorge
Ramsey, Janine
Ribeiro, Isabela
Sosa-estani, Sergio Alejandro
López, Manuel Carlos
Gascon, Joaquim
author Pinazo, Maria Jesús
author_facet Pinazo, Maria Jesús
Thomas Carazo, María del Carmen
Bua, Jacqueline Elena
Perrone, Alina Elizabeth
Schijman, Alejandro Gabriel
Viotti, Rodolfo Jorge
Ramsey, Janine
Ribeiro, Isabela
Sosa-estani, Sergio Alejandro
López, Manuel Carlos
Gascon, Joaquim
author_role author
author2 Thomas Carazo, María del Carmen
Bua, Jacqueline Elena
Perrone, Alina Elizabeth
Schijman, Alejandro Gabriel
Viotti, Rodolfo Jorge
Ramsey, Janine
Ribeiro, Isabela
Sosa-estani, Sergio Alejandro
López, Manuel Carlos
Gascon, Joaquim
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Biological Marker
Biomarker
Chagas Disease
Cure Marker
Humoral And Cellular Immune Response
Pcr
Treatment
Trypanosoma Cruzi
topic Biological Marker
Biomarker
Chagas Disease
Cure Marker
Humoral And Cellular Immune Response
Pcr
Treatment
Trypanosoma Cruzi
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The most neglected aspects of Chagas disease (CD) have been patient care and treatment. Despite recent progress in the development of potentially improved drugs, there is no consensus among different research groups on the lack of therapeutic response markers to evaluate efficacy of newly proposed drugs early after treatment. A systematic review of current evidence regarding molecules which are potential biomarkers for therapeutic response has been conducted using quality assessment and target responses as primary criteria. The review provides a panorama of the cumulative evidence and specific needs for development of a battery of complementary biomarkers which together fulfill ideal or acceptable criteria to evaluate early responses to treatment for chronic CD. There are several marker candidates which together may fulfill acceptable criteria to indicate the efficacy of a trypanocidal treatment. Data from ongoing studies are considered essential to improve assessment of existing markers and to identify those for early follow-up of treated patients.
Fil: Pinazo, Maria Jesús. Universidad de Barcelona; España
Fil: Thomas Carazo, María del Carmen. Consejo Superior de Investigaciones Científicas; España
Fil: Bua, Jacqueline Elena. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Perrone, Alina Elizabeth. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Viotti, Rodolfo Jorge. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Ramsey, Janine. Instituto Nacional de Salud Pública. Centro Regional de Investigación en Salud Pública; México
Fil: Ribeiro, Isabela. Drugs for Neglected Diseases Initiative; Suiza
Fil: Sosa-estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: López, Manuel Carlos. Consejo Superior de Investigaciones Científicas; España
Fil: Gascon, Joaquim. Universidad de Barcelona; España
description The most neglected aspects of Chagas disease (CD) have been patient care and treatment. Despite recent progress in the development of potentially improved drugs, there is no consensus among different research groups on the lack of therapeutic response markers to evaluate efficacy of newly proposed drugs early after treatment. A systematic review of current evidence regarding molecules which are potential biomarkers for therapeutic response has been conducted using quality assessment and target responses as primary criteria. The review provides a panorama of the cumulative evidence and specific needs for development of a battery of complementary biomarkers which together fulfill ideal or acceptable criteria to evaluate early responses to treatment for chronic CD. There are several marker candidates which together may fulfill acceptable criteria to indicate the efficacy of a trypanocidal treatment. Data from ongoing studies are considered essential to improve assessment of existing markers and to identify those for early follow-up of treated patients.
publishDate 2014
dc.date.none.fl_str_mv 2014-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/33330
Pinazo, Maria Jesús; Thomas Carazo, María del Carmen; Bua, Jacqueline Elena; Perrone, Alina Elizabeth; Schijman, Alejandro Gabriel; et al.; Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review; Taylor & Francis; Expert Review of Anti-infective Therapy; 12; 4; 3-2014; 479-496
1478-7210
CONICET Digital
CONICET
url http://hdl.handle.net/11336/33330
identifier_str_mv Pinazo, Maria Jesús; Thomas Carazo, María del Carmen; Bua, Jacqueline Elena; Perrone, Alina Elizabeth; Schijman, Alejandro Gabriel; et al.; Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review; Taylor & Francis; Expert Review of Anti-infective Therapy; 12; 4; 3-2014; 479-496
1478-7210
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1586/14787210.2014.899150
info:eu-repo/semantics/altIdentifier/doi/10.1586/14787210.2014.899150
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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